Immune maturation and lymphocyte characteristics in relation
... This thesis provides novel insights into S. aureus- and SE-mediated activation of Tregs, unconventional T-cells and NK-cells and suggests an overall impairment of immuneresponsiveness towards this bacterium in children. Further, S. aureus-colonization may influence the maturation of peripheral Tregs ...
... This thesis provides novel insights into S. aureus- and SE-mediated activation of Tregs, unconventional T-cells and NK-cells and suggests an overall impairment of immuneresponsiveness towards this bacterium in children. Further, S. aureus-colonization may influence the maturation of peripheral Tregs ...
Evasion of Host Immune Surveillance by Hepatitis C Virus: Potential
... for HCV persistent infection. Such hypervariability within the E2 protein may be under selective pressure from protective B cell or T cell responses and be able to escape immune recognition by rapid mutation of antigenic site. In addition to antigenic variation, HCV may also suppress immune response ...
... for HCV persistent infection. Such hypervariability within the E2 protein may be under selective pressure from protective B cell or T cell responses and be able to escape immune recognition by rapid mutation of antigenic site. In addition to antigenic variation, HCV may also suppress immune response ...
Five Prime Therapeutics, Inc.
... This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate" and similar expressions (as well as other words or expressions referencing future events or circumstances) ar ...
... This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Words such as "may," "will," "expect," "plan," "anticipate" and similar expressions (as well as other words or expressions referencing future events or circumstances) ar ...
approach to the patient with lymphadenopathy and splenomegaly
... Primary cutaneous anaplastic large cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Enteropathy-type intestinal T-cell lymphoma Hepatosplenic g/d T-cell lymphoma Angioimmunoblastic T-cell lymphoma Peripheral T-cell lymphoma (unspecified) Anaplastic large cell lymphoma, primary systemic t ...
... Primary cutaneous anaplastic large cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Enteropathy-type intestinal T-cell lymphoma Hepatosplenic g/d T-cell lymphoma Angioimmunoblastic T-cell lymphoma Peripheral T-cell lymphoma (unspecified) Anaplastic large cell lymphoma, primary systemic t ...
Ablation of Proliferating Cells in the CNS
... motor neurons subset of astrocytes and ependymal cells, a considerable number of mature oligodendrocytes have been shown to be immunoreactive for Olig2 in the adult brain [36,37]. Further study of the role of oligodendrocytes in the pathology of ALS is warranted. In vitro and in vivo studies have sh ...
... motor neurons subset of astrocytes and ependymal cells, a considerable number of mature oligodendrocytes have been shown to be immunoreactive for Olig2 in the adult brain [36,37]. Further study of the role of oligodendrocytes in the pathology of ALS is warranted. In vitro and in vivo studies have sh ...
Splenic autotransplantation in a patient with human
... Autotransplantation of splenic tissue decreases the risk of opportunistic infection or sepsis, but its role in patients with HIV is debated because in people with HIV the spleen is a replication site, especially in the asymptomatic phase of the disease. However, previous studies have demonstrated th ...
... Autotransplantation of splenic tissue decreases the risk of opportunistic infection or sepsis, but its role in patients with HIV is debated because in people with HIV the spleen is a replication site, especially in the asymptomatic phase of the disease. However, previous studies have demonstrated th ...
Get - Wiley Online Library
... murine tumours. In this study, we have investigated the potency of human ovarian cancer-derived CRCL to activate dendritic cells (DC) and to generate tumour-specific T cells in vitro. CRCL was generated from primary ovarian cancers and SKOV3-A2, a HER2/neu,Wilm’s tumour gene 1 (WT1) and human leucoc ...
... murine tumours. In this study, we have investigated the potency of human ovarian cancer-derived CRCL to activate dendritic cells (DC) and to generate tumour-specific T cells in vitro. CRCL was generated from primary ovarian cancers and SKOV3-A2, a HER2/neu,Wilm’s tumour gene 1 (WT1) and human leucoc ...
Inflammation and Colon Cancer
... cells (DC), and tumor-associated macrophages can be easily detected in these tumors (Table 2).8 In addition, advanced tumors recruit specific myeloid subsets that represent phenotypically heterogeneous but a functionally similar population of CD11b⫹Gr1⫹ cells, called myeloid-derived suppressor cells ...
