... BCR/ABL P210 comprises the first 902 or 927 amino acids from BCR, P190 only the 427 N-term from BCR; BCR/ABL has a cytoplasmic localization, in contrast with ABL, mostly nuclear. Oncogenesis That BCR/ABL has a cytoplasmic localization may have a carcinogenetic role. The hybrid protein has an increas ...
Splicing regulation: a structural biology perspective
... years, biochemical and structural studies have shown that this domain is not only involved in RNA/DNA recognition but also in protein-protein interaction. Both modes of interactions play crucial role in splicing regulation. 1.1. RRM-RNA interaction and splicing regulation An RRM is approximately 90 ...
... years, biochemical and structural studies have shown that this domain is not only involved in RNA/DNA recognition but also in protein-protein interaction. Both modes of interactions play crucial role in splicing regulation. 1.1. RRM-RNA interaction and splicing regulation An RRM is approximately 90 ...
Correction of copy number induced false positives in
... We used the data published by Munoz et al. (5), where the copy number artefact has been observed (Fig. 1), i.e. a negative correlation of sensitivity (calculated as Log FC) with copy number. To illustrate the methods, we focused on the astrocytoma cell line sf268 and the gastric cancer cell line mkn ...
... We used the data published by Munoz et al. (5), where the copy number artefact has been observed (Fig. 1), i.e. a negative correlation of sensitivity (calculated as Log FC) with copy number. To illustrate the methods, we focused on the astrocytoma cell line sf268 and the gastric cancer cell line mkn ...
Article Selection Is No More Efficient in Haploid than in Diploid Life
... Two major factors could counteract the effect of masking on the evolutionary rate of genes, especially in multicellular organisms with biphasic life cycles. The first is gene expression breadth, which strongly affects the rate of evolution, so much so that it is one of the best predictors of evoluti ...
... Two major factors could counteract the effect of masking on the evolutionary rate of genes, especially in multicellular organisms with biphasic life cycles. The first is gene expression breadth, which strongly affects the rate of evolution, so much so that it is one of the best predictors of evoluti ...
Use of QTL analysis in physiological research
... upper regions of the roots (root 1 and root 2). Other QTL were confined to one or a few organs, e.g., at the top of chromosome 4, where a locus was found affecting activity in one region of the root only (Fig. 2). In Arabidopsis six Susy genes have been annotated, partly based on sequence homologies ...
... upper regions of the roots (root 1 and root 2). Other QTL were confined to one or a few organs, e.g., at the top of chromosome 4, where a locus was found affecting activity in one region of the root only (Fig. 2). In Arabidopsis six Susy genes have been annotated, partly based on sequence homologies ...
Multiple Barriers to Nonhomologous DNA End Joining
... Surprisingly, the triple mutants also produced a low frequency of ventralized embryos, indicating the DSB repair checkpoint is suppressed despite the persistence of unrepaired DSBs (Table 2). Thus, an alternative explanation for the suppression of eggshell phenotypes in the triple mutants is that ME ...
... Surprisingly, the triple mutants also produced a low frequency of ventralized embryos, indicating the DSB repair checkpoint is suppressed despite the persistence of unrepaired DSBs (Table 2). Thus, an alternative explanation for the suppression of eggshell phenotypes in the triple mutants is that ME ...
Discriminating Between Annual and Perennial
... Currently, the Fluorescence test is used to determine seed purity Problem Fluorescence test is less effective as a result of the two species intermingling and tends to overestimate the annual types. i.e It docks the farmer’s pay more than necessary ...
... Currently, the Fluorescence test is used to determine seed purity Problem Fluorescence test is less effective as a result of the two species intermingling and tends to overestimate the annual types. i.e It docks the farmer’s pay more than necessary ...
Evidence for autosomal recessive inheritance in SPG3A
... supported the homozygous mutation as a plausible cause of the disease. The clinical presentation in affected individuals is consistent with SPG3A and an autosomal recessive inheritance is further supported by the investigation of seven healthy family members shown to be heterozygous carriers for the ...
... supported the homozygous mutation as a plausible cause of the disease. The clinical presentation in affected individuals is consistent with SPG3A and an autosomal recessive inheritance is further supported by the investigation of seven healthy family members shown to be heterozygous carriers for the ...
