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Immune System
Immune System

... • Plasma cells: antibody-producing effector B-cells • Secondary immune response: immune response if the individual is exposed to the same antigen at some later time~ Immunological memory ...
open lecture in Powerpoint
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... have been correlated to asthma severity. Our aim was to longitudinally study these cells populations in severe asthma, to better understand immune mechanism that underlies exacerbations. Methods 23 severe refractory asthmatics were enrolled in the EXPRESA study, with a longitudinal follow-up of 12 m ...
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... What is a lysozyme and where are they located? When a microbe enters the body via a break in the skin, what is the body’s first line of defense? Include the term phagocytosis in your answer. Phagocytes are examples of a non-specific, cell mediated immune response. Outline the mechanism of how these ...
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... through the lymphatic vessels. Describe the function(s) of lymph nodes, tonsils, the thymus, Peyer's patches, and the spleen. Body Defenses (pp. 624-637) Describe the protective functions of skin and mucous membranes. Explain the importance of phagocytes and natural killer cells. Describe the inflam ...
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... • Respond to presence of antigens and lymphokines produced by T-4 cells • Seek out, bind to, and destroy: – Cells infected by viruses – Some tumor cells – Cells of tissue transplants ...
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... Specific Immunity  Innate Immunity: Immunity present at birth  Adaptive Immunity: immunity developed during life ...
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... TH cells T helper cells stimulate B cell activity stimulate NK cell activity Memory TH cells Remember antigens for future encounter TS cells T suppressor cells Inhibit T cell and B cell activity ...
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... systemic immune response that can potentially lead to death. However this same immune response, if controlled, has promise to act as a last line antiviral and/or a potential anticancer agent by potentially turning the immune system against previously ignored virus-infected or tumour cells. The Trant ...
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Mechanisms of Immunity

... • Ongoing inflammatory process • Inability to clear pathogen • Less defined onset & resolution • Macrophages and lymphocytes involved • Loss of tissue function – Granuloma formation – Scar tissue ...
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... b. humoral and cell mediated immunity 3) Explain how the physical barrier of skin is reinforced by chemical defenses. 4) Define phagocytosis. Name four types of phagocytic leukocytes. 5) Explain how interferon limits cell-to-cell spread of viruses. 6) Describe the inflammation response, including ho ...
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... (antigens) from the invading bacteria and present them on its own surface ...
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... 4. The ability to resist most types of diseases will increase. ...
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... (1) From the word bank, assign each term to the immunity heading with which it is associated. Some terms may fit more than one category and should be placed in all categories that apply. antibodies in breast milk lymphocytes stomach acid, saliva, tears complement first line of defense ...
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Topic 6 Checkpoint Answers File

... Q6.7 Write a definition for each of the four types of immunity: passive natural immunity, active natural immunity, active artificial immunity and passive artificial immunity. Passive natural immunity occurs when antibodies pass from a mother to baby either across the placenta before birth, or via b ...
cell-mediated immunity.
cell-mediated immunity.

... Immunity is the ability of organisms to resist infection by protecting themselves against disease-causing microorganisms that invade their bodies. It involves the recognition of foreign material (antigens). ...
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... the capillary membranes into the tissues. Once in thetissues, they swell to much larger sizes to become tissuemacrophages, and, in this form, can live for monthsunless destroyed while performing phagocytic functhons. These tissue macrophages are the basis of the tissue macrophage system, which provi ...
Generation of ligands for the T cell receptor
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... Cells that have experienced specific antigen previously but need to be triggered to differentiate again to become effector cells ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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