Pseudomonas syringae Virulence Factor Syringolin A Counteracts
... regulatory pathways such as hormone signaling and responses to environmental stimuli and pathogens (Vierstra 2009), inhibition of the proteasome is expected to elicit pleiotropic responses and it is not evident from which of these the pathogen would benefit. Here, we report that syringolin A-produci ...
... regulatory pathways such as hormone signaling and responses to environmental stimuli and pathogens (Vierstra 2009), inhibition of the proteasome is expected to elicit pleiotropic responses and it is not evident from which of these the pathogen would benefit. Here, we report that syringolin A-produci ...
Differential Expression of the Melatonin Receptor in Human
... performed using fresh monocytes and different concentrations of [125I]melatonin. As shown in Figure 1, specific [125I]melatonin binding was saturable in human monocytes and reproducible. Kd ranges were obtained. The Kd for human monocytes was 270 6 60 pM, and human monocytes expressed an average of ...
... performed using fresh monocytes and different concentrations of [125I]melatonin. As shown in Figure 1, specific [125I]melatonin binding was saturable in human monocytes and reproducible. Kd ranges were obtained. The Kd for human monocytes was 270 6 60 pM, and human monocytes expressed an average of ...
Dendritic cells expand antigen-specific Foxp3+ CD25+ CD4+
... cotransfer of CD25+CD4+ T cells (8, 9). Thus, autoreactivity is an intrinsic feature of peripheral T cells, but autoimmune disease is prevented by natural Tregs. CD25+CD4+ Tregs were then shown to regulate not only autoimmunity but also tumor immunity, antimicrobial resistance, allergy, and transpla ...
... cotransfer of CD25+CD4+ T cells (8, 9). Thus, autoreactivity is an intrinsic feature of peripheral T cells, but autoimmune disease is prevented by natural Tregs. CD25+CD4+ Tregs were then shown to regulate not only autoimmunity but also tumor immunity, antimicrobial resistance, allergy, and transpla ...
Human Immunodeficiency Virus (HIV) Tat
... Assay of Serafor IgM Reactivity with Tat. Sera of 66 HIVnegative and 60 HIV-positive adult males and females, none of whom had received antiviral or immune-corrective therapy, were assayed for IgM antibodies reactive with HIV Tat. As shown (Fig. 1 A), of the HIV-negative sera from clinically normal ...
... Assay of Serafor IgM Reactivity with Tat. Sera of 66 HIVnegative and 60 HIV-positive adult males and females, none of whom had received antiviral or immune-corrective therapy, were assayed for IgM antibodies reactive with HIV Tat. As shown (Fig. 1 A), of the HIV-negative sera from clinically normal ...
Autoimmune Hepatitis Handout
... The liver is the second largest organ in your body and is located under your rib cage on the right side. It weighs about three pounds and is shaped like a football that is flat on one side. The liver performs many jobs in your body. It processes what you eat and drink into energy and nutrients your ...
... The liver is the second largest organ in your body and is located under your rib cage on the right side. It weighs about three pounds and is shaped like a football that is flat on one side. The liver performs many jobs in your body. It processes what you eat and drink into energy and nutrients your ...
Antigen-Specific Antibody Glycosylation Is Regulated via
... antibodies [15,24], it is possible that antibody glycosylation may be actively controlled by the immune system. Moreover, over 30 different glycan structures have been identified in naturally produced antibodies, each with the theoretical capacity to drive distinct effector functional profiles [25,2 ...
... antibodies [15,24], it is possible that antibody glycosylation may be actively controlled by the immune system. Moreover, over 30 different glycan structures have been identified in naturally produced antibodies, each with the theoretical capacity to drive distinct effector functional profiles [25,2 ...
Drug-Induced Hematologic Disorders
... effects of drugs. The incidence varies based on geography, which suggests that genetic differences may be important determinants of susceptibility. Drug-induced thrombocytopenia is the most common drug-induced hematologic disorders, with some reports suggesting that as many as 5% of patients who rec ...
... effects of drugs. The incidence varies based on geography, which suggests that genetic differences may be important determinants of susceptibility. Drug-induced thrombocytopenia is the most common drug-induced hematologic disorders, with some reports suggesting that as many as 5% of patients who rec ...
