Beads on a string Bowater Biochem Soc Trans 2012
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
... for the interaction of ISW1 on a unit of two nucleosome particles and showed how ISW1 could set the spacing between adjacent nucleosomes. The data from the Richmond laboratory provide support for ATP-dependent remodelling factors as the important driver of nucleosome positioning. The location of nuc ...
Challenging the dogma: the hidden layer of non-protein
... regulation controlled by RNA, including chromatin architecture, transcription and alternative splicing. These matters go to the heart of understanding how the trajectories of differentiation and development may be controlled, and are linked to three assertions: (1) that the majority of the genomic s ...
... regulation controlled by RNA, including chromatin architecture, transcription and alternative splicing. These matters go to the heart of understanding how the trajectories of differentiation and development may be controlled, and are linked to three assertions: (1) that the majority of the genomic s ...
genetic control of the malaria mosquito using gene
... gene drive technology has been significantly boosted by the rise of CRISPR/Cas9 (but is not identical to it) gene drive can be used to suppress mosquito populations or to render them unable to transmit disease proof of principle implementations for both approaches have been demonstrated not a silver ...
... gene drive technology has been significantly boosted by the rise of CRISPR/Cas9 (but is not identical to it) gene drive can be used to suppress mosquito populations or to render them unable to transmit disease proof of principle implementations for both approaches have been demonstrated not a silver ...
The Pax and large Maf families of genes in mammalian eye development Vertebrate eye development is dependent on the coordinated action of thousands of genes. A specific group of over one hundred of regulatory genes is both responsible for ocular cell
... Specific roles of the Pax genes in the development of various organs including the brain, eye, inner ear, kidney, pancreas and thyroid are determined by the genetic networks operating both downstream and upstream from the particular Pax gene. Genetic studies of muscle, pituitary and retinal devel ...
... Specific roles of the Pax genes in the development of various organs including the brain, eye, inner ear, kidney, pancreas and thyroid are determined by the genetic networks operating both downstream and upstream from the particular Pax gene. Genetic studies of muscle, pituitary and retinal devel ...
Probing Lymphocyte Biology by Genomic-Scale Gene Expression Analysis.
... were found to be maximally repressed at 3 and 6 hr following activation and then return to near-resting levels after 24 hr. This suggests that a window of time exists early during T cell activation in which the trafficking of the cell is inhibited. A second repressed gene that may illuminate T cell ...
... were found to be maximally repressed at 3 and 6 hr following activation and then return to near-resting levels after 24 hr. This suggests that a window of time exists early during T cell activation in which the trafficking of the cell is inhibited. A second repressed gene that may illuminate T cell ...
Gene-Engineered Models for Genetic Manipulation and Functional
... switch" should be reversible and specific for the targeted gene, and should not interfere with other cellular components or with general metabolism.(17) The development of tissue-specific conditional mutations could allow the mutation to be inserted into specific cell types, and moreover allow induc ...
... switch" should be reversible and specific for the targeted gene, and should not interfere with other cellular components or with general metabolism.(17) The development of tissue-specific conditional mutations could allow the mutation to be inserted into specific cell types, and moreover allow induc ...
Hippocampal Formation
... subiculum, presubiculum, parasubiculum, and entorhinal cortex. In other nomenclatures the entorhinal cortex, presubiculum, and parasubiculum are separated from the hippocampal formation and are gathered under the term ‘parahippocampal region.’ When the term ‘hippocampus’ is used it often refers to t ...
... subiculum, presubiculum, parasubiculum, and entorhinal cortex. In other nomenclatures the entorhinal cortex, presubiculum, and parasubiculum are separated from the hippocampal formation and are gathered under the term ‘parahippocampal region.’ When the term ‘hippocampus’ is used it often refers to t ...
Supporting Information Legends Figure S1. Characterization of the
... cpk5 cpk6 cpk11 14-day-old seedlings were treated for 30 min with water, OGs or flg22 and the accumulation of extracellular hydrogen peroxide in the incubation medium was determined by a xylenol orange based assay. Results are means of three independent experiments (± SE; n = 40 in each experiment). ...
