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Energetics and Catabolism
Energetics and Catabolism

... G = Go’ + RT ln [C] [D]/[A][B] G = Go’ + 2.303 RT log [C] [D]/[A][B] At equilibrium G = 0 Go’ = - 2.303 RT log [C] [D]/[A][B] The direction of a reaction can be predicted by a thermodynamic quantity called Gibbs free energy change, G. - If Go’ < 0, the process may go forward. - If Go’ > 0, th ...
Current Uses of Synthetic Biology for Chemicals
Current Uses of Synthetic Biology for Chemicals

... The LS9 processes are unique in that all of the chemical conversions from carbohydrate to finished fuel are catalyzed in the cell, with the finished product secreted. The fuel forms an immiscible light organic phase that is non-toxic to the organism and is easily recovered from the broth through cen ...
Lecture 7: Metabolic Regulation - University of California, Berkeley
Lecture 7: Metabolic Regulation - University of California, Berkeley

... Glucagon levels goes down in response to high [glucose]. The opposite regulation of the PFK2/FBPase-2 will occur. The enzyme will become dephosphorylated, which results in the activation of the PFK-2 activity. You will now have much more fructose-2,6-bisphosphate. The glucose-6phosphate that your li ...
SBI4U: Unit 2 Review, Metabolic Processes SAMPLE TEST
SBI4U: Unit 2 Review, Metabolic Processes SAMPLE TEST

... 4. What are the three specific goals of aerobic cellular respiration? 5. What are the four main stages of aerobic cellular respiration? 6. Compare and contrast substrate-level phosphorylation and oxidative phosphorylation. 7. What is the role of NAD+ and FAD (and subsequently NADH and FADH2) in cell ...
УДК: 547
УДК: 547

... Based on the positions of metabolomics, the amino acid pool of biological fluids and tissues fund free amino acids evaluated as a single information unit, which is a kind of "chemical projection" of the genome, proteome realized through. This approach not only develops ideas about the pool of amino ...
Metabolic flux rewiring in mammalian cell cultures
Metabolic flux rewiring in mammalian cell cultures

Bio-Chemistry Course Descriptions
Bio-Chemistry Course Descriptions

... Fayetteville State University Department: Natural Sciences Program: Biochemistry Courses Course Descriptions ...
Plant cell biotechnology for the production of secondary metabolites
Plant cell biotechnology for the production of secondary metabolites

IMPaLA  tutorial  1.  Introduction
IMPaLA tutorial 1. Introduction

... The identifiers I have for my genes/proteins/metabolites are not in your list of identifiers, how can I use your tool? o IMPaLA supports all popular identifier types for genes and metabolites, but there are many identifier types out there. There are many free tools available for changing between dif ...
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... Source Bohringer-Mannheim ...
Deaths Associated With MH in North America 1987
Deaths Associated With MH in North America 1987

...  Minute ventilation with ETCO2  Dantrolene amount given & response  Muscular rigidity status  Electrolytes  I.V. site  Urinary catheter & urine color ...
Chapter 6 2015 - Franklin College
Chapter 6 2015 - Franklin College

... organization)? Expend energy. • It’s work to stay alive! • The key is that the cell decreases its entropy at the expense of increasing the entropy of its surroundings. • Cells take ordered (high energy molecules from the environment and return unordered waste products). • The cell is an open system ...
active site
active site

... There has to be a system for shutting down a metabolic pathway or the cell would not only be inefficient there would be chemical chaos. The pathways must be tightly controlled so only substances that are needed and the right amounts are produced. This is accomplished by two ways: gene regulation and ...
Distinguish between - mvhs
Distinguish between - mvhs

... Anaerobic Process: Process that does not require oxygen to occur. ...
Prescott`s Microbiology, 9th Edition 12 Anabolism: The Use of
Prescott`s Microbiology, 9th Edition 12 Anabolism: The Use of

... synthesized even when the TCA cycle is not functioning to catabolize pyruvate or to provide NADH for electron transport 2. Anaplerotic reactions replenish TCA cycle intermediates so that biosynthesis can occur; two major types of anaplerotic reactions have been observed a. Anaplerotic carbon dioxide ...
Chemical Reactions
Chemical Reactions

... In a compound, it can’t be a diatomic element because it’s not an element anymore, it’s a compound! ...
ppt - Chair of Computational Biology
ppt - Chair of Computational Biology

... 1. Sequence the genome and assign functions to genes using protein sequence and structural similarities. Using primary sequence similarity of the H. salinarum proteins to characterized orthologs in other organisms left a significant fraction (38%) of ~2,400 putative protein-coding genes that could n ...
to get the file - Chair of Computational Biology
to get the file - Chair of Computational Biology

... 1. Sequence the genome and assign functions to genes using protein sequence and structural similarities. Using primary sequence similarity of the H. salinarum proteins to characterized orthologs in other organisms left a significant fraction (38%) of ~2,400 putative protein-coding genes that could n ...
Genetics Ch 7 128-148 [4-20
Genetics Ch 7 128-148 [4-20

... -Most are inherited in an autosomal recessive pattern (only two mutant alleles show disease) -Most common blood tests are for phenylketonuria and galactosemia -The carrier state of disease is not associated with morbidity, can be tested readily Types of Metabolic Processes -Metabolic disorders are c ...
Facts About Metabolic Diseases of Muscle
Facts About Metabolic Diseases of Muscle

... In general, people with defects in their carbohydrate-processing pathways tend to become very tired at the beginning of exercise but may experience a renewed feeling of energy after 10 or 15 minutes. On the other hand, those with carnitine palmityl transferase deficiency (CPT) may experience fatigue ...
lecture1
lecture1

... protease, lipases and cellulase respectively. Furthermore, most natural products have been known to be biodegradable due to the action of enzymes inherent in environmental microorganisms. Thus, production of substances of good economic, social and commercial values in the industrial processes have b ...
chapter 8 notes - 8.4 and 8.5 - APBio09-10
chapter 8 notes - 8.4 and 8.5 - APBio09-10

... 4. Catalysis – enzymes lower the Ea barrier 5. Enzymes cannot a. modify the overall change in energy of a reaction b. Make an endergonic reaction an exergonic one. 6. Enzymes DO a. Hasten reactions b. Make it possible for cells to have dynamic metabolisms c. Determine which process are going on in t ...
Determination of Genetic Network from Micro
Determination of Genetic Network from Micro

... From the developed genetic network further work can be carried out to modify its present metabolic pathway to fetch some important products from the bacteria that could not be done in its normal activity. This means in growth process many enzymes play important role at different instants of time. Th ...
RBTopic3_6 Enzymes - wfs
RBTopic3_6 Enzymes - wfs

... this, the reactions may occur faster. Enzymes are organic catalysts. They are proteins. 2. The amino acids that make up these enzymes allow a tertiary and/or quaternary structure. Because each enzyme has a specific amino acid sequence, enzymes have a specific three-dimensional shape. 3. The molecule ...
Caught in the act – modelling how a biological catalyst works
Caught in the act – modelling how a biological catalyst works

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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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