Understanding the regulation of surfactant gene expression EDITORIAL W. Jacot, J. Bousquet
... growth (gestational day 10) and throughout foetal lung development, but SP-B expression is not detected until a later gestational stage (gestational day 17) [8]. This suggests that TTF-1 and/or HNF-3 alone cannot fully account for the differential regulation of SP-B gene expression during the develo ...
... growth (gestational day 10) and throughout foetal lung development, but SP-B expression is not detected until a later gestational stage (gestational day 17) [8]. This suggests that TTF-1 and/or HNF-3 alone cannot fully account for the differential regulation of SP-B gene expression during the develo ...
Chemistry Review
... 3. Tertiary Structure – occurs when the secondary structure folds up in a very specific shape and forms a specific protein. The tertiary structure comes from interactions/bonds between the R groups of the amino acid. Some of the interactions that occur between amino acid R groups are: ...
... 3. Tertiary Structure – occurs when the secondary structure folds up in a very specific shape and forms a specific protein. The tertiary structure comes from interactions/bonds between the R groups of the amino acid. Some of the interactions that occur between amino acid R groups are: ...
Variation in Regulatory Information Within and Between Species
... can switch on a whole new transcriptional program and phenotype! 2) Explain how large significant phenotypic changes can be rapidly acquired.! ...
... can switch on a whole new transcriptional program and phenotype! 2) Explain how large significant phenotypic changes can be rapidly acquired.! ...
cDNA cloning, expression and chromosomal localization of the
... identified a unique intron-like sequence that showed homology with members of the Alu sequence family while the human Trx1 gene is organized in 5 exons and 4 introns (Figure 1) (Kaghad et al. 1994; Tonissen and Wells 1991). Second, an imperfect polyA tail is present exactly 3´ after the point at whi ...
... identified a unique intron-like sequence that showed homology with members of the Alu sequence family while the human Trx1 gene is organized in 5 exons and 4 introns (Figure 1) (Kaghad et al. 1994; Tonissen and Wells 1991). Second, an imperfect polyA tail is present exactly 3´ after the point at whi ...
Food Microbiology-Single Cell Protein-UNIT-2-2012
... used successfully, there are five main criteria to be satisfied; 1. The SCP must be safe to eat. 2. The nutritional value dependent on the amino acid composition must be high. 3. It must be acceptable to the general public. 4. It must have the functionality, i.e. characteristics, which are found in ...
... used successfully, there are five main criteria to be satisfied; 1. The SCP must be safe to eat. 2. The nutritional value dependent on the amino acid composition must be high. 3. It must be acceptable to the general public. 4. It must have the functionality, i.e. characteristics, which are found in ...
Introduction to Cell Theory
... • 2 sheets – one of labeled cell parts, and one is the table of all the organelle functions HW: Rough draft due Wednesday: Detailed paragraph (typed or neatly written on separate paper) Describe how the organelles in a cell work together to make and use proteins. Include at least 5 different organel ...
... • 2 sheets – one of labeled cell parts, and one is the table of all the organelle functions HW: Rough draft due Wednesday: Detailed paragraph (typed or neatly written on separate paper) Describe how the organelles in a cell work together to make and use proteins. Include at least 5 different organel ...
File S1.
... PyMol Homework NAME: In LAB 8 we will explore Gene and Protein Structure. We will be using Pymol throughout the lab and thus, it is important that you come to class having practiced how to work with this software. You instructor will give you a short demo during a previous lab or in lecture. There a ...
... PyMol Homework NAME: In LAB 8 we will explore Gene and Protein Structure. We will be using Pymol throughout the lab and thus, it is important that you come to class having practiced how to work with this software. You instructor will give you a short demo during a previous lab or in lecture. There a ...
Arabidopsis nucleolar protein database (AtNoPDB)
... These processes require a large number of protein and small nucleolar RNA (snoRNA) components. Some snoRNAs are involved in cleavage of pre-rRNAs to generate the 18S, 25S and 5.8S rRNAs, while the majority are required for 20 -Oribose methylation or pseudouridylation of specific nucleotides (2,3). I ...