... cpk5 cpk6 cpk11 14-day-old seedlings were treated for 30 min with water, OGs or flg22 and the accumulation of extracellular hydrogen peroxide in the incubation medium was determined by a xylenol orange based assay. Results are means of three independent experiments (± SE; n = 40 in each experiment). ...
On the energy and material cost of gene duplication
... ribosomes, rendering them unavailable for expressing other genes at appropriate levels. Experimental approaches like these are powerful, because they can directly demonstrate the effects of gene expression on cell growth. However, they can detect the expression costs of only the most highly expresse ...
... ribosomes, rendering them unavailable for expressing other genes at appropriate levels. Experimental approaches like these are powerful, because they can directly demonstrate the effects of gene expression on cell growth. However, they can detect the expression costs of only the most highly expresse ...
Plant Gravitational and Space Genomics Tour
... We have carried out microarray analysis of Arabidopsis root tips after gravistimulation (reorientation) and mechanical stress and monitored transcript levels ca. 24,000 genes during the first hour after either stimuli. We identified genes responding to either stimulus specifically as well as genes s ...
... We have carried out microarray analysis of Arabidopsis root tips after gravistimulation (reorientation) and mechanical stress and monitored transcript levels ca. 24,000 genes during the first hour after either stimuli. We identified genes responding to either stimulus specifically as well as genes s ...
Cancer Prone Disease Section Beckwith-Wiedemann syndrome Atlas of Genetics and Cytogenetics
... tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation; mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumour suppressor candidate; in BWS however, no evidence for tumour association wa ...
... tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation; mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumour suppressor candidate; in BWS however, no evidence for tumour association wa ...
Modifiers of epigenetic reprogramming show paternal effects in the mouse
... Studies in D. melanogaster have also shown that epigenetic modifiers function in a dynamic equilibrium, as silencing events are sensitive to fluctuations in their cellular concentration6. In D. melanogaster, the heterochromatic Y chromosome acts as a sink for proteins associated with gene silencing7 ...
... Studies in D. melanogaster have also shown that epigenetic modifiers function in a dynamic equilibrium, as silencing events are sensitive to fluctuations in their cellular concentration6. In D. melanogaster, the heterochromatic Y chromosome acts as a sink for proteins associated with gene silencing7 ...
Clustering Time-Series Gene Expression Data Using Smoothing
... rather than on the absolute level of expression. The shapes of the curves may provide meaningful information on coordinate gene regulation. ...
... rather than on the absolute level of expression. The shapes of the curves may provide meaningful information on coordinate gene regulation. ...
Gene expression in early and progression phases of autosomal
... Figure 1gene expression levels in Pkd1L3/L3 kidney compared to control Relative gene expression levels in Pkd1L3/L3 kidney compared to control. (A) Hierarchical clustering of Pkd1L3/L3/wildtype expression ratios for 4,231 genes differentially expressed in kidney at one or more ages between PNW 1 and ...
... Figure 1gene expression levels in Pkd1L3/L3 kidney compared to control Relative gene expression levels in Pkd1L3/L3 kidney compared to control. (A) Hierarchical clustering of Pkd1L3/L3/wildtype expression ratios for 4,231 genes differentially expressed in kidney at one or more ages between PNW 1 and ...
Sigma Xi, Montreal Nov 2004 - Biology Department | UNC Chapel Hill
... Differences in the chromosomal position of genes among individuals may affect the transcriptional regulation of those genes and thus contribute to phenotypic variation. However, we do not know how frequently such variations in gene location occur among individuals within populations. Additionally, w ...
... Differences in the chromosomal position of genes among individuals may affect the transcriptional regulation of those genes and thus contribute to phenotypic variation. However, we do not know how frequently such variations in gene location occur among individuals within populations. Additionally, w ...
Development and validation of a diagnostic service for epimutations
... LOMM at GNAS exon 1A. This epigenotype has been associated with maternally inherited microdeletions in STX16 gene. Sporadic PHP-1b Variable GNAS imprinting defects that may involve the upstream DMRs NESP55 & NESPAS, in addition to GNAS exon 1A. This epigenotype can result from: - maternally inherite ...
... LOMM at GNAS exon 1A. This epigenotype has been associated with maternally inherited microdeletions in STX16 gene. Sporadic PHP-1b Variable GNAS imprinting defects that may involve the upstream DMRs NESP55 & NESPAS, in addition to GNAS exon 1A. This epigenotype can result from: - maternally inherite ...
