Elevated serum BAFF levels in patients with sarcoidosis: association
... formation and all samples were stored at 80 C before use. For comparison, serum from 21 age- and sexmatched healthy Japanese volunteers was collected and stored in the same manner. The diagnosis of sarcoidosis was established on the basis of clinical and radiological findings, supported by histolog ...
... formation and all samples were stored at 80 C before use. For comparison, serum from 21 age- and sexmatched healthy Japanese volunteers was collected and stored in the same manner. The diagnosis of sarcoidosis was established on the basis of clinical and radiological findings, supported by histolog ...
Phagocytosis: a repertoire of receptors and Ca as a key second
... It is becoming apparent that a growing number of cell-surface receptors can mediate phagocytic uptake of particles. These include non-complement-receptor integrins, such as α5β1 and αvβ3, which mediate uptake of particles coated with fibronectin [43], lectins, such as the mannose receptor [44], the ...
... It is becoming apparent that a growing number of cell-surface receptors can mediate phagocytic uptake of particles. These include non-complement-receptor integrins, such as α5β1 and αvβ3, which mediate uptake of particles coated with fibronectin [43], lectins, such as the mannose receptor [44], the ...
Barrier-protective function of intestinal epithelial TLR2 Barrier
... Division of Gastroenterology & Hepatology University Hospital of Essen Essen, Germany ...
... Division of Gastroenterology & Hepatology University Hospital of Essen Essen, Germany ...
The Function of the Immune System
... Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. ...
... Copyright © 2008 Thomson Delmar Learning, a division of Thomson Learning Inc. All rights reserved. ...
Microbial Exposure and Asthma - Digital Commons @ Liberty
... specifically Th1, Th 2, and Th 17; activation of antigen presenting cells (APCs) and eosinophils; and mast cell synthesis of cytokines. When dendritic cells (DCs), a specific class of APCs, are activated during an allergic response, TLR engagement on the cell surface of DCs leads to the differentiat ...
... specifically Th1, Th 2, and Th 17; activation of antigen presenting cells (APCs) and eosinophils; and mast cell synthesis of cytokines. When dendritic cells (DCs), a specific class of APCs, are activated during an allergic response, TLR engagement on the cell surface of DCs leads to the differentiat ...
Table 1: Membrane damaging toxins
... There are seven serologically distinct botulinum neurotoxins (BoNTs) defined, each produced by single serotype of Clostridium botulinum, and given the addition of a letter A-G [chronology of discovery described in Erbguth et al, 2008]. All have a similar, conserved amino acid sequence. Only four of ...
... There are seven serologically distinct botulinum neurotoxins (BoNTs) defined, each produced by single serotype of Clostridium botulinum, and given the addition of a letter A-G [chronology of discovery described in Erbguth et al, 2008]. All have a similar, conserved amino acid sequence. Only four of ...
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for
... CpG motif triggers ⬃60% of human peripheral blood B cells to proliferate and express high levels of CD86. We also demonstrated that this ODN, of sequence 2080, promotes growth, activation, and maturation of human peripheral blood dendritic cells (30). To have in vivo clinical utility, ODN must be ad ...
... CpG motif triggers ⬃60% of human peripheral blood B cells to proliferate and express high levels of CD86. We also demonstrated that this ODN, of sequence 2080, promotes growth, activation, and maturation of human peripheral blood dendritic cells (30). To have in vivo clinical utility, ODN must be ad ...
Nlrp3-inflammasome activation in non-myeloid- derived cells aggravates diabetic nephropathy
... Diabetic nephropathy is the leading cause of end-stage renal disease in adults, putting an enormous burden on affected individuals and health-care systems. Current therapies are insufficient, necessitating the search for new therapeutic strategies in diabetic nephropathy. Inflammatory processes have ...
... Diabetic nephropathy is the leading cause of end-stage renal disease in adults, putting an enormous burden on affected individuals and health-care systems. Current therapies are insufficient, necessitating the search for new therapeutic strategies in diabetic nephropathy. Inflammatory processes have ...
Combining Human and Rat Sequences in Her
... receptor tyrosine kinase inhibitor. On the other hand, receptor tyrosine kinase inhibitor–resistant BamIR-5 or neu-transfected D2F2/neu cell lines were refractory to antibody therapy. Nevertheless, all test cells could be controlled by CTL, demonstrating the importance of inducing both T-cell and B- ...
