Advances in siRNA delivery to T-cells: potential clinical applications
... delivery into T-cells for therapeutic purposes is an ex vivo route, whereby T-cells could be isolated from a patient, manipulated with siRNAs and infused back into the same patient. Re-infusion of autologous human T-cells that have been genetically modified ex vivo to redirect them towards tumour an ...
... delivery into T-cells for therapeutic purposes is an ex vivo route, whereby T-cells could be isolated from a patient, manipulated with siRNAs and infused back into the same patient. Re-infusion of autologous human T-cells that have been genetically modified ex vivo to redirect them towards tumour an ...
Cervarix-H-C-721-P46-0088: EPAR - EMA
... and anti HPV-18 antibodies (Cervarix 2-dose schedule divided by Gardasil 2-dose schedule) is above 1. CHMP’s comment The primary objective of the study was met. After Cervarix vaccination as compared to Gardasil vaccination, both administered according to a 2dose schedule in females aged 9-14 years ...
... and anti HPV-18 antibodies (Cervarix 2-dose schedule divided by Gardasil 2-dose schedule) is above 1. CHMP’s comment The primary objective of the study was met. After Cervarix vaccination as compared to Gardasil vaccination, both administered according to a 2dose schedule in females aged 9-14 years ...
Innate cellular responses to rotavirus infection
... activation of the IFN response factors (IRF) 3 and IRF7 is primarily responsible for the induction of IFN types I and III (Fig. 1). Following secretion from infected cells, IFN-a/b and IFN-l bind to their specific receptors, IFN-a/b receptor (IFNa/bR) and IFN-l receptor (IFN-lR), respectively, on su ...
... activation of the IFN response factors (IRF) 3 and IRF7 is primarily responsible for the induction of IFN types I and III (Fig. 1). Following secretion from infected cells, IFN-a/b and IFN-l bind to their specific receptors, IFN-a/b receptor (IFNa/bR) and IFN-l receptor (IFN-lR), respectively, on su ...
Study Objectives
... Anxiety and Stress Disorders 1. Identify the adrenal hormones, pituitary hormones, and hypothalamic hormones involved in stress responses. Describe the feedback loops among these structures and hormones. 2. Describe the acute physiological effects of cortisol and the catecholamines. 3. Define psycho ...
... Anxiety and Stress Disorders 1. Identify the adrenal hormones, pituitary hormones, and hypothalamic hormones involved in stress responses. Describe the feedback loops among these structures and hormones. 2. Describe the acute physiological effects of cortisol and the catecholamines. 3. Define psycho ...
24. Lymphatic System
... fluid from the blood into the interstitial spaces around cells. This fluid is called interstitial fluid (not to be confused with extracellular fluid, a term that encompasses both interstitial fluid and plasma [see chapter 2]). Most of this fluid is reabsorbed at the venous end of the capillaries, b ...
... fluid from the blood into the interstitial spaces around cells. This fluid is called interstitial fluid (not to be confused with extracellular fluid, a term that encompasses both interstitial fluid and plasma [see chapter 2]). Most of this fluid is reabsorbed at the venous end of the capillaries, b ...
Pathogen-Induced Apoptotic Neutrophils Express Heat
... apoptosis in neutrophils represents a pathogenic strategy for microbes to eliminate these key immune cells and use them as “Trojan horses” to enter M. However, in the cited studies, neutrophil apoptosis was induced by age or irradiation; thus, the results may not apply to the very early phase of in ...
... apoptosis in neutrophils represents a pathogenic strategy for microbes to eliminate these key immune cells and use them as “Trojan horses” to enter M. However, in the cited studies, neutrophil apoptosis was induced by age or irradiation; thus, the results may not apply to the very early phase of in ...
Tartrate‐Resistant Acid Phosphatase Deficiency in the
... Conclusion. Our findings indicate that TRAP and OPN colocalize and that OPN is a substrate for TRAP in human immune cells. TRAP deficiency in PDCs leads to increased IFNa production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of spondyloenchondrodyspla ...
... Conclusion. Our findings indicate that TRAP and OPN colocalize and that OPN is a substrate for TRAP in human immune cells. TRAP deficiency in PDCs leads to increased IFNa production, providing at least a partial explanation for how ACP5 mutations cause lupus in the context of spondyloenchondrodyspla ...
Tumors and Ly6Chigh Monocytes Fatemeh Zare
... My PhD has been a lengthy journey and many people have helped me along the way. Firstly I would like to acknowledge my supervisor for all his help and support throughout this time. Prof. Antonio Celada, thank you for encouraging me to work independently as a scientist and for providing me the opport ...
... My PhD has been a lengthy journey and many people have helped me along the way. Firstly I would like to acknowledge my supervisor for all his help and support throughout this time. Prof. Antonio Celada, thank you for encouraging me to work independently as a scientist and for providing me the opport ...
Vaccines
... already finished his or her vaccination schedule with Prevnar? Children 15 months to 5 years of age who have received four doses of Prevnar may receive one dose of Prevnar 13 to help protect children against the six additional serotypes that can cause IPD, including increasingly drug-resistant serot ...
... already finished his or her vaccination schedule with Prevnar? Children 15 months to 5 years of age who have received four doses of Prevnar may receive one dose of Prevnar 13 to help protect children against the six additional serotypes that can cause IPD, including increasingly drug-resistant serot ...