Classical Conditioning
... of time between presentations of the UCS/US – Combined with trace conditioning based on a period of time • i.e. dog starts to salivate at 7:59am because s/he is fed at 8am everyday ...
... of time between presentations of the UCS/US – Combined with trace conditioning based on a period of time • i.e. dog starts to salivate at 7:59am because s/he is fed at 8am everyday ...
A Yale geneticist and a Chinese lab are creating the Amazon.com of
... created a simple system for disabling genes—a sort of assembly line for mutant mice. properly, mice that have kidney disease, mice with neurological problems, mice that lack sex appeal— in hopes that researchers around the world can use those mice to better understand human development and disease. ...
... created a simple system for disabling genes—a sort of assembly line for mutant mice. properly, mice that have kidney disease, mice with neurological problems, mice that lack sex appeal— in hopes that researchers around the world can use those mice to better understand human development and disease. ...
Genetic and epigenetic processes in seed development Allan R
... Parent-of-origin effects such as these suggest the occurrence of genomic imprinting [43]. Usually, such effects are manifested early in development, and they can occur in both plants and animals. Epigenetic mechanisms such as DNA methylation or chromatin remodeling may be responsible for imprinting ...
... Parent-of-origin effects such as these suggest the occurrence of genomic imprinting [43]. Usually, such effects are manifested early in development, and they can occur in both plants and animals. Epigenetic mechanisms such as DNA methylation or chromatin remodeling may be responsible for imprinting ...
Prokaryotic Regulation of Transcription
... polycictronic, can have several genes involved in a metabolic pathway expressed together (coordinated expression) Control translation and degradation of protein product ...
... polycictronic, can have several genes involved in a metabolic pathway expressed together (coordinated expression) Control translation and degradation of protein product ...
DNA technology
... that is then taken up by a bacterial cell. 2. Gene markers are used to indemnify the bacteria with the healthy gene 3. The bacterial cells then multiply and so clone the plasmid with the gene 4. The plasmid is isolated from the bacteria and wrapped in a lipid soluble molecule forming a liposome 5. T ...
... that is then taken up by a bacterial cell. 2. Gene markers are used to indemnify the bacteria with the healthy gene 3. The bacterial cells then multiply and so clone the plasmid with the gene 4. The plasmid is isolated from the bacteria and wrapped in a lipid soluble molecule forming a liposome 5. T ...
Annotation of Drosophila virilis
... For many genes the locations of donor and acceptor sites will be easily identified based on the locations and quality of the alignments of the individual exons and how these regions compare with evidence of expression from RNA-seq. However when amino acid conservation is absent, other evidence must ...
... For many genes the locations of donor and acceptor sites will be easily identified based on the locations and quality of the alignments of the individual exons and how these regions compare with evidence of expression from RNA-seq. However when amino acid conservation is absent, other evidence must ...
Identification of porcine Lhx3 and SF1 as candidate genes for QTL
... primers (MARC6871/6872) were used to obtain higher quality ampli®cation for direct sequencing of PCR products. The nucleotide sequence of the amplicon produced, with polymorphic positions indicated in the submission via standard nomenclature, has been deposited in GenBank (accession number AF356175) ...
... primers (MARC6871/6872) were used to obtain higher quality ampli®cation for direct sequencing of PCR products. The nucleotide sequence of the amplicon produced, with polymorphic positions indicated in the submission via standard nomenclature, has been deposited in GenBank (accession number AF356175) ...
A mutation in the Zn-finger of the GAL4
... of which is involved in DNA binding (15,19). The L4C genes of K lactis LAC12 and LAC4, encoding lactose permease and f-galactosidase, respectively (20,21), each contain two LAC9 binding sites in their 5' non-coding region located between the divergently transcribed genes (18,22) our unpublished data ...
... of which is involved in DNA binding (15,19). The L4C genes of K lactis LAC12 and LAC4, encoding lactose permease and f-galactosidase, respectively (20,21), each contain two LAC9 binding sites in their 5' non-coding region located between the divergently transcribed genes (18,22) our unpublished data ...