... These processes require a large number of protein and small nucleolar RNA (snoRNA) components. Some snoRNAs are involved in cleavage of pre-rRNAs to generate the 18S, 25S and 5.8S rRNAs, while the majority are required for 20 -Oribose methylation or pseudouridylation of specific nucleotides (2,3). I ...
Improved techniques for assayinq protein concentration in
... during developmental sequences, such as conidial getminImproved techniques for assaying protein ation, are directly related to the accuracy of the protein determinations (Schmit and Brady 1976 Bacterial. concentration in germinating Neurospora Rev. 4O:l). A permeabalization procedure (Basabe Sal. 19 ...
... during developmental sequences, such as conidial getminImproved techniques for assaying protein ation, are directly related to the accuracy of the protein determinations (Schmit and Brady 1976 Bacterial. concentration in germinating Neurospora Rev. 4O:l). A permeabalization procedure (Basabe Sal. 19 ...
Designer science and the "omic" revolution
... example, what is a “gene function?” What is its “context?” And what is the modular entity to which the concept of context applies: a protein domain, a single protein, a stable complex, or a whole pathway? Recently, the principle of “modularity” in cellular processes has been proposed to facilitate t ...
... example, what is a “gene function?” What is its “context?” And what is the modular entity to which the concept of context applies: a protein domain, a single protein, a stable complex, or a whole pathway? Recently, the principle of “modularity” in cellular processes has been proposed to facilitate t ...
I1284 - Sigma
... Isopropyl thiogalactose (IPTG) is a sugar derivative widely used for the induction of recombinant protein ...
... Isopropyl thiogalactose (IPTG) is a sugar derivative widely used for the induction of recombinant protein ...
Biomolecules
... result of functional groups- a configuration of atoms attached to the carbon skeleton • Functional groups maintain chemical properties no matter where they occur • Polar molecules are hydrophilic • Nonpolar molecules are hydrophobic • The degree to which organic molecules interact with water affects ...
... result of functional groups- a configuration of atoms attached to the carbon skeleton • Functional groups maintain chemical properties no matter where they occur • Polar molecules are hydrophilic • Nonpolar molecules are hydrophobic • The degree to which organic molecules interact with water affects ...
Slides - Celebrating the 20th anniversary of Swiss-Prot
... homology and absence of transcription data, seems unlikely No database evidence for increased bsence smORF discovery mammals The observation that only ~1% of mouse genes have no detectable human homology contradicts the idea of large order-specific gene expansion in mammals Although small proteins e ...
... homology and absence of transcription data, seems unlikely No database evidence for increased bsence smORF discovery mammals The observation that only ~1% of mouse genes have no detectable human homology contradicts the idea of large order-specific gene expansion in mammals Although small proteins e ...
MicroScale Thermophoresis Measurements on in vitro Synthesized
... highly pure sample and a successful and time consuming immobilization strategy. ITC requires vast amounts of material that can be a challenge to produce at sufficient high quality. The present study was designed to show that the novel and powerful technology MST used in combination with cell-free pr ...
... highly pure sample and a successful and time consuming immobilization strategy. ITC requires vast amounts of material that can be a challenge to produce at sufficient high quality. The present study was designed to show that the novel and powerful technology MST used in combination with cell-free pr ...
03/09/05, 1 Endosymbiosis Theory I. Introduction A. Evolution of
... 1. circular DNA molecule 2. similar ribosomes 3. sensitivity to antibiotics 4. no histones 5. same tRNAs: can use E coli t RNAs in protein synthesis in chloroplasts 6. transcription promoters and terminators identical B. but most important – in age of genomics – high gene homologies with prokaryotes ...
... 1. circular DNA molecule 2. similar ribosomes 3. sensitivity to antibiotics 4. no histones 5. same tRNAs: can use E coli t RNAs in protein synthesis in chloroplasts 6. transcription promoters and terminators identical B. but most important – in age of genomics – high gene homologies with prokaryotes ...
