Large Sex Differences in Chicken Behavior and Differences in Promoter DNA-Methylation
... birds partially use mammalian-type dosage compensation to circumvent some of the problems [12] [13]. In this context, a so called male hypermethylated region (MHM) on the Z-chromosome has been identified [14], and just like Xist it transcribes a large noncoding RNA that is thought to mediate DNA-met ...
... birds partially use mammalian-type dosage compensation to circumvent some of the problems [12] [13]. In this context, a so called male hypermethylated region (MHM) on the Z-chromosome has been identified [14], and just like Xist it transcribes a large noncoding RNA that is thought to mediate DNA-met ...
High Efficiency Transient Expression System for
... Work at the Sainsbury Laboratory has demonstrated that post-transcriptional gene silencing (PTGS) is the limiting factor in Agrobacterium-mediated transient expression in tobacco. By mixing Agrobacterium cultures prior to agro-infiltration, one carrying a standard binary expression vector for the ge ...
... Work at the Sainsbury Laboratory has demonstrated that post-transcriptional gene silencing (PTGS) is the limiting factor in Agrobacterium-mediated transient expression in tobacco. By mixing Agrobacterium cultures prior to agro-infiltration, one carrying a standard binary expression vector for the ge ...
SERIES ‘‘GENETICS OF ASTHMA AND COPD IN THE POSTGENOME ERA’’
... structure is not yet apparent. Emphysema in some of these strains, such as the pallid mouse [14], has been attributed to reduced a1-antitrypsin (a1-AT) levels; however, if similar to humans, the levels of a1-AT are not low enough to cause emphysema. In fact, the genetic locus for a1-AT in the mouse ...
... structure is not yet apparent. Emphysema in some of these strains, such as the pallid mouse [14], has been attributed to reduced a1-antitrypsin (a1-AT) levels; however, if similar to humans, the levels of a1-AT are not low enough to cause emphysema. In fact, the genetic locus for a1-AT in the mouse ...
Supplementary Data Files Transcriptome Analysis on Monocytes
... Table S11: HOCOMOCO database and MEME results for transcription factor (TF) motifs enriched in differentially expressed genes (log2 FC>1.5, P<0.05) (tab 1, 79 genes) or log2 FC>1.2 (tab 2, 506 genes). Italics indicate TF which was found in both nvAMD and controls, eliminating it from results. Bold+ ...
... Table S11: HOCOMOCO database and MEME results for transcription factor (TF) motifs enriched in differentially expressed genes (log2 FC>1.5, P<0.05) (tab 1, 79 genes) or log2 FC>1.2 (tab 2, 506 genes). Italics indicate TF which was found in both nvAMD and controls, eliminating it from results. Bold+ ...
document
... affect a single phenotype. This is easy to understand in terms of a character such as eye color, in which there are complex metabolic pathways with numerous enzymatic steps, each encoded by one or more gene products. Genetic heterogeneity is the term used to refer to a given condition that may be ca ...
... affect a single phenotype. This is easy to understand in terms of a character such as eye color, in which there are complex metabolic pathways with numerous enzymatic steps, each encoded by one or more gene products. Genetic heterogeneity is the term used to refer to a given condition that may be ca ...
Suppl. Material
... showed that the DNA sequences of the inserted DNA were identical to kdsA and waaG of P. aeruginosa (data not shown). Subcloning of kdsA306 and waaG507 gene fragments into suicide vector pFS100 In order to construct negative mutant, kdsA421 and waaG459 fragments from pJET vector derivative were furth ...
... showed that the DNA sequences of the inserted DNA were identical to kdsA and waaG of P. aeruginosa (data not shown). Subcloning of kdsA306 and waaG507 gene fragments into suicide vector pFS100 In order to construct negative mutant, kdsA421 and waaG459 fragments from pJET vector derivative were furth ...
BIOL 504: Molecular Evolution
... So gene duplications (particularly those in tandem) can beget more duplications ...
... So gene duplications (particularly those in tandem) can beget more duplications ...
The Arabinose Operon (http://faculty.clintoncc.suny.edu/faculty
... The operon contains three different genes (ara A, ara B, and ara D) that code for three enzymes needed to convert arabinose to a usable form. A fourth gene codes for a protein (ara C) that acts to regulate the structural genes. ...
