Pair-rule genes
... • Bicoid encodes a transcription factor that includes a homeodomain; • Bicoid transcripts were concentrated in the cortical cytoplasm in the form of an anterior cap; • Bicoid mRNA is transported to the apical nuclear ...
... • Bicoid encodes a transcription factor that includes a homeodomain; • Bicoid transcripts were concentrated in the cortical cytoplasm in the form of an anterior cap; • Bicoid mRNA is transported to the apical nuclear ...
Simulation of Gene Splicing (Genetic Engineering
... was not nearly so great now as it had been when she was a little kid. In fact, Julie seemed pretty normal for a 10-yearold, Terry thought. Sure, she was a girl and sometimes a pest. But, overall, they got along and even shared some interests like soccer and music. The next Monday, while Julie was ge ...
... was not nearly so great now as it had been when she was a little kid. In fact, Julie seemed pretty normal for a 10-yearold, Terry thought. Sure, she was a girl and sometimes a pest. But, overall, they got along and even shared some interests like soccer and music. The next Monday, while Julie was ge ...
constans - Araport
... What happens if genes are expressed in the wrong place, or at the wrong time? When gene expression goes wrong, it’s kind of like saying the wrong thing at the wrong time. Awkward, right? ...
... What happens if genes are expressed in the wrong place, or at the wrong time? When gene expression goes wrong, it’s kind of like saying the wrong thing at the wrong time. Awkward, right? ...
The role of synaptic ion channels in synaptic
... The molecular mechanisms underlying the effects of nAChR on learning and memory are not fully understood. nAChR currents are likely to take part in postsynaptic calcium signalling either directly through their calcium component or indirectly by contributing to postsynaptic depolarization. Notably, u ...
... The molecular mechanisms underlying the effects of nAChR on learning and memory are not fully understood. nAChR currents are likely to take part in postsynaptic calcium signalling either directly through their calcium component or indirectly by contributing to postsynaptic depolarization. Notably, u ...
Microarray Image Data Analysis
... redundant features, e.g., a microarray can be represented as a pattern consisting of 13574 features corresponding to 13574 effected genes. The goal is to select a small subset of features for “Recognition” ...
... redundant features, e.g., a microarray can be represented as a pattern consisting of 13574 features corresponding to 13574 effected genes. The goal is to select a small subset of features for “Recognition” ...
Identification and Characterization of a Novel Human Testis
... fundamental mechanism for the direct or indirect control of all cellular processes. Considering the integral role that protein kinases play in the control of cellular mechanisms and signal transduction, it is not surprising that several protein kinases have been shown to be involved in spermatogenes ...
... fundamental mechanism for the direct or indirect control of all cellular processes. Considering the integral role that protein kinases play in the control of cellular mechanisms and signal transduction, it is not surprising that several protein kinases have been shown to be involved in spermatogenes ...
Package `GESTr`
... The TranSAM algorithm constructs balanced permutations of the input data and uses these to estimate the false-discovery rates of identifying genes as belonging to different expression states in the two specified sample groups. The balanced permutations are constructed so that an equal number of samp ...
... The TranSAM algorithm constructs balanced permutations of the input data and uses these to estimate the false-discovery rates of identifying genes as belonging to different expression states in the two specified sample groups. The balanced permutations are constructed so that an equal number of samp ...
A Molecular Profile of the Malignant Transformation of Plasma Cells
... We performed two-dimensional cluster analysis of the 74 MM cases alone. The sample dendrogram identified two major branches with two distinct subgroups within each branch (Figure 1E). We designated the four subgroups MM1, MM2, MM3, and MM4 containing 20, 21, 15, and 18 patients, respectively. The MM ...
... We performed two-dimensional cluster analysis of the 74 MM cases alone. The sample dendrogram identified two major branches with two distinct subgroups within each branch (Figure 1E). We designated the four subgroups MM1, MM2, MM3, and MM4 containing 20, 21, 15, and 18 patients, respectively. The MM ...
Ch 15 Clicker Question
... Histone de-acetylases (HDACs) are enzymes that remove acetyl groups from histone proteins. With regard to their effects on transcription, HDACs should do which of the following? A. B. C. D. ...
... Histone de-acetylases (HDACs) are enzymes that remove acetyl groups from histone proteins. With regard to their effects on transcription, HDACs should do which of the following? A. B. C. D. ...
