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Host Defense Against Infection
Host Defense Against Infection

... - Innate immune system is phylogenetically conserved and is present in almost all multicellular organisms. - Recently-identified Toll-like receptors recognize specific patterns of microbial components and regulates the activation of innate immunity. ...
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... cascade of signals that end in the rapid transcription of several host cell proteins that contribute to the slowing down of viral proliferation. One of these proteins is the enzyme oligoadenylate synthetase (OAS) that catalyses the synthesis of specific 2’-5’ linked nucleotides that activate a host ...
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3.3mb

... Both the humoral and the cell-mediated immune response are aided by interaction w ith T cells. Antigen presenting cells present processed Ag in the context of MHC molecules to activate T cells Molecules that cannot be degraded (e.g. D-amino acids) are poor immunogens Treatment to increase uptake by ...
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... and Blood Transfusion, Leiden University Medical Center, The Netherlands, have discovered that stem cells harvested from fat (adipose) are more potent than those collected from bone marrow in helping to modulate the body's immune system. The research, which was led by led by Dr Helene Roelofs, has b ...
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White blood cells - The Silver Sword

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... signalling and acting as an energy supply. They also act as superantigens for the immune system when they are part of certain fat molecules called glycosphingolipids. These molecules are able to activate invariant Natural Killer T-Cells (iNKT cells), white blood cells that mount a dangerous non-spec ...
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... Evasion of immune mechanisms by intracellular bacteria Inhibition of phagolysosome formation Mycobacterium tuberculosis Legionella pneumophilia Scavenging of reactive oxigen intermediates Mycobacterium leprae (phenolic glycolipid) ...
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... pathogens that enter the body from the external environment. The mucous membranes of the respiratory and digestive system trap infectious agents so they can be worked on by the immune system. A variety of white blood cells, lymphatic tissues, and other antimicrobial molecules are sequestered within ...
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... are attached to needs to be destroyed.  T cells – (white blood cells) attack and destroy infected cells that have antigens on their surface. DRUGS: 1. Antibiotics (e.g. Penicillin – a type of FUNGI!) – drugs used to TREAT a bacterial infection; they work by killing bacteria, stopping bacteria from ...
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... • Physical: skin, mucous membranes of mouth, nose, trachea, lungs -block pathogen from entering • Chemical: fluids of eyes, mouth, stomach -enzymes and acid kills pathogen ...
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Innate immune system



The innate immune system, also known as the nonspecific immune system, is an important subsystem of the overall immune system that comprises the cells and mechanisms that defend the host from infection by other organisms. The cells of the innate system recognize and respond to pathogens in a generic way, but, unlike the adaptive immune system (which is found only in vertebrates), it does not confer long-lasting or protective immunity to the host. Innate immune systems provide immediate defense against infection, and are found in all classes of plant and animal life. They include both humoral immunity components and cell-mediated immunity components.The innate immune system is an evolutionarily older defense strategy, and is the dominant immune system found in plants, fungi, insects, and primitive multicellular organisms.The major functions of the vertebrate innate immune system include: Recruiting immune cells to sites of infection, through the production of chemical factors, including specialized chemical mediators, called cytokines Activation of the complement cascade to identify bacteria, activate cells, and promote clearance of antibody complexes or dead cells The identification and removal of foreign substances present in organs, tissues, the blood and lymph, by specialised white blood cells Activation of the adaptive immune system through a process known as antigen presentation Acting as a physical and chemical barrier to infectious agents.↑ ↑ ↑
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