Antibodies Targeting Hsa and PadA Prevent Platelet - Serval
... LysA2 (Hsa-LysA2 and PadA-LysA2, respectively) and investigation of their ability to elicit antibodies in rats and to protect them from S. gordonii experimental IE. Immunized and control animals with catheter-induced sterile aortic valve vegetations were inoculated with 106 CFU of S. gordonii. The p ...
... LysA2 (Hsa-LysA2 and PadA-LysA2, respectively) and investigation of their ability to elicit antibodies in rats and to protect them from S. gordonii experimental IE. Immunized and control animals with catheter-induced sterile aortic valve vegetations were inoculated with 106 CFU of S. gordonii. The p ...
Humoral and cellular immune responses to Helicobacter
... Helicobacter pylori (Hp) colonizes the human gastric and duodenal mucosa and the infection may cause peptic ulcers and gastric adenocarcinoma. Half of the world’s population is infected with Hp with the highest prevalence in developing countries. Hp infection is normally acquired during childhood, b ...
... Helicobacter pylori (Hp) colonizes the human gastric and duodenal mucosa and the infection may cause peptic ulcers and gastric adenocarcinoma. Half of the world’s population is infected with Hp with the highest prevalence in developing countries. Hp infection is normally acquired during childhood, b ...
Epitope Specificity of Anti-Citrullinated Protein Antibodies
... As presented in Table 1, the process of citrullination is not specific to RA; however, an aberrant B cell response against citrullinated epitopes may be specific to RA. Moreover, other rheumatologic diseases with synovitis, including inflammatory osteoarthritis, reactive arthritis, undifferentiated ...
... As presented in Table 1, the process of citrullination is not specific to RA; however, an aberrant B cell response against citrullinated epitopes may be specific to RA. Moreover, other rheumatologic diseases with synovitis, including inflammatory osteoarthritis, reactive arthritis, undifferentiated ...
THE IMMUNOLOGICAL BASIS OF ME/CFS: what is already
... “Our research and that of others working in collaboration with us has shown conclusively that post-viral fatigue state, ie. myalgic encephalomyelitis, has an undisputed organic basis….We were also able to show by looking at receptors on lymphocytes ie. markers on white blood cells, that there was an ...
... “Our research and that of others working in collaboration with us has shown conclusively that post-viral fatigue state, ie. myalgic encephalomyelitis, has an undisputed organic basis….We were also able to show by looking at receptors on lymphocytes ie. markers on white blood cells, that there was an ...
INNOVATIONS IN CANCER RESEARCH
... and public health professionals involved in this work understand that one size does not fit all when it comes to health education. Although their research on narrative persuasion has implications for virtually all communication, their recent research has focused on the issue of cervical cancer. Acco ...
... and public health professionals involved in this work understand that one size does not fit all when it comes to health education. Although their research on narrative persuasion has implications for virtually all communication, their recent research has focused on the issue of cervical cancer. Acco ...
An Introduction to Lipid Rafts
... Relation between caveolae and lipid rafts In comparison with classical lipid rafts which are short of structural protein components, liquid-ordered domains may have a specific structural protein component, which tends to alter the features of lipid rafts in both appearance and function. In particul ...
... Relation between caveolae and lipid rafts In comparison with classical lipid rafts which are short of structural protein components, liquid-ordered domains may have a specific structural protein component, which tends to alter the features of lipid rafts in both appearance and function. In particul ...
Topical Ivermectin 10 mg/g and Oral Doxycycline 40 mg Modified
... understood [12, 25, 26]. Overall, the various inflammatory cells and pathways involved in the pathophysiology of these overlapping yet distinct signs of rosacea highlight the necessity to implement optimized combination therapies for greater benefit to the patient. This fact is also supported by evi ...
... understood [12, 25, 26]. Overall, the various inflammatory cells and pathways involved in the pathophysiology of these overlapping yet distinct signs of rosacea highlight the necessity to implement optimized combination therapies for greater benefit to the patient. This fact is also supported by evi ...
Integrin-associated protein (CD47) and its ligands
... distinct from ligation of αvβ3 on these cells37. Ligation of T cell CD47 can synergize with the antigen receptor to activate synthesis of interleukin 2 (IL-2), an effect not reproduced by ligation of αvβ3 or α2β138–40. Because the CD47 ligand SIRPα is highly expressed on macrophages and dendritic ce ...
... distinct from ligation of αvβ3 on these cells37. Ligation of T cell CD47 can synergize with the antigen receptor to activate synthesis of interleukin 2 (IL-2), an effect not reproduced by ligation of αvβ3 or α2β138–40. Because the CD47 ligand SIRPα is highly expressed on macrophages and dendritic ce ...