Hemoglobin A2: origin, evolution, and aftermath
... striking in the coding regions where there are 10 amino acid differences and 31 nucleotide differences. However, the quantitative expression of these two genes is strikingly different. HbA makes up more than 95% of the adult hemolysate, while HbA, comprises only 2% to 3%. The molecular stability of ...
... striking in the coding regions where there are 10 amino acid differences and 31 nucleotide differences. However, the quantitative expression of these two genes is strikingly different. HbA makes up more than 95% of the adult hemolysate, while HbA, comprises only 2% to 3%. The molecular stability of ...
Gene families and evolution of trehalose
... dramatically increased the catalytic activity of the enzymes when expressed in yeast (van Dijck et al. 2002), suggesting that it acts as an autoinhibitory domain. The class I TPS2–4 isoforms from A. thaliana do not appear to possess this domain. In addition to the TPS-like domain, the A. thaliana TP ...
... dramatically increased the catalytic activity of the enzymes when expressed in yeast (van Dijck et al. 2002), suggesting that it acts as an autoinhibitory domain. The class I TPS2–4 isoforms from A. thaliana do not appear to possess this domain. In addition to the TPS-like domain, the A. thaliana TP ...
RHD - Labex
... The importance of the Rh factor was the better blood finger print for criminal matters M, N, or P factors where known and Rh factor was just an additional one Later it was recognized that the new Rh factor was associated with problem in transfusions Between 1940 to 1946 Philip Levine discove ...
... The importance of the Rh factor was the better blood finger print for criminal matters M, N, or P factors where known and Rh factor was just an additional one Later it was recognized that the new Rh factor was associated with problem in transfusions Between 1940 to 1946 Philip Levine discove ...
Engineering of steroid biotransformation in rhodococcus van
... protocol allowed transformation efficiencies of up to 1·106 transformants per µg of plasmid DNA (pMVS301). This protocol was shown to be effective in obtaining targeted gene disruption mutants as well, using non-replicative plasmids containing the aphII kanamycin resistance marker (Chapter 2). Elect ...
... protocol allowed transformation efficiencies of up to 1·106 transformants per µg of plasmid DNA (pMVS301). This protocol was shown to be effective in obtaining targeted gene disruption mutants as well, using non-replicative plasmids containing the aphII kanamycin resistance marker (Chapter 2). Elect ...
Definition of historical models of gene function and their relation to
... or external-consistency in this process. The internal problems are often resolved by scientists during the research process and do therefore not so often become noticeable in the literature. Accordingly the structure as well as the conceptual meaning of the model can be altered. If the revised model ...
... or external-consistency in this process. The internal problems are often resolved by scientists during the research process and do therefore not so often become noticeable in the literature. Accordingly the structure as well as the conceptual meaning of the model can be altered. If the revised model ...
Gene Section EVI1 (ecotropic viral integration site 1 (EVI1) and
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
... Exon 3 of the human EVI1 gene contains two closely spaced ATG codons, either of which may serve as the translation initiation site. Depending on which ATG is used, proteins of 1051 or 1041 amino acids will be formed. EVI1 contains two domains of seven and three zinc finger motifs, respectively, a re ...
A rough guide to Drosophila mating schemes (light version 2.1) 1
... single-domain antibodies [2]. GAIN-OF-FUNCTION (GOF) approaches attempt to obtain functional information by creating conditions where the gene is excessively or ectopically expressed or its function exaggerated. This can be achieved through targeted over-expression of genes, either of their wild typ ...
... single-domain antibodies [2]. GAIN-OF-FUNCTION (GOF) approaches attempt to obtain functional information by creating conditions where the gene is excessively or ectopically expressed or its function exaggerated. This can be achieved through targeted over-expression of genes, either of their wild typ ...
The evolutionary mechanics of bacterial protein toxins
... Alouf, Joseph E, and Michel R Popoff. The Comprehensive Sourcebook of Bacterial Protein Toxins. 3rd. Burlington: ...
... Alouf, Joseph E, and Michel R Popoff. The Comprehensive Sourcebook of Bacterial Protein Toxins. 3rd. Burlington: ...
Powerpoint
... Perform a new group comparison: select the Experiment group To perform a new group comparison you select the experiment group E from the list of all groups that are owned by you or that are shared with you by a colleague ...