... cells (DC), and tumor-associated macrophages can be easily detected in these tumors (Table 2).8 In addition, advanced tumors recruit specific myeloid subsets that represent phenotypically heterogeneous but a functionally similar population of CD11b⫹Gr1⫹ cells, called myeloid-derived suppressor cells ...
Blackcurrant phenolic extract induces hemeoxygenase
... These data suggest that blackcurrant and boysenberry phenolic extracts act synergistically to suppress IL-4-induced CCL26 in lung epithelial cells, which involves the prevention of STAT-6 phosphorylation and subsequent CCL26 transcription. IFNg enhances the ability of blackcurrant phenolic extract t ...
... These data suggest that blackcurrant and boysenberry phenolic extracts act synergistically to suppress IL-4-induced CCL26 in lung epithelial cells, which involves the prevention of STAT-6 phosphorylation and subsequent CCL26 transcription. IFNg enhances the ability of blackcurrant phenolic extract t ...
Extracellular membrane vesicles as a mechanism of cell-to
... Vertebrates also express a set of leukocyte-specific integrins, which are able to recognize the Ig-superfamily receptors. In addition to mediating cell adhesion, integrins make transmembrane connections to the cytoskeleton, thus activating intracellular signaling pathways involved in development, im ...
... Vertebrates also express a set of leukocyte-specific integrins, which are able to recognize the Ig-superfamily receptors. In addition to mediating cell adhesion, integrins make transmembrane connections to the cytoskeleton, thus activating intracellular signaling pathways involved in development, im ...
On the evolutionary ecology of specific immune defence
... porates the costs of defence. This places the issue within a general framework of an adaptive defence portfolio. We neither address other functions of the immune system, such as wound healing or tumour control, nor explicitly make reference to the plant literature, which adopts yet further approache ...
... porates the costs of defence. This places the issue within a general framework of an adaptive defence portfolio. We neither address other functions of the immune system, such as wound healing or tumour control, nor explicitly make reference to the plant literature, which adopts yet further approache ...
Focus Article
... or wounding, generates a complex stress response that extends beyond the nervous system and contributes to the experience of pain. Through a common chemical language comprising neurotransmitters, peptides, endocannabinoids, cytokines, and hormones, an ensemble of interdependent nervous, endocrine, a ...
... or wounding, generates a complex stress response that extends beyond the nervous system and contributes to the experience of pain. Through a common chemical language comprising neurotransmitters, peptides, endocannabinoids, cytokines, and hormones, an ensemble of interdependent nervous, endocrine, a ...
A Concise Textbook of Human Psychology
... between presentation of the CS and the UCS. Presumably, if too much time passes between the presentation of these two stimuli, the animal is unlikely to associate them, and conditioning is less likely to occur. For most responses, the optimal interval between the CS and UCS is very brief, usually a ...
... between presentation of the CS and the UCS. Presumably, if too much time passes between the presentation of these two stimuli, the animal is unlikely to associate them, and conditioning is less likely to occur. For most responses, the optimal interval between the CS and UCS is very brief, usually a ...
Human Lymphatic Filariasis Cells Is Associated with Clinical
... in experimental disease models, such as colitis, peripheral neuritis and experimental autoimmune encephalitis (3, 7, 20); however, IL-9 has also been shown to participate in peripheral tolerance by increasing the survival and activity of regulatory T cells (21). Therefore, it is still unclear whethe ...
... in experimental disease models, such as colitis, peripheral neuritis and experimental autoimmune encephalitis (3, 7, 20); however, IL-9 has also been shown to participate in peripheral tolerance by increasing the survival and activity of regulatory T cells (21). Therefore, it is still unclear whethe ...
How Mycobacterium tuberculosis Manipulates Innate and Adaptive Immunity: New Views of
... establishment and progression of M. tuberculosis infection. This chapter describes experiments ranging from macrophage infections to immunological analysis of pathogenesis in clinical tissue and cell samples obtained from the site of infection of TB infected patients. The presented methods include m ...
... establishment and progression of M. tuberculosis infection. This chapter describes experiments ranging from macrophage infections to immunological analysis of pathogenesis in clinical tissue and cell samples obtained from the site of infection of TB infected patients. The presented methods include m ...
