Lin, R., C. D. Allis and S. J. Elledge. 1996. PAT1
... the silent mating site locus in yeast, suggesting that this domain might play a role in the formation of heterochromatin in vivo (Kayne et al. 1988). The N-terminal domain of histone H4 contains several highly conserved lysines that are differentially subjected to reversible acetylation. Acetylation ...
... the silent mating site locus in yeast, suggesting that this domain might play a role in the formation of heterochromatin in vivo (Kayne et al. 1988). The N-terminal domain of histone H4 contains several highly conserved lysines that are differentially subjected to reversible acetylation. Acetylation ...
PowerPoint Presentation - Antigenic variation in Trypanosoma brucei
... proteins is transcribed by the RNA polymerase Pol2 (this enzyme can be inhibited by the toxin a amanitin) Ribosomal RNA is generally transcribed by Pol1 (which is resistant to the toxin) VSG transcription is insensitive to aamanitin suggesting it is transcribed by the highly processive Pol I (ho ...
... proteins is transcribed by the RNA polymerase Pol2 (this enzyme can be inhibited by the toxin a amanitin) Ribosomal RNA is generally transcribed by Pol1 (which is resistant to the toxin) VSG transcription is insensitive to aamanitin suggesting it is transcribed by the highly processive Pol I (ho ...
Gene Set Enrichment Analysis
... 1. Open the project file that we have used for the other exercises. 2. Select the data set “Log(2) Quantile normalized intensity data” in the Project window 3. Open “Methods | Supervised Analysis | Gene Set Enrichment Analysis”. 4. You will now be asked if you want to collapse probes to genes. This ...
... 1. Open the project file that we have used for the other exercises. 2. Select the data set “Log(2) Quantile normalized intensity data” in the Project window 3. Open “Methods | Supervised Analysis | Gene Set Enrichment Analysis”. 4. You will now be asked if you want to collapse probes to genes. This ...
XIXth INTERNATIONAL CONFERENCE OF GENETIC DAYS, 5th …
... Microsatellite genotyping Statistical methods for accurate estimation of gene frequency from pooled samples. Problems in determination of gene frequency. Problems in interpreting pooling results by visual inspection. Application of Selective DNA pooling in farm animals. Advantages of Sel ...
... Microsatellite genotyping Statistical methods for accurate estimation of gene frequency from pooled samples. Problems in determination of gene frequency. Problems in interpreting pooling results by visual inspection. Application of Selective DNA pooling in farm animals. Advantages of Sel ...
Slide 1
... platforms identified more co-expressed gene pairs with common biological processes than expected by chance, and, as the Pearson correlation for a gene pair increased, it was more likely to be confirmed by GO. The Affymetrix dataset performed best, with gene pairs of correlation 0.9-1.0 confirmed by ...
... platforms identified more co-expressed gene pairs with common biological processes than expected by chance, and, as the Pearson correlation for a gene pair increased, it was more likely to be confirmed by GO. The Affymetrix dataset performed best, with gene pairs of correlation 0.9-1.0 confirmed by ...
Supplementary Information (docx 2885K)
... and missense mutation with Polyphen score ≧ 0.90 and/or SIFT p ≦ 0.05 and/orGrantham score ≧ 100 and/or phyloP score ≧ 2.013-16. ③MAF(Minor Allele Frequency)≦0.1%;The reason why we focus on ultra rare variants is that shaun et al17 have proved these kinds of variants may contribute more to schizophr ...
... and missense mutation with Polyphen score ≧ 0.90 and/or SIFT p ≦ 0.05 and/orGrantham score ≧ 100 and/or phyloP score ≧ 2.013-16. ③MAF(Minor Allele Frequency)≦0.1%;The reason why we focus on ultra rare variants is that shaun et al17 have proved these kinds of variants may contribute more to schizophr ...
Characterization of PIR1, a GATA family transcription factor involved
... previously described (Livak and Schmittgen, 2001). Levels of mRNA from the glyceraldehyde-3-phosphate dehydrogenase (gapdh) gene were used for normalization, as previously described (Canessa et al., 2008). Under the culture condition tested, no significant differences (p < 0.05) were observed for thi ...
... previously described (Livak and Schmittgen, 2001). Levels of mRNA from the glyceraldehyde-3-phosphate dehydrogenase (gapdh) gene were used for normalization, as previously described (Canessa et al., 2008). Under the culture condition tested, no significant differences (p < 0.05) were observed for thi ...