THE LYMPHATIC SYSTEM AND LYMPHOID TISSUE
... was required. In many women with early-stage breast cancer, however, the axillary bodies do not contain cancerous cells. In addition, about 20 percent of the women whose lymphatic ...
... was required. In many women with early-stage breast cancer, however, the axillary bodies do not contain cancerous cells. In addition, about 20 percent of the women whose lymphatic ...
LMP1 signaling can replace CD40 signaling in B cells in vivo and
... the chimeric protein specifically in B cells.16 For simplicity, mice carrying the CD40/LMP1 knockin and the CD19-Cre alleles will be referred to as CD40/LMP1⫹ mice. As controls, wt//CD40⫹/⫹ and CD19-Cre⫹/⫺//CD40⫹/⫹ mice on the same mixed background as the CD40/LMP1⫹ mice were used, and will be refer ...
... the chimeric protein specifically in B cells.16 For simplicity, mice carrying the CD40/LMP1 knockin and the CD19-Cre alleles will be referred to as CD40/LMP1⫹ mice. As controls, wt//CD40⫹/⫹ and CD19-Cre⫹/⫺//CD40⫹/⫹ mice on the same mixed background as the CD40/LMP1⫹ mice were used, and will be refer ...
CLINICAL IMPLICATIONS OF THE p53 GENE
... in the core region of p53 that disrupts specific DNA binding and transcriptional activation of downstream genes under p53 regulation. Closer scrutiny of the exact types of these DNA base changes, however, reveals major differences among cancer types, and there are also examples of mutation frequency ...
... in the core region of p53 that disrupts specific DNA binding and transcriptional activation of downstream genes under p53 regulation. Closer scrutiny of the exact types of these DNA base changes, however, reveals major differences among cancer types, and there are also examples of mutation frequency ...
The Role of Antibodies in Mouse Models of Rheumatoid Arthritis
... inflammatory lesions in the skin, lungs, and other organs are common, the disease hallmark is severe, often destructive, inflammation of peripheral joints. Although manifestations vary among patients, RA is usually a symmetric polyarthritis affecting distal [metacarpophalangeal (MCP), metatarsophala ...
... inflammatory lesions in the skin, lungs, and other organs are common, the disease hallmark is severe, often destructive, inflammation of peripheral joints. Although manifestations vary among patients, RA is usually a symmetric polyarthritis affecting distal [metacarpophalangeal (MCP), metatarsophala ...
Complement-targeted therapeutics
... per cell per minute. In principle, this attack is not specifically directed against foreign cells. However, interplay of time, location and moleculebased regulation mechanisms generally prevents the complement cascade from attacking host tissues. Both the thioester group of C3b and the C3 convertase ...
... per cell per minute. In principle, this attack is not specifically directed against foreign cells. However, interplay of time, location and moleculebased regulation mechanisms generally prevents the complement cascade from attacking host tissues. Both the thioester group of C3b and the C3 convertase ...
UNIVERSIDAD DE MURCIA FACULTAD DE BIOLOGÍA
... IL-1 is the common name for a diverse family of proteins, of which IL-1α, IL1β, IL-1 receptor antagonist (IL-1ra) and IL-18 are the most representative and studied, although several newly discovered molecules show a clear homology to this group (Dinarello, 1997; Dinarello, 1999; Busfield et al., 200 ...
... IL-1 is the common name for a diverse family of proteins, of which IL-1α, IL1β, IL-1 receptor antagonist (IL-1ra) and IL-18 are the most representative and studied, although several newly discovered molecules show a clear homology to this group (Dinarello, 1997; Dinarello, 1999; Busfield et al., 200 ...
Preview the material
... of their destruction is also increased, which only further potentiates the effects of decreased red blood cells in the rest of the body. An individual with splenomegaly is also at risk of splenic hemorrhage, the spleen may be more likely to become damaged or may rupture because of its enlarged size. ...
... of their destruction is also increased, which only further potentiates the effects of decreased red blood cells in the rest of the body. An individual with splenomegaly is also at risk of splenic hemorrhage, the spleen may be more likely to become damaged or may rupture because of its enlarged size. ...
The purpose of this summary is exclusively educational, to provide
... a drug (e.g. HLA-B*57:01 ↑ risk of abacavir hypersensitivity; HLA-B*58:01 ↑ risk of allopurinolinduced SJS/TEN/DRESS; HLA-B*15:02 ↑ risk of carbamazepine-induced SJS/TEN; HLAB*57:01 ↑ risk of flucoxacilline-induced liver injury; variants of FcεRIβ, STAT6, IL-4, IL-13, IL4RA and TNFα may ↑ risk of pe ...
