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Evidence for Variable Selective Pressures at a
Evidence for Variable Selective Pressures at a

... become available and incorporated into computer software packages (SantaLucia 1998; Markham and Zuker 2005). The recent developments in DNA folding prediction, as well as the increasing number of available control region sequences, prompted us to reevaluate the mtDNA control region potential for int ...
The Genetics of Microcephaly
The Genetics of Microcephaly

... affected for no definite reason and the medical tests that they undergo fail to provide any clues as to the cause. Some causes of microcephaly Genetic chromosome disorders Genetic single gene disorders Certain prenatal infections affecting the fetus Cerebrovascular accident in the fetus (stroke) Sev ...
Slide 1
Slide 1

... gene with a working functional gene. So far there have not been any accepted gene therapy treatments but researchers have found success of the gene therapy treatment in mice. ...
Identification and Analysis of Arabidopsis Expressed Sequence
Identification and Analysis of Arabidopsis Expressed Sequence

... virtually absent from the literature. The analysis of additional ncRNA candidates should indicate whether kingdom specificity is a common feature of ncRNAs. Data supporting the existence of additional ncRNAs in Arabidopsis have emerged recently. One putative ncRNA described in Arabidopsis was identi ...
A catalogue of imprinted genes and parent-of
A catalogue of imprinted genes and parent-of

... gene, UBE3A, was thought not to be imprinted until allele-specific transcription was detected in the brain. Secondly, several conditions show an imprinted pattern of inheritance, for example familial glomus tumours only occur by paternal inheritance. However, in this situation, linkage to the diseas ...
M.Sc., Biotechnology - Alagappa University
M.Sc., Biotechnology - Alagappa University

... of diseases and in designing appropriate therapies. Currently the smart use of various biochemical laboratory tests have become an integral part of disease diagnosis and monitoring the treatment. A high understanding of biochemistry and of other related basic disciplines such as cell biology, molecu ...
Radiation Hybrid Mapping: A Somatic Cell Genetic Method for
Radiation Hybrid Mapping: A Somatic Cell Genetic Method for

... use of RH mapping, in conjunction with PFGE, to construct a highresolution map of the proximal 20 Mb of the long arm of human chromosome 21. Theory and practice o f radiation hybrid mapping. In this method, which is based on earlier studies by Goss and Harris (6), a high dose of x-rays is used to br ...
Spectrum of Mutations in MMAB Identified by
Spectrum of Mutations in MMAB Identified by

... I would like to express my appreciation to my mentor, David Rosenblatt, for providing me the opportunity, not only once but twice, to be actively engaged in a field of personal interest. Being a member of the Rosenblatt team provides the friendship, support and unquestioning assistance of a very spe ...
Translational Repression of C. elegans p53 by GLD
Translational Repression of C. elegans p53 by GLD

... 2003; Vassilev et al., 2004). Such a therapeutic approach highlights the need to uncover additional pathways and mechanisms that negatively regulate p53 levels or activity. Most studies on p53 signaling have been conducted in cell culture-based systems, and their translation into mouse models is oft ...
Mechanisms of translational regulation in bacteria
Mechanisms of translational regulation in bacteria

... the growing peptide chain is determined by triplets of nucleotides, so called codons. However, there are only 20 amino acids but 64 different triplets of nucleotides encoding them. Consequently, the genetic code is degenerate: Except for tryptophan and methionine, the amino acids are encoded by two, ...
MAK, a computational tool kit for automated MITE
MAK, a computational tool kit for automated MITE

... with minimal damages to the TIRs. An additional long element (AB025602, from 7658 to 11 849) showed an overall 98% DNA sequence identity to A-MathE1. Since the element on AB025602 is situated on a different locus of chromosome 5 from A-MathE1 on AC007123 and they share no flanking sequence similarit ...
mutation and Y486D mutation in exon 5 of the UGT1A1 - Funpec-RP
mutation and Y486D mutation in exon 5 of the UGT1A1 - Funpec-RP

... the patient had a normal wild-type A(TA)6TAA promoter, was homozygous for the c.211G>A missense mutation, and showed the compound heterozygous mutation between c.10691070insC and c.1456T>G. The first mutation, the c.211G>A missense mutation, was at position 211 in exon 1 and caused substitution of g ...
Molecular Analysis of the Coprinus cinereus Mating Type A Factor
Molecular Analysis of the Coprinus cinereus Mating Type A Factor

