assembling the aging puzzle - Biomedical Computation Review
... Kim, PhD, professor of developmental biology and genetics at Stanford University. “Understanding aging is really in its beginning stages. I feel we aren't anywhere near a good understanding.” One thing is certain: genes play a role. They may or may not direct aging, but they do influence it. In the ...
... Kim, PhD, professor of developmental biology and genetics at Stanford University. “Understanding aging is really in its beginning stages. I feel we aren't anywhere near a good understanding.” One thing is certain: genes play a role. They may or may not direct aging, but they do influence it. In the ...
The rapidly evolving field of plant centromeres
... These satellites can be homogenized through unequal crossover, which would provide an explanation for chromosome-specific variation and the formation of higherorder satellite arrays [23–27]. Another model suggests that satellite evolution is driven by the selection and coevolution of satellites and ...
... These satellites can be homogenized through unequal crossover, which would provide an explanation for chromosome-specific variation and the formation of higherorder satellite arrays [23–27]. Another model suggests that satellite evolution is driven by the selection and coevolution of satellites and ...
FX 8 - ACMG
... Result: PCR analysis using DNA obtained from a blood sample detected 48 CGG repeats. Using standard nomenclature, this genotype is described as c.-129CGG[48]. Interpretation: These studies indicate that this patient is not a carrier of a premutation or full mutation for the fragile X gene. If the fa ...
... Result: PCR analysis using DNA obtained from a blood sample detected 48 CGG repeats. Using standard nomenclature, this genotype is described as c.-129CGG[48]. Interpretation: These studies indicate that this patient is not a carrier of a premutation or full mutation for the fragile X gene. If the fa ...
Chromatin DNA Methylayion
... Agents that inhibit DNA methyltransferase such as 5-aza-CdR stimulate tumor invasion and metastasis. ...
... Agents that inhibit DNA methyltransferase such as 5-aza-CdR stimulate tumor invasion and metastasis. ...
Mugisha, L., Leendertz, FH, Opuda-Asibo, J., Olobo, JO, Ehlers, B. A
... immune system have been implicated in the initiation of infection leading to substantial acute phase replication and subsequent establishment of a maximal level of latency. In addition, it is not known whether the gammaherpesviruses found in great apes present the same way as their human counterpart ...
... immune system have been implicated in the initiation of infection leading to substantial acute phase replication and subsequent establishment of a maximal level of latency. In addition, it is not known whether the gammaherpesviruses found in great apes present the same way as their human counterpart ...
microbial genetics
... least some (Fig.4a). The daughter cells do not have to inherit exactly half of the plasmid molecules. Thus, even if a daughter cell only receives a fewer copies of the plasmid than the copy number, this can be redeemed through replication of the plasmid. For this reason, high copy number plasmids do ...
... least some (Fig.4a). The daughter cells do not have to inherit exactly half of the plasmid molecules. Thus, even if a daughter cell only receives a fewer copies of the plasmid than the copy number, this can be redeemed through replication of the plasmid. For this reason, high copy number plasmids do ...
Title: Gene Interactions in Corn. Introduction. The phenotype of an
... genotype of an organism, and an understanding of how the various genes and alleles interact, we can predict the phenotype of the progeny of a particular cross. For example, given that flower colour in pea plants is controlled by a single gene, and that the allele that gives rise to purple flowers is ...
... genotype of an organism, and an understanding of how the various genes and alleles interact, we can predict the phenotype of the progeny of a particular cross. For example, given that flower colour in pea plants is controlled by a single gene, and that the allele that gives rise to purple flowers is ...
Pattern of diversity in the genomic region near the
... Domesticated maize and its wild ancestor (teosinte) differ strikingly in morphology and afford an opportunity to examine the connection between strong selection and diversity in a major crop species. The tb1 gene largely controls the increase in apical dominance in maize relative to teosinte, and a ...
... Domesticated maize and its wild ancestor (teosinte) differ strikingly in morphology and afford an opportunity to examine the connection between strong selection and diversity in a major crop species. The tb1 gene largely controls the increase in apical dominance in maize relative to teosinte, and a ...
Genetic or epigenetic difference causing discordance between
... Thus, loss of imprinting is the cause of BWS in these cases. A similar finding, discordant DNA methylation, was also seen in lymphocytes. However, it is of note that loss of imprinting was observed in both twins in some of the MZ twin pairs. This could be due to the blood transfusion in utero. Since ...
