Vitiligo and alopecia areata: apples and oranges?
... and both diseases have been reported to develop or worsen following this treatment (39,40). Therefore, vitiligo and alopecia areata appear to depend primarily on IFN-c, while psoriasis and other TH17 diseases (inflammatory bowel disease, rheumatoid arthritis) require IL-17, IL-23, IL-22 and TNF-a. B ...
... and both diseases have been reported to develop or worsen following this treatment (39,40). Therefore, vitiligo and alopecia areata appear to depend primarily on IFN-c, while psoriasis and other TH17 diseases (inflammatory bowel disease, rheumatoid arthritis) require IL-17, IL-23, IL-22 and TNF-a. B ...
Immune Responses In Vitro and In Vivo Oligodeoxynucleotide for
... Robert H. Purcell,储 Heather L. Davis,‡** and Arthur M. Krieg2*§** ...
... Robert H. Purcell,储 Heather L. Davis,‡** and Arthur M. Krieg2*§** ...
Critical Review A role for anti-HSP60 antibodies in arthritis: a critical review
... Figure 2: Immunological interactions triggered by HSP60 biology. Cellular stress can be triggered by external changes in pH, O2, from the presence of oxygen radicals, toxic metabolites from inflammation and the recognition of pathogen-associated molecular patterns (PAMPs) through toll-like receptor ...
... Figure 2: Immunological interactions triggered by HSP60 biology. Cellular stress can be triggered by external changes in pH, O2, from the presence of oxygen radicals, toxic metabolites from inflammation and the recognition of pathogen-associated molecular patterns (PAMPs) through toll-like receptor ...
The Role and Immunobiology of Eosinophils in the Respiratory
... inflamed tissue. This is a result of eosinophils highly expressing CCR3, a receptor that binds eosinophil-specific chemokines, including eotaxin, eotaxin-2, monocyte chemoattractant protein (MCP-3, MCP-4), and regulated on activation, normal T cell expressed and secreted (RANTES or CCL5) [11]. The p ...
... inflamed tissue. This is a result of eosinophils highly expressing CCR3, a receptor that binds eosinophil-specific chemokines, including eotaxin, eotaxin-2, monocyte chemoattractant protein (MCP-3, MCP-4), and regulated on activation, normal T cell expressed and secreted (RANTES or CCL5) [11]. The p ...
No Slide Title
... Slices through MHC class II molecules, when viewed from above reveal shallow, poorly conserved pockets compared with those in MHC class I molecules ...
... Slices through MHC class II molecules, when viewed from above reveal shallow, poorly conserved pockets compared with those in MHC class I molecules ...
Platelets: versatile effector cells in hemostasis, inflammation, and the
... and formation of platelet–leukocyte aggregates. Under some conditions, bacterial toxins of several classes can trigger these responses of human and murine platelets. Each functional activity is considered in detail in the text. There is evidence that these activities can mediate the containment, imm ...
... and formation of platelet–leukocyte aggregates. Under some conditions, bacterial toxins of several classes can trigger these responses of human and murine platelets. Each functional activity is considered in detail in the text. There is evidence that these activities can mediate the containment, imm ...
Fragile Skin: Benefit of Cosmeceuticals based on Rhealba® Oat
... keratinocytes differentiate into corneocytes, which will then desquamate and lost from the stratum corneum surface.[20] In acne vulgaris, changes in the lipid content of sebum associated with the inflammation in and around the sebaceous gland result in keratinocytes hyperproliferation and increased ...
... keratinocytes differentiate into corneocytes, which will then desquamate and lost from the stratum corneum surface.[20] In acne vulgaris, changes in the lipid content of sebum associated with the inflammation in and around the sebaceous gland result in keratinocytes hyperproliferation and increased ...
Homeostatic MyD88-dependent signals cause lethal
... contain intracellular Toll/IL-1 receptor (TIR) domains that trigger signals via homotypic interactions with proximal adaptor proteins (6, 7). All TLRs signal via the adaptor MyD88, leading to activation of NF-B and mitogen-activated protein (MAP) kinase pathways. NF-B activation leads to a transcr ...
... contain intracellular Toll/IL-1 receptor (TIR) domains that trigger signals via homotypic interactions with proximal adaptor proteins (6, 7). All TLRs signal via the adaptor MyD88, leading to activation of NF-B and mitogen-activated protein (MAP) kinase pathways. NF-B activation leads to a transcr ...
Thesis_Panitz
... machinery in pDCs. Moreover up to 60% of the transcriptional machinery of pDCs is involved in producing type I IFNs [84]. IFNs induce the transcription of interferon-stimulated genes (ISGs) in diverse cell types. The expression of these anti-viral molecules makes the cells more resistant to viral in ...
... machinery in pDCs. Moreover up to 60% of the transcriptional machinery of pDCs is involved in producing type I IFNs [84]. IFNs induce the transcription of interferon-stimulated genes (ISGs) in diverse cell types. The expression of these anti-viral molecules makes the cells more resistant to viral in ...
NIH Public Access Author Manuscript The immune system and cardiac repair Abstract
... with dilative remodeling of the ventricle. Cardiac injury activates innate immune mechanisms initiating an inflammatory reaction. Toll Like Receptor-mediated pathways, the complement cascade and reactive oxygen generation induce Nuclear Factor (NF)-κB activation and upregulate chemokine and cytokine ...
... with dilative remodeling of the ventricle. Cardiac injury activates innate immune mechanisms initiating an inflammatory reaction. Toll Like Receptor-mediated pathways, the complement cascade and reactive oxygen generation induce Nuclear Factor (NF)-κB activation and upregulate chemokine and cytokine ...
