Molecular Imaging - Engineering Computing Facility
... proteins to create internal biological light. For conciseness, only the basic concept of bioluminescent imaging (BLI) is presented here. To illustrate, consider the example of luciferase, which is a class of enzymes that emit light (bioluminescence) in the presence of oxygen and a substrate. The lig ...
... proteins to create internal biological light. For conciseness, only the basic concept of bioluminescent imaging (BLI) is presented here. To illustrate, consider the example of luciferase, which is a class of enzymes that emit light (bioluminescence) in the presence of oxygen and a substrate. The lig ...
Imprinted Genes and Human Disease
... sociated with these genes share a common motif. Second, we consider the nature and frequency of mutations of imprinted genes. We ask whether we should expect that imprinted genes are particularly fragile. That is, are they more likely to undergo mutation and/or are mutations of imprinted genes parti ...
... sociated with these genes share a common motif. Second, we consider the nature and frequency of mutations of imprinted genes. We ask whether we should expect that imprinted genes are particularly fragile. That is, are they more likely to undergo mutation and/or are mutations of imprinted genes parti ...
MGI
... ° dysmorphic facial features (beaked nose, high arched palate, characteristic grimacing) ° increased tumor risk ...
... ° dysmorphic facial features (beaked nose, high arched palate, characteristic grimacing) ° increased tumor risk ...
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase
... genome (Eichinger et al., 2005) that encodes chromatin proteins and modifying enzymes conserved with those in higher eukaryotes. In addition, the organism is highly amenable, with powerful haploid molecular genetics (De Lozanne and Spudich, 1987). Individual Dictyostelium cells enter their program o ...
... genome (Eichinger et al., 2005) that encodes chromatin proteins and modifying enzymes conserved with those in higher eukaryotes. In addition, the organism is highly amenable, with powerful haploid molecular genetics (De Lozanne and Spudich, 1987). Individual Dictyostelium cells enter their program o ...
Solid Tumour Section Liver: Intrahepatic cholangiocarcinoma Atlas of Genetics and Cytogenetics
... Clinics The clinical features of intrahepatic cholangiocarcinoma are primarily governed by its anatomical location and growth pattern. Biliary obstructive symptoms are rare. Generally, early stages of intrahepatic cholangiocarcinoma do not produce specific clinical symptoms that are recognized by af ...
... Clinics The clinical features of intrahepatic cholangiocarcinoma are primarily governed by its anatomical location and growth pattern. Biliary obstructive symptoms are rare. Generally, early stages of intrahepatic cholangiocarcinoma do not produce specific clinical symptoms that are recognized by af ...
Mouse models of obesity
... to result in early-onset obesity, non–insulin-dependent diabetes, and other obesityassociated syndromes. These symptoms are a parallel to the yellow agouti mouse syndrome, indicating that agouti expression in the hypothalamus inhibits Mc4r function, leading to obesity. Targeted deletion of the Mc3r ...
... to result in early-onset obesity, non–insulin-dependent diabetes, and other obesityassociated syndromes. These symptoms are a parallel to the yellow agouti mouse syndrome, indicating that agouti expression in the hypothalamus inhibits Mc4r function, leading to obesity. Targeted deletion of the Mc3r ...
Supertaster
... Mammals, such as humans, have a unique sense that makes consuming certain substances pleasant and consuming other substances unpleasant – the ability to taste. Special receptors in the taste buds on our tongues allow us to taste five different flavors – sweet, salty, bitter, sour, and umami (savory) ...
... Mammals, such as humans, have a unique sense that makes consuming certain substances pleasant and consuming other substances unpleasant – the ability to taste. Special receptors in the taste buds on our tongues allow us to taste five different flavors – sweet, salty, bitter, sour, and umami (savory) ...
Molecular Dynamics of a Presynaptic Active Zone
... GFP (green fluorescent protein) fusion proteins have revolutionized research on protein dynamics at synapses. However, corresponding analyses usually involve protein expression methods that override endogenous regulatory mechanisms, and therefore cause overexpression and temporal or spatial misexpre ...
... GFP (green fluorescent protein) fusion proteins have revolutionized research on protein dynamics at synapses. However, corresponding analyses usually involve protein expression methods that override endogenous regulatory mechanisms, and therefore cause overexpression and temporal or spatial misexpre ...
