Environmental Microbiology
... the binding of regulatory proteins at specific sites, and thus alter gene expression (Nou et al., 1995; van der Woude et al., 1996). A paradigm for regulation via differential methylation is presented in Fig. 3. Examples of genes controlled via differential methylation are presented in Table 1. Unpr ...
... the binding of regulatory proteins at specific sites, and thus alter gene expression (Nou et al., 1995; van der Woude et al., 1996). A paradigm for regulation via differential methylation is presented in Fig. 3. Examples of genes controlled via differential methylation are presented in Table 1. Unpr ...
ADVANTAGES OF FETAL CELLS IN NON
... genomes but may not be linked directly to a specific disease Polymorphic segments of DNA that vary between the maternal and paternal genomes, such as short tandem repeats (STRs) Epigenetic modifications, specifically DNA methylation of certain genes, which differs between cells of the mother versus ...
... genomes but may not be linked directly to a specific disease Polymorphic segments of DNA that vary between the maternal and paternal genomes, such as short tandem repeats (STRs) Epigenetic modifications, specifically DNA methylation of certain genes, which differs between cells of the mother versus ...
Note for Guidance on the Quality, Preclinical and Clinical
... the inoculation of nucleic acids for the purpose of vaccination against foreign antigens (e.g. DNA vaccination) ...
... the inoculation of nucleic acids for the purpose of vaccination against foreign antigens (e.g. DNA vaccination) ...
BMB 400 PART THREE
... the amino acid encoded. These are called silent or synonymous nucleotide substitutions. They do not alter the encoded protein. This is discussed in more detail below. c. The pattern of degeneracy allows one to organize the codons into "families" and "pairs". In 9 groups of codons, the nucleotides at ...
... the amino acid encoded. These are called silent or synonymous nucleotide substitutions. They do not alter the encoded protein. This is discussed in more detail below. c. The pattern of degeneracy allows one to organize the codons into "families" and "pairs". In 9 groups of codons, the nucleotides at ...
The Drosophila Gene Disruption Project: Progress
... and currently available at the BDSC are shown. The numbers of strains containing insertions in genes (see Methods) or within intergenic regions are also given. The New Genes column gives the number of genes hit by insertions in that collection that are not hit by insertions from the collections abov ...
... and currently available at the BDSC are shown. The numbers of strains containing insertions in genes (see Methods) or within intergenic regions are also given. The New Genes column gives the number of genes hit by insertions in that collection that are not hit by insertions from the collections abov ...
Exercise 14 Overview of Amino Acid and Protein
... Macromolecules form by the step-wise addition of similar monomeric subunits onto the end of a growing polymeric chain. Each monomeric subunit is covalently attached to the growing chain by a condensation reaction, in which one molecule of water is lost with the addition of each monomer to one end of ...
... Macromolecules form by the step-wise addition of similar monomeric subunits onto the end of a growing polymeric chain. Each monomeric subunit is covalently attached to the growing chain by a condensation reaction, in which one molecule of water is lost with the addition of each monomer to one end of ...
MCScanX`s manual
... pair-wise homologous relationships. The optional third column shows the scores of pair-wise homologous relationships. When the third column is used, users need to specify whether higher or lower values are preferred. As an example, users can use the combination of “orthologs.txt” and “coortholog.txt ...
... pair-wise homologous relationships. The optional third column shows the scores of pair-wise homologous relationships. When the third column is used, users need to specify whether higher or lower values are preferred. As an example, users can use the combination of “orthologs.txt” and “coortholog.txt ...
Activation of the JNK pathway during dorsal closure in Drosophila
... acids with homology to Cdc42/Rac interacting binding (CRIB) motifs that may serve as a site of interaction with those small GTPases (Burbelo et al. 1995; Teramoto et al. 1996; Bock et al. 2000). The remainder of the Slpr protein ...
... acids with homology to Cdc42/Rac interacting binding (CRIB) motifs that may serve as a site of interaction with those small GTPases (Burbelo et al. 1995; Teramoto et al. 1996; Bock et al. 2000). The remainder of the Slpr protein ...
Bacteroides mobilizable and conjugative genetic elements
... The repeated sequences bordering the erm genes of these three plasmids have been shown to be a related, if no identical, insertion sequence (IS) elements (IS4400 on pBFTM10, IS4351 on pBF4, and iso-IS4351 on pBI136). These flanking IS elements form compound transposons with their associated erm gene ...