... The operon contains three different genes (ara A, ara B, and ara D) that code for three enzymes needed to convert arabinose to a usable form. A fourth gene codes for a protein (ara C) that acts to regulate the structural genes. ...
Simulating and cleaning gene expression data using
... p × n matrix of regression coefficients associated with X, m × k matrix of unobserved covariates introducing systematic noise, k × n matrix of regression coefficients associated with W m × n matrix of random noise. ...
... p × n matrix of regression coefficients associated with X, m × k matrix of unobserved covariates introducing systematic noise, k × n matrix of regression coefficients associated with W m × n matrix of random noise. ...
Organoid assays
... Supplementary Figure 6. Intestinal homeostasis is not changed by MybER-activation alone but its effect is revealed upon heterozygous loss of the cell cycle inhibitor p27 gene. MybER mice were fed Tamoxifen chow for 2 weeks and cell proliferation was assessed using IHC for the proliferation marker Pr ...
... Supplementary Figure 6. Intestinal homeostasis is not changed by MybER-activation alone but its effect is revealed upon heterozygous loss of the cell cycle inhibitor p27 gene. MybER mice were fed Tamoxifen chow for 2 weeks and cell proliferation was assessed using IHC for the proliferation marker Pr ...
Unusual mutations in high functioning fragile X males
... repeat expansions to CGG copy numbers between 45 and 200. They are usually not associated with methylation. Premutations are carried by transmitting males and by some of the transmitting females. Carriers of premutations are generally unaffected and show normal expression of the premutated gene both ...
... repeat expansions to CGG copy numbers between 45 and 200. They are usually not associated with methylation. Premutations are carried by transmitting males and by some of the transmitting females. Carriers of premutations are generally unaffected and show normal expression of the premutated gene both ...
Genetics advances and learning disability
... explored (Smith et al, al, 1997). One such mouse displaying specific learning deficits was trisomic for a region containing the human form of the Drosophila minibrain ...
... explored (Smith et al, al, 1997). One such mouse displaying specific learning deficits was trisomic for a region containing the human form of the Drosophila minibrain ...
Maintenance of DNA Methylation during the Arabidopsis Life Cycle
... that control other epigenetic marks (Tariq et al., 2003; Chan et al., 2005; Takeda and Paszkowski, 2006; Vire et al., 2006), and the effect of met1-3 and MET1as could be indirect. Thus, we tested whether other epigenetic mechanisms might be involved, including DNA methylation and histone methylation ...
... that control other epigenetic marks (Tariq et al., 2003; Chan et al., 2005; Takeda and Paszkowski, 2006; Vire et al., 2006), and the effect of met1-3 and MET1as could be indirect. Thus, we tested whether other epigenetic mechanisms might be involved, including DNA methylation and histone methylation ...
DNA interference: DNA-induced gene silencing in the
... organisms [11,12]. In C. elegans, introduction of transgenic copies of a gene inhibits expression of the transgene as well as endogenous homologous genes, partly using cellular components of RNAi [12]. This co-suppression is distinct from DNAi, because co-suppression depends on the presence of a pro ...
... organisms [11,12]. In C. elegans, introduction of transgenic copies of a gene inhibits expression of the transgene as well as endogenous homologous genes, partly using cellular components of RNAi [12]. This co-suppression is distinct from DNAi, because co-suppression depends on the presence of a pro ...
The promoter of the Arabidopsis nuclear gene COX5b
... A COX5b-1 EST clone encoding exons two to six (clone 234B12T7; accession no. N65183) was obtained from ABRC. For the isolation of clones containing the COX5b-1 gene, the cDNA probe was used to screen 13105 pfu from an Arabidopsis genomic library (Voytas et al., 1990). Phage DNA was transferred to Hy ...
... A COX5b-1 EST clone encoding exons two to six (clone 234B12T7; accession no. N65183) was obtained from ABRC. For the isolation of clones containing the COX5b-1 gene, the cDNA probe was used to screen 13105 pfu from an Arabidopsis genomic library (Voytas et al., 1990). Phage DNA was transferred to Hy ...
Chapter 7
... • Differences between cell types result from differential gene expression, the expression of different genes by cells with the same genome • Errors in gene expression can lead to diseases including cancer • Gene expression is regulated at many stages Bui Tan Anh – College of Natural Sciences ...
... • Differences between cell types result from differential gene expression, the expression of different genes by cells with the same genome • Errors in gene expression can lead to diseases including cancer • Gene expression is regulated at many stages Bui Tan Anh – College of Natural Sciences ...
