QUESTION
... (2) Enter all answers and questions in the normal view. (view/normal) (3) Change the category headings in the normal view (view/normal) (4) View as a slideshow. (5) Use the home red button after each question. ...
... (2) Enter all answers and questions in the normal view. (view/normal) (3) Change the category headings in the normal view (view/normal) (4) View as a slideshow. (5) Use the home red button after each question. ...
35 Kortylewski Nat Biotechnol 2009
... The ability of siRNAs to control the expression of specific genes makes them an attractive new class of drugs with broad potential for the treatment of diverse human diseases. Several recent studies have shown the feasibility of in vivo siRNA delivery, demonstrating therapeutic efficacy in mouse mod ...
... The ability of siRNAs to control the expression of specific genes makes them an attractive new class of drugs with broad potential for the treatment of diverse human diseases. Several recent studies have shown the feasibility of in vivo siRNA delivery, demonstrating therapeutic efficacy in mouse mod ...
Human Osteoblasts Interaction with Mouse or Salmonella or
... expression by these cells. Cultured mouse and human osteoblasts were exposed to various numbers of S. aureus or Salmonella dublin bacteria, and a comprehensive analysis of granulocyte-macrophage (GM)-CSF, granulocyte (G)-CSF, macrophage (M)-CSF, and interleukin-3 (IL-3) mRNA expression and cytokine ...
... expression by these cells. Cultured mouse and human osteoblasts were exposed to various numbers of S. aureus or Salmonella dublin bacteria, and a comprehensive analysis of granulocyte-macrophage (GM)-CSF, granulocyte (G)-CSF, macrophage (M)-CSF, and interleukin-3 (IL-3) mRNA expression and cytokine ...
Complement Opsonization of HIV-1 Enhances Endocytic Lectin and Integrin Receptor
... Competing Interests: The authors have declared that no competing interests exist. * E-mail: [email protected] . These authors contributed equally to this work. ...
... Competing Interests: The authors have declared that no competing interests exist. * E-mail: [email protected] . These authors contributed equally to this work. ...
BACKGROUND OF THE INVENTION
... including a gene of SEQ ID NO. 1 �3. A host cell transformed to a recombinant vector including a gene of SEQ ID NO. 1 [note] This case is recognized only when the description is sufficiently supported by the detailed description of the ...
... including a gene of SEQ ID NO. 1 �3. A host cell transformed to a recombinant vector including a gene of SEQ ID NO. 1 [note] This case is recognized only when the description is sufficiently supported by the detailed description of the ...
Toward a Universal Influenza Vaccine
... threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influenza-infecte ...
... threats without the need to generate new vaccines for each strain. Neutralizing Abs to the influenza virus hemagglutinin glycoprotein are effective at controlling influenza infection but generally target highly variable regions. Abs that can mediate other functions, such as killing influenza-infecte ...
The immune response to resistive breathing REVIEW
... The stimulus for the upregulation of cytokine induction in response to resistive breathing is not known. Resistive breathing increases the production of reactive oxygen species (ROS), both within the working respiratory muscles and in the extracellular and vascular compartments [23]. ROS are able to ...
... The stimulus for the upregulation of cytokine induction in response to resistive breathing is not known. Resistive breathing increases the production of reactive oxygen species (ROS), both within the working respiratory muscles and in the extracellular and vascular compartments [23]. ROS are able to ...
Multiple Organ Dysfunction Syndrome
... – Larger multi-center RCT’s to adequately power studies as mortality percentages fall – More refined definitions and consistent usage of the SIRSSepsis-MODS spectrum – A better understanding of what is common to all patients and what is associated with host variations (e.g., gene polymorphisms) ...
... – Larger multi-center RCT’s to adequately power studies as mortality percentages fall – More refined definitions and consistent usage of the SIRSSepsis-MODS spectrum – A better understanding of what is common to all patients and what is associated with host variations (e.g., gene polymorphisms) ...
small cell lung cancer
... Lack of access to SCLC biospecimens to identify biomarkers and new therapeutic targets Inefficient clinical trial enrollment processes and data sharing As a result, SCLC patients and their families are still waiting for innovative medical solutions that could dramatically improve and or save the ...
... Lack of access to SCLC biospecimens to identify biomarkers and new therapeutic targets Inefficient clinical trial enrollment processes and data sharing As a result, SCLC patients and their families are still waiting for innovative medical solutions that could dramatically improve and or save the ...
Sphingosine-1-Phosphate Metabolism and Its Role in the
... Sphinx creature, to emphasize its enigmatic nature. Recently, the significance of phospholipids and their derivatives in regulating cell function has been appreciated. Initially described for their role as cellular building material or in metabolic processes [10], we now know that lipids can act as ...
... Sphinx creature, to emphasize its enigmatic nature. Recently, the significance of phospholipids and their derivatives in regulating cell function has been appreciated. Initially described for their role as cellular building material or in metabolic processes [10], we now know that lipids can act as ...
Accurate pan-specific prediction of peptide-MHC class II
... polymorphic residues in potential contact with a bound peptide (Nielsen et al. 2007a). We used the same pseudosequences of 34 residues for the MHC alpha and beta chains defined by Karosiene et al. (2013), resulting in additional 34× 20=680 inputs. As a result, the total size of the input layer amoun ...
... polymorphic residues in potential contact with a bound peptide (Nielsen et al. 2007a). We used the same pseudosequences of 34 residues for the MHC alpha and beta chains defined by Karosiene et al. (2013), resulting in additional 34× 20=680 inputs. As a result, the total size of the input layer amoun ...
