Monoclonal Antibodies for Therapeutic Use: Specific Characteristics
... is based on the following points: – therapeutic efficacy is sometimes spectacular. An action on key players in the pathophysiology of disease is possible; – knowledge of potential targets is rapidly growing. The number of antigens that can be targeted by MoAb is potentially infinite; the only limita ...
... is based on the following points: – therapeutic efficacy is sometimes spectacular. An action on key players in the pathophysiology of disease is possible; – knowledge of potential targets is rapidly growing. The number of antigens that can be targeted by MoAb is potentially infinite; the only limita ...
Sawsan Mohammed Kareem, et al
... among clinical samples of S. aureus specially MRSA isolates more frequently in urine, blood and general secretions, this founding relatively similar with Bottega et al. (2014) he mentioned (3 isolates of MRSA showed D- test positive (2.1%). Furthermore the results disagree with anther author mention ...
... among clinical samples of S. aureus specially MRSA isolates more frequently in urine, blood and general secretions, this founding relatively similar with Bottega et al. (2014) he mentioned (3 isolates of MRSA showed D- test positive (2.1%). Furthermore the results disagree with anther author mention ...
Host susceptibility to malaria in human and mice: compatible
... the hypothesis of recent positive selection (150, 164). Other red blood cell polymorphisms, such as the ...
... the hypothesis of recent positive selection (150, 164). Other red blood cell polymorphisms, such as the ...
Maternal allergy is associated with surfacebound IgE on cord blood
... allergy. CB basophils and pDCs have surface-bound IgE and express FceRI; however, only IgE on CB basophils appears influenced by maternal allergy. ...
... allergy. CB basophils and pDCs have surface-bound IgE and express FceRI; however, only IgE on CB basophils appears influenced by maternal allergy. ...
- Journal of Allergy and Clinical Immunology
... Gram-negative bacteria. A population-based case-control study was conducted during a major pertussis outbreak in 2004-2005 in Olmsted County, Minnesota. The results showed a significantly increased risk of Bordetella pertussis infection among children and adults with versus those without asthma (adj ...
... Gram-negative bacteria. A population-based case-control study was conducted during a major pertussis outbreak in 2004-2005 in Olmsted County, Minnesota. The results showed a significantly increased risk of Bordetella pertussis infection among children and adults with versus those without asthma (adj ...
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
Immune dysfunctionality of replicative senescent
... Figure 1. Phenotypical characteristics of replicative senescent MSCs. (A) MSCs derived from the bone marrow of 2 healthy individuals were culture-passaged at the indicated time points. Doubling time was calculated based on the cell numbers at seeding and harvesting time points and duration of the cu ...
... Figure 1. Phenotypical characteristics of replicative senescent MSCs. (A) MSCs derived from the bone marrow of 2 healthy individuals were culture-passaged at the indicated time points. Doubling time was calculated based on the cell numbers at seeding and harvesting time points and duration of the cu ...
Transmission-Blocking Immunity against Malaria: From Antigen
... pathogen transmission from the infected to the uninfected hosts. These candidates may be monoor polyclonal antibodies from the vertebrate host or recombinant DNA plasmids containing the gene encoding such molecules.17 TBV candidates should have these qualities: first of all they should be inducing a ...
... pathogen transmission from the infected to the uninfected hosts. These candidates may be monoor polyclonal antibodies from the vertebrate host or recombinant DNA plasmids containing the gene encoding such molecules.17 TBV candidates should have these qualities: first of all they should be inducing a ...
Alopecia areata update
... pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer c ...
... pathogenesis of the disease remains to be clarified. Disease prevalence rates from 0.1% to 0.2% have been estimated for the United States. AA can affect any hair-bearing area. It often presents as well demarcated patches of nonscarring alopecia on skin of overtly normal appearance. Recently, newer c ...
Vitiligo and alopecia areata: apples and oranges?
... reflect a TH17 response (IL-17, IL-23 and IL-22) is not clear in vitiligo or alopecia areata, as they are reportedly associated in some studies but not in others (21,27–30). TNF-a, a highly inflammatory cytokine, is consistently elevated in TH17-mediated diseases and appears to be required for their ...
... reflect a TH17 response (IL-17, IL-23 and IL-22) is not clear in vitiligo or alopecia areata, as they are reportedly associated in some studies but not in others (21,27–30). TNF-a, a highly inflammatory cytokine, is consistently elevated in TH17-mediated diseases and appears to be required for their ...
SERIES ‘‘HOT TOPICS IN PAEDIATRIC ASTHMA’’ Number 2 in this Series
... to a lesser extent [39]. Among the more recently identified viruses, human metapneumovirus has been associated with wheezing episodes, mostly in younger children, whereas bocavirus claims ,5% of asthma exacerbations [40–42]. Nevertheless, RV remains by far the major player in asthma exacerbations; i ...
... to a lesser extent [39]. Among the more recently identified viruses, human metapneumovirus has been associated with wheezing episodes, mostly in younger children, whereas bocavirus claims ,5% of asthma exacerbations [40–42]. Nevertheless, RV remains by far the major player in asthma exacerbations; i ...
Human norovirus transmission and evolution in a
... and evolution, together with an improved characterization of the genetic determinants of transmission and disease severity. In this Review, we describe recent advances in the study of norovirus transmission and pathogenesis, with an emphasis on the role of viral evolution and genetic diversity. Furt ...