... polymorphic. Approximately 40 A and B factors have been identified and over 100 may exist worldwide (WHITEHOUSE 1949). In C. cinereus, some of this polymorphism can be explained by the observations of A factor is made up of at DAY(1 960, 1963b) that the least two closely linked subunits, termed (Y a ...
Document
Document

... specific type of a more general parent term. For example: a caryopsis is a type of fruit; a panicle is an inflorescence. Part of: Used to indicate the relationship between a child term that is a part of the parent term. For example: the ectocarp is a part of the pericarp, which in turn is part of th ...
Rapid and Quantitative Detection of Toxoplasma Gondii by PCR
Rapid and Quantitative Detection of Toxoplasma Gondii by PCR

... brew” applications for prenatal diagnosis of toxoplasmosis, in particular, making it faster, more sensitive, and decreases morbidity, because it is currently based on amniocentesis alone [4]. However, the main risk concerns false-positive results arising from contamination with previously amplified ...
Opioid receptor delta as a global modulator of skin
Opioid receptor delta as a global modulator of skin

... nervous, immune, cutaneous, endocrine (NICE) systems [2]. In order to respond to the nervous system, the skin expresses several receptors, including opioids receptors [3]. These receptors are G protein-coupled receptors (GPCR) mediating the effects of opioid ligands either of endogenous or exogenous ...
PDF
PDF

... in Oncopeltus. These differences in local behavior of the amnion and in the amnion-serosa connection are all the more striking given that Of-zen and Tc-zen2, the second Tribolium paralog, both act extraembryonically to ensure that EE rupture occurs (Figure 1: green diamonds; van der Zee et al., 2005 ...
Gene conversion and purifying selection shape nucleotide variation
Gene conversion and purifying selection shape nucleotide variation

... region including residue 277 and five surrounding nucleotide sites at which the human L (GenBank Accession number Z68193) and M (GenBank AC092402) opsin genes differ. This primer site does not contain the residue 285, which is attributable to the relatively few nucleotide differences reported betwee ...
10p proximal deletions from 10p11 and 10p12
10p proximal deletions from 10p11 and 10p12

... Each new version of the genome is often referred to as an ‘assembly’ or a ‘build’. Every few years a new assembly is released. The genetic information in this guide is based on the Genome Reference Consortium (GRC) human (h) genome assembly number 37 (GRCh37), which was released in 2009. Confusingly ...
Protocadherin-1: epithelial barrier dysfunction in asthma and eczema Grissel Faura Tellez
Protocadherin-1: epithelial barrier dysfunction in asthma and eczema Grissel Faura Tellez

... skin tissue are therefore urgently needed to assess their functional relevance. Thirdly, coding SNPs may have generic effects by affecting PCDH1 protein function. The coding SNP Ala514Thr maps to an EC domain in the PCDH1 protein, which is compatible with a potential effect on cell–cell adhesion tha ...
PDF - 2.6 MB
PDF - 2.6 MB

... (a 6 pts.) You obtain genomic DNA samples from other men with poor sperm production and sequence their SPG gene. You find that six such men, apparently unrelated, are mutant in SPG. Are these six men likely to carry the same frame shift mutation found in the first man because of the mutation having ...
345 - Timstar
345 - Timstar

... One common problem that occurs during PCR is the production of unwanted amplification products. This may be due to contamination of the sample or nonspecific annealing (to the wrong segment). If this were to occur in an early cycle, the incorrect copy will also be amplified. To reduce contamination, ...
Efficient Virus-Induced Gene Silencing in Roots
Efficient Virus-Induced Gene Silencing in Roots

... The relative ability of TRV-2b-GFP and TRV-D2b-GFP vectors (Fig. 1a; ‘‘Materials and Methods’’) to invade and spread systemically in shoots and roots of N. benthamiana and Arabidopsis was investigated. Viral movement was monitored by observation of GFP fluorescence (Fig. 1b). TRV-2b-GFP was able to ...
Analysis of the first polar body: preconception genetic
Analysis of the first polar body: preconception genetic

HL7 V2.5.1 Genetic Test Result Message
HL7 V2.5.1 Genetic Test Result Message

... In March, 2008, the United States Department of Health and Human Services, Office of the National Coordinator for Health IT published the Personalized Healthcare Detailed Use Case (Click here to see the use case) in response to a request and specifications from the American Health Information Commun ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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