Thymosin α1 accelerates restoration of T cell
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
... is related to the restoration of CD4q T cells. Thymosin a 1 was reported to have significant potentiating effects on thymocyte maturation as shown in Figs. 2 and 3 and immunologic functions which include promotion of IFN-g , interleukin-2 and interleukin-2 receptor production, enhanced proliferation ...
Increased sexual activity reduces male immune function in
... resistance to disease: as males respond to increased sexual selection by increasing their mating effort, we expect a decrease in their ability to mount an immune response. This prediction has been experimentally tested indirectly among a number of vertebrates (mostly birds) by using testosterone imp ...
... resistance to disease: as males respond to increased sexual selection by increasing their mating effort, we expect a decrease in their ability to mount an immune response. This prediction has been experimentally tested indirectly among a number of vertebrates (mostly birds) by using testosterone imp ...
Molecular and Biological Characteristics of Stroma and Tumor Cells
... studies carried out with transplantable tumors in chickens, mice and rats (Rous, 1911). The causative agent for such tumors was found to be an RNA virus, and the first oncogene identified was a viral gene (v-src) responsible for the sarcoma-producing properties of the Rous sarcoma virus. Subsequentl ...
... studies carried out with transplantable tumors in chickens, mice and rats (Rous, 1911). The causative agent for such tumors was found to be an RNA virus, and the first oncogene identified was a viral gene (v-src) responsible for the sarcoma-producing properties of the Rous sarcoma virus. Subsequentl ...
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... activity against tumor cells, and augmentation of humoral immunity to facilitate long term anti-tumor immunity will ultimately yield success. Investigators have taken many different angles to address these questions. From viruses as cancer vaccines to engineered immune cells in combination with vira ...
... activity against tumor cells, and augmentation of humoral immunity to facilitate long term anti-tumor immunity will ultimately yield success. Investigators have taken many different angles to address these questions. From viruses as cancer vaccines to engineered immune cells in combination with vira ...
The structural network of inflammation and cancer: Merits and
... The link between inflammation and cancer appears to stem from two pathways [29], the intrinsic and extrinsic inflammation pathways, as shown in Fig. 2. Intrinsic inflammation is initiated by mutations that lead to activation of oncogenes and inactivation of tumor suppressors (tumor-promoter role) [24]. ...
... The link between inflammation and cancer appears to stem from two pathways [29], the intrinsic and extrinsic inflammation pathways, as shown in Fig. 2. Intrinsic inflammation is initiated by mutations that lead to activation of oncogenes and inactivation of tumor suppressors (tumor-promoter role) [24]. ...
Chronic Dry Eye Disease is Principally Mediated by Effector Memory
... (Figure 1c) were consistent with previous findings indicating that there is increased Th1associated IFN-γ8 and Th17-associated IL-17 in the conjunctiva.8,10 However, in chronic DED (day 126), conjunctival IFN-γ returned to near-normal levels, while IL-17 levels remained elevated at a level comparabl ...
... (Figure 1c) were consistent with previous findings indicating that there is increased Th1associated IFN-γ8 and Th17-associated IL-17 in the conjunctiva.8,10 However, in chronic DED (day 126), conjunctival IFN-γ returned to near-normal levels, while IL-17 levels remained elevated at a level comparabl ...
IgG plasma cells display a unique spectrum of
... Long-lived plasma cells have recently been identified as an important component of B-cell memory,1,2 and the majority of long-lived plasma cells are localized in the bone marrow.2,3 Migration of newly formed plasma cells from the lymph nodes and spleen to bone marrow is therefore an important step i ...
... Long-lived plasma cells have recently been identified as an important component of B-cell memory,1,2 and the majority of long-lived plasma cells are localized in the bone marrow.2,3 Migration of newly formed plasma cells from the lymph nodes and spleen to bone marrow is therefore an important step i ...
The origins of the identification and isolation of hematopoietic stem
... tissues. Till and McCulloch proposed that these latter cells were hematopoietic stem cells, that these cells could self-renew, and that they could make all blood cell types. Wolf and Trentin showed that colonies formed in the marrow also, and that while the majority of day 7 spleen colonies were pre ...
... tissues. Till and McCulloch proposed that these latter cells were hematopoietic stem cells, that these cells could self-renew, and that they could make all blood cell types. Wolf and Trentin showed that colonies formed in the marrow also, and that while the majority of day 7 spleen colonies were pre ...
Causes of disease_adaptive responses
... Replacement of airway pseudostratified mucinproducing ciliated columnar epithelium by an epithelium consisting almost entirely of goblet cells (cigarette smokers and asthmatics) ...
... Replacement of airway pseudostratified mucinproducing ciliated columnar epithelium by an epithelium consisting almost entirely of goblet cells (cigarette smokers and asthmatics) ...
Fat Soluble Vitamins
... • Dietary Vitamin D is absorbed from a micelle, along with other fats. • About 50% of dietary D3 is absorbed. Most absorbed in distal small intestine. • Incorporated into chylomicrons • Cholecalciferol from the skin is bound to DBP and travels primarily to the liver, but can be picked up by other t ...
... • Dietary Vitamin D is absorbed from a micelle, along with other fats. • About 50% of dietary D3 is absorbed. Most absorbed in distal small intestine. • Incorporated into chylomicrons • Cholecalciferol from the skin is bound to DBP and travels primarily to the liver, but can be picked up by other t ...
Exploiting Immune Response Dynamics in HIV Therapy
... and growing problem worldwide. No cure exists, and current treatments are unsatisfactory for a number of reasons, including cost, severe side-effects, and the eventual emergence of resistance. To combat these problems, the medical community is actively researching both new therapeutic agents and new ...