... The repeated sequences bordering the erm genes of these three plasmids have been shown to be a related, if no identical, insertion sequence (IS) elements (IS4400 on pBFTM10, IS4351 on pBF4, and iso-IS4351 on pBI136). These flanking IS elements form compound transposons with their associated erm gene ...
Development of novel computational tools based on
... (Jain et al., 1999). Informational genes, defined as the core and most conserved segments in a genome are present in almost all organisms. Such genes encode rRNA operons and conserved proteins, they therefore are less likely transferred, as genomes naïve to their functions are rare (Ochman, 2001; Du ...
... (Jain et al., 1999). Informational genes, defined as the core and most conserved segments in a genome are present in almost all organisms. Such genes encode rRNA operons and conserved proteins, they therefore are less likely transferred, as genomes naïve to their functions are rare (Ochman, 2001; Du ...
Noise in transcription negative feedback loops
... loop should be mainly owing to elimination of the fluctuations introduced by changes in the plasmid number. This would suggest that negative feedback loops do not suppress intrinsic noise, but rather eliminate external noise that might arise for example from plasmid variation, or other external sourc ...
... loop should be mainly owing to elimination of the fluctuations introduced by changes in the plasmid number. This would suggest that negative feedback loops do not suppress intrinsic noise, but rather eliminate external noise that might arise for example from plasmid variation, or other external sourc ...
A rule-based kinetic model of RNA polymerase II C
... Ser2 phosphorylation increases towards the 30 end of the gene and is a requirement for 30 end maturation. Serine phosphorylation has been linked to cotranscriptional splicing (the excision of an intron, in red, is illustrated). (b) The actions of the kinases Kin28, Ctk1, Bur1 and Srb10, and the phos ...
... Ser2 phosphorylation increases towards the 30 end of the gene and is a requirement for 30 end maturation. Serine phosphorylation has been linked to cotranscriptional splicing (the excision of an intron, in red, is illustrated). (b) The actions of the kinases Kin28, Ctk1, Bur1 and Srb10, and the phos ...
Conservation of Brachyury (T) genes in amphioxus and vertebrates
... The roles of Brachyury in mesoderm and notochord formation, therefore, might not be common to all vertebrates. Alternatively, since neither mesoderm nor notochord are unique to the vertebrates, the conserved roles deduced for Brachyury could have an earlier origin. To resolve these ambiguities, the ...
... The roles of Brachyury in mesoderm and notochord formation, therefore, might not be common to all vertebrates. Alternatively, since neither mesoderm nor notochord are unique to the vertebrates, the conserved roles deduced for Brachyury could have an earlier origin. To resolve these ambiguities, the ...
Mild trifunctional protein deficiency is associated with - UvA-DARE
... tract infection. Since then, the patient has experienced recurrent episodes of muscle weakness and myoglobinuria precipitated by infection, fasting, exertion, or cold exposure. At long-term follow-up, the patient had slow progressive sensorimotor polyneuropathy characterized by bilateral foot drop, ...
... tract infection. Since then, the patient has experienced recurrent episodes of muscle weakness and myoglobinuria precipitated by infection, fasting, exertion, or cold exposure. At long-term follow-up, the patient had slow progressive sensorimotor polyneuropathy characterized by bilateral foot drop, ...
Lecture9_10_extra2 - Welcome to people.pharmacy.purdue.edu!
... HLA-DQ, HLA-DP, HLA-DR Each MHC II locus encodes a gene for the chain and a gene for the chain: e.g. HLA-DQA, HLA-DQB => MHC II isoforms HLA-DPA, HLA-DPB => MHC II isoforms HLA-DRA, HLA-DRB => MHC II isoforms ...
... HLA-DQ, HLA-DP, HLA-DR Each MHC II locus encodes a gene for the chain and a gene for the chain: e.g. HLA-DQA, HLA-DQB => MHC II isoforms HLA-DPA, HLA-DPB => MHC II isoforms HLA-DRA, HLA-DRB => MHC II isoforms ...
letters - Centre for Social Evolution
... sex-determining function by RNAi knockdown experiments. Only csd and the new fem gene, located 12 kb upstream of csd, have sex determination function (Fig. 1b). RNAi-induced knockdowns of fem in females result in a developmental switch to entire male head differentiation (Fig. 1b), whereas knockdown ...
