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Profile Documents Logout
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Slides
Slides

... • edge is enrichment of the GO term in the set of genes most correlated with the miRNA. • right = GO summary network for GO terms in the left enrichment network. Each GO nodes color-coded by cumulative enrichment score for its set of pivot nodes. • parent terms are added, to complete the GO hierarch ...
Enzyme MCAS Practice Name: Date: 1. There are many different
Enzyme MCAS Practice Name: Date: 1. There are many different

... There are many di erent enzymes located in the cytoplasm of a single cell. How is a speci c enzyme able to catalyze a speci c reaction? ...
Mathematical modeling reveals additional links between
Mathematical modeling reveals additional links between

Supplemental notes in pdf
Supplemental notes in pdf

... The brain is the control center of our bodies, consisting of 100 billion nerve cells (neurons) that transmit electrical information along the neuronal axon using action potentials that are driven by changes in charge distribution across the plasma membrane. The key to these electrical impulses are i ...
Profound metabolic acidosis from pyroglutamic acidemia
Profound metabolic acidosis from pyroglutamic acidemia

1 - Oregon State University
1 - Oregon State University

... domestic and wild species. Additionally, I have served on numerous graduate committees of Masters and Ph.D. students in Fisheries and Wildlife. In several instances, I have noted that their research involves nutritional aspects, but they don’t have the nutritional background to fully interpret their ...
Energy and Enzymes
Energy and Enzymes

... low due to the presence of hydrochloric acid. Trypsin is found in the duodenum, and therefore, its optimum pH is in the neutral range to match the pH of the duodenum. ...
iRsp1095: A genome-scale reconstruction of the Rhodobacter
iRsp1095: A genome-scale reconstruction of the Rhodobacter

... detailed knowledge of its metabolic pathways is necessary. To provide this knowledge, we are generating computational models of the metabolic network of R. sphaeroides that are based on genomic information, which can be informed and integrated with laboratory analysis of wild type and mutant strains ...
ana-l-cia-brunialti-godard-federal-university-of
ana-l-cia-brunialti-godard-federal-university-of

... Lrrk2 Pathway The dopamine transporter protein (DAT) is one of the proteins that are endocytosed by this pathway. ...
METABOLISM: BASIC CONSEPTS & DESIGN
METABOLISM: BASIC CONSEPTS & DESIGN

...  Thrombin is very specific ...
Metabolic Reactions Responsible for Glucose
Metabolic Reactions Responsible for Glucose

Chapter 8
Chapter 8

... Enzymes and Biotechnology • Human babies are born with lactase, an enzyme that breaks down lactose found in milk • Naturally, as humans age they become increasingly lactose intolerant as they stop producing lactase • Some cultures have higher percentages of people who are lactose intolerant (Asia) ...
Acid-Base Regulation Modified
Acid-Base Regulation Modified

... H+ are derived from hydrogen atoms. Hydrogen atom has proton a positive electrical charge with a negative charge electron which is revolving around it. The hydrogen ion is formed when negative ion (electron) is lost and it contains only proton. The H+ is the smallest ionic particle, highly reactive ...
Biochemistry - CEU Cardenal Herrera
Biochemistry - CEU Cardenal Herrera

... Biochemistry is the study of the molecular basis of life. This subject aims to provide students with the fundamental knowledge to understand the molecular basis of biology and its subsequent implementation and relationship with other subjects such as physiology, pathology and nutrition. In the first ...
lec27_2013 - Andrew.cmu.edu
lec27_2013 - Andrew.cmu.edu

... Citric acid (TCA, Krebs) cycle Electron transport Oxidative phosphorylation (ATP synthesis) ...
Gabriele Marras
Gabriele Marras

O - MCDS Biology
O - MCDS Biology

... • May contain prosthetic groups or cofactors such as metal ions or organic compounds (vitamins) • Only changes the rate of reaction. They do not change the equilibrium or end products. • Specific to one particular reaction (substrate / reactant products) ...
File
File

Identification and Classification of Prokaryote
Identification and Classification of Prokaryote

...  Classification historically based on phenotype  Size, shape, staining characteristics and metabolic capabilities  New molecular techniques make identification more ...
CHAPTER 4: CELLULAR METABOLISM
CHAPTER 4: CELLULAR METABOLISM

unit 1: introduction to biology
unit 1: introduction to biology

... B) Ribulose-5-phosphate C) 6-phosphogluconate D) Phosphoenolpyruvate (PEP) E) both, b and c Q. 12: The Entner-Doudoroff pathway does NOT generate ATP for a bacterial cell, but only reduction equivalents in form of NADH + H+. A) True B) False Q. 13: The key enzyme which converts pyruvate into acetyl- ...
S2 Table: Contribution of different substrates to respiration of
S2 Table: Contribution of different substrates to respiration of

... muscle of A. aegypti males. Values were expressed as mean ± SD of nmol oxygen consumed/min/mg protein with the following substrates: 10 mM pyruvate + 10 mM proline (Pyr+Pro), 20 mM sn glycerol-3 phosphate (G3P) or 10 µM palmitoylcarnitine + 5 mM malate (PC+Mal). Addition of OXPHOS modulators were in ...
Outline
Outline

... 5. During carbohydrate starvation or diabetes mellitus, the incomplete break down of fats results in the formation of (keto-acids) which can be deadly because they lower the blood pH resulting in E. Protein Metabolism 1. To be used for energy, amino acids are converted into pyruvic acid or keto-acid ...
III. The History of Glycolysis: An Example of a Linear Metabolic
III. The History of Glycolysis: An Example of a Linear Metabolic

... The second area of research was alcoholic fermentation, the process by which yeast converts glucose to ethanol and carbon dioxide. The elucidation of this process was a major preoccupation of the French wine industry in the late 19'th century. In 1860 Pasteur showed that whenever alcoholic fermentat ...
Energetics and Catabolism
Energetics and Catabolism

... G = Go’ + RT ln [C] [D]/[A][B] G = Go’ + 2.303 RT log [C] [D]/[A][B] At equilibrium G = 0 Go’ = - 2.303 RT log [C] [D]/[A][B] The direction of a reaction can be predicted by a thermodynamic quantity called Gibbs free energy change, G. - If Go’ < 0, the process may go forward. - If Go’ > 0, th ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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