• Study Resource
  • Explore Categories
    • Arts & Humanities
    • Business
    • Engineering & Technology
    • Foreign Language
    • History
    • Math
    • Science
    • Social Science

    Top subcategories

    • Advanced Math
    • Algebra
    • Basic Math
    • Calculus
    • Geometry
    • Linear Algebra
    • Pre-Algebra
    • Pre-Calculus
    • Statistics And Probability
    • Trigonometry
    • other →

    Top subcategories

    • Astronomy
    • Astrophysics
    • Biology
    • Chemistry
    • Earth Science
    • Environmental Science
    • Health Science
    • Physics
    • other →

    Top subcategories

    • Anthropology
    • Law
    • Political Science
    • Psychology
    • Sociology
    • other →

    Top subcategories

    • Accounting
    • Economics
    • Finance
    • Management
    • other →

    Top subcategories

    • Aerospace Engineering
    • Bioengineering
    • Chemical Engineering
    • Civil Engineering
    • Computer Science
    • Electrical Engineering
    • Industrial Engineering
    • Mechanical Engineering
    • Web Design
    • other →

    Top subcategories

    • Architecture
    • Communications
    • English
    • Gender Studies
    • Music
    • Performing Arts
    • Philosophy
    • Religious Studies
    • Writing
    • other →

    Top subcategories

    • Ancient History
    • European History
    • US History
    • World History
    • other →

    Top subcategories

    • Croatian
    • Czech
    • Finnish
    • Greek
    • Hindi
    • Japanese
    • Korean
    • Persian
    • Swedish
    • Turkish
    • other →
 
Profile Documents Logout
Upload
HTML Web Page That Shows Its Own Source Code
HTML Web Page That Shows Its Own Source Code

... of) the source code, but in that source code we keep the X as shown here (or some other symbol) to mark the place where the DNA must be inserted. 9. As marker, we will use a character that does not otherwise appear in the scripts (X seems fine). However, in order to recognize the marker, we need a w ...
Phylogenetic Relationships between the Western Aster Yellows
Phylogenetic Relationships between the Western Aster Yellows

... dodecyl sulfate, and the DNA was bound to the filters by alkaline hydrolysis and baking. Nitrocellulose filters containing recombinant phage generated from the EcoRI fragment transformation were hybridized with the 5’ 18-mer. After clones that hybridized with the 18-mer were identified, the bound pr ...
SOP Criteria for Variant Classification
SOP Criteria for Variant Classification

...  Avoid applying similar evidence twice: e.g. PS2 and PM6 (de novo criteria) cannot be both invoked for a variant in a patient; if all evidences from the literature were considered and counted and related criteria are invoked, then PP5 or BP6 cannot be invoked again as an additional line of evidence ...
Leukaemia Section t(7;12)(q34;p13), t(12;14)(p13;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology
Leukaemia Section t(7;12)(q34;p13), t(12;14)(p13;q11) Atlas of Genetics and Cytogenetics in Oncology and Haematology

... interphasic nuclei from a patient with t(7;12)(q34;p13) using CCND2 flanking probes at 12p13. The centromeric BAC clone RP11-388F6 (red) and the telomeric BAC clone RP11-320N7 (green) show one fusion signal at the normal chromosome 12, and dissociated signals at der(12) (red signal) and der(7) ...
MacVector 14.0 Getting Started Guide
MacVector 14.0 Getting Started Guide

... Screening clones from a site-specific mutagenesis experiment to identify successful mutations Screening related clones for single nucleotide polymorphisms ...
A program for annotating and predicting the effects of single
A program for annotating and predicting the effects of single

... least 8 of the stop-gained SNPs are in genes that encode essential proteins, and these are Dif, dp, ex, MESR4, mew, oc/otd, tai and trol. It is not known whether the other stop-gained SNPs also affect essential protein-coding genes because their functions have not yet been characterized (according t ...
Research Project Final Report
Research Project Final Report

... the second parent. These lines have been used to make a genetic map that will inform future studies of quantitative variation in seed bleaching under field conditions. Besides this ‘open’ approach to gene identification, we have studied variation in two candidate genes, either or both of which may i ...
Ribosome profiling reveals post-transcriptional buffering of divergent
Ribosome profiling reveals post-transcriptional buffering of divergent

... depended upon orthologous genes identifiable across vast evolutionary distance, their results could be biased toward highly abundant housekeeping genes. Nonetheless, these works suggest that post-transcriptional processes, including mRNA translation and protein turnover, could act to reduce the effe ...
Molecular regulators of phosphate homeostasis in plants
Molecular regulators of phosphate homeostasis in plants

... hypothesized to be involved in PHR1 activity. In support of this notion, PHR1 was later revealed to be sumoylated by SIZ1, a SUMO E3 ligase (Miura et al., 2005). A siz1 mutant showing a suppression phenotype of a salt-sensitive mutant was initially isolated (Miura et al., 2005). Surprisingly, the si ...
Seven
Seven

... for the sensitivity and specificity of gene recognition. They are shown in the Sn2 and Sp2 columns of Table 1. Comparing with GLIMMER gene-finder To compare the results obtained by our algorithm with some well-established genefinding program, we introduced new simple rules for deciding if a given OR ...
The cyanobacterial genome core and the origin of photosynthesis
The cyanobacterial genome core and the origin of photosynthesis

