Host-range expansion of Spodoptera exigua multiple
... columnar epithelial cells. The nucleocapsids (NCs) enter the cytoplasm by direct membrane fusion (Granados & Lawler, 1981; Horton & Burand, 1993). The NCs are transported to the nucleus in a cytoskeleton-dependent manner and enter the nucleus through nuclear pores (Ohkawa et al., 2002), after which ...
... columnar epithelial cells. The nucleocapsids (NCs) enter the cytoplasm by direct membrane fusion (Granados & Lawler, 1981; Horton & Burand, 1993). The NCs are transported to the nucleus in a cytoskeleton-dependent manner and enter the nucleus through nuclear pores (Ohkawa et al., 2002), after which ...
CHAPTER 7 TUNING THE DRAGON PROMOTER FINDER SYSTEM FOR HUMAN PROMOTER RECOGNITION
... signal thresholds are also used. These parameters have to be adjusted so that the tuned system achieves the desired performance. The tuning process is conducted 10 times for each selected level of sensitivity, and different models are produced in the process. Then, from all of the models, the select ...
... signal thresholds are also used. These parameters have to be adjusted so that the tuned system achieves the desired performance. The tuning process is conducted 10 times for each selected level of sensitivity, and different models are produced in the process. Then, from all of the models, the select ...
Increased carrier prevalence of deficient CYP2C9, CYP2C19 and
... CYP2C19 and CYP2D6 alleles in depressed patients referred to a tertiary psychiatric hospital Objective: This study compared the types and carrier prevalences of clinically significant DNA polymorphisms in the cytochrome P450 (CYP450) genes CYP2C9, CYP2C19 and CYP2D6 in major depressive disorder pati ...
... CYP2C19 and CYP2D6 alleles in depressed patients referred to a tertiary psychiatric hospital Objective: This study compared the types and carrier prevalences of clinically significant DNA polymorphisms in the cytochrome P450 (CYP450) genes CYP2C9, CYP2C19 and CYP2D6 in major depressive disorder pati ...
Mechanistic Comparison of High-Fidelity and Error
... to DNA polymerization, it is first necessary to define fidelity. DNA polymerase fidelity has been measured in different ways, including (a) comparison of kinetic constants for Watson-Crick and mismatched nucleotide incorporation reactions and (b) measurement of misincorporation frequency when compet ...
... to DNA polymerization, it is first necessary to define fidelity. DNA polymerase fidelity has been measured in different ways, including (a) comparison of kinetic constants for Watson-Crick and mismatched nucleotide incorporation reactions and (b) measurement of misincorporation frequency when compet ...
Genetics and Genomics
... 2. Y-linked (holandric) Inheritance ......................................................................................... 3. Sex influenced inheritance .................................................................................................. 4. Sex limited inheritance .................. ...
... 2. Y-linked (holandric) Inheritance ......................................................................................... 3. Sex influenced inheritance .................................................................................................. 4. Sex limited inheritance .................. ...
Foundations of Biology
... their genetic information to the nucleus. The hydrogenosome, a structure involved in carbohydrate metabolism found in some Archezoans (Muller, 1992), is now thought to represent a mitochondria that has lost its genetic information completely and along with that loss, the ability to do the Krebs cycl ...
... their genetic information to the nucleus. The hydrogenosome, a structure involved in carbohydrate metabolism found in some Archezoans (Muller, 1992), is now thought to represent a mitochondria that has lost its genetic information completely and along with that loss, the ability to do the Krebs cycl ...
Genome Rearrangements Caused by Depletion of Essential DNA
... cycle following gene-product depletion by promoter shut off (Yu et al. 2006). Spontaneous DNA damage was measured by the relocalization of the DNA damage checkpoint protein Ddc2 from a diffuse nuclear pattern to discrete subnuclear foci (Figure 1A) (Melo et al. 2001; Lisby et al. 2004). Following gr ...
... cycle following gene-product depletion by promoter shut off (Yu et al. 2006). Spontaneous DNA damage was measured by the relocalization of the DNA damage checkpoint protein Ddc2 from a diffuse nuclear pattern to discrete subnuclear foci (Figure 1A) (Melo et al. 2001; Lisby et al. 2004). Following gr ...
credits - CiteSeerX
... approximated these ideal ratios because his samples were of a limited size. This explanation led to the principle of segregation, which in modern terms would be stated this way: when gametes are formed, the genes in a pair segregate so that each gamete has only one gene, rather than the normal two. ...