... a drug (e.g. HLA-B*57:01 ↑ risk of abacavir hypersensitivity; HLA-B*58:01 ↑ risk of allopurinolinduced SJS/TEN/DRESS; HLA-B*15:02 ↑ risk of carbamazepine-induced SJS/TEN; HLAB*57:01 ↑ risk of flucoxacilline-induced liver injury; variants of FcεRIβ, STAT6, IL-4, IL-13, IL4RA and TNFα may ↑ risk of pe ...
Evaluation of Immune Responses to Novel Adeno-Associated Viruses
... contain capsids with equal amounts of both negative and positive sense ssDNA that are linear and approximately 4.7 kb in size. The genome is structurally characterized by 145bp inverted terminal repeats (ITRs) at each end of the AAV genome which flank two open reading frames (ORFs) encoding the vir ...
... contain capsids with equal amounts of both negative and positive sense ssDNA that are linear and approximately 4.7 kb in size. The genome is structurally characterized by 145bp inverted terminal repeats (ITRs) at each end of the AAV genome which flank two open reading frames (ORFs) encoding the vir ...
Document
... The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD; Deutsche Börse:YP1B.DE). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification ...
... The purpose of the presentation is to provide an update of the business of Prima BioMed Ltd ACN 009 237 889 (ASX:PRR; NASDAQ:PBMD; Deutsche Börse:YP1B.DE). These slides have been prepared as a presentation aid only and the information they contain may require further explanation and/or clarification ...
Testing the Effect of Changing Heat Shock Protein 90:
... Figure 1: Results “Hsp90 in tumour cells has a significantly higher binding affinity for 17-AAG than does Hsp90 from normal cells.” (Kamal ...
... Figure 1: Results “Hsp90 in tumour cells has a significantly higher binding affinity for 17-AAG than does Hsp90 from normal cells.” (Kamal ...
Cenchao Shen - RMIT Research Repository
... I certify that except where due acknowledgement has been made, the work is that of the author alone; the work has not been submitted previously, in whole or in part, to qualify for any other academic award; the content of the thesis is the result of work which has been carried out since the official ...
... I certify that except where due acknowledgement has been made, the work is that of the author alone; the work has not been submitted previously, in whole or in part, to qualify for any other academic award; the content of the thesis is the result of work which has been carried out since the official ...
The impact of Toll-like receptor activation on - diss.fu
... in the central nervous system (CNS), predominantly expressed in microglia, the major immune cells of the brain. Increasing evidence suggests that, along with microglia-mediated neuroinflammation, TLRs play a crucial role in CNS pathologies such as infection, stroke and classical neurodegenerative di ...
... in the central nervous system (CNS), predominantly expressed in microglia, the major immune cells of the brain. Increasing evidence suggests that, along with microglia-mediated neuroinflammation, TLRs play a crucial role in CNS pathologies such as infection, stroke and classical neurodegenerative di ...
Is lipid signaling through cannabinoid 2 receptors part of a protective
... anesthetics and solvents [33]. Some experimental work presumably gave support to this belief [35]. A further, conceptual, assumption also pointed in the same direction. Both enantiomers of THC were found to be active in some simple physiological assays, although the level of activity differed consid ...
... anesthetics and solvents [33]. Some experimental work presumably gave support to this belief [35]. A further, conceptual, assumption also pointed in the same direction. Both enantiomers of THC were found to be active in some simple physiological assays, although the level of activity differed consid ...
Combined action of anti-CD4 autoantibodies
... In sum, immunization of Wistar rats with HIV-1 gp120 induces chronic production of anti-CD4 autoantibodies and decreases CD4 lymphocytes in the blood. However, no correlation was found between antibodies to CD4 lymphocytes and the number of CD4 lymphocytes in the blood. Role of RF in the development ...
... In sum, immunization of Wistar rats with HIV-1 gp120 induces chronic production of anti-CD4 autoantibodies and decreases CD4 lymphocytes in the blood. However, no correlation was found between antibodies to CD4 lymphocytes and the number of CD4 lymphocytes in the blood. Role of RF in the development ...
Modelling T Cell Activation
... presenting cells, the dendritic cells (DCs), sit and wait at the interfaces between the body and the environment. DCs constantly sample the environment, and then migrate to the secondary lymphoid organs (lymph nodes and spleen) where they present their captured antigens to the T cells. If the T cel ...
... presenting cells, the dendritic cells (DCs), sit and wait at the interfaces between the body and the environment. DCs constantly sample the environment, and then migrate to the secondary lymphoid organs (lymph nodes and spleen) where they present their captured antigens to the T cells. If the T cel ...