Shared mutations: Common descent or common mechanism?
... between individuals, a key role to explain the origin of species. The origin and nature of mutations is one of the most fundamental questions of biology, and are a hot topic in origin debates. If mutations are merely a matter of chance, then the alignment of mutations in distinct species that do not ...
... between individuals, a key role to explain the origin of species. The origin and nature of mutations is one of the most fundamental questions of biology, and are a hot topic in origin debates. If mutations are merely a matter of chance, then the alignment of mutations in distinct species that do not ...
NIH Public Access - University of Chicago
... which also includes Helios and Aiolos9,10. The canonical Ikaros protein contains two multizinc finger domains: the N-terminal domain mediates sequence-specific DNA binding, while the C-terminal domain is involved in homo-or hetero-dimerization11. The Ikaros gene (denoted Ikzf1) encodes multiple isof ...
... which also includes Helios and Aiolos9,10. The canonical Ikaros protein contains two multizinc finger domains: the N-terminal domain mediates sequence-specific DNA binding, while the C-terminal domain is involved in homo-or hetero-dimerization11. The Ikaros gene (denoted Ikzf1) encodes multiple isof ...
REVIEW Mouse models of human disease. Part I: Techniques and
... see Justice et al. 1992). These strains are derived from the systematic inbreeding of randomly selected pairs of the F2 generation of a cross between two different inbred strains of mice (Bailey 1981). During inbreeding, the genes from the progenitor strains segregate and randomly reassort, and are ...
... see Justice et al. 1992). These strains are derived from the systematic inbreeding of randomly selected pairs of the F2 generation of a cross between two different inbred strains of mice (Bailey 1981). During inbreeding, the genes from the progenitor strains segregate and randomly reassort, and are ...
The Incompatible Desiderata of Gene Cluster Properties
... have a homolog elsewhere in the genome). The max-gap cluster definition also ignores gene order and allows insertions and deletions, but does not constrain the maximum length of the cluster to r genes. Instead, a max-gap cluster is described by a single parameter g, and is defined as a set of marked ...
... have a homolog elsewhere in the genome). The max-gap cluster definition also ignores gene order and allows insertions and deletions, but does not constrain the maximum length of the cluster to r genes. Instead, a max-gap cluster is described by a single parameter g, and is defined as a set of marked ...
Dynamic Model of Paclitaxel Biosynthesis Suggests That the Key
... pathways: MVA pathway in cytosol and MEP/DXP pathway in plastid. ...
... pathways: MVA pathway in cytosol and MEP/DXP pathway in plastid. ...
Gene Section PAX8 (paired box 8) Atlas of Genetics and Cytogenetics
... Dario de Biase, Luca Morandi, Giovanni Tallini Bologna University School of Medicine, Anatomia Patologica, Ospedale Bellaria, Via Altura 3, 40139 ...
... Dario de Biase, Luca Morandi, Giovanni Tallini Bologna University School of Medicine, Anatomia Patologica, Ospedale Bellaria, Via Altura 3, 40139 ...
Chapter 1.
... The other type of resistance that can be considered opposite to major gene resistance can be called quantitative resistance, polygenic resistance, race-nonspecific resistance, field resistance, durable resistance, slow resistance, partial resistance, or minor gene resistance. This type of resistance ...
... The other type of resistance that can be considered opposite to major gene resistance can be called quantitative resistance, polygenic resistance, race-nonspecific resistance, field resistance, durable resistance, slow resistance, partial resistance, or minor gene resistance. This type of resistance ...
Sequence Heterogeneities Among 16s
... For phylogeny, rRNA sequences have become popular because they are universally present and have a conserved function (they are homologous in all organisms), because they are easy to sequence, and finally because they are constituted of an interspersion of highly conserved to very variable domains. R ...
... For phylogeny, rRNA sequences have become popular because they are universally present and have a conserved function (they are homologous in all organisms), because they are easy to sequence, and finally because they are constituted of an interspersion of highly conserved to very variable domains. R ...
Multiplex in-vitro Detection using SERS
... beneficial in obtaining further enhancement in the form of surface enhanced resonance Raman scattering (SERRS). This occurs when the analyte contains a chromophore close in energy to the exciting radiation. However, a dye label can also be used to achieve this enhancement if the chromophore is not p ...