Differential requirement for A2a and A3 adenosine
... different initiating stimuli (polyclonal T-cell receptor [TCR] activator ConA vs Toll-like receptor activating LPS) and different types of immune cells. In mice, ConA-induced liver damage in mice is a welldescribed in vivo inflammation model of viral and autoimmune hepatitis that is mediated by T ce ...
... different initiating stimuli (polyclonal T-cell receptor [TCR] activator ConA vs Toll-like receptor activating LPS) and different types of immune cells. In mice, ConA-induced liver damage in mice is a welldescribed in vivo inflammation model of viral and autoimmune hepatitis that is mediated by T ce ...
Lesson 65. Organ transplantation
... possible in unrelated people if drugs were taken to suppress the body's immune reaction Human transplantation antigens (HLA) ---- MHC. ...
... possible in unrelated people if drugs were taken to suppress the body's immune reaction Human transplantation antigens (HLA) ---- MHC. ...
Nanotechnologies Applied in Biomedical Vaccines
... Vaccines have not only successfully reduced the incidence rate of many devastating diseases to be always low but also prevented many infectious diseases from persistently bursting out. At present, only few people have ever experienced the detrimental effects of many illnesses. The two main advantage ...
... Vaccines have not only successfully reduced the incidence rate of many devastating diseases to be always low but also prevented many infectious diseases from persistently bursting out. At present, only few people have ever experienced the detrimental effects of many illnesses. The two main advantage ...
Program - Albion
... Associative learning processes play many important roles in the control of food consumption. Although these processes can complement regulatory mechanisms in the control of eating by providing opportunities for the anticipation of upcoming needs, they may also contribute to inappropriate or path ...
... Associative learning processes play many important roles in the control of food consumption. Although these processes can complement regulatory mechanisms in the control of eating by providing opportunities for the anticipation of upcoming needs, they may also contribute to inappropriate or path ...
MHC
... II MHC molecules), which means the alleles inherited from both parents are expressed equally. This maximizes the number of MHC molecules available to bind peptides for presentation to T cells. ...
... II MHC molecules), which means the alleles inherited from both parents are expressed equally. This maximizes the number of MHC molecules available to bind peptides for presentation to T cells. ...
Patterned, But Not Tonic, Optogenetic Stimulation in Motor
... The number of reaches per 5 min period was recorded. Blue (13–20 mW/mm 2) and yellow (20 –26 mW/mm 2) light power exceeded the 5–12 mW/mm 2 required to activate ChR2 (Zhang et al., 2006). To exclude experiments where the haloperidol injection failed to produce adequate akinesia, we analyzed the numb ...
... The number of reaches per 5 min period was recorded. Blue (13–20 mW/mm 2) and yellow (20 –26 mW/mm 2) light power exceeded the 5–12 mW/mm 2 required to activate ChR2 (Zhang et al., 2006). To exclude experiments where the haloperidol injection failed to produce adequate akinesia, we analyzed the numb ...
CXCL10 Inhibits Viral Replication Through Recruitment of Natural
... cells expressing the CXCR3 receptor.8 Among these chemokines, CXCL10 has been widely studied and is known to be involved in the regulation of lymphocyte recruitment observed in autoimmune inflammatory lesions,9 delayed-type hypersensitivity,10 many viral infections,11 and certain tumors. In a number ...
... cells expressing the CXCR3 receptor.8 Among these chemokines, CXCL10 has been widely studied and is known to be involved in the regulation of lymphocyte recruitment observed in autoimmune inflammatory lesions,9 delayed-type hypersensitivity,10 many viral infections,11 and certain tumors. In a number ...
PD-L1 Expression as a Predictive Biomarker in Cancer
... well as on activated B cells and NK cells (9). PD-1/PD-L1 activation results in peripheral immunologic tolerance in T cells. In PD1 and PD-L1 knockout mice, the autoimmune phenotype is milder as compared to that in CTLA-4 knockouts (10, 11). This parallels the clinical severity of observed toxicitie ...
... well as on activated B cells and NK cells (9). PD-1/PD-L1 activation results in peripheral immunologic tolerance in T cells. In PD1 and PD-L1 knockout mice, the autoimmune phenotype is milder as compared to that in CTLA-4 knockouts (10, 11). This parallels the clinical severity of observed toxicitie ...
Classical Conditioning
... Yerkes, who would later become president of the American Psychological Association, and Sergius Morgulis published a thorough review of the methods and results obtained by Pavlov. Although these reports provided a true flavor of the potential value of classical conditioning, the method was not immedi ...
... Yerkes, who would later become president of the American Psychological Association, and Sergius Morgulis published a thorough review of the methods and results obtained by Pavlov. Although these reports provided a true flavor of the potential value of classical conditioning, the method was not immedi ...
Psychoneuroimmunology
Psychoneuroimmunology (PNI), also referred to as psychoendoneuroimmunology (PENI), is the study of the interaction between psychological processes and the nervous and immune systems of the human body. PNI takes an interdisciplinary approach, incorporating psychology, neuroscience, immunology, physiology, genetics, pharmacology, molecular biology, psychiatry, behavioral medicine, infectious diseases, endocrinology, and rheumatology.The main interests of PNI are the interactions between the nervous and immune systems and the relationships between mental processes and health. PNI studies, among other things, the physiological functioning of the neuroimmune system in health and disease; disorders of the neuroimmune system (autoimmune diseases; hypersensitivities; immune deficiency); and the physical, chemical and physiological characteristics of the components of the neuroimmune system in vitro, in situ, and in vivo.