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Industrial Biotechnology
Industrial Biotechnology

... • (iv) Compensatory antagonism of feedback regulation: • This system operates where one of the endproducts, F, is an intermediate in another pathway J, K, F (Fig. 6.4). • In order to prevent the other end-product, H, of the original pathway from inhibiting the primary Enzyme E1, and thus ultimately ...
energy - Old Saybrook Public Schools
energy - Old Saybrook Public Schools

... carbohydra te  6O2  6CO2  6H 2O  chemical energy Photosynthesis is a major anabolic pathway. Light energy is converted to chemical energy: 6CO2  6H 2O  light energy  6O2  carbohydra te ...
carbohydrate metabolism
carbohydrate metabolism

... • Reactions of Glycolysis take place in the cytosol of cells • Unique; it can utilize O2 if available and can also work in the absence of O2 • Glycolytic sequence of reactions differ from one specie to another only in: 1. how the rate is regulated 2. subsequent metabolic fate of pyruvate formed • B ...
Slovgen s
Slovgen s

... Genotype MDR1 +/– or N/P (carrier): Subjects with confirmed heterozygous genotype are carriers. Defective gene can be transmitted to offspring. Unwanted side effects are unlikely to occur but cannot be excluded. Genotype MDR1 –/– or P/P (affected): Particular caution is necessary in case an individu ...
Lecture 17/18 - Aerobic and Anaerobic Metabolism
Lecture 17/18 - Aerobic and Anaerobic Metabolism

... 1.) What are the 3 “stages” of cellular respiration? 2.) Is glycolysis an aerobic or anaerobic pathway? If you oxidize one molecule of glucose, what is the approximate net yield of ATP? 3.) The reactions of glycolysis can all be categorized into one type of chemical reaction, what are these reaction ...
NCEA Level 2 Biology (91159) 2012 Assessment Schedule
NCEA Level 2 Biology (91159) 2012 Assessment Schedule

... A metabolic pathway is a series of biochemical reactions that are connected by their intermediates: The reactants (or substrates) of one reaction are the products of the previous one, and so on. Because there are a series of biochemical reactions, each one usually controlled by an enzyme, there are ...
Enzyme - kyoussef-mci
Enzyme - kyoussef-mci

... molecules in solution (increase conc’n) (2)Increase the number of enzymes in solution (increase conc’n) (3)Increase the temperature of the solution (up to a certain point) ...
CELL RESPIRATION
CELL RESPIRATION

... specifying the number of ATP molecules used to start these reactions, the number of ATP molecules synthesized, and the net gain. 4. Explain what is meant by coupled reactions, and describe how exergonic reactions can be used to push or pull endergonic reactions in order to get them to proceed. ...
the current state of treatment of genetic disease
the current state of treatment of genetic disease

... deficiency of the enzyme glucocerebrosidase. Its substrate, glucocerebroside, is a complex lipid normally degraded in the lysosome.  The disease results from glucocerebroside accumulation, particularly in the lysosomes of macrophages in the reticuloendothelial system, leading to gross enlargement o ...
Small-molecule metabolism: an enzyme mosaic
Small-molecule metabolism: an enzyme mosaic

... and Cyrus Chothia Escherichia coli has been a popular organism for studying metabolic pathways. In an attempt to find out more about how these pathways are constructed, the enzymes were analysed by defining their protein domains. Structural assignments and sequence comparisons were used to show that ...
13 respiration overview 9 30 05
13 respiration overview 9 30 05

... Metabolism – totality of all chemical reactions of an organism digestion Hydrolysis of polymers to monomers No energy Harvested ! occurs “outside” the cell ...
28. Acute renal failure
28. Acute renal failure

...  Orders: PD fluid: 1.5%, or 2.5 %, or 4.25% dextrose (higher dextrose removes more fluid)  Typical prescription. Volume 2 L, dwell time 6 hours, dextrose 1.5% for a total of 4 exchanges in 24 hour period. Prescription written generally by peritoneal dialysis nurse (PD unit 617-720-1317). PD nurse ...
Metabolic Crosstalk: Interactions between the
Metabolic Crosstalk: Interactions between the

