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Slide - Smith Lab
Slide - Smith Lab

... Retention of T cells with specificity to ocular antigens due to Weak negative selection in individuals with particular HLA types Previous infection or trauma primed for ocular antigens in an ...
Document
Document

... Autoimmune diseases are multifactorial – genetic & environment Contributing factors • Genetics. Presentation of self-antigens by MHC molecules: Linkage to certain MHC alleles in many autoimmune diseases •Initiating Event: Environmental: Chemical exposure Infection: Viral and bacterial infection mol ...
Immune_System_Vocabulary
Immune_System_Vocabulary

... Lymphocytes – T and B cells Cell mediated response – part of the adaptive immune response, in which T cells elicit B cells to produce antibodies, and also go themselves to destroy pathogens Humoral response – part of the adaptive immune response, in which B cells produce antibodies to incapacitate ...
Innate vs. Adaptive Immunity - Welcome to people.pharmacy.purdue
Innate vs. Adaptive Immunity - Welcome to people.pharmacy.purdue

... (“differentiation”) and recognized by a group (“cluster”) of monoclonal antibodies is called a member of a cluster of differentiation (CD) CD molecules (CD antigens, CD markers) are: • Identified by numbers • Used to classify leukocytes into functionally distinct subpopulations, e.g. helper T cells ...
THE IMMUNE SYSTEM
THE IMMUNE SYSTEM

... Viral DNA is created and inserts into cell’s DNA Infected cell divides with new DNA code Cell division creates raw protein material Raw infected material is packaged into an immature virus cell Leaves infected cell through “budding” New immature cell matures and then attacks another healthy cell New ...
Immune Response
Immune Response

...  Skin/cells are damaged, pathogens enter  Cells recognize invaders and release chemicals called histamines  These cause increased blood flow (which causes swelling) to get more white blood cells  WBCs attack pathogens  Lymph nodes may also swell with fluid when they fight infection ...
Chronic inflammation
Chronic inflammation

the-immune-system
the-immune-system

... The Immune system is an integration of organs, tissues, cells and cell products that identifies, non-self and neutralizes potentially pathogenic organisms and substances. What does the Immune system do? Do you ever think about the thousands of foreign particles your body comes into contact daily? Th ...
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microbio 7 [4-20

... 16. What dendritic surveilance system are pathogen-associated molecular patterns (PAMPs) associated with?  PAMPs are recognized as part of direct sensing in dendritic cells 17. What heterodimer transports peptides that result from proteasome digestion? What’s their destination?  TAP-1 and TAP-2 tr ...
The Immune System
The Immune System

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Chapter 43 Guided Reading
Chapter 43 Guided Reading

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Important Immune System Handout
Important Immune System Handout

... against the invaders, which may be bacteria, viruses or parasites. Other types of T-cells recognise and kill virusinfected cells directly. Some help B-cells to make antibodies, which circulate and bind to antigens. B-cells make special Y-shaped proteins called antibodies. Antibodies stick to antigen ...
Immunity
Immunity

... • Active cells- release chemicals (lymphokines) that attract macrophages and stimulate phagocytosis "killer cells" • T- "helper" cells: necessary for activation of both B lymphocyte and cytotoxic T cells • T- "Suppressor"-cells: moderate the activities of B cells and other T cells , inhibit their di ...
The Immune Response - Point Pleasant Beach School District
The Immune Response - Point Pleasant Beach School District

... • Active cells- release chemicals (lymphokines) that attract macrophages and stimulate phagocytosis "killer cells" • T- "helper" cells: necessary for activation of both B lymphocyte and cytotoxic T cells • T- "Suppressor"-cells: moderate the activities of B cells and other T cells , inhibit their di ...
IMMUNE SYSTEM
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... MATURE IN RED BONE MARROW  PRODUCE SPECIFIC PROTEINNS CALLED ANTIBODIES WHICH BIND TO ANTIGENS- this either KILLS the PATHOGEN OR MARKS IT FOR ATTACK by T-cells  PLASMA CELLS MAKE ANTIBODIES MEMORY CELLS ARE DORMANT but CAN BE REACTIVATED ...
Lecture 21: Virus offence meets host defense
Lecture 21: Virus offence meets host defense

... passive defenses to enable us to ward off infection • Successful pathogens have evolved gene products that modify, redirect and block host defenses  For every host defense, there is a viral offense. ...
guide2109.ppt [Compatibility Mode]
guide2109.ppt [Compatibility Mode]

... can quickly reach the site of an invasion where they can react directly with antigens - molecules that the body recognizes as foreign substances. When activated, the complement proteins can trigger inflammation attract eater cells such as macrophages to the area coat intruders so that eater cells ar ...
The Body`s Defenses
The Body`s Defenses

... Define the following terms: adaptive immunity, antigen, antibody, histamine, immunology, innate immunity, lymphocyte, pathogen  Use leucocytes to describe the process of cell differentiation  Describe the immune response  Identify four major types of infectious agents ...
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Reminder: Review the Histology lectures* about Cells and Organs of

... first line of defense against microorganisms via phagocytosis and intracellular killing, recruitment of other inflammatory cells, and presentation of antigens. Innate defense barriers include (1) anatomic barriers, (2) physiologic barriers, (3) Phagocytic barriers, and (4) inflammatory barriers. Tis ...
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As Powerpoint Slide

... Elevated level of these inflammatory cytokines in BM results in immune cell infiltration from blood, such as T cells, monocytes and macrophages. CD40CD40L mediated Cellcell communication between T cells and BM stromal cells further enhances NF-#cod#x003BA;B signal, promoting stromal cells express mo ...
The immune system consists of a variety of white blood cells and
The immune system consists of a variety of white blood cells and

... 1. Blood vessels dilate: Non-phagocytic leucocytes arrive at the site of infection and release histamine into the bloodstream which .causes the blood; vessels to dilate. Dilatation causes the blood vessels to allow white blood.eelsto pass more readily. Due to an increase in blood flow, the infected ...
Introduction_to_Infection_and_Immunity_part_two
Introduction_to_Infection_and_Immunity_part_two

... the bone marrow exclusively after birth; they “mature” when they come into contact with a specific antigen Activated B cells develop into plasma cells; plasma cells secrete antibodies into the blood; circulating antibodies provide immunity ...
Chapter 13 Physical Activity and the Immune System
Chapter 13 Physical Activity and the Immune System

... Monocytes are a type of white blood cell and are part of the innate immune system of vertebrates including all mammals (humans included), birds, reptiles, and fish. Monocytes play multiple roles in immune function. Such roles include: (1) replenish resident macrophages and dendritic cells under norm ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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