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1. seminar 2012
1. seminar 2012

... - phagocyting cells - does not present in healthy tissues - tissue damage, migration, elimination of pathogens (enzymes, reactive oxygen intermediers) - main participants in acute inflammatory processes ...
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...  Basophils appear in many specific kinds of inflammatory reactions, particularly those that cause allergic symptoms  Basophils contain anticoagulant heparin, which prevents blood from clotting too quickly.  They also contain the vasodilator histamine, which promotes blood flow to tissues.  They ...
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... • In humans: human leukocyte antigens (HLA) • ENORMOUS variation (polymorphic) • 2 Types: • Class 1: found on all nucleated cells • Class 2 : found on macrophages, B cells, CD4 T cells ...
1. seminar 2011
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... - function: - upon activation they regulate the permeability of the vessels with their secreted molecules - native and adaptive immunity - allergic reactions (cell surface FceRI receptors) - main types: a) mucosal b) connective tissue ...
IMMUNOLOGICAL ASPECT OF BACTERIAL INFECTION
IMMUNOLOGICAL ASPECT OF BACTERIAL INFECTION

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... Granulocytes — There are three types of white blood cells known as granulocytes, which are part of the immune system. Neutrophils are the most common white blood cells in the body. When an infection is present in the body, it increases their numbers. They are the major components of abscesses and ar ...
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... antigens that have been partly degraded inside the antigenpresenting cell. The peptide fragments are then carried to the surface of the presenting cell on special molecules called MHC proteins; The second difference is that, once activated, effector T cells act only at short range, either within a s ...
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... 14. Urine is carried from the kidneys to the urinary bladder by two tubes called ____________________. 15. Urine passes out of the body from the urinary bladder through a tube called the ____________________. 16. The __________________ filter blood, remove waste, and balance the water content of the ...
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Title: Unravelling the host innate immune response to enteral

... Crohn’s Disease (CD) is a chronic incurable inflammatory bowel disorder that has recently become increasingly common, including in childhood. Although the precise pathogenesis of CD is not fully clarified, gut bacteria play key roles. One candidate bacterial species is Adherent Invasive Escherichia ...
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Cell-mediated (T cells)
Cell-mediated (T cells)

... DNA strand breaks (Comet assay) 3) Protein carbonyls using dinitrophenylhydrazine Protein oxidation - cysteine, methionine, histidine Protein AGEs 4) Fructose oxidation forms toxic glyoxal ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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