... receptor tyrosine kinase inhibitor. On the other hand, receptor tyrosine kinase inhibitor–resistant BamIR-5 or neu-transfected D2F2/neu cell lines were refractory to antibody therapy. Nevertheless, all test cells could be controlled by CTL, demonstrating the importance of inducing both T-cell and B- ...
Immunological and Genetic Aspects of Narcolepsy
... to narcolepsy, and is found in 90% of narcolepsy cases. Nevertheless, the allele is quite common, ranging in frequency across ethnic groups from 12% in Japanese to 38% in African Americans, and is therefore not sufficient for the development of the disease. Furthermore, the association between narco ...
... to narcolepsy, and is found in 90% of narcolepsy cases. Nevertheless, the allele is quite common, ranging in frequency across ethnic groups from 12% in Japanese to 38% in African Americans, and is therefore not sufficient for the development of the disease. Furthermore, the association between narco ...
Chronic inflammation
... components, which are converted to the С3а, C5a С567 fraction with high chemotactic activity by proteases secreted by the same macrophages. Lysosomal enzymes are secreted by macrophages as collagenase cleaved collagen. The products of partial collagen degradation have a strong ability to attract fr ...
... components, which are converted to the С3а, C5a С567 fraction with high chemotactic activity by proteases secreted by the same macrophages. Lysosomal enzymes are secreted by macrophages as collagenase cleaved collagen. The products of partial collagen degradation have a strong ability to attract fr ...
Abstract Book - 27th Annual Meeting of the Society for Virology
... Enteroviruses, like all other (+)RNA viruses, extensively rearrange intracellular membranes to create replication organelles (ROs), which are generally thought to provide a scaffold for genome replication and lend protection against sensors that can initiate antiviral host responses. First insights ...
... Enteroviruses, like all other (+)RNA viruses, extensively rearrange intracellular membranes to create replication organelles (ROs), which are generally thought to provide a scaffold for genome replication and lend protection against sensors that can initiate antiviral host responses. First insights ...
STUDIES ON THE IMMOBILIZATION ANTIGENS OF PARAMECIUM
... solution and ten parts of a culture containing primarily animals of the serotype being studied (homologous) as well as a few animals of a non-homologous serotype. After one half hour the animals were observed under the microscope. I n all mixtures the non-homologous animals should be unaffected, sho ...
... solution and ten parts of a culture containing primarily animals of the serotype being studied (homologous) as well as a few animals of a non-homologous serotype. After one half hour the animals were observed under the microscope. I n all mixtures the non-homologous animals should be unaffected, sho ...
Atypical serological profiles in hepatitis B virus infection Robério A
... suggest infection by an HBV mutant, factors that can compromise anti-HBc antibodies production. The immune tolerance to HBcAg is known by the incapacity of the individual to produce anti-HBc or to produce it in undetectable levels. The immune tolerance can be mediated by a variety of mechanisms. For ...
... suggest infection by an HBV mutant, factors that can compromise anti-HBc antibodies production. The immune tolerance to HBcAg is known by the incapacity of the individual to produce anti-HBc or to produce it in undetectable levels. The immune tolerance can be mediated by a variety of mechanisms. For ...
Toxins , , doi. /toxins toxins ISSN www.mdpi.com/journal/toxins
... directly responsible for skin exfoliation while mitogenic activity. Overall. The superantigen activity of highly purified ETA and ETB was also confirmed by Monday et al. where exfoliation was not induced and therefore the other effects of ETs could be easily distinguished. As a most striking example ...
... directly responsible for skin exfoliation while mitogenic activity. Overall. The superantigen activity of highly purified ETA and ETB was also confirmed by Monday et al. where exfoliation was not induced and therefore the other effects of ETs could be easily distinguished. As a most striking example ...
Allergic conjunctivitis: a comprehensive review of the literature Open Access
... [15]. Young people are typically affected [16]. In this form, a nonspecific hyperreactivity occurs that explain the ocular symptoms induced by nonspecific stimuli – such as wind, dust and sunlight – as well as their variability, which is not related to allergen levels in the environment. Indeed, ski ...
... [15]. Young people are typically affected [16]. In this form, a nonspecific hyperreactivity occurs that explain the ocular symptoms induced by nonspecific stimuli – such as wind, dust and sunlight – as well as their variability, which is not related to allergen levels in the environment. Indeed, ski ...