... sex-determining function by RNAi knockdown experiments. Only csd and the new fem gene, located 12 kb upstream of csd, have sex determination function (Fig. 1b). RNAi-induced knockdowns of fem in females result in a developmental switch to entire male head differentiation (Fig. 1b), whereas knockdown ...
Survey of Conserved Alternative Splicing Events
... To detect AS events, we identified the exon-intron structures of SR protein genes. For Arabidopsis and rice, we identified exon-intron structures by mapping transcripts to the genomes. We mapped transcripts in two steps. First, we roughly mapped transcripts to the genomes using Blast and determined ...
... To detect AS events, we identified the exon-intron structures of SR protein genes. For Arabidopsis and rice, we identified exon-intron structures by mapping transcripts to the genomes. We mapped transcripts in two steps. First, we roughly mapped transcripts to the genomes using Blast and determined ...
Evolution of the Actin Gene Family in Testate Lobose Amoebae
... The evolution of actin gene families is characterized by independent expansions and contractions across the eukaryotic tree of life. Here, we assess diversity of actin gene sequences within three lineages of the genus Arcella, a free-living testate (shelled) amoeba in the Arcellinida. We established ...
... The evolution of actin gene families is characterized by independent expansions and contractions across the eukaryotic tree of life. Here, we assess diversity of actin gene sequences within three lineages of the genus Arcella, a free-living testate (shelled) amoeba in the Arcellinida. We established ...
Searching for Mobile Genetic Elements in the Genome of the
... Transposable elements (TEs) make up a significant percentage of genome in all organisms. These elements are mobile and can have effects on the organism's expression of genes if allowed to transpose . When the relationship between TEs and ...
... Transposable elements (TEs) make up a significant percentage of genome in all organisms. These elements are mobile and can have effects on the organism's expression of genes if allowed to transpose . When the relationship between TEs and ...
Community Attitudes to Biotechnology Report on Health and
... Trade-offs may occur among these factors. For instance, harm to animals may be acceptable to some if the application can save human lives, but not if it only is for corporate profit. ...
... Trade-offs may occur among these factors. For instance, harm to animals may be acceptable to some if the application can save human lives, but not if it only is for corporate profit. ...
MicroReview Paradigms of plasmid organization
... plasmid pair find themselves. Bacteria carrying such DNA may initially have fared better than bacteria lacking the new plasmid because of the altered phenotype but, if the plasmid started as a relatively high-copy-number element, then mutations that led to tighter control, and therefore reduced copy ...
... plasmid pair find themselves. Bacteria carrying such DNA may initially have fared better than bacteria lacking the new plasmid because of the altered phenotype but, if the plasmid started as a relatively high-copy-number element, then mutations that led to tighter control, and therefore reduced copy ...
Models of Selection, Isolation, and Gene Flow in Speciation
... In particular, several classes of such codon models (sometimes called branch sites models; Yang and Nielsen, 2002) can identify the effects of positive selection acting on particular parts of a sequence alignment or on particular lineages within a gene tree. In comparison to other populationgenetic ...
... In particular, several classes of such codon models (sometimes called branch sites models; Yang and Nielsen, 2002) can identify the effects of positive selection acting on particular parts of a sequence alignment or on particular lineages within a gene tree. In comparison to other populationgenetic ...
The journey of a thousand miles EDITORIAL A. Bush and J. Davies
... therapy would cure CF within 5 yrs, has been replaced by more realistic prognostications. There are numerous promising candidates for genotype specific therapies (table 1), including gene therapy (which is of course potentially applicable irrespective of genotype), PTC124 [5], vertex compounds (VX80 ...
... therapy would cure CF within 5 yrs, has been replaced by more realistic prognostications. There are numerous promising candidates for genotype specific therapies (table 1), including gene therapy (which is of course potentially applicable irrespective of genotype), PTC124 [5], vertex compounds (VX80 ...
- LSHTM Research Online
... vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its natural resistance to most antibiotics, the development of new antimicrobial therapies is imperative. To identify drug targets and better understand the complex B. pseudomallei geno ...
... vaccine. B. pseudomallei is listed as a tier 1 select agent, and as current therapeutic options are limited due to its natural resistance to most antibiotics, the development of new antimicrobial therapies is imperative. To identify drug targets and better understand the complex B. pseudomallei geno ...