Predicting pathogen-specific CD8 T cell immune responses
... are based on live viruses and stay contraindicated for some people [19, 20, 21]. Moreover vaccinia virus could also be used as a platform for the design of vaccines directed against other pathogens [4]. Listeria monocytogenes, a Gram-positive bacteria, causes disease mainly in immunocompromised huma ...
... are based on live viruses and stay contraindicated for some people [19, 20, 21]. Moreover vaccinia virus could also be used as a platform for the design of vaccines directed against other pathogens [4]. Listeria monocytogenes, a Gram-positive bacteria, causes disease mainly in immunocompromised huma ...
Autoimmune Destruction of Pancreatic b Cells
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
... study suggested that a strong humoral response to GAD may actually be associated with less destructive pathology, as indicated by the negative correlation between insulitis and anti-GAD antibody levels. It was found that the initial immune response directed against pancreatic islets in NOD mice is a ...
SFTA3, a novel protein of the lung: Three
... model. While the PTMs had nearly no effect on the model stability, they influenced protein surface properties. They could form polar or hydrophobic areas (depending on the PTM type) on the protein surface with a significant impact on water solubility or the protein–lipid interaction potential of SP- ...
... model. While the PTMs had nearly no effect on the model stability, they influenced protein surface properties. They could form polar or hydrophobic areas (depending on the PTM type) on the protein surface with a significant impact on water solubility or the protein–lipid interaction potential of SP- ...
Spin models inferred from patient-derived viral sequence data faithfully
... PACS number(s): 87.10.−e, 87.19.xd, 87.18.Vf, 87.23.Cc ...
... PACS number(s): 87.10.−e, 87.19.xd, 87.18.Vf, 87.23.Cc ...
The Influence of Melatonin on Immune System and Cancer
... Melatonin has been shown to play a fundamental part in neuro immune modulation. Besides regulating the circadian rhythm it works as a natural antioxidant with immune stimulatory and anti-cancer properties. Melatonin is a regulator of hemopoiesis and modifies various cells and cytokines of the immune ...
... Melatonin has been shown to play a fundamental part in neuro immune modulation. Besides regulating the circadian rhythm it works as a natural antioxidant with immune stimulatory and anti-cancer properties. Melatonin is a regulator of hemopoiesis and modifies various cells and cytokines of the immune ...
Nonspecific Defenses
... Mechanical barriers physically block pathogens from entering the body. The skin is the most important mechanical barrier. In fact, it is the single most important defense the body has. The outer layer of the skin is tough and very difficult for pathogens to penetrate. Mucous membranes provide a mech ...
... Mechanical barriers physically block pathogens from entering the body. The skin is the most important mechanical barrier. In fact, it is the single most important defense the body has. The outer layer of the skin is tough and very difficult for pathogens to penetrate. Mucous membranes provide a mech ...
Human Immunodeficiency Virus and HIV Disease
... HIV can attach to the CXCR4 coreceptor that is present on CD8+ cells, so it can also attack T cytotoxic cells, which have a lower concentration of CD4 than T helper cells. It has also been shown that HIV can hitch a ride on B cells, but not infect them. This ride takes the virus into the lymph nodes ...
... HIV can attach to the CXCR4 coreceptor that is present on CD8+ cells, so it can also attack T cytotoxic cells, which have a lower concentration of CD4 than T helper cells. It has also been shown that HIV can hitch a ride on B cells, but not infect them. This ride takes the virus into the lymph nodes ...
Interplay between the Hepatitis B Virus and Innate Immunity: From
... significant/measurable gene expression change in their liver, including innate immunity genes [37]. In agreement with this analysis, no (or a weak) seric production of IFNs and cytokines/chemokines was found in acutely HBV-infected patients (i.e., patients who consulted before clearing acute infecti ...
... significant/measurable gene expression change in their liver, including innate immunity genes [37]. In agreement with this analysis, no (or a weak) seric production of IFNs and cytokines/chemokines was found in acutely HBV-infected patients (i.e., patients who consulted before clearing acute infecti ...
