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Slide 1
Slide 1

... pathways that produce acetyl-CoA for different metabolic functions  How glucose and glutamine derived C2 units are maintained as functionally distinct pools and transported from their respective organelles to different sites of acetylation remains to be investigated  The metabolic labeling data su ...
ch3b_SP13x
ch3b_SP13x

... • Collection of biochemical rxns within a cell • Metabolic pathways – Sequence of rxns – Each step catalyzed by a different enzyme • Enzymes of a pathway often physically interact to form large complexes – Limits amount of diffusion needed at each step of the pathway – The product of the preceding s ...
APCh40_AnimalFormFunction_BriefVersion
APCh40_AnimalFormFunction_BriefVersion

... can vary their insulation • When temperatures are subzero, some ectotherms produce “antifreeze” compounds to prevent ice formation in their cells • Link to NatGeo antifreeze frogs article ...
CH395 G Exam 3 Fall 2004 - Multiple Choice 1. Which of the
CH395 G Exam 3 Fall 2004 - Multiple Choice 1. Which of the

... Write a balanced equation for NH4+ production from this compound. (2 points) ...
Jordan University of Science and Technology Faculty of Medicine
Jordan University of Science and Technology Faculty of Medicine

... Department of Biochemistry and Molecular Biology Biochemistry M222; Course Description and Objectives: This course deals with structure and properties of biomolecules, such as amino acids, proteins, carbohydrates, lipids, and nucleic acids. The focus of this course will be on the relationship betwee ...
Metabolic Changes and Nutritional Management of Surgical Patients
Metabolic Changes and Nutritional Management of Surgical Patients

... (INTERLEUKIN I).  The degree and duration (-) nitrogen balance is related to severity of injury. The net CHON catabolism depends on the age, sex and physical condition of the patient (> in young, healthy and male)  (-) nitrogen balance can be reduced by high caloric nitrogen supplement ...
Aims of lecture
Aims of lecture

... 1. Obesity, particularly around the waist (having an "apple shape") 2. Elevated blood pressure 3. An elevated level of triglycerides and a low level of high-density lipoprotein (HDL) — the "good" cholesterol 4. Resistance to insulin ...
OSCE 26th March, 2014
OSCE 26th March, 2014

... should be given and what will be the maximal rate of increase of sodium per hour?  Hypertonic saline (3% or 5.85% NaCl solution)  Maximal rate 0.5mM/hr elevation  What is the risk of rapid rise of sodium level?  Central pontine myelinolysis ...
Covalent Inhibition
Covalent Inhibition

... o The enzyme-substrate binding energy is used to immobilize the substrate at the active site and hold it next to the catalytic groups. This binding energy is inherently available for use but it is generally not utilized in uncatalyzed reactions. Enzyme Kinetics ...
Gene Co-Expression Network Design from RNA
Gene Co-Expression Network Design from RNA

... well suited for large datasets of RNA-Seq data and can be used to find biologically meaningful gene modules. However, the discovery of a number of gene modules for which no biological function exists could suggest that the methods of WGCNA are too crude and identify modules which can be attributed t ...
Chap 4 Study Guide
Chap 4 Study Guide

... second laws 3. the cell's “universal energy carrier” 7. reactions that require energy input 10. oxidizing or reducing ________ 11. different model of the same enzyme 13. compounds mainly derived from water-soluble vitamins 15. inborn error of phenylalanine (amino acid) metabolism 17. when an atom or ...
physiology – metabolism
physiology – metabolism

... Red cells uses 20-30% of glucose in the body at rest 5% of ingested glucose is converted to hepatic glycogen Resting muscle uses fatty acid as substrate for metabolism All of the above ...
Solutions - MIT OpenCourseWare
Solutions - MIT OpenCourseWare

BIO 101
BIO 101

... b. What is/are its beginning substrate(s)? How many carbon do/does this/these molecule(s) contain? c. Which mechanism(s) is/are used to produce ATP in this cycle? Describe/Explain. d. How many “trips” through this cycle can be fueled by 1 molecule of Acetyl CoA? e. How many electron carriers are pr ...
Bioinformatics in the post
Bioinformatics in the post

... which has transformed databases and access to data, publications and other aspects of information infrastructure. The Internet has become so commonplace that it is hard to imagine that we were living in a world without it only 10 years ago. The rise of bioinformatics has been largely due to the dive ...
Section 2 Types of Chemical Reactions Chapter 8
Section 2 Types of Chemical Reactions Chapter 8

... • The order in which the elements are listed is usually determined by single-displacement reactions. • The most-active element is placed at the top in the series. • It can replace each of the elements below it from a compound in a singledisplacement reaction. • Activity series are used to help predi ...
Energy
Energy

... • Type II diabetes is thought to result when cell membrane receptors fail to recognize insulin. Drugs that increase either insulin or insulin receptor levels are an effective treatment because more of the undamaged receptors are put to work. • Type I diabetes is classified as an autoimmune disease, ...
Approach to an unconscious Patient
Approach to an unconscious Patient

... Vestibulo-ocular reflexes – douching of one ear with cold water produces ipsi-lateral deviation of both eyes with a contralateral quick phase nystagmus lasting for 1—2 minutes. Use of hot water produces the opposite effect i.e. contralateral deviation with ipsilateral quick phase nystagmus. Bilatera ...
Powerpoint Slides for Chapter Seven
Powerpoint Slides for Chapter Seven

... Chapter seven Metabolism: Transformations and Interactions ...
Allosteric enzymes
Allosteric enzymes

... methanol for binding enzyme c. Ethanol will alter the Vmax of ADH for oxidation of methanol. d. Ethanol is effective inhibitor of methanol oxidation regardless of the concentration of methanol e. Ethanol will inhibit enzyme by binding the formadehydebinding site on the enzyme, even though it cannot ...
biocyc-data-content - Bioinformatics Research Group at SRI
biocyc-data-content - Bioinformatics Research Group at SRI

... A Tour of BioCyc Follow along on your laptop computer while we explore BioCyc: • Databases • Genome Browser • Genes, Proteins, Regulation, Reactions, Pathways • Overviews ...
C454_lect1 - University of Wisconsin
C454_lect1 - University of Wisconsin

... Pyrophosphate ...
The Hunt for Red October - HFRO
The Hunt for Red October - HFRO

... reconstituting the NAD+ pool required for glycolysis. Fermentation allows cells to make ATP in the absence of oxygen. Cells metabolizing glucose by fermentation harvest only about 5% of the available energy in glucose, however. Most organisms use molecular oxygen in a process called cellular respira ...
metabolic pathways - MPG Systems Biology Forum
metabolic pathways - MPG Systems Biology Forum

... indeed realized in Clusia minor (Borland et al, 1994). • Interestingly, (almost) pure elementary modes are realized here, although this should reduce robustness S. Schuster, D.A. Fell: Modelling and simulating metabolic networks. In: Bioinformatics: From Genomes to Therapies (T. Lengauer, ed.) Wiley ...
glutathion-s-Transferase
glutathion-s-Transferase

... It is obtained from the glycolysis pathway .This reaction occurs in kupffer ...
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Metabolic network modelling



Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑
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