The history of gene duplication Phylogenies are not just useful for
... When biologists began sequencing genomes they were surprised to find that many genes have closely related genes within the very same genome. We now understand that during evolution genes often duplicate – an ancestral genome with one copy gives rise to a descendant genome with two copies of a partic ...
... When biologists began sequencing genomes they were surprised to find that many genes have closely related genes within the very same genome. We now understand that during evolution genes often duplicate – an ancestral genome with one copy gives rise to a descendant genome with two copies of a partic ...
Age-Related Loss of the Transforming Growth Factor β Receptor
... response to growth factors. Over the course of 8 years, expression of the Smad2/3p response gene Serpine1 (Pai1) became 11fold less ( p = 0.01) responsive to 1 ng/ml of the ALK5 ligand TGFβ1 (fig. 1B). In contrast, the response of 8 year old cartilage to the ALK1 ligand BMP9 (5 ng/ml) was not signif ...
... response to growth factors. Over the course of 8 years, expression of the Smad2/3p response gene Serpine1 (Pai1) became 11fold less ( p = 0.01) responsive to 1 ng/ml of the ALK5 ligand TGFβ1 (fig. 1B). In contrast, the response of 8 year old cartilage to the ALK1 ligand BMP9 (5 ng/ml) was not signif ...
Impact of early-life stress on the medial prefrontal cortex functions
... the mPFC and by the atrophy of dendritic trees and reduced spine density in layer II/III pyramidal neurons of the mPFC [15]. Interestingly, in adult animals subjected to ELS, Baudin et al. (2012) revealed an upregulation of LTP processes in the mPFC and deficits in mPFC-dependent cognitive tasks [3] ...
... the mPFC and by the atrophy of dendritic trees and reduced spine density in layer II/III pyramidal neurons of the mPFC [15]. Interestingly, in adult animals subjected to ELS, Baudin et al. (2012) revealed an upregulation of LTP processes in the mPFC and deficits in mPFC-dependent cognitive tasks [3] ...
STM
... Upstream regulators control the expression of Knotted1-like homeobox (KNOX) genes. KNOX proteins function as heterodimers with BELL protein co-factors to activate or repress target genes, thus producing a cellular read-out. The mechanistic basis for KNOX gene regulation is either direct, mediated th ...
... Upstream regulators control the expression of Knotted1-like homeobox (KNOX) genes. KNOX proteins function as heterodimers with BELL protein co-factors to activate or repress target genes, thus producing a cellular read-out. The mechanistic basis for KNOX gene regulation is either direct, mediated th ...
X inactivation Xplained
... see how to discriminate between different models if not by analysis of molecular components. XCI starts with the accumulation of Xist along the future inactive X chromosome. Recent work indicates that Xist up-regulation is the consequence of sex-specific induction of Xist transcription on the future ...
... see how to discriminate between different models if not by analysis of molecular components. XCI starts with the accumulation of Xist along the future inactive X chromosome. Recent work indicates that Xist up-regulation is the consequence of sex-specific induction of Xist transcription on the future ...
The purB gene of Escherichia coli K-12 is
... carrying pSG108 (Fig. 1). Primer extension was initiated by the addition of avian myeloblastosis virus reverse transcriptase, and the DNA products were analysed on 6 % (w/v) denaturing polyacrylamide gels alongside either sequencing ladders or the end-labelled DNA size markers (Hi& fragments of 4x17 ...
... carrying pSG108 (Fig. 1). Primer extension was initiated by the addition of avian myeloblastosis virus reverse transcriptase, and the DNA products were analysed on 6 % (w/v) denaturing polyacrylamide gels alongside either sequencing ladders or the end-labelled DNA size markers (Hi& fragments of 4x17 ...
Lec 10 - Regulation of Gene
... Each cell of a living organism contains thousands of genes. But all genes do not function at a time. Genes function according to requirements of the cell. Genes control the phenotypic expression of various characters through the production of specific enzymes. Enzymes are special proteins which cata ...
... Each cell of a living organism contains thousands of genes. But all genes do not function at a time. Genes function according to requirements of the cell. Genes control the phenotypic expression of various characters through the production of specific enzymes. Enzymes are special proteins which cata ...
DNA methylation profiling identifies epigenetic dysregulation in
... of T2D in offspring (Inoue et al, 2009) while chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring (Ng et al, 2010). In humans, a reduced birth weight together with an accelerated growth in infancy has been associated with impaired glucose tolerance (IGT) in adulthood ...
