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Where It Starts: Photosynthesis
Where It Starts: Photosynthesis

...  Enzymes of glycolysis use two ATP to convert one molecule of glucose to two molecules of three-carbon pyruvate  Reactions transfer electrons and hydrogen atoms to two NAD+ (reduces to NADH)  4 ATP form by substrate-level phosphorylation ...
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... – Pharmacogenetics: single gene differences among population groups and the effects on pharmacodynamics. – Pharmacegenomics: genome-wide variations in DNA sequences responsible for pharmacodynamic differences. – In practice, these two terms are used interchangeably. ...
This project aims to investigate the use of Petri Nets to model
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... This project aims to investigate the use of Petri Nets to model complex bacterial regulatory systems. Developments in post-genomic technology are providing genome wide data enabling the holistic modelling of complex cellular regulatory systems. In particular gene-expression arrays and new proteomics ...
Jordan University of Science and Technology Faculty of Medicine
Jordan University of Science and Technology Faculty of Medicine

... Biochemistry M123; Course Description and Objectives: This course deals with structure and properties of biomolecules, such as amino acids, proteins, carbohydrates, lipids, and nucleic acids. The focus of this course will be on the relationship between protein structure and its biological function, ...
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123 biochemistry - Jordan University of Science and Technology

... Department of Biochemistry and Molecular Biology Biochemistry M123; Course Description and Objectives: This course deals with structure and properties of biomolecules, such as amino acids, proteins, carbohydrates, lipids, and nucleic acids. The focus of this course will be on the relationship betwee ...
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123 - Jordan University of Science and Technology

... Biochemistry M123; Course Description and Objectives: This course deals with structure and properties of biomolecules, such as amino acids, proteins, carbohydrates, lipids, and nucleic acids. The focus of this course will be on the relationship between protein structure and its biological function, ...
Sample Chapters - Pearson Canada
Sample Chapters - Pearson Canada

... It may appear from Figure 12.2 that some pathways operate simply as the reversal of other pathways. For example, fatty acids are synthesized from acetyl-CoA, but they are also converted to acetyl-CoA by b-oxidation. Similarly, glucose-6-phosphate is synthesized from pyruvate in gluconeogenesis, whic ...
Network types and their application in natural variation studies
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... successful in science’s history and consider their composite nature. This is challenging due to the heterogeneity of genomic datasets, and the non-linear relationship between molecular events and phenotypes. Luckily, the development of methods, sometimes derived from social sciences, engineering or ...
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Midterm 1 - Version A

Jordan University of Science and Technology
Jordan University of Science and Technology

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06_Isoenzymes. Enzymodiagnostics. Enzymopathy. Enzymotherapy

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HOCl wt/wt 0.06 x mL 90 one cy
HOCl wt/wt 0.06 x mL 90 one cy

... What was the appearance of the product after recrystallization. Can you explain why these changes are occurring? Compare actual melting point to literature. Is it pretty accurate or any discrepancies? Use curved arrows to propose a detailed mechanism (if known). For this lab on oxidation reduction r ...
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Metabolism and Glycolysis
Metabolism and Glycolysis

... energy (from food or other sources), synthesizes and degrades the molecules that form the organism. Life could be defined as a system of steady state reactions that take place in an open system and is endowed with the potential capability of producing similar systems. For the sake of didactics, meta ...
Metabolic modeling of muscle metabolism identifies key reactions
Metabolic modeling of muscle metabolism identifies key reactions

... 3.1. The model captures fasted to fed transitions We simulated dynamic shifts across the fasting-fed transition by modulating fatty acid and glucose uptake (Figure 2A). Specifically, we constrained CPT1 (the rate-limiting step of mitochondrial fatty acid uptake), assigning maximal activity in fasting ...
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Metabolic production and renal disposal of hydrogen ions
Metabolic production and renal disposal of hydrogen ions

... acid residues daily. Assuming a typical blend of proteins is eaten, for example, beefsteak, this will provide the liver with some 12 mmoles of cysteine and 24 mmoles of methionine and therefore generate about 72 mEq of sulphuric acid daily. 'A metabolic pathway has been defined as the conversion of ...
Biochemistry 2000  Sample Questions 5  Transport, Carbohydrates, Metabolism
Biochemistry 2000 Sample Questions 5 Transport, Carbohydrates, Metabolism

... (d) The energetically least favourable reaction in glycolysis is catalyzed by ________________. (8) Glucose-6-phosphate isomerase catalyzes the interconversion of glucose-6phosphate (an aldose) and fructose-6-phosphate (a ketose). Draw the structure(s) of the reaction intermediate(s). (9) Which glyc ...
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... Other genetic neurocutaneous syndromes such as Sturge-Weber syndrome Urea cycle disorders ...
Surgery AB and K11
Surgery AB and K11

... Normal Acid-Base Physiology Buffering H+ added to body water must be buffered:  Without buffering, one day’s protein intake would decrease blood pH to 3!  Main buffer is bicarbonate: H+ + HCO3-  H2CO3  CO2 + H2O  Buffering greatly reduces the  [pH]  Buffering would gradually reduce ECF [HCO3 ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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