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The DNA Connection - Conackamack Middle School
The DNA Connection - Conackamack Middle School

... • The young, white, ringtailed lemur was born in a forest in Madagascar. • White lemurs are extremely rare. • Why was this lemur born with such an uncommon phenotype? • To answer this question, you need to know how the genes on the chromosome control an organism’s traits. ...
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... Processing the mRNA Transcript In eukaryotic cells, the newly-formed mRNA transcript (also called heterogenous nuclear RNA or hnRNA) must be further modified before it can be used. A cap is added to the 5’ end and a poly-A tail (150 to 200 Adenines) is added to the 3’end of the molecule. The newly-f ...
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< 1 ... 466 467 468 469 470 471 472 473 474 ... 498 >

Primary transcript



A primary transcript is the single-stranded ribonucleic acid (RNA) product synthesized by transcription of DNA, and processed to yield various mature RNA products such as mRNAs, tRNAs, and rRNAs. The primary transcripts designated to be mRNAs are modified in preparation for translation. For example, a precursor messenger RNA (pre-mRNA) is a type of primary transcript that becomes a messenger RNA (mRNA) after processing.There are several steps contributing to the production of primary transcripts. All these steps involve a series of interactions to initiate and complete the transcription of DNA in the nucleus of eukaryotes. Certain factors play key roles in the activation and inhibition of transcription, where they regulate primary transcript production. Transcription produces primary transcripts that are further modified by several processes. These processes include the 5' cap, 3'-polyadenylation, and alternative splicing. In particular, alternative splicing directly contributes to the diversity of mRNA found in cells. The modifications of primary transcripts have been further studied in research seeking greater knowledge of the role and significance of these transcripts. Experimental studies based on molecular changes to primary transcripts the processes before and after transcription have led to greater understanding of diseases involving primary transcripts.
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