SI - Evolocus LLC
... absolutely dormant gene in time. We suppose that rather wide variety of treatments can lead to deblocking of some previously dormant gene, whose expression was permanently switched off in a given laboratory line of animals previously, as it was supposed by J.W. Harms many years ago (1929, 1934)19,20 ...
... absolutely dormant gene in time. We suppose that rather wide variety of treatments can lead to deblocking of some previously dormant gene, whose expression was permanently switched off in a given laboratory line of animals previously, as it was supposed by J.W. Harms many years ago (1929, 1934)19,20 ...
Molecular bases of Down syndrome: differential gene
... Although the perception of DS as a metabolic disease is not prevalent, overexpression of genes encoding specific enzymes directly leads to biochemical aberrations that affect multiple interacting metabolic pathways, culminate in cellular dysfunction and contribute to the pathogenesis of DS. A metabo ...
... Although the perception of DS as a metabolic disease is not prevalent, overexpression of genes encoding specific enzymes directly leads to biochemical aberrations that affect multiple interacting metabolic pathways, culminate in cellular dysfunction and contribute to the pathogenesis of DS. A metabo ...
PDF
... alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The mechanism by which the IG-DMR regulates Dlk1-Gtl2 imprinting is unclear. It is likely that the IG-DMR acts as a positive regulator activating Gtl2 transcription and its downstream no ...
... alleles of the PEGs. However, a deletion on the paternal chromosome does not have this effect (Lin et al., 2003). The mechanism by which the IG-DMR regulates Dlk1-Gtl2 imprinting is unclear. It is likely that the IG-DMR acts as a positive regulator activating Gtl2 transcription and its downstream no ...
Genetic basis of neural tube defects. I. Regulatory genes for the
... Also no correlation has been found between two frequent polymorphisms in the BRCA1 gene: (A4956G (S1613G), A1186G (Q365R)) and NTD, although it cannot be excluded that these polymorphisms are risk factor for the defect. Probably, additional environmental factors are necessary for incorrect neurulati ...
... Also no correlation has been found between two frequent polymorphisms in the BRCA1 gene: (A4956G (S1613G), A1186G (Q365R)) and NTD, although it cannot be excluded that these polymorphisms are risk factor for the defect. Probably, additional environmental factors are necessary for incorrect neurulati ...
Ding, Yi : Singular Value Decomposition applied to the building of class predictor
... different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of human diseases. By comparing the differentially expressed profiles, we can find out the mechanism of gene expression, hence obtain information useful for clinical diagnos ...
... different times or from different sources (patients belonging to different phenotype). This has a profound impact on the study of human diseases. By comparing the differentially expressed profiles, we can find out the mechanism of gene expression, hence obtain information useful for clinical diagnos ...
Birth of fertile bimaternal offspring following
... with more than 1 FPKM were shown. The red and blue points represent imprinted genes expressed from maternal and paternal alleles, respectively. Dashed lines depict 2-fold changes. The R2 was determined by Pearson’s correlation. (D) Five imprinted genes with more than 2-fold changes in expression lev ...
... with more than 1 FPKM were shown. The red and blue points represent imprinted genes expressed from maternal and paternal alleles, respectively. Dashed lines depict 2-fold changes. The R2 was determined by Pearson’s correlation. (D) Five imprinted genes with more than 2-fold changes in expression lev ...
functional_enrichment_new - Baliga Lab at Institute for Systems
... • How can you apply these tools to large, complex analysis problems (i.e. automation)? ...
... • How can you apply these tools to large, complex analysis problems (i.e. automation)? ...
[PDF]
... 310Luc and 310Luc/Sg2/2 mice (data not shown). Similarly increased expression (, twofold) of luciferase was present in the CNS and heart of 310Luc/Sp42/2 mice compared with wildtype 310Luc mice (P ,0.02) (Fig. 3B). The exception was in the eye of 310Luc/Sp42/2 animals, in which expression levels wer ...
... 310Luc and 310Luc/Sg2/2 mice (data not shown). Similarly increased expression (, twofold) of luciferase was present in the CNS and heart of 310Luc/Sp42/2 mice compared with wildtype 310Luc mice (P ,0.02) (Fig. 3B). The exception was in the eye of 310Luc/Sp42/2 animals, in which expression levels wer ...