... of T2D in offspring (Inoue et al, 2009) while chronic high-fat diet in fathers programs b-cell dysfunction in female rat offspring (Ng et al, 2010). In humans, a reduced birth weight together with an accelerated growth in infancy has been associated with impaired glucose tolerance (IGT) in adulthood ...
Gene Expression Profiling of DNA Microarray Data using Association rule and Structural Equation Modeling
... other goodness of fit indices. This is because the Chi-square test can be influenced by factors in addition to the validity of the theoretical model; these factors include departures from multivariate normality, sample size, and even the complexity of the model. The SAS/STAT Users Guide says the chi ...
... other goodness of fit indices. This is because the Chi-square test can be influenced by factors in addition to the validity of the theoretical model; these factors include departures from multivariate normality, sample size, and even the complexity of the model. The SAS/STAT Users Guide says the chi ...
Host-induced epidemic spread of the cholera bacterium
... Statistical Analysis reveals significant genes are responsible for gene expressions • 237 genes were differentially regulated • 44 genes were induced • 193 genes were repressed in human stool samples • Transcriptomes were similar to strain DSMV999, 3120 out of 3357 open reading frames that were exa ...
... Statistical Analysis reveals significant genes are responsible for gene expressions • 237 genes were differentially regulated • 44 genes were induced • 193 genes were repressed in human stool samples • Transcriptomes were similar to strain DSMV999, 3120 out of 3357 open reading frames that were exa ...
localization of histone gene transcripts in newt lampbrush
... as the size of RNA polymerase molecules permits (Miller & Beatty, 1969; Angelier & Lacroix, 1975; Scheer, Franke, Trendelenburg & Spring, 1976). The retention of RNA transcripts on the lateral loops produces a situation akin to amplification, in that identical sequences are concentrated in space. Pu ...
... as the size of RNA polymerase molecules permits (Miller & Beatty, 1969; Angelier & Lacroix, 1975; Scheer, Franke, Trendelenburg & Spring, 1976). The retention of RNA transcripts on the lateral loops produces a situation akin to amplification, in that identical sequences are concentrated in space. Pu ...
cis-Regulatory Elements and Chromatin State
... of several mutants in PRC2 encoding genes further corroborates this conclusion (Farrona et al., 2008). Previous studies have demonstrated the importance of transcriptional regulation of FT to ensure flowering time control in response to environmental and endogenous factors. Several transcription fac ...
... of several mutants in PRC2 encoding genes further corroborates this conclusion (Farrona et al., 2008). Previous studies have demonstrated the importance of transcriptional regulation of FT to ensure flowering time control in response to environmental and endogenous factors. Several transcription fac ...
NeuroD2 Is Necessary for Development and Survival of Central
... this bHLH transcription factor was necessary for normal brain development, we used homologous recombination to replace the neuroD2 coding region with a -galactosidase reporter gene. The neuroD2 gene expressed the reporter in a subset of neurons in the central nervous system, including in neurons of ...
... this bHLH transcription factor was necessary for normal brain development, we used homologous recombination to replace the neuroD2 coding region with a -galactosidase reporter gene. The neuroD2 gene expressed the reporter in a subset of neurons in the central nervous system, including in neurons of ...
Loss of Function but No Gain of Function Caused by
... hexapeptide sequences were mutated. The resulting phenotypes are indicative of activity changes relying on the modulation of DNA binding or the transregulatory potential of the proteins. Indeed, the Hoxb8 hexapeptide mutant behaves like a dominant negative, interfering with the activities of other H ...
... hexapeptide sequences were mutated. The resulting phenotypes are indicative of activity changes relying on the modulation of DNA binding or the transregulatory potential of the proteins. Indeed, the Hoxb8 hexapeptide mutant behaves like a dominant negative, interfering with the activities of other H ...
High-throughput engineering of the mouse genome coupled with
... then generating mice harboring the corresponding genetic changes3–6. The resulting phenotypes often provide insight into the function of the altered genes. Unfortunately, this approach is dependent upon highly skilled scientists employing time-consuming methodologies to produce custom alterations on ...
... then generating mice harboring the corresponding genetic changes3–6. The resulting phenotypes often provide insight into the function of the altered genes. Unfortunately, this approach is dependent upon highly skilled scientists employing time-consuming methodologies to produce custom alterations on ...