... approximated these ideal ratios because his samples were of a limited size. This explanation led to the principle of segregation, which in modern terms would be stated this way: when gametes are formed, the genes in a pair segregate so that each gamete has only one gene, rather than the normal two. ...
... were isolated with a tightly linked RAPD marker, and subsequently the regions flanking the Rps1 locus were nearly saturated with AFLP markers. Identification and mapping of RAPD markers linked to the Rps1 locus. The screening of 400 decamer primers against the cultivar Williams (rps1-k) and its NIL ...
Mechanisms of Transcription-Replication
... tRNA genes in S. cerevisiae (11). The replication fork stalls when it encounters tRNA genes transcribed head-on, but not when it encounters those transcribed codirectionally. Since replication fork pause site activity was dependent on the functionality of both the gene promoter and RNA polymerase II ...
... tRNA genes in S. cerevisiae (11). The replication fork stalls when it encounters tRNA genes transcribed head-on, but not when it encounters those transcribed codirectionally. Since replication fork pause site activity was dependent on the functionality of both the gene promoter and RNA polymerase II ...
SHORT COMMUNICATION One-step multiplex RT-PCR
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
... The patient who was negative for BCR/ABL had clinical features and peripheral blood film suggestive of chronic myeloproliferative disease. Her condition was complicated by carcinoma of the breast that developed later. The use of conventional cytogenetic analysis has complemented PCR at initial diagn ...
投影片 1 - cmcmurillo
... Ethical issues of gene therapy • Is it right to replace a 'defective' gene with a 'normal' one? • Is the answer the same for a gene which causes the bearer pain, as it is where the gene has a merely cosmetic effect? • Who decides what is 'defective' and what is 'normal'? A 'defective' gene may actu ...
... Ethical issues of gene therapy • Is it right to replace a 'defective' gene with a 'normal' one? • Is the answer the same for a gene which causes the bearer pain, as it is where the gene has a merely cosmetic effect? • Who decides what is 'defective' and what is 'normal'? A 'defective' gene may actu ...
Mycobacterium tuberculosis: Potassium uptake systems of
... appears most likely. In support of this contention, exposure to clofazimine is accompanied by a rapid increase in phospholipase activity in MTB.40,43 Although increased phospholipase activity is not primarily linked to inhibition of uptake of K+, it is, nevertheless, compatible with membrane destabi ...
... appears most likely. In support of this contention, exposure to clofazimine is accompanied by a rapid increase in phospholipase activity in MTB.40,43 Although increased phospholipase activity is not primarily linked to inhibition of uptake of K+, it is, nevertheless, compatible with membrane destabi ...
THE LOCI OF EVOLUTION: HOW PREDICTABLE IS GENETIC
... amino-acid sequence and are thus likely to affect protein structure, stability, activity, or binding properties. In contrast, synonymous mutations do not alter the amino-acid sequence, although they can modify gene function through other mechanisms, such as changes in translation efficiency or mRNA ...
... amino-acid sequence and are thus likely to affect protein structure, stability, activity, or binding properties. In contrast, synonymous mutations do not alter the amino-acid sequence, although they can modify gene function through other mechanisms, such as changes in translation efficiency or mRNA ...
the loci of evolution: how predictable is genetic
... amino-acid sequence and are thus likely to affect protein structure, stability, activity, or binding properties. In contrast, synonymous mutations do not alter the amino-acid sequence, although they can modify gene function through other mechanisms, such as changes in translation efficiency or mRNA ...
... amino-acid sequence and are thus likely to affect protein structure, stability, activity, or binding properties. In contrast, synonymous mutations do not alter the amino-acid sequence, although they can modify gene function through other mechanisms, such as changes in translation efficiency or mRNA ...
Genetic Polymorphism of Human CYP2E1
... was detected by Northern blot, and the CYP2E1 apoprotein levels were quantified by Western blot. The CYP2E1-dependent catalytic activities were determined by measuring NADPHdependent hydroxylation of chlorzoxazone in 10,000 3 g supernatants of the transfected cells. All constructs except the pCMV4 v ...