... Thus, loss of imprinting is the cause of BWS in these cases. A similar finding, discordant DNA methylation, was also seen in lymphocytes. However, it is of note that loss of imprinting was observed in both twins in some of the MZ twin pairs. This could be due to the blood transfusion in utero. Since ...
FTZ-Factor1 and Fushi tarazu interact via conserved nuclear
... et al., 1984; Martinez-Arias and Lawrence, 1985) and aFtz-F1 (Guichet et al., 1997; Yu et al., 1997) mutant embryos. Thus, ftz provides the spatial information for the combinatorial function of the two genes. Nuclear receptors are transcription factors that bind DNA via type II zinc-®nger motifs (re ...
... et al., 1984; Martinez-Arias and Lawrence, 1985) and aFtz-F1 (Guichet et al., 1997; Yu et al., 1997) mutant embryos. Thus, ftz provides the spatial information for the combinatorial function of the two genes. Nuclear receptors are transcription factors that bind DNA via type II zinc-®nger motifs (re ...
Genetic suppression
... UAG (amber), UAA (ochre) or UGA (opal), resulting in polypeptide chain termination and (usually) complete or almost complete loss of gene function. These nonsense mutants can potentially be suppressed by nonsense suppressor tRNAs, in which a sense codon has been changed to be able to decode the nons ...
... UAG (amber), UAA (ochre) or UGA (opal), resulting in polypeptide chain termination and (usually) complete or almost complete loss of gene function. These nonsense mutants can potentially be suppressed by nonsense suppressor tRNAs, in which a sense codon has been changed to be able to decode the nons ...
FTZFactor1 and Fushi tarazu interact via conserved nuclear receptor
... et al., 1984; Martinez-Arias and Lawrence, 1985) and aFtz-F1 (Guichet et al., 1997; Yu et al., 1997) mutant embryos. Thus, ftz provides the spatial information for the combinatorial function of the two genes. Nuclear receptors are transcription factors that bind DNA via type II zinc-®nger motifs (re ...
... et al., 1984; Martinez-Arias and Lawrence, 1985) and aFtz-F1 (Guichet et al., 1997; Yu et al., 1997) mutant embryos. Thus, ftz provides the spatial information for the combinatorial function of the two genes. Nuclear receptors are transcription factors that bind DNA via type II zinc-®nger motifs (re ...
Identification of genes that regulate the left
... experiments with cosmid clones in the region showed that hu176 could be rescued by T28F12 and H06N16, indicating that the gene mutated in hu176 is within the region of overlap between these two cosmid clones. A gene in this region, T28F12.2, is the previously identified locus unc-62, which encodes a ...
... experiments with cosmid clones in the region showed that hu176 could be rescued by T28F12 and H06N16, indicating that the gene mutated in hu176 is within the region of overlap between these two cosmid clones. A gene in this region, T28F12.2, is the previously identified locus unc-62, which encodes a ...
Single Nucleotide Polymorphism of Interleukin-27 Gene
... in non-coding regions (e.g. promoters) and coding regions such as gene body (at a total frequency of approximately every 200 ± 1000 bases). SNPs in promoters might affect the transcription factor binding which in turns could impact the production of the interleukin that associated with the RPL [15]. ...
... in non-coding regions (e.g. promoters) and coding regions such as gene body (at a total frequency of approximately every 200 ± 1000 bases). SNPs in promoters might affect the transcription factor binding which in turns could impact the production of the interleukin that associated with the RPL [15]. ...
MOLECULAR PROFILING OF RICE (Oryza sativa L
... many characteristics, making a particular variety more popular in one region of the world than another. Rice can have a short, medium or long grain size. It can also be waxy (sticky) or non-waxy. Some rice varieties are considered aromatic. Rice also comes in many different colours including brown, ...
... many characteristics, making a particular variety more popular in one region of the world than another. Rice can have a short, medium or long grain size. It can also be waxy (sticky) or non-waxy. Some rice varieties are considered aromatic. Rice also comes in many different colours including brown, ...
The Importance of the TSHR-gene in Domestic Chicken Hanna Johnsen
... completely fixed. Out of 271 analyzed domestic chickens, both commercial and landraces, only seven were heterozygous for the selective sweep haplotype (the genes inherited from one of the two chromosome pairs), while 264 were homozygous. Such a degree of fixation was not seen in any of the other det ...
... completely fixed. Out of 271 analyzed domestic chickens, both commercial and landraces, only seven were heterozygous for the selective sweep haplotype (the genes inherited from one of the two chromosome pairs), while 264 were homozygous. Such a degree of fixation was not seen in any of the other det ...