David E. Elder, MB, CHB, FRCPA
... conditions need to be discussed in multiple different places. We have taken into account the modern emphasis on pattern recognition in several ways. First, within each chapter, the conditions considered are, when appropriate, organized and discussed along pattern lines. Second, we have, as in the pa ...
... conditions need to be discussed in multiple different places. We have taken into account the modern emphasis on pattern recognition in several ways. First, within each chapter, the conditions considered are, when appropriate, organized and discussed along pattern lines. Second, we have, as in the pa ...
Insulin Delivery
... sugar level (ie after a meal) Promotes the transfer of glucose from blood to various body cells by binding and activating glucose receptors Aids in conversion of absorbed glucose into glycogen No Insulin = No glucose breakdown and no energy to cells ...
... sugar level (ie after a meal) Promotes the transfer of glucose from blood to various body cells by binding and activating glucose receptors Aids in conversion of absorbed glucose into glycogen No Insulin = No glucose breakdown and no energy to cells ...
Transplant Outcome in Mice Effects of T Cell Frequency and Graft
... recipients acutely rejected minor Ag-disparate male B6 skin grafts, but male B6 heart grafts survived indefinitely in female B6 mice (Fig. 1). Skin-derived Langerhans cells are more frequent in number and may be more immunogenic than heart-derived dendritic cells (34, 35). In addition, because skin ...
... recipients acutely rejected minor Ag-disparate male B6 skin grafts, but male B6 heart grafts survived indefinitely in female B6 mice (Fig. 1). Skin-derived Langerhans cells are more frequent in number and may be more immunogenic than heart-derived dendritic cells (34, 35). In addition, because skin ...
Department of Microbiology and Immunology (GRAD)
... directly on discussion of the primary literature (e.g., MCRO 710, MCRO 711, MCRO 712), and MCRO 795 are required. Students typically finish four of the six classes while in BBSP and the remainder during year two. There is no language requirement. • The written preliminary exam (also known as the doc ...
... directly on discussion of the primary literature (e.g., MCRO 710, MCRO 711, MCRO 712), and MCRO 795 are required. Students typically finish four of the six classes while in BBSP and the remainder during year two. There is no language requirement. • The written preliminary exam (also known as the doc ...
b1-Adrenergic Receptor Function, Autoimmunity, and Pathogenesis
... lymphocytes from anti-h1-AR antibodypositive DCM patients into immunodeficient mice may lead to an early stage of cardiac dilatation. Nonetheless, direct evidence for a cause-and-effect relation between anti-h1-EC II antibodies and DCM still remained to be obtained. To analyze the pathogenetic poten ...
... lymphocytes from anti-h1-AR antibodypositive DCM patients into immunodeficient mice may lead to an early stage of cardiac dilatation. Nonetheless, direct evidence for a cause-and-effect relation between anti-h1-EC II antibodies and DCM still remained to be obtained. To analyze the pathogenetic poten ...
Eliminating latent tuberculosis - Institute of Infectious Disease and
... persons who are co-infected with HIV: the 5%–10% lifetime risk of disease is increased to a 5%–10% annual risk in association with HIV infection, resulting in dramatic increases in TB rates in sub-Saharan Africa [5]. In addition to efforts to enhance protective immunity by vaccination before infecti ...
... persons who are co-infected with HIV: the 5%–10% lifetime risk of disease is increased to a 5%–10% annual risk in association with HIV infection, resulting in dramatic increases in TB rates in sub-Saharan Africa [5]. In addition to efforts to enhance protective immunity by vaccination before infecti ...
REVIEWS - Max-Planck-Institut für Biochemie
... mycobacterial survival9. So mycobacteria can survive and replicate intracellularly through other strategies that protect them from subsequent attack by antimicrobial components in the phagosomal maturation pathway. Phagosomal maturation involves a series of sequential fusion events with various vesi ...