... and evolution, together with an improved characterization of the genetic determinants of transmission and disease severity. In this Review, we describe recent advances in the study of norovirus transmission and pathogenesis, with an emphasis on the role of viral evolution and genetic diversity. Furt ...
Peer-Review Draft: Report on Carcinogens Monograph on Merkel Cell Polyomavirus
... definition for infectious diseases that emerge from complex interactions of multiple factors and may be caused by more than a single agent. An important consideration regarding multicausality is that most of the identified causes are neither necessary nor sufficient in the absence of other factors t ...
... definition for infectious diseases that emerge from complex interactions of multiple factors and may be caused by more than a single agent. An important consideration regarding multicausality is that most of the identified causes are neither necessary nor sufficient in the absence of other factors t ...
Performance-enhancing effects of dietary nucleotides
... of a nitrogen-containing base, ribose or deoxyribose, and one or more phosphate groups. They build the structure of nucleic acids (such as DNA and RNA) and energy-rich molecules (e.g. adenosine triphosphate, ATP), and act as signaling molecules and/or metabolic co-factors in human metabolism. Utiliz ...
... of a nitrogen-containing base, ribose or deoxyribose, and one or more phosphate groups. They build the structure of nucleic acids (such as DNA and RNA) and energy-rich molecules (e.g. adenosine triphosphate, ATP), and act as signaling molecules and/or metabolic co-factors in human metabolism. Utiliz ...
投影片 1 - 口腔病理科教學網
... If the surface epithelium is destroyed by injury, epithelial cells create a new surface tissue at the same time that granulation tissue forms in the injured connective tissue Epithelial cells from borders of the healing injured area lose their cell junctions and become mobile They can divide and mig ...
... If the surface epithelium is destroyed by injury, epithelial cells create a new surface tissue at the same time that granulation tissue forms in the injured connective tissue Epithelial cells from borders of the healing injured area lose their cell junctions and become mobile They can divide and mig ...
Pathogenesis of Noroviruses, Emerging RNA Viruses
... from physical, histological, and biochemical studies of infected human volunteers. In recent years, work in porcine, bovine, and murine models has also begun to contribute to our understanding of norovirus pathogenesis. 3.1. Histological Alterations in the Intestine Histological analysis of proximal ...
... from physical, histological, and biochemical studies of infected human volunteers. In recent years, work in porcine, bovine, and murine models has also begun to contribute to our understanding of norovirus pathogenesis. 3.1. Histological Alterations in the Intestine Histological analysis of proximal ...
Leukocyte surface antigen CD47
... IAP and OA3 were shown to be identical to CD47 (Lindberg et al. 1994; Mawby et al. 1994). CD47 is a type I integral membrane protein composed of an extracellular immunoglobulin variable (IgV)-like domain, five membranespanning segments, and an alternatively spliced carboxyterminal cytoplasmic tail ( ...
... IAP and OA3 were shown to be identical to CD47 (Lindberg et al. 1994; Mawby et al. 1994). CD47 is a type I integral membrane protein composed of an extracellular immunoglobulin variable (IgV)-like domain, five membranespanning segments, and an alternatively spliced carboxyterminal cytoplasmic tail ( ...
host susceptibility to rotavirus infection and
... residues (12), but the role of subterminal sialic acid in infection with rotaviruses has not been demonstrated. The lack of a defined receptor for the sialidaseinsensitive rotaviruses has prompted further studies. The type 1 chain histo-blood group antigens (HBGAs) are expressed in several cell type ...
... residues (12), but the role of subterminal sialic acid in infection with rotaviruses has not been demonstrated. The lack of a defined receptor for the sialidaseinsensitive rotaviruses has prompted further studies. The type 1 chain histo-blood group antigens (HBGAs) are expressed in several cell type ...
Effects of sleep deprivation on immune function via cortisol and
... The relationship between sleep and the immune system was first uncovered by Krueger et al. in 1982 with the discovery of the sleep-inducing muramyl peptide Factor S. (Krueger et al., 1984; Cardinali et al., 2006) Krueger discovered that Factor S induced the release of interleukin-1, a highly inflamm ...
... The relationship between sleep and the immune system was first uncovered by Krueger et al. in 1982 with the discovery of the sleep-inducing muramyl peptide Factor S. (Krueger et al., 1984; Cardinali et al., 2006) Krueger discovered that Factor S induced the release of interleukin-1, a highly inflamm ...
The Role of Complement in Retinal Ganglion Cell Loss in
... the common pathology of a progressive, irreversible vision loss associated with atrophy of retinal ganglion cells. Together, the various forms of glaucoma constitute the second leading cause of vision loss in the developed world. Current therapies for the treatment of glaucoma focus on alleviating t ...
... the common pathology of a progressive, irreversible vision loss associated with atrophy of retinal ganglion cells. Together, the various forms of glaucoma constitute the second leading cause of vision loss in the developed world. Current therapies for the treatment of glaucoma focus on alleviating t ...
High salivary secretory IgA antibody levels are sensitized infants
... Sweden (12). Skin prick tests (SPT) were performed at one year of age in 1040 children. All children with at least one positive SPT (n=71) and a random sample of three SPT negative children (n=213) with birthdates close to that of each index child, in all 284 children, were invited to an interview a ...
... Sweden (12). Skin prick tests (SPT) were performed at one year of age in 1040 children. All children with at least one positive SPT (n=71) and a random sample of three SPT negative children (n=213) with birthdates close to that of each index child, in all 284 children, were invited to an interview a ...