Package `TCGAbiolinks`
... query <- GDCquery(project = "TCGA-COAD", data.category = "Clinical", barcode = c("TCGA-RU-A8FL","TCGA-AA-3972")) GDCdownload(query) clinical <- GDCprepare_clinic(query,"patient") clinical.drug <- GDCprepare_clinic(query,"drug") clinical.radiation <- GDCprepare_clinic(query,"radiation") clinical.admi ...
... query <- GDCquery(project = "TCGA-COAD", data.category = "Clinical", barcode = c("TCGA-RU-A8FL","TCGA-AA-3972")) GDCdownload(query) clinical <- GDCprepare_clinic(query,"patient") clinical.drug <- GDCprepare_clinic(query,"drug") clinical.radiation <- GDCprepare_clinic(query,"radiation") clinical.admi ...
An accessible database for mouse and human whole transcriptome
... Quantitative polymerase chain reaction (qPCR) is an efficient tool to quantify changes in abundance of DNA/RNA molecules. Its main advantage is that it has a large dynamic range and requires only basic sample preparation steps (reverse transcription of RNA). Double-stranded DNA dye (such as SYBR) ba ...
... Quantitative polymerase chain reaction (qPCR) is an efficient tool to quantify changes in abundance of DNA/RNA molecules. Its main advantage is that it has a large dynamic range and requires only basic sample preparation steps (reverse transcription of RNA). Double-stranded DNA dye (such as SYBR) ba ...
Concept_Paper
... Genes are compact in genomic space. Introns are few, small and are not spliced in alternative forms. They comprise at most about a third of the transcribed DNA [from ref. 37]. This compactness is also evident in the related ciliate Paramecium, in which an 8- ...
... Genes are compact in genomic space. Introns are few, small and are not spliced in alternative forms. They comprise at most about a third of the transcribed DNA [from ref. 37]. This compactness is also evident in the related ciliate Paramecium, in which an 8- ...
Signal transduction pathways under abiotic stresses in plants
... signal transduction pathways by salt tolerance germination was difficult. Two mutants for salt tolerance during growth at seedling stage of Arabidopsis were isolated. In one pst 1 mutant, it was shown that salt tolerance was due to enhanced scavenging of reactive oxygen species (ROS)30. The reduced ...
... signal transduction pathways by salt tolerance germination was difficult. Two mutants for salt tolerance during growth at seedling stage of Arabidopsis were isolated. In one pst 1 mutant, it was shown that salt tolerance was due to enhanced scavenging of reactive oxygen species (ROS)30. The reduced ...
A String-based Model for Simple Gene Assembly
... (called MDSs), placed in a shuffled order on the chromosome, separated by noncoding blocks. Moreover, some of the MDSs are even presented in an inverted form. In macronuclei however, genes are contiguous sequences of nucleotides, with all blocks sorted in the orthodox order. The assembly of genes fr ...
... (called MDSs), placed in a shuffled order on the chromosome, separated by noncoding blocks. Moreover, some of the MDSs are even presented in an inverted form. In macronuclei however, genes are contiguous sequences of nucleotides, with all blocks sorted in the orthodox order. The assembly of genes fr ...
Dynamics and control of DNA sequence amplification
... types of amplification reactions13 corresponding to specified sequence amplification objectives, as well as to enhance existing reactions. A simple example of a temperature cycling protocol that involves modifications to the conventional prescription is the use of two-step PCR cycles, wherein anneal ...
... types of amplification reactions13 corresponding to specified sequence amplification objectives, as well as to enhance existing reactions. A simple example of a temperature cycling protocol that involves modifications to the conventional prescription is the use of two-step PCR cycles, wherein anneal ...
Key concepts in genetics
... To encourage pupils to think for themselves by prompting them to reorganise their existing ideas. ...
... To encourage pupils to think for themselves by prompting them to reorganise their existing ideas. ...
Transgenic mice: generation and husbandry
... Applications of Transgenic Animals Transgenic mice are often generated to 1. characterize the ability of a promoter to direct tissue-specific gene expression e.g. a promoter can be attached to a reporter gene such as LacZ or GFP 2. examine the effects of overexpressing and misexpressing endogenous ...
... Applications of Transgenic Animals Transgenic mice are often generated to 1. characterize the ability of a promoter to direct tissue-specific gene expression e.g. a promoter can be attached to a reporter gene such as LacZ or GFP 2. examine the effects of overexpressing and misexpressing endogenous ...