... mycobacterial survival9. So mycobacteria can survive and replicate intracellularly through other strategies that protect them from subsequent attack by antimicrobial components in the phagosomal maturation pathway. Phagosomal maturation involves a series of sequential fusion events with various vesi ...
Comparison of Macrophages and Lymphocytes in Non
... tumors, though contributing to only 0.29% of all cancers diagnosed in these animals. Although considered a rare tumor in cats, late studies showed that feline endometrial adenocarcinomas (FEA) can to be more frequent than once thought. Aware of the importance of the immune system, through a dynamic ...
... tumors, though contributing to only 0.29% of all cancers diagnosed in these animals. Although considered a rare tumor in cats, late studies showed that feline endometrial adenocarcinomas (FEA) can to be more frequent than once thought. Aware of the importance of the immune system, through a dynamic ...
Chapter 15 The Lymphatic System and Immunity
... – Development of B cells • Second stage—inactive B cell develops into activated B cell – Initiated by inactive B cell’s contact with antigens, which bind to its surface antibodies, plus signal chemicals from T cells – Activated B cell, by dividing repeatedly, forms two clones of cells—plasma (effect ...
... – Development of B cells • Second stage—inactive B cell develops into activated B cell – Initiated by inactive B cell’s contact with antigens, which bind to its surface antibodies, plus signal chemicals from T cells – Activated B cell, by dividing repeatedly, forms two clones of cells—plasma (effect ...
Cytokine production of RSV/PHA-stimulated tonsillar mononuclear S. Ichinohe , I.R. Hussain
... -5, -10, -12, -13 and -15. However, it contained IL-6, -8, -18 and RANTES at detectable levels (data not shown), presumably since RSV infected epithelial cells have previously been shown to produce most of these cytokines [14, 15]. For this reason the authors analysed levels of all cytokines followi ...
... -5, -10, -12, -13 and -15. However, it contained IL-6, -8, -18 and RANTES at detectable levels (data not shown), presumably since RSV infected epithelial cells have previously been shown to produce most of these cytokines [14, 15]. For this reason the authors analysed levels of all cytokines followi ...
Kite Pharma and Leiden University Medical Center Sign Research
... tumors, and in particular focuses on ways by which immunomodulation can help improve the outcome of treatment of patients with solid tumors, including human papillomavirus-driven cancers, ovarian cancer and melanoma. Current strategies aim at improving the immune response against cancer cells by the ...
... tumors, and in particular focuses on ways by which immunomodulation can help improve the outcome of treatment of patients with solid tumors, including human papillomavirus-driven cancers, ovarian cancer and melanoma. Current strategies aim at improving the immune response against cancer cells by the ...
Treatment-dependent Loss of Polyfunctional CD8+ T
... setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunistic infections and may thus hamper overall clinical outc ...
... setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunistic infections and may thus hamper overall clinical outc ...
Plasma Cells - Roitt`s Essential Immunology
... both the contact and growth factors B cells need to progress through stages of maturation. Both plasma cells and developing B cells are likely to interact with stromal cells in the bone marrow. Therefore, an important understanding of the components required for B-cell development may elucidate simi ...
... both the contact and growth factors B cells need to progress through stages of maturation. Both plasma cells and developing B cells are likely to interact with stromal cells in the bone marrow. Therefore, an important understanding of the components required for B-cell development may elucidate simi ...
Immune maturation and lymphocyte characteristics in relation
... This thesis provides novel insights into S. aureus- and SE-mediated activation of Tregs, unconventional T-cells and NK-cells and suggests an overall impairment of immuneresponsiveness towards this bacterium in children. Further, S. aureus-colonization may influence the maturation of peripheral Tregs ...
... This thesis provides novel insights into S. aureus- and SE-mediated activation of Tregs, unconventional T-cells and NK-cells and suggests an overall impairment of immuneresponsiveness towards this bacterium in children. Further, S. aureus-colonization may influence the maturation of peripheral Tregs ...