The intertwined metabolism of Medicago truncatula and its nitrogen
The intertwined metabolism of Medicago truncatula and its nitrogen

幻灯片 1
幻灯片 1

... “actual condition” which refers to the actual status of the patient. A comparison between SB and AB can provide some information for the differentiation of respiratory acid-base disturbance from metabolic acid-base disturbance. ...
Ingenuity Pathway Analysis of metabolomics data including cross
Ingenuity Pathway Analysis of metabolomics data including cross

... biomarkers, encouraging more scientists to include these strategies in their investigations. Metabolomics is unique among these technologies in providing potential for exploring genotype-phenotype relationships (2, 3, 4, 5, 7, 8) and environmental influences (6, 8, 10) and may also reflect function ...
Chapter 9: Cellular Respiration and Fermentation (Lectures 12 + 13)
Chapter 9: Cellular Respiration and Fermentation (Lectures 12 + 13)

... 1.) What are the 3 “stages” of cellular respiration? 2.) Is glycolysis an aerobic or anaerobic pathway? If you oxidize one molecule of glucose, what is the approximate net yield of ATP? 3.) The reactions of glycolysis can all be categorized into one type of chemical reaction, what are these reaction ...
Metabonomic analysis of HIV-infected biofluids†
Metabonomic analysis of HIV-infected biofluids†

... metabolomics are often used interchangeably because they differ more in practice than in definition. The goal of metabolomics is generally to characterize and quantify low molecular weight metabolites from cells, tissues and/or biofluids under specific conditions.3,10 Metabonomics on the other hand m ...
CARBOHYDRATES: METABOLISM (cont.)
CARBOHYDRATES: METABOLISM (cont.)

... • Cellulose: a component of most plant tissue; passes through the system without being broken down • Disaccharides: found in refined sugar; must be broken down before they can be absorbed • Monosaccharides: found in fruits; move directly into the internal environment without being processed directly ...
Guo, Ming: Biological Pathways - A pathway to explore diseases mechanism
Guo, Ming: Biological Pathways - A pathway to explore diseases mechanism

... null hypothesis is that genes of the same pathway are not co-regulated more strongly than a randomly selected group of genes without any functional relationship. This is more powerful than the previous approaches because the joint score of gene sets that are known to be in a functional relationship ...
Unit 4 Cell Structure, Metabolism and the Nutrients that Support
Unit 4 Cell Structure, Metabolism and the Nutrients that Support

... May be limited to specific organs or tissues ___________________________________ is the site of energy production in the nucleus of the cell Additional chemical reactions _____________________________ is an anabolic process Water is released as a by-product ...
Metabolism
Metabolism

... which, after chemical conversions, can be metabolized in glycolysis or the Krebs cycle. But first the amino acids must be deaminated (NH2 removed) which creates ammonia (NH3 or NH4+), a toxic by-product. 1. The amino acid tryptophan can enter glycolysis and, therefore, converted into pyruvate. A by- ...
Acid base balance hossam
Acid base balance hossam

... Venous blood gas analysis is an essential part of diagnosing and managing a patient’s acid-base balance. The usefulness of this diagnostic tool is dependent on being able to correctly interpret the results. in This presentation we will examine the components of an venous blood gas and what each comp ...
network analysis - George C. Tseng
network analysis - George C. Tseng

... predicted regulatory role of a regulator (named in one of the ‘Reg’ columns) in a given module (each row of the table). M, C and G column headers and different colors of boxes represent different sorts of experimental evidence that validate the model’s prediction. C(%): functional coherence of modul ...
Fundamentals of Biochemistry 2/e
Fundamentals of Biochemistry 2/e

... Glycolysis converts to two C3 units. The free energy released in this process is harvested to synthesize ATP from ADP and Pi ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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