... and growing problem worldwide. No cure exists, and current treatments are unsatisfactory for a number of reasons, including cost, severe side-effects, and the eventual emergence of resistance. To combat these problems, the medical community is actively researching both new therapeutic agents and new ...
- Wiley Online Library
... growth [19–21]. Previously, we and others have shown that myeloid-derived suppressor cells (MDSC) function as a direct source of osteoclasts [22–24]. An important finding in our studies was only MDSC within the bone TME differentiated into osteoclast, whereas MDSC from nonbone sites of BCa metastasi ...
... growth [19–21]. Previously, we and others have shown that myeloid-derived suppressor cells (MDSC) function as a direct source of osteoclasts [22–24]. An important finding in our studies was only MDSC within the bone TME differentiated into osteoclast, whereas MDSC from nonbone sites of BCa metastasi ...
Inflammation and Cellular Immune Responses in Abdominal Aortic
... extensive perianeurysmal and retroperitoneal fibrosis, and dense adhesions of adjacent abdominal organs. Patients with such inflammatory aortic aneurysms more commonly present with a triad of abdominal or back pain, weight loss, and an elevated erythrocyte sedimentation rate (65% to 90% versus 8% to ...
... extensive perianeurysmal and retroperitoneal fibrosis, and dense adhesions of adjacent abdominal organs. Patients with such inflammatory aortic aneurysms more commonly present with a triad of abdominal or back pain, weight loss, and an elevated erythrocyte sedimentation rate (65% to 90% versus 8% to ...
Dicer Functions in Aquatic Species
... many plant and animal viruses possess proteins that suppress host RNA silencing mediated by siRNA or miRNA pathways. Striped jack nervous necrosis virus (SJNNV), which infects fish, has a bipartite genome of positive-strand RNAs. The SJNNV protein B2 has a potent RNA-silencing suppression activity [ ...
... many plant and animal viruses possess proteins that suppress host RNA silencing mediated by siRNA or miRNA pathways. Striped jack nervous necrosis virus (SJNNV), which infects fish, has a bipartite genome of positive-strand RNAs. The SJNNV protein B2 has a potent RNA-silencing suppression activity [ ...
The frequency of enteric fever among children in Al
... The zinc level of infected child was ( 136.2 ± 46.99 std.) µg/dl , in control group the level was ( 120.04±21.20) µg/dl and the differences was insignificant between these groups. Also, the study shown no significant differences in the copper levels for the previous groups under (P<0.05). Where the ...
... The zinc level of infected child was ( 136.2 ± 46.99 std.) µg/dl , in control group the level was ( 120.04±21.20) µg/dl and the differences was insignificant between these groups. Also, the study shown no significant differences in the copper levels for the previous groups under (P<0.05). Where the ...
Lung cancer-initiating cells: a novel target for cancer therapy
... tumor-initiating cells, has received considerable recent ...
... tumor-initiating cells, has received considerable recent ...
PAMP recognition and the plant-pathogen arms race
... mutations within these epitopes that rendered them inactive as elicitors of plant defence systems. However, it would seem that, in many cases, such mutations also have a deleterious effect on the function of these proteins in the pathogen. For example, in Pep-13, substitution of Trp231 to Ala abolis ...
... mutations within these epitopes that rendered them inactive as elicitors of plant defence systems. However, it would seem that, in many cases, such mutations also have a deleterious effect on the function of these proteins in the pathogen. For example, in Pep-13, substitution of Trp231 to Ala abolis ...
Innate Immunity: Nonspecific Defenses of the Host
... KEY CONCEPTS The complement system is another way the body fights infection and destroys pathogens. This component of innate immunity “complements” other immune reactions. Complement is a group of over 30 proteins circulating in serum that are activated in a cascade: one complement protein triggers ...
... KEY CONCEPTS The complement system is another way the body fights infection and destroys pathogens. This component of innate immunity “complements” other immune reactions. Complement is a group of over 30 proteins circulating in serum that are activated in a cascade: one complement protein triggers ...
Three-Dimensional Rotating Wall Vessel
... at mucosal epithelial sites additionally influences virus-host interactions at the epithelial barrier and ultimately impacts viral infection and transmission [5–7]. While some of these features may be present in conventional monolayer cell cultures, they often lack the polarity and other topographic ...
... at mucosal epithelial sites additionally influences virus-host interactions at the epithelial barrier and ultimately impacts viral infection and transmission [5–7]. While some of these features may be present in conventional monolayer cell cultures, they often lack the polarity and other topographic ...
Jennifer Orthmann-Murphey, M.D., Ph.D., Postdoctoral Fellow
... University of Chicago Medical Center Chicago, IL ...
... University of Chicago Medical Center Chicago, IL ...
(From the Variety Club Heart Hospital Pediatric Research
... resistance. Although some of these are well developed in invertebrates and m a y indeed be the effective mechanisms of defense, they have been reviewed heretofore (I) and will not be considered in this paper. Contact with antigen is an event necessary for the immunologic maturation of lymphoid cells ...
... resistance. Although some of these are well developed in invertebrates and m a y indeed be the effective mechanisms of defense, they have been reviewed heretofore (I) and will not be considered in this paper. Contact with antigen is an event necessary for the immunologic maturation of lymphoid cells ...
NK cell development, homeostasis and function: parallels
... cells exist in the liver of adult mice21. It is not entirely clear whether these thymic‑, lymph node- and liverderived populations represent distinct NK cell lineages or merely consist of predominantly less-mature peripheral cells that originated from the bone marrow. The bone marrow is certainly th ...
... cells exist in the liver of adult mice21. It is not entirely clear whether these thymic‑, lymph node- and liverderived populations represent distinct NK cell lineages or merely consist of predominantly less-mature peripheral cells that originated from the bone marrow. The bone marrow is certainly th ...