Genome Evolution and Developmental Constraint in Caenorhabditis
... Department of Organismic and Evolutionary Biology, Harvard University It has been hypothesized that evolutionary changes will be more frequent in later ontogeny than early ontogeny because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through o ...
... Department of Organismic and Evolutionary Biology, Harvard University It has been hypothesized that evolutionary changes will be more frequent in later ontogeny than early ontogeny because of developmental constraint. To test this hypothesis, a genomewide examination of molecular evolution through o ...
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... polyploidy-associated effects on plant reproduction is essential for polyploid breeding program. In the present study, our cytological analysis firstly demonstrated that an overall course of meiosis was apparently distorted in the synthetic polyploid Brassica rapa in comparison with its diploid prog ...
... polyploidy-associated effects on plant reproduction is essential for polyploid breeding program. In the present study, our cytological analysis firstly demonstrated that an overall course of meiosis was apparently distorted in the synthetic polyploid Brassica rapa in comparison with its diploid prog ...
Repeated Sequences in CASPASE-5 and FANCD2 but not NF1 Are
... MSH6, and MSH3 genes form a series of heterodimeric complexes that recognize promutagenic replication errors and initiate their correction. A defect in any of these proteins compromises repair efficiency (reviewed in ref. 2). MMR is particularly efficient at reversing unpaired nucleotides that arise ...
... MSH6, and MSH3 genes form a series of heterodimeric complexes that recognize promutagenic replication errors and initiate their correction. A defect in any of these proteins compromises repair efficiency (reviewed in ref. 2). MMR is particularly efficient at reversing unpaired nucleotides that arise ...
Robust gene silencing mediated by antisense small RNAs in the
... knockdown efficiency varies, (ii) not all genes appear to be amenable to silencing, (iii) the small hairpin RNA (shRNA) approach is labor intensive and (iv) reversal of gene silencing mediated by both double stranded RNA and shRNA has been reported (24) [W. A. Petri Jr. (personal communication)]. Add ...
... knockdown efficiency varies, (ii) not all genes appear to be amenable to silencing, (iii) the small hairpin RNA (shRNA) approach is labor intensive and (iv) reversal of gene silencing mediated by both double stranded RNA and shRNA has been reported (24) [W. A. Petri Jr. (personal communication)]. Add ...
Imprinted gene expression in hybrids: perturbed
... The developmental establishment and maintenance of imprinting involve complex interactions between cis-regulatory elements and trans-acting factors, some of which are themselves subject to imprinting (Kelsey and Feil, 2013; Wolf, 2013). The transcription factor gene ZAC1 is imprinted in both mice an ...
... The developmental establishment and maintenance of imprinting involve complex interactions between cis-regulatory elements and trans-acting factors, some of which are themselves subject to imprinting (Kelsey and Feil, 2013; Wolf, 2013). The transcription factor gene ZAC1 is imprinted in both mice an ...
Evolution of synonymous codon usage in metazoans Laurent Duret
... rules out the possibility that the relationship between codon bias and gene expression is due to a transcriptioncoupled mutational process [8•] and thus shows directly that synonymous codon usage is shaped by natural selection in these two invertebrates. Few experimental data on the cellular abundan ...
... rules out the possibility that the relationship between codon bias and gene expression is due to a transcriptioncoupled mutational process [8•] and thus shows directly that synonymous codon usage is shaped by natural selection in these two invertebrates. Few experimental data on the cellular abundan ...
The role of Cdx genes in the mammalian gut
... expressed in the early definitive gut endoderm but appears at postsomite stages just before transition of the multilayered intestinal endoderm to a single layered epithelium at 14 days post coitum (dpc).6 Cdx4 is expressed in the earliest hindgut invagination7 but little is known of its distribution ...
... expressed in the early definitive gut endoderm but appears at postsomite stages just before transition of the multilayered intestinal endoderm to a single layered epithelium at 14 days post coitum (dpc).6 Cdx4 is expressed in the earliest hindgut invagination7 but little is known of its distribution ...
reviews - Department of Genetics
... b | Dominance modification. Modifiers move the threshold for expressing the trait relative to the distribution of trait values. By moving the threshold into (or out of) the range of the heterozygotes, some mutant heterozygotes are (or are no longer) affected, thereby converting a trait with recessiv ...
... b | Dominance modification. Modifiers move the threshold for expressing the trait relative to the distribution of trait values. By moving the threshold into (or out of) the range of the heterozygotes, some mutant heterozygotes are (or are no longer) affected, thereby converting a trait with recessiv ...