... was detected by Northern blot, and the CYP2E1 apoprotein levels were quantified by Western blot. The CYP2E1-dependent catalytic activities were determined by measuring NADPHdependent hydroxylation of chlorzoxazone in 10,000 3 g supernatants of the transfected cells. All constructs except the pCMV4 v ...
The coiled-coil of the human Rad50 DNA repair protein contains
... For polymers like DNA, this method yields an average persistence length that is in good agreement with values obtained by other techniques (8). This method has been modified to describe known segments of different persistence length (9). Another method for the determination of overall flexibility of ...
... For polymers like DNA, this method yields an average persistence length that is in good agreement with values obtained by other techniques (8). This method has been modified to describe known segments of different persistence length (9). Another method for the determination of overall flexibility of ...
View PDF - OMICS International
... cardiomyopathy [21,22]; echocardiography showed normal diameters and volumes of cardiac chambers, normal thickness of septum and left posterior wall and a normal ejection fraction. The analysis of DMD gene, by 80-plex PCR analysis, failed to demonstrate any deletion of the dystrophin gene, while the ...
... cardiomyopathy [21,22]; echocardiography showed normal diameters and volumes of cardiac chambers, normal thickness of septum and left posterior wall and a normal ejection fraction. The analysis of DMD gene, by 80-plex PCR analysis, failed to demonstrate any deletion of the dystrophin gene, while the ...
The Origin of Subfunctions and Modular Gene Regulation
... However, the model that we present highlights the logical distinction between the causal nonadaptive forces that may lead to the restructuring of genomic architecture and the secondary consequences of such change for phenotypic evolution. We now formalize the theory for the two phases contributing t ...
... However, the model that we present highlights the logical distinction between the causal nonadaptive forces that may lead to the restructuring of genomic architecture and the secondary consequences of such change for phenotypic evolution. We now formalize the theory for the two phases contributing t ...
Base-pair neutral homozygotes can be discriminated by calibrated
... variants, which comprise 16% of all human single nucleotide polymorphisms (SNPs). We used internal oligonucleotide calibrators and custom analysis software to improve small amplicon (42–86 bp) genotyping on the LightScannerÕ . Three G/C (PAH c.1155C>G, CHK2 c.1-3850G>C and candidate gene BX647987 c ...
... variants, which comprise 16% of all human single nucleotide polymorphisms (SNPs). We used internal oligonucleotide calibrators and custom analysis software to improve small amplicon (42–86 bp) genotyping on the LightScannerÕ . Three G/C (PAH c.1155C>G, CHK2 c.1-3850G>C and candidate gene BX647987 c ...
light - Microbiology
... damage repairable by a mechanism involving excision of single-stranded fragments, also induces new donor bacteria. Other agents such as X-rays and methyl methansulphonate (MMS) do not stimulate the production of new donors but may enhance the recombination frequency since cells killed by them may co ...
... damage repairable by a mechanism involving excision of single-stranded fragments, also induces new donor bacteria. Other agents such as X-rays and methyl methansulphonate (MMS) do not stimulate the production of new donors but may enhance the recombination frequency since cells killed by them may co ...
Are 100 enough? Inferring acanthomorph teleost phylogeny using
... taxonomic sampling than what was used for the original UCE design, increasing capture efficiency for a wider taxonomic range relative to those markers. This facilitates the capture of homologous loci that are useful for both old and more recent divergences, a property shared with UCEs [22, 27]. One ...
... taxonomic sampling than what was used for the original UCE design, increasing capture efficiency for a wider taxonomic range relative to those markers. This facilitates the capture of homologous loci that are useful for both old and more recent divergences, a property shared with UCEs [22, 27]. One ...
REVIEWS - The SHINE Library
... SCO and vel, it is apparent that there is extreme heterogeneity underlying hydrocephalus. It should also be mentioned that other transcription factors, such as Otx2, are known to be associated with hydrocephalus when inactivated in mice; however, such a phenotype is unlikely to be SCO-specific and l ...
... SCO and vel, it is apparent that there is extreme heterogeneity underlying hydrocephalus. It should also be mentioned that other transcription factors, such as Otx2, are known to be associated with hydrocephalus when inactivated in mice; however, such a phenotype is unlikely to be SCO-specific and l ...