View PDF - Cardiovascular Research
... prove useful as anti-hypertensive drugs in IL-17-associated auto-immune diseases. ...
... prove useful as anti-hypertensive drugs in IL-17-associated auto-immune diseases. ...
... Our data indicate that the frequency of FcγRIIa-R/R131 genotype was significantly higher in Sudanese patients with severe malaria when compared to patients with mild malaria, while the FcγRIIa-H/H131 genotype showed a significant association with mild malaria. The levels of IgG1 and IgG3 subclass an ...
Heat Shock Proteins-an
... 1989). Although, these experiments were the first indication that HSP could be released by an active mechanism, the exact mechanism of release was not yet addressed. Further studies by Guzhova and colleagues demonstrated that Hsp70 is released by glia cells in the absence of necrotic cell death (Guz ...
... 1989). Although, these experiments were the first indication that HSP could be released by an active mechanism, the exact mechanism of release was not yet addressed. Further studies by Guzhova and colleagues demonstrated that Hsp70 is released by glia cells in the absence of necrotic cell death (Guz ...
BEBPA 2015 Nab Conference Brochure
... human, carry unique stretches of amino acids, which form the antigenbinding site and determine their specificity. These sequences are frequently seen as foreign by the immune system of the patient and induce the formation of ADA. By forming a complex with the drug, ADA can neutralize drug activity, ...
... human, carry unique stretches of amino acids, which form the antigenbinding site and determine their specificity. These sequences are frequently seen as foreign by the immune system of the patient and induce the formation of ADA. By forming a complex with the drug, ADA can neutralize drug activity, ...
Preeclampsia and the Systemic Inflammatory Response
... syncytiotrophoblast layer, expresses no known polymorphic major histocompatibility (HLA) antigens. Histocompatibility antigens are the targets for immune rejection that are executed by cytotoxic T cells. However, because the placental hemochorial surface is a syncytium, it is unclear how it could be ...
... syncytiotrophoblast layer, expresses no known polymorphic major histocompatibility (HLA) antigens. Histocompatibility antigens are the targets for immune rejection that are executed by cytotoxic T cells. However, because the placental hemochorial surface is a syncytium, it is unclear how it could be ...
Steht die Psyche unter Druck, leiden die Haare – eine
... epithelium of organ-cultured anagen hair bulbs, likely via interferon regulatory factor-1, along with up-regulation of the MHC class I pathway molecules beta(2)microglobulin and transporter associated with antigen processing (TAP-2). In the first report to identify natural immunomodulators capable o ...
... epithelium of organ-cultured anagen hair bulbs, likely via interferon regulatory factor-1, along with up-regulation of the MHC class I pathway molecules beta(2)microglobulin and transporter associated with antigen processing (TAP-2). In the first report to identify natural immunomodulators capable o ...
Cancer Vaccine Therapies: Failures and Future Opportunities
... new all-time high of $140 with a market capitalization above $3.3 billion (see Appendix D: Idec Pharmaceuticals - Anatomy of a Success). Worldwide net sales of Rituxan® reached $1.5 billion in 2002 and the following summer IDEC Pharmaceuticals acquired Biogen, Inc. in a stock transaction valued at a ...
... new all-time high of $140 with a market capitalization above $3.3 billion (see Appendix D: Idec Pharmaceuticals - Anatomy of a Success). Worldwide net sales of Rituxan® reached $1.5 billion in 2002 and the following summer IDEC Pharmaceuticals acquired Biogen, Inc. in a stock transaction valued at a ...
Psoriasis - New England Journal of Medicine
... epithelial and mesenchymal cells. This disease vividly highlights the pathogenic importance of T cells and simultaneously illustrates how advances in our understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation ...
... epithelial and mesenchymal cells. This disease vividly highlights the pathogenic importance of T cells and simultaneously illustrates how advances in our understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation ...
Immunogenicity - Biologics and Biosimilars
... Neutralizing Abs are typically not done in non-human primates but is considered in a case by case basis and depends upon a variety of factors that include: Type of drug and MOA ...
... Neutralizing Abs are typically not done in non-human primates but is considered in a case by case basis and depends upon a variety of factors that include: Type of drug and MOA ...
Fc lessons from murine mercury-induced autoimmunity. -receptors in systemic autoimmune conditions -
... humorally mediated immune response compared to males [8, 9]. The concept that sex hormones alone could explain the dominance of autoimmunity found in females is however an oversimplification [10]. The role of X-chromosome linked autoimmune-related loci [11] and X-chromosome dosage, including differe ...
... humorally mediated immune response compared to males [8, 9]. The concept that sex hormones alone could explain the dominance of autoimmunity found in females is however an oversimplification [10]. The role of X-chromosome linked autoimmune-related loci [11] and X-chromosome dosage, including differe ...
Cancer Growth and Metastasis curcuma contra cancer? curcumin
... The NFKB pathway is often deregulated in cancer cells. One example is Hodgkin’s lymphoma (HL), one of the most frequent lymphomas in Western countries.128 The etiology of HL is unclear, but immunological and molecular properties suggest that in most cases HL cells are derived from B cells.129–131 HL ...
... The NFKB pathway is often deregulated in cancer cells. One example is Hodgkin’s lymphoma (HL), one of the most frequent lymphomas in Western countries.128 The etiology of HL is unclear, but immunological and molecular properties suggest that in most cases HL cells are derived from B cells.129–131 HL ...