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innate immunity
innate immunity

... immune response (which could be governed by T Cells). The principal functions of B cells are to make antibodies against antigens and eventually develop into memory B cells after activation by antigen interaction.  Produced in Bone marrow as immature B-Cells, then immature B-Cells move into spleen a ...
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(4) Adaptive Immune System and the Humoral Immune Response

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九十九學年度 生技 /生醫系免疫學期中考(II) 姓名: 學號: 周開平副教授
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... 8. The homing of effector T cells to inflammatory sites is dependent upon the antigen presented by the endothelial cells in the inflammatory tissue. 9. CD40L and IFNγ of activated Th1 can activate macrophages for the elimination of intracellular infection. 10. CD40L of activated Th2 stimulates B cel ...
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ANTIBODIES - immunology.unideb.hu

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BIOL 256 SI, Molly 4/13/16 Exam 4 Review Distinguish among
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... 1.) Distinguish among macrophages, neutrophils, mast cells, eosinophils, and natural killer cells. Macrophages – chief phagocytic cells/ wander through body in search of debris/ Kupffer cells Neutrophils – phagocytize microbes Mast cells – bind bacteria and ingest them Eosinophil – weak phagocytic a ...
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Phagocyte



Phagocytes are cells that protect the body by ingesting (phagocytosing) harmful foreign particles, bacteria, and dead or dying cells. Their name comes from the Greek phagein, ""to eat"" or ""devour"", and ""-cyte"", the suffix in biology denoting ""cell"", from the Greek kutos, ""hollow vessel"". They are essential for fighting infections and for subsequent immunity. Phagocytes are important throughout the animal kingdom and are highly developed within vertebrates. One litre of human blood contains about six billion phagocytes. They were first discovered in 1882 by Ilya Ilyich Mechnikov while he was studying starfish larvae. Mechnikov was awarded the 1908 Nobel Prize in Physiology or Medicine for his discovery. Phagocytes occur in many species; some amoebae behave like macrophage phagocytes, which suggests that phagocytes appeared early in the evolution of life.Phagocytes of humans and other animals are called ""professional"" or ""non-professional"" depending on how effective they are at phagocytosis. The professional phagocytes include many types of white blood cells (such as neutrophils, monocytes, macrophages, mast cells, and dendritic cells). The main difference between professional and non-professional phagocytes is that the professional phagocytes have molecules called receptors on their surfaces that can detect harmful objects, such as bacteria, that are not normally found in the body. Phagocytes are crucial in fighting infections, as well as in maintaining healthy tissues by removing dead and dying cells that have reached the end of their lifespan.During an infection, chemical signals attract phagocytes to places where the pathogen has invaded the body. These chemicals may come from bacteria or from other phagocytes already present. The phagocytes move by a method called chemotaxis. When phagocytes come into contact with bacteria, the receptors on the phagocyte's surface will bind to them. This binding will lead to the engulfing of the bacteria by the phagocyte. Some phagocytes kill the ingested pathogen with oxidants and nitric oxide. After phagocytosis, macrophages and dendritic cells can also participate in antigen presentation, a process in which a phagocyte moves parts of the ingested material back to its surface. This material is then displayed to other cells of the immune system. Some phagocytes then travel to the body's lymph nodes and display the material to white blood cells called lymphocytes. This process is important in building immunity, and many pathogens have evolved methods to evade attacks by phagocytes.
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