Characterization of thymic hyperplasia associated with autoimmune
... Autoimmune myasthenia gravis (MG) is a muscular disease mediated by autoantibodies, mainly directed against the acetylcholine receptor (AChR). The pathogenic antibodies are especially produced in the thymus, which is often characterized by a hyperplasia with germinal centers. Recent studies demonstr ...
... Autoimmune myasthenia gravis (MG) is a muscular disease mediated by autoantibodies, mainly directed against the acetylcholine receptor (AChR). The pathogenic antibodies are especially produced in the thymus, which is often characterized by a hyperplasia with germinal centers. Recent studies demonstr ...
Cenchao Shen - RMIT Research Repository
... which has been carried out since the official commencement date of the approved research program; any editorial work, paid or unpaid, carried out by a third party is acknowledged; and, ethics procedures and guidelines have been followed. ...
... which has been carried out since the official commencement date of the approved research program; any editorial work, paid or unpaid, carried out by a third party is acknowledged; and, ethics procedures and guidelines have been followed. ...
Cancer Growth and Metastasis curcuma contra cancer? curcumin
... Abstract: Curcumin, a phytochemical isolated from curcuma plants which are used as coloring ingredient for the preparation of curry powder, has several activities which suggest that it might be an interesting drug for the treatment or prevention of cancer. Curcumin targets different pathways which a ...
... Abstract: Curcumin, a phytochemical isolated from curcuma plants which are used as coloring ingredient for the preparation of curry powder, has several activities which suggest that it might be an interesting drug for the treatment or prevention of cancer. Curcumin targets different pathways which a ...
Histones Activate the NLRP3 Inflammasome in Kupffer Cells during
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
... cells, secreting cytokines, and recruiting other inflammatory cells, such as neutrophils and circulating monocytes (1). Because of their immune-triggering capability, responses driven by KCs are recognized as key mechanisms in liver I/R injury (3). Nucleotide-binding domain, leucine-rich repeat cont ...
Micro Chapter 13 [4-20
... Strep pneumonia has a thick layer of polysaccharide on its surface, which inhibits host clearance by complement and phagocytosis Strep pneumonia is α-hemolytic, and ferments, but can tolerate oxygen, which lets it survive in the airway Strep pneumonia, like other strep, lacks catalase, so its metabo ...
... Strep pneumonia has a thick layer of polysaccharide on its surface, which inhibits host clearance by complement and phagocytosis Strep pneumonia is α-hemolytic, and ferments, but can tolerate oxygen, which lets it survive in the airway Strep pneumonia, like other strep, lacks catalase, so its metabo ...
Topical Ivermectin 10 mg/g and Oral Doxycycline 40 mg Modified
... recruited by chemotactic factors released from inflamed dermal structures [35]. Leukocytes ...
... recruited by chemotactic factors released from inflamed dermal structures [35]. Leukocytes ...
- IRep - Nottingham Trent University
... Abbreviations .................................................................................................................. vi Abstract ..............................................................................................................................1 ...
... Abbreviations .................................................................................................................. vi Abstract ..............................................................................................................................1 ...
7 CHAPTER Diverging effects of classically (M1) and alternatively (M2)
... Exposure of neuronal cultures to conditioned medium from differently activated macrophages To determine the effect of conditioned medium of the differentially activated macrophages on neuronal integrity, primary neurons were cultured in a 96-wells plate. After 7 days in culture, the medium was remov ...
... Exposure of neuronal cultures to conditioned medium from differently activated macrophages To determine the effect of conditioned medium of the differentially activated macrophages on neuronal integrity, primary neurons were cultured in a 96-wells plate. After 7 days in culture, the medium was remov ...
Our focus is on vaccines
... • Significant response following the secondary immunization • Kinetics of the antibody response similar to commercial HBV sAg vaccine (Engerix-B, GSK), but with no added adjuvant • Chimigen® HBV Vaccine induced a dose-dependent cell-mediated immune response • Specificity for S1/S2 protein • Signific ...
... • Significant response following the secondary immunization • Kinetics of the antibody response similar to commercial HBV sAg vaccine (Engerix-B, GSK), but with no added adjuvant • Chimigen® HBV Vaccine induced a dose-dependent cell-mediated immune response • Specificity for S1/S2 protein • Signific ...
JAK3 deficiency, (SCID T-B+)
... normal number of NK cells are present), both Xlinked SCID and JAK3 deficiencies are characterized by virtual absence of NK cells, and are therefore more properly defined as [T-, B+, NK-, SCID]. The immunological and clinical phenotype of JAK3 deficiency is virtually undistinguishable from that of X- ...
... normal number of NK cells are present), both Xlinked SCID and JAK3 deficiencies are characterized by virtual absence of NK cells, and are therefore more properly defined as [T-, B+, NK-, SCID]. The immunological and clinical phenotype of JAK3 deficiency is virtually undistinguishable from that of X- ...
Saccharomyces boulardii effects on gastrointestinal diseases
... including more than 2000 micro-organism species coexisting in a complex equilibrium with the host. This microflora has various effects including metabolic activities, trophic effects on the intestinal epithelium, interactions with the host immune system (Guarner and Malagelada, 2003) and acts as a b ...
... including more than 2000 micro-organism species coexisting in a complex equilibrium with the host. This microflora has various effects including metabolic activities, trophic effects on the intestinal epithelium, interactions with the host immune system (Guarner and Malagelada, 2003) and acts as a b ...
Innate immune system
The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