Allergic conjunctivitis: a comprehensive review of the literature
... [15]. Young people are typically affected [16]. In this form, a nonspecific hyperreactivity occurs that explain the ocular symptoms induced by nonspecific stimuli – such as wind, dust and sunlight – as well as their variability, which is not related to allergen levels in the environment. Indeed, ski ...
... [15]. Young people are typically affected [16]. In this form, a nonspecific hyperreactivity occurs that explain the ocular symptoms induced by nonspecific stimuli – such as wind, dust and sunlight – as well as their variability, which is not related to allergen levels in the environment. Indeed, ski ...
The Innate and Adaptive Immune Response to
... response to measles virus has not been characterized. Th17 cell differentiation was inhibited early after measles virus infection in vitro. There was a significant decrease in IL-23A transcript ts and a significant increase in IL-27 transcripts, both of which affect Th17 cell differentiation negativ ...
... response to measles virus has not been characterized. Th17 cell differentiation was inhibited early after measles virus infection in vitro. There was a significant decrease in IL-23A transcript ts and a significant increase in IL-27 transcripts, both of which affect Th17 cell differentiation negativ ...
Wolbachia confers sex-specific resistance and tolerance to
... melanogaster carrying wMel shows reduced mortality during enteric – but not systemic ...
... melanogaster carrying wMel shows reduced mortality during enteric – but not systemic ...
chapter 1
... infants might differ from term infants and this predisposition may vary for different allergic diseases such as atopic dermatitis and asthma.17-21 In a recent study, Kvenshagen et al. found no difference in prevalence of atopic dermatitis between preterm and term infants.22 The association between l ...
... infants might differ from term infants and this predisposition may vary for different allergic diseases such as atopic dermatitis and asthma.17-21 In a recent study, Kvenshagen et al. found no difference in prevalence of atopic dermatitis between preterm and term infants.22 The association between l ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
... Use of concomitant medication (e.g. prophylactic use of antibiotics or antipyretics) throughout the study period (from Day 0 up to Month 36) in all groups. ...
Characterisation and co-expression of the two outer serotype 3
... outer capsid consists of two major outer capsid proteins, VP2 and VP5. VP2 has been shown to carry neutralising serotype specific epitopes. The VP2 protein is therefore a candidate for the development of subunit vaccine, a possible alternative to the available live attenuated virus vaccine used pres ...
... outer capsid consists of two major outer capsid proteins, VP2 and VP5. VP2 has been shown to carry neutralising serotype specific epitopes. The VP2 protein is therefore a candidate for the development of subunit vaccine, a possible alternative to the available live attenuated virus vaccine used pres ...
in the Cartilaginous Fish Forms Transmembrane and Secretory
... In most jawed vertebrates including cartilaginous fish, membrane-bound IgM is expressed as a five Ig superfamily (Igsf)-domain H chain attached to a transmembrane (Tm) region. Heretofore, bony fish IgM was the one exception with IgM mRNA spliced to produce a four-domain Tm H chain. We now demonstrat ...
... In most jawed vertebrates including cartilaginous fish, membrane-bound IgM is expressed as a five Ig superfamily (Igsf)-domain H chain attached to a transmembrane (Tm) region. Heretofore, bony fish IgM was the one exception with IgM mRNA spliced to produce a four-domain Tm H chain. We now demonstrat ...
Generation of Monoclonal Antibodies to Cryptic Collagen Sites by
... was effective in shifting the immune response toward the generation of antibodies that would reacted with denatured forms of collagen, solid-phase ELISA assays were carried out. Microtiter plates were coated with either triple helical or thermally denatured human collagen types I or IV. The microtit ...
... was effective in shifting the immune response toward the generation of antibodies that would reacted with denatured forms of collagen, solid-phase ELISA assays were carried out. Microtiter plates were coated with either triple helical or thermally denatured human collagen types I or IV. The microtit ...
Reliability of Rabbit Monoclonal Antibodies
... the greater affinity of rabbit monoclonal antibodies than mouse monoclonal equivalents, and, therefore, these antibodies may be effectively used at higher dilutions and, in some cases, without the need for heat-induced antigen retrieval.17 A recent article suggested that this increased sensitivity r ...
... the greater affinity of rabbit monoclonal antibodies than mouse monoclonal equivalents, and, therefore, these antibodies may be effectively used at higher dilutions and, in some cases, without the need for heat-induced antigen retrieval.17 A recent article suggested that this increased sensitivity r ...