Introduction - University of Kentucky
... vaccines utilize whole tumor cells, which are rendered safe by irradiation (Armstrong, 2001a). The irradiation process prevents cell division of the tumor cells (Goldsby, 2003). The irradiated cells are then mixed with an adjuvant. Tumor cell vaccines have the benefit that tumor antigens do not have ...
... vaccines utilize whole tumor cells, which are rendered safe by irradiation (Armstrong, 2001a). The irradiation process prevents cell division of the tumor cells (Goldsby, 2003). The irradiated cells are then mixed with an adjuvant. Tumor cell vaccines have the benefit that tumor antigens do not have ...
General Summary - edoc
... The molecular mechanisms of ectocytosis are still largely unknown, as are the various functions ectosomes might have for each cell-type they derived from. However, data have accumulated recently suggesting that ectosomes act as vesicular mediators that adopt cellspecific functions, most of which bei ...
... The molecular mechanisms of ectocytosis are still largely unknown, as are the various functions ectosomes might have for each cell-type they derived from. However, data have accumulated recently suggesting that ectosomes act as vesicular mediators that adopt cellspecific functions, most of which bei ...
Inflammatory Monocytes Activate Memory CD8+ T and
... similarly to natural killer (NK) cells (Chaix et al., 2008; Lucas et al., 2007; Nguyen et al., 2002), memory CD8+ T cells can respond to distinct inflammatory cytokines (Berg et al., 2003; Kambayashi et al., 2003; Kohlmeier et al., 2010; Liu et al., 2002; Yajima et al., 2005; Zhang et al., 1998). Up ...
... similarly to natural killer (NK) cells (Chaix et al., 2008; Lucas et al., 2007; Nguyen et al., 2002), memory CD8+ T cells can respond to distinct inflammatory cytokines (Berg et al., 2003; Kambayashi et al., 2003; Kohlmeier et al., 2010; Liu et al., 2002; Yajima et al., 2005; Zhang et al., 1998). Up ...
Non-immune Hemolysis_ Diagnostic Considerations
... by mutations in the SPTA, SPTB, or EPB4.1 genes impairing spectrin polymerization and inducing a fragility of the red blood cell cytoskeleton.8,13 Transmission is autosomaldominant. Although striking on a blood film (Figure 3C), this condition is asymptomatic in most affected subjects, who present no ...
... by mutations in the SPTA, SPTB, or EPB4.1 genes impairing spectrin polymerization and inducing a fragility of the red blood cell cytoskeleton.8,13 Transmission is autosomaldominant. Although striking on a blood film (Figure 3C), this condition is asymptomatic in most affected subjects, who present no ...
Long-Term Protective Immunity Induced Against
... America (Urbina, 2001; Camandaroba et al., 2003). Thus, vaccination should be seriously considered as an alternative approach in therapy and prophylaxis of Chagas’ disease. Protective immunity against this parasite seems to be highly dependent on the induction of CD8 T cell responses and interferon ...
... America (Urbina, 2001; Camandaroba et al., 2003). Thus, vaccination should be seriously considered as an alternative approach in therapy and prophylaxis of Chagas’ disease. Protective immunity against this parasite seems to be highly dependent on the induction of CD8 T cell responses and interferon ...
Sex differences in carotenoid status and immune performance in
... integument (e.g. skin, feathers) and become sexually attractive (Hill, 1999a). In these situations, males typically circulate higher levels of carotenoids through the body than do females (Hill, 1995; Bortolotti et al., 1996; Figuerola and Gutierrez, 1998; Negro et al., 1998). Circulating carotenoid ...
... integument (e.g. skin, feathers) and become sexually attractive (Hill, 1999a). In these situations, males typically circulate higher levels of carotenoids through the body than do females (Hill, 1995; Bortolotti et al., 1996; Figuerola and Gutierrez, 1998; Negro et al., 1998). Circulating carotenoid ...
Insights into Seven and Single Transmembrane
... GTP-␣ subunit that activate various intracellular effector molecules. To turn off the activation of G proteins, the ␣ subunit that possesses an intrinsic GTPase activity digests the GTP into GDP, resulting in the reassociation of the ␣ subunit with the ␥ complex and hence reverting to the inactive ...
... GTP-␣ subunit that activate various intracellular effector molecules. To turn off the activation of G proteins, the ␣ subunit that possesses an intrinsic GTPase activity digests the GTP into GDP, resulting in the reassociation of the ␣ subunit with the ␥ complex and hence reverting to the inactive ...