The role of Cdx genes in the mammalian gut
... expressed in the early definitive gut endoderm but appears at postsomite stages just before transition of the multilayered intestinal endoderm to a single layered epithelium at 14 days post coitum (dpc).6 Cdx4 is expressed in the earliest hindgut invagination7 but little is known of its distribution ...
... expressed in the early definitive gut endoderm but appears at postsomite stages just before transition of the multilayered intestinal endoderm to a single layered epithelium at 14 days post coitum (dpc).6 Cdx4 is expressed in the earliest hindgut invagination7 but little is known of its distribution ...
Distinct functions of two olfactory marker protein genes derived from
... specifically expressed in mature olfactory sensory neurons and is expected to be involved in olfactory transduction. Results: Our genome database search identified two OMPs (OMP1 and OMP2) in teleosts, whereas only one was present in other vertebrates. Phylogenetic and synteny analyses suggested tha ...
... specifically expressed in mature olfactory sensory neurons and is expected to be involved in olfactory transduction. Results: Our genome database search identified two OMPs (OMP1 and OMP2) in teleosts, whereas only one was present in other vertebrates. Phylogenetic and synteny analyses suggested tha ...
Identification and functional analysis of two ZIP metal Thlaspi caerulescens
... lation and homeostasis (Assunção et al. 2003a). Hyperaccumulation of metals requires an adapted metal homeostasis allowing enhanced tolerance to metals and their accumulation. Therefore, functional and/or transcriptional modification of metal transporters, metal chelators and other proteins are need ...
... lation and homeostasis (Assunção et al. 2003a). Hyperaccumulation of metals requires an adapted metal homeostasis allowing enhanced tolerance to metals and their accumulation. Therefore, functional and/or transcriptional modification of metal transporters, metal chelators and other proteins are need ...
Document
... dust had a bitter taste, but Fox tasted nothing. The inability to taste PTC is a recessive trait that varies in the human population. Bitter-tasting compounds are recognized by receptor proteins on the surface of taste cells. There are approximately 30 genes for different bitter taste receptors in m ...
... dust had a bitter taste, but Fox tasted nothing. The inability to taste PTC is a recessive trait that varies in the human population. Bitter-tasting compounds are recognized by receptor proteins on the surface of taste cells. There are approximately 30 genes for different bitter taste receptors in m ...
100 letí - originál
... work has led him to a series of discoveries about the very old. They are healthier than anyone ever thought they were, first of all. They avoid the most devastating diseases of old age until the last few years of their lives. And almost all of them seem to be exceptionally good at managing stress an ...
... work has led him to a series of discoveries about the very old. They are healthier than anyone ever thought they were, first of all. They avoid the most devastating diseases of old age until the last few years of their lives. And almost all of them seem to be exceptionally good at managing stress an ...
The nucleotide sequence of Saccharomyces cerevisiae
... IX contains 221 open reading frames (ORFs), of which approximately 30% have been sequenced previously. This chromosome shows features typical of a small Saccharomyces cerevisiae chromosome. The sequence derived for chromosome IX is 439,886 nucleotides in length, and 71.6% codes for proteins or predi ...
... IX contains 221 open reading frames (ORFs), of which approximately 30% have been sequenced previously. This chromosome shows features typical of a small Saccharomyces cerevisiae chromosome. The sequence derived for chromosome IX is 439,886 nucleotides in length, and 71.6% codes for proteins or predi ...
Handouts BIO301-Essentials of Genetics Virtual University of Pakistan
... Labrador retrievers one gene locus affects coat color by controlling pigment eumelanin deposited in the fur. Example A dominant allele B for black, recessive allele b brown coat, a second gene (e) locus controls eumelanin deposited in fur. Dogs homozygous recessive at this locus (ee) will have ...
... Labrador retrievers one gene locus affects coat color by controlling pigment eumelanin deposited in the fur. Example A dominant allele B for black, recessive allele b brown coat, a second gene (e) locus controls eumelanin deposited in fur. Dogs homozygous recessive at this locus (ee) will have ...
Plant meristems: CLAVATA3/ESR-related signaling in the shoot
... domains were expanded in the crn/sol2 mutant. The expression of CLV3 and WUS also expanded in the clv mutants, in comparison with that in the wild-type. Therefore, it is postulated that CLV and CRN/SOL2 act closely to repress the WUS expression in the SAM. When carpel number is used as an indicator ...