... acceptors and are similar to the cyanobacterial PSI. The reaction centers of proteobacteria and Chloroflexi (RC2-type) use bound quinones as electron acceptors and are similar to the cyanobacterial PSII. Since all these phyla, except for Cyanobacteria and, perhaps, Chlorobi, also contain non-photos ...
M3 Multiplex Master Mix – PCR (2x)
M3 Multiplex Master Mix – PCR (2x)

... MgCl2 concentrations are required, prepare a 25 mM MgCl2 stock solution (or request us to ship an aliquot along with your order) and add an appropriate amount to the reaction. Adding 1 μl of a 25 mM MgCl2 solution to a total reaction volume of 50 μl will add 25 nmol MgCl2 and thus increase total MgC ...
RT2 Profiler™ PCR Arrays: Pathway
RT2 Profiler™ PCR Arrays: Pathway

... or disease state. Wells H1 through H5 contain a panel of housekeeping genes (HK1-HK5) used for normalizing the PCR Array data. Well H6 contains a Genomic DNA Control (GDC) primer set that specifically detects non-transcribed, repetitive genomic DNA with a high level of sensitivity. Wells H7 through H ...
2- pcr primer design and reaction optimisation
2- pcr primer design and reaction optimisation

... The specific complementary association due to hydrogen bonding of singlestranded nucleic acids is referred to as "annealing": two complementary sequences will form hydrogen bonds between their complementary bases (G to C, and A to T or U) and form a stable double-stranded, anti-parallel "hybrid" mol ...
final1-eu-marie-curie-final-report
final1-eu-marie-curie-final-report

... (dml). We proposed the following putative modular assembly for homodolastatin 16: ...
Siamese Breeding Policy - Seal Point Siamese Cat Club
Siamese Breeding Policy - Seal Point Siamese Cat Club

... chromosomes, each made up of thousands of genes. Each gene has a complicated chemical structure which acts as a template for the construction of components of the body. The exceptional cells are the egg and the sperm, which have only one set of chromosomes - formed by random selection of one from ea ...
Detection of Large Expansions in SCA8 Using a Fluorescent Repeat
Detection of Large Expansions in SCA8 Using a Fluorescent Repeat

... Genomic DNA was extracted from peripheral blood leukocytes using the conventional method. We analyzed the DNA of 17 SCA8 patients and 258 controls from our collection of DNA from patients with ataxia. Each sample had known expansions tested by Southern blot analysis. The research protocol was approv ...
Siamese Breeding Policy - Siamese Cat Joint Advisory Committee
Siamese Breeding Policy - Siamese Cat Joint Advisory Committee

... chromosomes, each made up of thousands of genes. Each gene has a complicated chemical structure which acts as a template for the construction of components of the body. The exceptional cells are the egg and the sperm, which have only one set of chromosomes - formed by random selection of one from ea ...
Secondary Leukemia Associated With The Anti-Cancer Agent
Secondary Leukemia Associated With The Anti-Cancer Agent

... depends on the cumulative dose of alkylating agents. Predisposing factors for the alkylating agentassociated secondary leukemias are germline NF-1 [8] and p53 gene mutations [9] and a null GSTT1 genotype [10], and Ras mutations are frequently accompanied with those leukemias [11,12]. On the other ha ...
No Slide Title
No Slide Title

... pathways in MetaCyc for which there is at least one enzyme identified in the target organism are considered for possible inclusion.  Algorithm errs on side of inclusivity – easier to manually delete a pathway from an organism than to find a pathway that should have been predicted but wasn’t. ...


... BCR/ABL P210 comprises the first 902 or 927 amino acids from BCR, P190 only the 427 N-term from BCR; BCR/ABL has a cytoplasmic localization, in contrast with ABL, mostly nuclear. Oncogenesis That BCR/ABL has a cytoplasmic localization may have a carcinogenetic role. The hybrid protein has an increas ...
Origin and evolution of the slime molds (Mycetozoa)
Origin and evolution of the slime molds (Mycetozoa)

... closely related to animals 1 fungi than are green plants. With our data there are now three proteins that consistently support a monophyletic Mycetozoa and at least four that place these taxa within the ‘‘crown’’ of the eukaryote tree. We suggest that ribosomal RNA data should be more closely examin ...
An Empirical Test for Branch-Specific Positive Selection
An Empirical Test for Branch-Specific Positive Selection

... when two protein-coding sequences are identical. But how different must two sequences be for the currently available methods to detect statistically significant positive selection? Statistical methods based on models of codon substitution patterns have been developed to identify positive selection s ...
Splicing regulation: a structural biology perspective
Splicing regulation: a structural biology perspective

... years, biochemical and structural studies have shown that this domain is not only involved in RNA/DNA recognition but also in protein-protein interaction. Both modes of interactions play crucial role in splicing regulation. 1.1. RRM-RNA interaction and splicing regulation An RRM is approximately 90 ...
Review Article Viral Bacterial Artificial - diss.fu
Review Article Viral Bacterial Artificial - diss.fu

... absence of the gene in the virus context. This solution would work in most cases but was not always possible due to the toxicity of some viral proteins. A solution to the problems was the maintenance and modification of virus genomes ...
< 1 ... 84 85 86 87 88 89 90 91 92 ... 1045 >

Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
  • studyres.com © 2025
  • DMCA
  • Privacy
  • Terms
  • Report