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Structural Energetics of a RNA-DNA Hybrid
Structural Energetics of a RNA-DNA Hybrid

... angle of 30, and helical rise of 3.7 Å). Structures of the three forms are shown in Figure 1.1.3. RNA can adopt a greater variety of structures, including hairpin loops, bulges, internal loops, and single strands. Double-stranded RNA is typically in the Aform. The properties of nucleic acids play ...
Noureddine Loukili  Studies on UEV, a new regulator of polyubiquitination:
Noureddine Loukili Studies on UEV, a new regulator of polyubiquitination:

... lymphocyte differentiation promoting factor, and which he called ubiquitin (Goldstein and Dayhoff, 1975) as he thought it was probably ubiquitous to living cells. A few years later, the non-histone protein component of the nuclear protein A24 was identified as ubiquitin (Hunt et al., 1977) and A24 w ...
mic.sgmjournals.org
mic.sgmjournals.org

... contain the unusual non-proteinogenic amino acid Nmethyldehydroalanine (Mdha) (Fig. 1). N-Methylation of the microcystins is achieved by the N-methyltransferase (NMT) domain in the first module of McyA (Nishizawa et al., 1999; Tillett et al., 2000; Christiansen et al., 2003; Rouhiainen et al., 2004) ...
Prader-Willi and Angelman syndromes: Sister imprinted disorders
Prader-Willi and Angelman syndromes: Sister imprinted disorders

... SmN (small nuclear ribonuclear protein) ...
1 - Quizbowl Packet
1 - Quizbowl Packet

... insert the gene for the diphtheria toxin during this process via the namesake conversion, which can also result in an increase in the imperviousness of the host cell’s external membrane. Induction, often involving UV radiation, ends this process to begin its counterpart. In this process, the viral D ...
Detection and analysis of disease-associated single nucleotide
Detection and analysis of disease-associated single nucleotide

... near the gene, such as NearGene-3, MirSNP, NearGene5 and UTR-3 were higher disease-associated proportion than SNPs in intron because they might affect protein functions by indirect way like regulating protein expressions. On the other hand SNPs around PTM site can give a potent influence on the prot ...
A component of calcium-activated potassium channels encoded by
A component of calcium-activated potassium channels encoded by

... the data a nonparameaic test was used. Each daily settlement value consisted of the average of two or three settlement plates per site. One site was observed from 29 April until 8 August 1989; the Spearman correlation coefficients between settlement and water temperature anomaly were -0.258 for Chth ...
Polyploidy Enhances F Pollen Sterility Loci
Polyploidy Enhances F Pollen Sterility Loci

... analysis identified a prominent functional gene class consisting of seven genes related to photosystem I (Gene Ontology 0009522). Moreover, 55 meiosis-related or meiosis stage-specific genes were associated with IPE in autotetraploid rice, including Os02g0497500, which encodes a DNA repair-recombinati ...
Multiple Roles of the Y Chromosome in the Biology of
Multiple Roles of the Y Chromosome in the Biology of

... The discovery of the structure of the double helix[11] and the identification of the genetic code[12,13] transformed the definition of “gene” as a “transcribed code”, and it was rapidly found that not all genes have proteins as their final output; for example, the genes encoding ribosomal and transf ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami

... arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instability depending upon mouse strain. However, to date the genetic modifiers underlying these differences have not been identifi ...
Package 'MatrixEQTL'
Package 'MatrixEQTL'

... heteroskedastic and/or correlated errors. Associations significant at pvOutputThreshold (pvOutputThreshold.cis) levels are saved to output_file_name (output_file_name.cis), with corresponding estimates of effect size (slope coefficient), test statistics, p-values, and q-values (false discovery rate) ...
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli
(type I) and mannose-resistant F8 (P) fimbriae of Escherichia coli

... mediated by adhesive fimbriae, which can be divided into different types (type I, P, S, M, and X fimbriae) on the basis of their receptor specificities. E. coli P-fimbriae associated with urinary tract infections can be subdivided into serologically distinct groups termed F 7 - F 1 4 [1-3]. All of t ...
Control of ribosome traffic by position-dependent
Control of ribosome traffic by position-dependent

... the ribosome binding site as well as the start codon, which varies depending on the gene [21]. Ks is an important parameter for the ribosome traffic; when Ks is low there will be few collisions between ribosomes, while it is likely that a high Ks will cause collisions and ribosome queuing. In order ...
A family of human Y chromosomes has dispersed throughout
A family of human Y chromosomes has dispersed throughout