Meiotic DSBs and the control of mammalian recombination
... restricted to hotspots when PRDM9 is present, but that SPO11 defaults to other sites of trimethylation in its absence. Exceptionally, PRDM9 does not activate the obligatory genetic crossover in male meiosis that occurs at the boundary of the pseudo-autosomal region (PAR), the region that is shared b ...
... restricted to hotspots when PRDM9 is present, but that SPO11 defaults to other sites of trimethylation in its absence. Exceptionally, PRDM9 does not activate the obligatory genetic crossover in male meiosis that occurs at the boundary of the pseudo-autosomal region (PAR), the region that is shared b ...
Gene Expression Analysis
... Machine learning techniques such as neural networks are adequate for this type of analysis for their well-known pattern recognition and data organization capabilities [28,6]. Advanced neural learning algorithms have not only improved the accuracy, reliability and efficiency of many medical pattern r ...
... Machine learning techniques such as neural networks are adequate for this type of analysis for their well-known pattern recognition and data organization capabilities [28,6]. Advanced neural learning algorithms have not only improved the accuracy, reliability and efficiency of many medical pattern r ...
Nat. Struct. Biol. 8, 192-194.
... Much of the work on chromatin insulators has centered on the characterization of associated proteins with the goal of explaining how these sequences affect enhancer function, however, progress in the field has been hampered by the lack of understanding of how enhancers activate transcription. Enhanc ...
... Much of the work on chromatin insulators has centered on the characterization of associated proteins with the goal of explaining how these sequences affect enhancer function, however, progress in the field has been hampered by the lack of understanding of how enhancers activate transcription. Enhanc ...
Gene Regulatory Network Discovery from Time-Series - kedri
... 1 Introduction Gene regulatory network is one of the two main targets in biological systems because they are systems controlling the fundamental mechanisms that govern biological systems. A single gene interacts with many other genes in the cell, inhibiting or promoting directly or indirectly, the e ...
... 1 Introduction Gene regulatory network is one of the two main targets in biological systems because they are systems controlling the fundamental mechanisms that govern biological systems. A single gene interacts with many other genes in the cell, inhibiting or promoting directly or indirectly, the e ...
Looping versus linking: toward a model for long
... sities (Andersson et al. 1982; Bjorkroth et al. 1988; Ericsson et al. 1989). When elongating polymerases were far enough apart, the chromatin structure of the transcribed region quickly reverted to the 30-nm fiber. These observations strongly suggest that the basal structure of an active chromatin d ...
... sities (Andersson et al. 1982; Bjorkroth et al. 1988; Ericsson et al. 1989). When elongating polymerases were far enough apart, the chromatin structure of the transcribed region quickly reverted to the 30-nm fiber. These observations strongly suggest that the basal structure of an active chromatin d ...
Sequence Analysis of the y-Globin Gene Locus from
... (HPFH) is a benign condition in which fetal hemoglobin expression persists into adulthood at levels greater than 1% in the absence of erythropietic stress or thala~semia.’-~ Because this condition can be viewed as a failure to switch from fetal (HbF, a2y2)to adult (HbA, ad2)hemoglobin synthesis, it ...
... (HPFH) is a benign condition in which fetal hemoglobin expression persists into adulthood at levels greater than 1% in the absence of erythropietic stress or thala~semia.’-~ Because this condition can be viewed as a failure to switch from fetal (HbF, a2y2)to adult (HbA, ad2)hemoglobin synthesis, it ...
CorrelateTalk
... Cor(X’u, Y’v) is big • Sparse CCA seeks weights u, v such that Cor(X’u, Y’v) is big, and most of the weights ...
... Cor(X’u, Y’v) is big • Sparse CCA seeks weights u, v such that Cor(X’u, Y’v) is big, and most of the weights ...
Detecting phenotype-specific interactions between
... Number of predicted biological pairs with significant interaction change Scheme ...
... Number of predicted biological pairs with significant interaction change Scheme ...
Chapter 16 Other RNA Processing Events
... Not a trivial change. It is extremely important for the normal development and function of the nervous system. In mammals, it appears to be part of the way that the nervous system generates diversity and complexity (ADAR 3 unique to brain). ...
... Not a trivial change. It is extremely important for the normal development and function of the nervous system. In mammals, it appears to be part of the way that the nervous system generates diversity and complexity (ADAR 3 unique to brain). ...