Full Text - Avicenna Journal of Dental Research
... pylori interaction with surface epithelial cells develops direct cell damage or produces pro-inflammatory mediators (29). Secondly, H. pylori reaches the underlying mucosa, hence stimulates immune response, which in turn leads to liberation of different cytokines and oxygen radicals (30). The presen ...
... pylori interaction with surface epithelial cells develops direct cell damage or produces pro-inflammatory mediators (29). Secondly, H. pylori reaches the underlying mucosa, hence stimulates immune response, which in turn leads to liberation of different cytokines and oxygen radicals (30). The presen ...
Management of CMV: Immune Monitoring, New therapies, Vaccines
... may not be followed as closely ...
... may not be followed as closely ...
curriculum vitae
... characterization of rat, mouse, human arthritis using gene array analysis (see publication) o Discovered ELISPOT response unique to type 1 diabetes subjects (see publications) Led Project Teams for three small-molecule GPCR drug discovery programs (immune-modulatory chemokine antagonists) Hired ...
... characterization of rat, mouse, human arthritis using gene array analysis (see publication) o Discovered ELISPOT response unique to type 1 diabetes subjects (see publications) Led Project Teams for three small-molecule GPCR drug discovery programs (immune-modulatory chemokine antagonists) Hired ...
The Origins, Specificity, and Potential Biological
... immunoglobulins. Humans have five classes of immunoglobulins: IgM, IgD, IgG, IgA, and IgE. The best characterized anti-immunoglobulin autoantibodies are those directed against the Fc region of IgG, known as rheumatoid factor, or those directed against the variable regions, known as anti-idiotype aut ...
... immunoglobulins. Humans have five classes of immunoglobulins: IgM, IgD, IgG, IgA, and IgE. The best characterized anti-immunoglobulin autoantibodies are those directed against the Fc region of IgG, known as rheumatoid factor, or those directed against the variable regions, known as anti-idiotype aut ...
Characterization of thymic hyperplasia associated with autoimmune
... was mediated by an autoimmune response indicated by (1) frequent association with other autoimmune diseases, (2) presence of transient MG symptoms in 10-15% of newborns from myasthenic mothers (neonatal MG), (3) inflammatory infiltrates in muscle and pathological changes in thymus, (4) beneficial ef ...
... was mediated by an autoimmune response indicated by (1) frequent association with other autoimmune diseases, (2) presence of transient MG symptoms in 10-15% of newborns from myasthenic mothers (neonatal MG), (3) inflammatory infiltrates in muscle and pathological changes in thymus, (4) beneficial ef ...
Leishmania infantum: molecular analysis for identification of
... fatal disease if left untreated. In Southern Europe, the number of HIV/Leishmania infantum co-infections is increasing and becomes an emerging concern for the public health. Dogs represent the main reservoir of this parasite. In order to control canine leishmaniasis, an early diagnosis system is nee ...
... fatal disease if left untreated. In Southern Europe, the number of HIV/Leishmania infantum co-infections is increasing and becomes an emerging concern for the public health. Dogs represent the main reservoir of this parasite. In order to control canine leishmaniasis, an early diagnosis system is nee ...
mRNA-based therapeutics — developing a new class of drugs
... various diseases (FIG. 1 (TIMELINE)). In the first decades after its discovery, the focus was on understanding the structural and functional aspects of mRNA and its metabolism in the eukaryotic cell. This is in addition to making tools for mRNA recombinant engineering more accessible to a broader re ...
... various diseases (FIG. 1 (TIMELINE)). In the first decades after its discovery, the focus was on understanding the structural and functional aspects of mRNA and its metabolism in the eukaryotic cell. This is in addition to making tools for mRNA recombinant engineering more accessible to a broader re ...
alopecia
... For all practical purposes, a few patches of hair loss is called Alopecia areata; while total hair loss all over the head, including eyebrows, eyes lashes is called Alopecia totalis. The treatment approach is different and the prognosis is also difference. That is, Alopecia Areata is treatable with ...
... For all practical purposes, a few patches of hair loss is called Alopecia areata; while total hair loss all over the head, including eyebrows, eyes lashes is called Alopecia totalis. The treatment approach is different and the prognosis is also difference. That is, Alopecia Areata is treatable with ...