... difference in the numbers of genes affected by the two deletions; the b2/b3 deletion removes one more copy of each of three gene families, but spares at least one copy of each family (Table 3). Based on the Y-chromosomal reference sequence, the sequences of the gene copies remaining ...
Are Restriction Enzymes Recognition Sites Underrepresented in the
Are Restriction Enzymes Recognition Sites Underrepresented in the

... The efficiency of restriction modification system II depends on the efficiency of both enzymes, the effective recognition of the host restriction site sequence and the foreign restriction site sequence by the methyltransferase enzyme and restriction enzymes, respectively. The net cellular concentrat ...
Gel Electrophoresis - Integrated DNA Technologies
Gel Electrophoresis - Integrated DNA Technologies

... can be thought of as semi-solid matrices whose pore sizes aid in separation. The semisolid nature of the gel participates through a process known as molecular sieving. The three common media for gel electrophoresis are starch, polyacrylamide, and agarose. Of these, the starch gel medium is the leas ...
- Wiley Online Library
- Wiley Online Library

... exhibiting secondary thickening (data not shown). We conclude from these results that the increase in vascular tissue size in let is caused by an increase in xylem, phloem (pro)cambial and pericycle cell number. The transformation of the 35SDE-LEP-VAS construct, which harbours the activation-tagged ...
Unit F215
Unit F215

... The production of a polypeptide is not simply determined by the length of DNA that actually codes for the polypeptide. In this case, there is a promoter and terminator (which indicate where to start and finish transcription) and the operator (which regulates the activity of three different genes, co ...
Simple identification of dominant p53 mutants by
Simple identification of dominant p53 mutants by

... transactivate its target genes. While this abortive activation/ impaired degradation model provides a satisfactory explanation for the high level p53 expression seen in tumours (5,6), it does not rule out the possibility that a selective growth advantage may be conferred by mutated p53 proteins, eit ...
Andrew Phillips
Andrew Phillips

... The Tet protein can inhibit the lambda gene Andrew Phillips - Trento 2006 ...
p53, the Cellular Gatekeeper Review for Growth and Division
p53, the Cellular Gatekeeper Review for Growth and Division

... damage can activate p53, including double-strand breaks in DNA produced by g-irradiation and the presence of DNA repair intermediates after ultraviolet irradiation or chemical damage to DNA. This results in a rapid increase in the level of p53 in the cell and activation of p53 as a transcription fac ...
Chromosomal Mutations - Virtual Learning Environment
Chromosomal Mutations - Virtual Learning Environment

... These extra copies can undergo mutations to take on altered roles in the cell, or they can become pseudogenes, which are the inactive forms of the gene. Unequal crossing over happens during the prophase of meiosis one. Homologous chromosomes pair at this stage, and sometimes pairing occurs between t ...
some inconvenient truths about sex chromosome dosage
some inconvenient truths about sex chromosome dosage

... sex chromosome divergence. This topic has been the subject of several recent reviews (e.g., see Straub and Becker 2007), so we will not go into great detail about the regulatory mechanics of sex chromosome dosage compensation. Briefly, Drosophila ...
Understanding the Scurred condition in Polled Cattle
Understanding the Scurred condition in Polled Cattle

... Understanding the Scurred condition in Polled Cattle Most calves that are horned can be identified at birth or shortly after, and almost always by weaning time. Distinguishing between smooth-polled and scurred-polled is more difficult. Scurs, a rudimentary horn growth, are often not seen until cattl ...
2.2 Australian Pilot Survey for GM Food Labelling
2.2 Australian Pilot Survey for GM Food Labelling

... All foods produced using gene technology must be safety assessed by FSANZ prior to release onto the market for human consumption. Hence, the labelling of GM food is not a safety issue but rather is one of consumer information and enables consumers to make a choice regarding selecting the food they w ...
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Therapeutic gene modulation

Therapeutic gene modulation refers to the practice of altering the expression of a gene at one of various stages, with a view to alleviate some form of ailment. It differs from gene therapy in that gene modulation seeks to alter the expression of an endogenous gene (perhaps through the introduction of a gene encoding a novel modulatory protein) whereas gene therapy concerns the introduction of a gene whose product aids the recipient directly.Modulation of gene expression can be mediated at the level of transcription by DNA-binding agents (which may be artificial transcription factors), small molecules, or synthetic oligonucleotides. It may also be mediated post-transcriptionally through RNA interference.
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