The CpG island methylator phenotype (CIMP) in
... Such studies revealed that in colorectal cancer, there appears to be two types of methylation that are associated with cancer progression: type A (for age-related) methylation, and type C (for cancerspecific) methylation. Initially, type A methylation arises as a function of age in normal colorectal ...
... Such studies revealed that in colorectal cancer, there appears to be two types of methylation that are associated with cancer progression: type A (for age-related) methylation, and type C (for cancerspecific) methylation. Initially, type A methylation arises as a function of age in normal colorectal ...
An intron nucleotide sequence variant in a
... been transcribed jri vitro, but the 5' Eco RI fragment isolated by Spritz et al. is transcribed efficiently _in vitro (35). The latter fragment has identical 5'-flanking sequences to the gene described here. The homology extends from the Eco RI site at codons 120-121 to at least 155 nucleotides beyo ...
... been transcribed jri vitro, but the 5' Eco RI fragment isolated by Spritz et al. is transcribed efficiently _in vitro (35). The latter fragment has identical 5'-flanking sequences to the gene described here. The homology extends from the Eco RI site at codons 120-121 to at least 155 nucleotides beyo ...
Genomic imprinting and kinship in the social Hymenoptera: What
... modification during gametogenesis, which can silence or upregulate the respective gene copy and thereby lead to parent-specific gene expression in the offspring (reviewed in Burt and Trivers, 2006). Imprinted genes are often involved in regulating embryonic growth and development and, as predicted by ...
... modification during gametogenesis, which can silence or upregulate the respective gene copy and thereby lead to parent-specific gene expression in the offspring (reviewed in Burt and Trivers, 2006). Imprinted genes are often involved in regulating embryonic growth and development and, as predicted by ...
slides
... Water maze task is complex and requires animals to learn the general task requirement as well as the specific location of the hidden platform Spatial pretraining can separate the two kinds of learning Rats first made familiar with the general task requirements and subsequently trained after receivin ...
... Water maze task is complex and requires animals to learn the general task requirement as well as the specific location of the hidden platform Spatial pretraining can separate the two kinds of learning Rats first made familiar with the general task requirements and subsequently trained after receivin ...
Table 2
... (K vs K, K vs U, …, V vs R, …). To get more expressive view the 623 genes (KUROV) present in all five organs are not taken into account. Each Venn’s diagram shows two cercles which intersect. The area of the circles as well as the area of the intersection are proportional to the number of genes pres ...
... (K vs K, K vs U, …, V vs R, …). To get more expressive view the 623 genes (KUROV) present in all five organs are not taken into account. Each Venn’s diagram shows two cercles which intersect. The area of the circles as well as the area of the intersection are proportional to the number of genes pres ...
Differentially Expressed Genes in Blood from Young Pigs between
... of two Yorkshire lines of pigs divergently selected for feed efficiency (FE) based on residual feed intake (RFI). Genes involved in several biosynthetic processes were overrepresented among genes more highly expressed in the low RFI line compared to the high RFI line. Weighted gene co-expression net ...
... of two Yorkshire lines of pigs divergently selected for feed efficiency (FE) based on residual feed intake (RFI). Genes involved in several biosynthetic processes were overrepresented among genes more highly expressed in the low RFI line compared to the high RFI line. Weighted gene co-expression net ...
Beyond the ABCs: ternary complex formation in the control of
... the DEF–GLO heterodimer as bait in the mature flowers clearly visible. (b) A petunia inflorescence from a plant in which FBP2 is ternary factor trap to screen cDNA exprescosuppressed and that carries flowers of approximately the same age. The replacement of sion libraries have revealed that the peta ...
... the DEF–GLO heterodimer as bait in the mature flowers clearly visible. (b) A petunia inflorescence from a plant in which FBP2 is ternary factor trap to screen cDNA exprescosuppressed and that carries flowers of approximately the same age. The replacement of sion libraries have revealed that the peta ...
Document
... containing either sucrose (Suc) or quinine (Qui). c, Plasma ethanol concentration (milligrams per deciliter) either 1 or 3 hr after ethanol injection (4.0 gm/kg; i.p). ANOVAs indicated that RII / mice recovered from ethanol-induced sedation significantly sooner than RII +/+ mice. On the other hand, ...
... containing either sucrose (Suc) or quinine (Qui). c, Plasma ethanol concentration (milligrams per deciliter) either 1 or 3 hr after ethanol injection (4.0 gm/kg; i.p). ANOVAs indicated that RII / mice recovered from ethanol-induced sedation significantly sooner than RII +/+ mice. On the other hand, ...