Cell Organelles
... its growth phase. New cell membrane is required. Describe the where it is made and its pathway to its destination on the outer cell membrane. ...
... its growth phase. New cell membrane is required. Describe the where it is made and its pathway to its destination on the outer cell membrane. ...
Leukaemia Section ins(5;11)(q31;q13q23) Atlas of Genetics and Cytogenetics in Oncology and Haematology
... DNA/RNA 13-15 kb mRNA. Protein 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation. ...
... DNA/RNA 13-15 kb mRNA. Protein 431 kDa; contains two DNA binding motifs (a AT hook, and Zinc fingers), a DNA methyl transferase motif, a bromodomain; transcriptional regulatory factor; nuclear localisation. ...
Protein C-mannosylation: Facts and questions.
... presence of C-mannosylation. In total, 49 C-mannosylated tryptophan residues were found in 11 proteins (Table 1). The second protein proven to be C-mannosylated was recombinant interleukin-12 (IL-12) from CHO cells (Doucey et al., 1999). An especially interesting group of proteins are those that con ...
... presence of C-mannosylation. In total, 49 C-mannosylated tryptophan residues were found in 11 proteins (Table 1). The second protein proven to be C-mannosylated was recombinant interleukin-12 (IL-12) from CHO cells (Doucey et al., 1999). An especially interesting group of proteins are those that con ...
Module 3: Genes and Sequences (NCBI)
... protein and each protein identified by BLink as highly similar. Scroll down the list of Protein Descriptions to view the protein names for these proteins. Homologs can also be identified through cross-species BLAST searches, as described in Module 2_iv. Since homologs often share similar naming conv ...
... protein and each protein identified by BLink as highly similar. Scroll down the list of Protein Descriptions to view the protein names for these proteins. Homologs can also be identified through cross-species BLAST searches, as described in Module 2_iv. Since homologs often share similar naming conv ...
Lecture 27
... • Some proteins have extensive sequence similarity in the same organism resulting from a gene duplication. • Gene duplication is an efficient mode of evolution because the new gene can evolve a new functionality while the original directs synthesis of the ancestral protein. • Globins-an example-see ...
... • Some proteins have extensive sequence similarity in the same organism resulting from a gene duplication. • Gene duplication is an efficient mode of evolution because the new gene can evolve a new functionality while the original directs synthesis of the ancestral protein. • Globins-an example-see ...
Monday 26 January 2004
... studies have suggested that GroEL may have other roles in the cell, including an involvement with protein transport across the inner membrane, and an effect on mRNA stability 16. According to the above passage, GroEL is a) present in all bacterial cells ...
... studies have suggested that GroEL may have other roles in the cell, including an involvement with protein transport across the inner membrane, and an effect on mRNA stability 16. According to the above passage, GroEL is a) present in all bacterial cells ...
Bio A
... Carbon, however, can make special bonds where they share multiple electrons with the same molecule o These are called double or triple bonds In addition to these special bonds, carbon can bond in different arrangements o Carbon can make long straight chains, carbon can make long branched chains, ...
... Carbon, however, can make special bonds where they share multiple electrons with the same molecule o These are called double or triple bonds In addition to these special bonds, carbon can bond in different arrangements o Carbon can make long straight chains, carbon can make long branched chains, ...
No Slide Title
... Regulatory Regulatory enzymes In a metabolic pathway, which utilizes numerous enzymes, a regulatory enzyme sets the rate of the overall sequence because it catalyzes the slowest, rate-limiting reaction Characteristics of regulatory enzymes 1. Allosteric control 2. Use of binding proteins 3. Reversib ...
... Regulatory Regulatory enzymes In a metabolic pathway, which utilizes numerous enzymes, a regulatory enzyme sets the rate of the overall sequence because it catalyzes the slowest, rate-limiting reaction Characteristics of regulatory enzymes 1. Allosteric control 2. Use of binding proteins 3. Reversib ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.