... beneficial in obtaining further enhancement in the form of surface enhanced resonance Raman scattering (SERRS). This occurs when the analyte contains a chromophore close in energy to the exciting radiation. However, a dye label can also be used to achieve this enhancement if the chromophore is not p ...
Comparative sequence analysis of the long repeat regions and
... recognized in R L, encoding the immediate early transcriptional regulatory protein IE 110 or ICP0; this gene is flanked by substantial sequences the roles of which were less well defined. Downstream of the IE110 gene is a region of some 3500 bp which has not been assigned any protein coding function ...
... recognized in R L, encoding the immediate early transcriptional regulatory protein IE 110 or ICP0; this gene is flanked by substantial sequences the roles of which were less well defined. Downstream of the IE110 gene is a region of some 3500 bp which has not been assigned any protein coding function ...
In vivo evidence for the prokaryotic model of extended codon
... we developed an oligonucleotide probe that allows one mismatch-speci®c recognition; this probe was a 19mer complementary to residues 29±46 of the mutant tRNA (allowing 10 G/C and 9 A/U base pairs with a complete match). As shown in Figure 2B, this gives no signal with the endogenously expressed WT t ...
... we developed an oligonucleotide probe that allows one mismatch-speci®c recognition; this probe was a 19mer complementary to residues 29±46 of the mutant tRNA (allowing 10 G/C and 9 A/U base pairs with a complete match). As shown in Figure 2B, this gives no signal with the endogenously expressed WT t ...
6.3 Mendel and Heredity
... – this is the phenotype (describes physical traits, what we can see) – F1 plants are all heterozygous this is the genotype (describes the internal makeup of the genes, what we ...
... – this is the phenotype (describes physical traits, what we can see) – F1 plants are all heterozygous this is the genotype (describes the internal makeup of the genes, what we ...
Myriad--Ambry -- Final Version of Ambry Preliminary Injunction
... can constitute a variant. Some variants are harmless, but some—termed “mutations”—can cause disease or increase the risk of disease. The patents-in-suit involve synthetic DNA molecules and methods of testing for mutations in the BRCA1 and BRCA2 genes that are known to result in a significantly incre ...
... can constitute a variant. Some variants are harmless, but some—termed “mutations”—can cause disease or increase the risk of disease. The patents-in-suit involve synthetic DNA molecules and methods of testing for mutations in the BRCA1 and BRCA2 genes that are known to result in a significantly incre ...
Fulltext PDF
... workers in their experiments on mutagenesis, fine structure genetic analysis, genetic code, deciphering nonsense codons and their mode of action. Benzer’s Work on the Fine Structure of T4 rII Region The uniqueness of rII mutants, namely, their inability to form plaques on E. coli K12 () was first r ...
... workers in their experiments on mutagenesis, fine structure genetic analysis, genetic code, deciphering nonsense codons and their mode of action. Benzer’s Work on the Fine Structure of T4 rII Region The uniqueness of rII mutants, namely, their inability to form plaques on E. coli K12 () was first r ...
Classification of plant-pathogenic mycoplasma
... Based on Southern hybridization with a DNA fragment of an MLO associated with aster yellows, a differentiation between organisms inducing decline symptoms and those causing floral virescence has been proposed (Kuske et al., 1991). Although several organisms have been differentiated using these metho ...
... Based on Southern hybridization with a DNA fragment of an MLO associated with aster yellows, a differentiation between organisms inducing decline symptoms and those causing floral virescence has been proposed (Kuske et al., 1991). Although several organisms have been differentiated using these metho ...
Compressed q-gram Indexing for Highly Repetitive Biological
... of all humans. Less than one decade later, DNA sequencing technologies have become so fast and cost-effective that sequencing individual genomes will soon become a common task [1], [2], [3]. Huge DNA collections are at the next corner. The computational challenges posed by handling collections of th ...
... of all humans. Less than one decade later, DNA sequencing technologies have become so fast and cost-effective that sequencing individual genomes will soon become a common task [1], [2], [3]. Huge DNA collections are at the next corner. The computational challenges posed by handling collections of th ...