... Perform a new group comparison: select the Experiment group To perform a new group comparison you select the experiment group E from the list of all groups that are owned by you or that are shared with you by a colleague ...
Molecular Characterization of a Powdery Mildew Resistance Gene
... and nitrogen fertilizer (1). Resistance to powdery mildew typically demonstrates a “boom-and-bust” cycle because the use of single resistance genes results in a shift to virulent pathogen races that quickly spread over long distances with subsequent loss of resistance in a relatively short time peri ...
... and nitrogen fertilizer (1). Resistance to powdery mildew typically demonstrates a “boom-and-bust” cycle because the use of single resistance genes results in a shift to virulent pathogen races that quickly spread over long distances with subsequent loss of resistance in a relatively short time peri ...
Leukaemia Section T-lineage acute lymphoblastic leukemia (T-ALL) Atlas of Genetics and Cytogenetics
... t(X;14)(q28;q11.2). The t(X;14)(q28;q11.2) is mostly observed in mature T-cell leukemias and dysregulates the MTCP1 gene. NON-TCR GENETIC LESIONS IN T-ALL del(1)(p32)/TAL1(SCL). A cryptic interstitial deletion of TAL1 in the chromosome region 1p32 is observed in as many as 30% of patients with T-ALL ...
... t(X;14)(q28;q11.2). The t(X;14)(q28;q11.2) is mostly observed in mature T-cell leukemias and dysregulates the MTCP1 gene. NON-TCR GENETIC LESIONS IN T-ALL del(1)(p32)/TAL1(SCL). A cryptic interstitial deletion of TAL1 in the chromosome region 1p32 is observed in as many as 30% of patients with T-ALL ...
Guppies – Quang Anh
... gene frequency of the brightest guppies was the highest, at 0.78, and so, it proves that those are the ones seen as the most attractive by the female guppies. And although the predation, natural force, played a role in the simulation, it was overwhelmed by sexual selection and even though the bright ...
... gene frequency of the brightest guppies was the highest, at 0.78, and so, it proves that those are the ones seen as the most attractive by the female guppies. And although the predation, natural force, played a role in the simulation, it was overwhelmed by sexual selection and even though the bright ...
HW4_final
... Make sure that you are using the “Single strand” mode for RNA sequences. Provide the motif logo. 2. What is the significance of the identified motif? Look at the occurrences distribution by clicking on “view occurrences distribution” or by downloading the motif occurrences file and explain how come ...
... Make sure that you are using the “Single strand” mode for RNA sequences. Provide the motif logo. 2. What is the significance of the identified motif? Look at the occurrences distribution by clicking on “view occurrences distribution” or by downloading the motif occurrences file and explain how come ...
Opposing Activities of DRM and MES
... somatic and germ cells, but dampening occurs by different mechanisms in the two cell types. In the hermaphrodite soma, a “dosage compensation complex” related to chromosome condensation factors binds the two X chromosomes and down-regulates their expression to equal that of the single X in males (Me ...
... somatic and germ cells, but dampening occurs by different mechanisms in the two cell types. In the hermaphrodite soma, a “dosage compensation complex” related to chromosome condensation factors binds the two X chromosomes and down-regulates their expression to equal that of the single X in males (Me ...
The ara Operon - University of Pennsylvania
... absent, AraC is produced and gets attached to araC. In this way araC acts as its own regulator. In the absence of arabinose, binding of AraC to araC prevents the attachment of RNA polymerase (RNAp) to PBAD and thus none of the genes can be transcribed. However, when arabinose becomes available, it b ...
... absent, AraC is produced and gets attached to araC. In this way araC acts as its own regulator. In the absence of arabinose, binding of AraC to araC prevents the attachment of RNA polymerase (RNAp) to PBAD and thus none of the genes can be transcribed. However, when arabinose becomes available, it b ...
Information Encoding in Biological Molecules: DNA and
... • open EDE for any of the exons of syx5:CG4214RB transcript • split exon 2 and make an intron of arbitrary length by dragging the exon boundaries • split new exon 3 and make an intron using “Set ...
... • open EDE for any of the exons of syx5:CG4214RB transcript • split exon 2 and make an intron of arbitrary length by dragging the exon boundaries • split new exon 3 and make an intron using “Set ...