Lymphatic System
... Filter and attack antigens. In some areas of the body, many lymphatic nodules group together to form larger structures. mucosa-associated lymphatic tissue (MALT) or tonsils very prominent in the mucosa of the small intestine, primarily in the ileum ...
... Filter and attack antigens. In some areas of the body, many lymphatic nodules group together to form larger structures. mucosa-associated lymphatic tissue (MALT) or tonsils very prominent in the mucosa of the small intestine, primarily in the ileum ...
Amino acid-derived hormones
... hormones. Hormones serve as chemical "messengers" that function in cellular and organ activity to maintain the body's homeostasis. Maintaining homeostasis within the body requires the coordination of many different systems and organs. Communication between neighboring cells and between cells and tis ...
... hormones. Hormones serve as chemical "messengers" that function in cellular and organ activity to maintain the body's homeostasis. Maintaining homeostasis within the body requires the coordination of many different systems and organs. Communication between neighboring cells and between cells and tis ...
Morphological Assessment of Lymph Nodes
... Various defense mechanisms are variably activated to withstand the progress of tumors. Cytotoxic T lymphocytes and natural killer cells are mediators of immune responses against tumor cells and, as TIL, they are constant companions. In the interaction between tumor cells and TILs resulting in recipr ...
... Various defense mechanisms are variably activated to withstand the progress of tumors. Cytotoxic T lymphocytes and natural killer cells are mediators of immune responses against tumor cells and, as TIL, they are constant companions. In the interaction between tumor cells and TILs resulting in recipr ...
Patients with oral erosive and cutaneous lichen planus may have
... Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corres ...
... Objective: The aim of this study is to verify whether stratified epithelium-specific antinuclear antibodies are present in the sera of patients with erosive oral lichen planus and cutaneous lichen planus. Methods: We studied the pre-immune and immune serum of a rabbit immunized with a peptide corres ...
Differential switching to IgG and IgA healthy controls
... ABSTRACT: Several studies have demonstrated the presence of B-cell follicles and autoantibodies in chronic obstructive pulmonary disease (COPD). It is unclear against which antigens this B-cell response is directed and whether it contributes to development or worsening of disease. We assessed differ ...
... ABSTRACT: Several studies have demonstrated the presence of B-cell follicles and autoantibodies in chronic obstructive pulmonary disease (COPD). It is unclear against which antigens this B-cell response is directed and whether it contributes to development or worsening of disease. We assessed differ ...
STP-A11, an oncoprotein of Herpesvirus saimiri augments
... family protein is activated by various stimuli including growth factors, cytokines, cell-matrix interactions and physical stresses (Shaulian and Karin, 2001; Lee et al., 2004; Milde-Langosch, 2005). AP com ponents can be activated through a direct phosphorylation of c-Jun at its N-terminus by JNK (D ...
... family protein is activated by various stimuli including growth factors, cytokines, cell-matrix interactions and physical stresses (Shaulian and Karin, 2001; Lee et al., 2004; Milde-Langosch, 2005). AP com ponents can be activated through a direct phosphorylation of c-Jun at its N-terminus by JNK (D ...
Two Distinct Mechanisms for Induction of Dendritic Cell Apoptosis in
... ineffective at inducing macrophage apoptosis (11). In contrast, pneumolysin induces in neurons and microglia a caspase-independent apoptosis associated with the release of apoptosis-inducing factor from mitochondria (16), which contributes to enhanced morbidity (17). Thus, various stimuli acting on ...
... ineffective at inducing macrophage apoptosis (11). In contrast, pneumolysin induces in neurons and microglia a caspase-independent apoptosis associated with the release of apoptosis-inducing factor from mitochondria (16), which contributes to enhanced morbidity (17). Thus, various stimuli acting on ...
Combined Haemophilus influenzae respiratory infection and allergic
... symptoms and neutrophilic inflammation are poorly responsive to corticosteroids, the mainstay of asthma therapy, and it has been suggested that airway neutrophilia may be a consequence of steroid treatment.2 3 Neutrophilic airway inflammation is also common to many obstructive airway diseases, includi ...
... symptoms and neutrophilic inflammation are poorly responsive to corticosteroids, the mainstay of asthma therapy, and it has been suggested that airway neutrophilia may be a consequence of steroid treatment.2 3 Neutrophilic airway inflammation is also common to many obstructive airway diseases, includi ...