... domains were expanded in the crn/sol2 mutant. The expression of CLV3 and WUS also expanded in the clv mutants, in comparison with that in the wild-type. Therefore, it is postulated that CLV and CRN/SOL2 act closely to repress the WUS expression in the SAM. When carpel number is used as an indicator ...
Carolina: Using SNP`s to Predict Bitter
... dust had a bitter taste, but Fox tasted nothing. The inability to taste PTC is a recessive trait that varies in the human population. Bitter-tasting compounds are recognized by receptor proteins on the surface of taste cells. There are approximately 30 genes for different bitter taste receptors in m ...
... dust had a bitter taste, but Fox tasted nothing. The inability to taste PTC is a recessive trait that varies in the human population. Bitter-tasting compounds are recognized by receptor proteins on the surface of taste cells. There are approximately 30 genes for different bitter taste receptors in m ...
Essential role of conserved DUF177A protein in plastid 23S rRNA
... a 293 amino acid protein containing a DUF177 between residues 152 and 289. Recessive mutations in Duf177A were identified in a screen of embryo-specific lethal seed mutants isolated from the UniformMu (W22 inbred) transposon population (McCarty et al., 2005). Ears of self-pollinated heterozygotes s ...
... a 293 amino acid protein containing a DUF177 between residues 152 and 289. Recessive mutations in Duf177A were identified in a screen of embryo-specific lethal seed mutants isolated from the UniformMu (W22 inbred) transposon population (McCarty et al., 2005). Ears of self-pollinated heterozygotes s ...
Tumor metastasis-associated human MTA1 gene and its MTA1
... cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-expressed in a variety of human cell lines (breast, ovarian, lung, gastric and colorectal cancer but not melanoma or sarcoma) ...
... cell lines, we previously cloned and sequenced the metastasis-associated gene mta1. Using homology to the rat mta1 gene, we cloned the human MTA1 gene and found it to be over-expressed in a variety of human cell lines (breast, ovarian, lung, gastric and colorectal cancer but not melanoma or sarcoma) ...
Full Text - Gene, Cell and Tissue
... as the most common disease-causing mutations (2). In 2008, patients with primary open-angle glaucoma were evaluated for mutations in the CYP1B1 and MYOC genes. Mutations in both genes were found to be equally involved in the disease. The p.G61E and p.R390H mutations in the CYP1B1 gene were the cause ...
... as the most common disease-causing mutations (2). In 2008, patients with primary open-angle glaucoma were evaluated for mutations in the CYP1B1 and MYOC genes. Mutations in both genes were found to be equally involved in the disease. The p.G61E and p.R390H mutations in the CYP1B1 gene were the cause ...
Solving Genetics Problems
... e. Are their any genotypes that this mother and father can not produce in their offspring? Why or why not? ...
... e. Are their any genotypes that this mother and father can not produce in their offspring? Why or why not? ...
The rapidly evolving field of plant centromeres
... These satellites can be homogenized through unequal crossover, which would provide an explanation for chromosome-specific variation and the formation of higherorder satellite arrays [23–27]. Another model suggests that satellite evolution is driven by the selection and coevolution of satellites and ...
... These satellites can be homogenized through unequal crossover, which would provide an explanation for chromosome-specific variation and the formation of higherorder satellite arrays [23–27]. Another model suggests that satellite evolution is driven by the selection and coevolution of satellites and ...
microbial genetics
... least some (Fig.4a). The daughter cells do not have to inherit exactly half of the plasmid molecules. Thus, even if a daughter cell only receives a fewer copies of the plasmid than the copy number, this can be redeemed through replication of the plasmid. For this reason, high copy number plasmids do ...
... least some (Fig.4a). The daughter cells do not have to inherit exactly half of the plasmid molecules. Thus, even if a daughter cell only receives a fewer copies of the plasmid than the copy number, this can be redeemed through replication of the plasmid. For this reason, high copy number plasmids do ...
Estimating lethal allele frequencies in complex pedigrees via gene
... The GC method was proposed by ALLAIRE et al. (1982). This approach calculates the expected lethal allele frequency from known individual genotypes (carriers) among a set of relevant ancestors. Here we used a Fortran program written by LIDAUER and ESSL (1994) based on a concept developed by ALLAIRE e ...
... The GC method was proposed by ALLAIRE et al. (1982). This approach calculates the expected lethal allele frequency from known individual genotypes (carriers) among a set of relevant ancestors. Here we used a Fortran program written by LIDAUER and ESSL (1994) based on a concept developed by ALLAIRE e ...