Alpha-Hemoglobin-Stabilizing Protein: An Erythroid Molecular
... implications for normal erythropoiesis and the pathogenesis of hemolytic disorders. Like many other genes that participate in hemoglobin synthesis, AHSP gene expression is controlled by GATA-1 [6], a transcription factor that is essential for the survival and maturation of lineagecommitted erythroid ...
... implications for normal erythropoiesis and the pathogenesis of hemolytic disorders. Like many other genes that participate in hemoglobin synthesis, AHSP gene expression is controlled by GATA-1 [6], a transcription factor that is essential for the survival and maturation of lineagecommitted erythroid ...
Regulation of Gene Expression
... mediate expression of cell-specific genes Cells contain factors that recognize promoters and enhancers in the genes they transcribe Transcription is accompanied by changes in chromosomal structure ...
... mediate expression of cell-specific genes Cells contain factors that recognize promoters and enhancers in the genes they transcribe Transcription is accompanied by changes in chromosomal structure ...
Back to the Future: Molecular Biology Meets Metabolism
... A similar thought process can be applied to the O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) enzyme discovered by Gerald Hart (Hart et al. 2011). OGT ...
... A similar thought process can be applied to the O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) enzyme discovered by Gerald Hart (Hart et al. 2011). OGT ...
Genetic Code Activity
... Genetic Code Activity Name_____________________________ Date_________ Period____ Standards: ...
... Genetic Code Activity Name_____________________________ Date_________ Period____ Standards: ...
biochemistry project
... Page 4 – “Nuts and Bolts”: Name the simplest monomer (basic building block, ex. Amino acid, monosaccharide) that makes up the macromolecule. Draw a simple diagram/representation of just the monomer (no cutting or pasting) and list 3 three specific examples of each the monomers (label with ”Monomer”) ...
... Page 4 – “Nuts and Bolts”: Name the simplest monomer (basic building block, ex. Amino acid, monosaccharide) that makes up the macromolecule. Draw a simple diagram/representation of just the monomer (no cutting or pasting) and list 3 three specific examples of each the monomers (label with ”Monomer”) ...
An Escherichia coli Host Strain Useful for Efficient
... more or less similar (data not shown, but see Fig. 3). Several target gene constructs (including, for example, that encoding rat PTP-S [17]) which could be expressed in the latter strain only in the presence of plasmid pLysS (which encodes phage T7 lysozyme, an antagonist of T7 RNAP, and therefore s ...
... more or less similar (data not shown, but see Fig. 3). Several target gene constructs (including, for example, that encoding rat PTP-S [17]) which could be expressed in the latter strain only in the presence of plasmid pLysS (which encodes phage T7 lysozyme, an antagonist of T7 RNAP, and therefore s ...
Gene Section ADAMTS1 (ADAM metallopeptidase with thrombospondin type 1 motif, 1)
... ADAMTS1 is an active metalloproteinase. The finding that a mutation of the zinc-binding motif of ADAMTS1 abrogates its capacity to bind to alpha2-macroglobulin confirmes the notion of an active proteinase (Kuno et al., 1999). However, in the potential zinc-binding motif of ADAMTS1, the Gly residue o ...
... ADAMTS1 is an active metalloproteinase. The finding that a mutation of the zinc-binding motif of ADAMTS1 abrogates its capacity to bind to alpha2-macroglobulin confirmes the notion of an active proteinase (Kuno et al., 1999). However, in the potential zinc-binding motif of ADAMTS1, the Gly residue o ...
Protein Synthesis
... Transfer RNA is the key to deciphering the code words in mRNA. Carries specific amino acids to the mRNA to synthesize the protein. Can only carry 1 amino acid at any particular time Cell may have many tRNAs for each amino acid. Codons - Anticodons - Codons are the triplet code of bases that designat ...
... Transfer RNA is the key to deciphering the code words in mRNA. Carries specific amino acids to the mRNA to synthesize the protein. Can only carry 1 amino acid at any particular time Cell may have many tRNAs for each amino acid. Codons - Anticodons - Codons are the triplet code of bases that designat ...
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... in the same conformation) and the binding of each ligand increases the probability that all subunits in that molecule are converted to the R-state (with a high activity). All-or-none model. 1.5.4 The interplay between these different ligand-binding sites is mediated primarily by changes in quaternar ...
... in the same conformation) and the binding of each ligand increases the probability that all subunits in that molecule are converted to the R-state (with a high activity). All-or-none model. 1.5.4 The interplay between these different ligand-binding sites is mediated primarily by changes in quaternar ...
IB Biology 1 Q3 Test Guide – 1314
... IB Biology 1 Q3 Test Guide – 1314 Estimated number of questions per topic is provided – 80 total questions Characteristics of Life - 1 ...
... IB Biology 1 Q3 Test Guide – 1314 Estimated number of questions per topic is provided – 80 total questions Characteristics of Life - 1 ...
J-Domain Protein CDJ2 and HSP70B Are a Plastidic Chaperone
... cochaperones, of which the J-domain cochaperones represent an important class. J-domain cochaperones contain a highly conserved J-domain that is responsible for the interaction with Hsp70. In addition, these cochaperones contain domains typical for protein–protein interactions, such as zinc finger or ...
... cochaperones, of which the J-domain cochaperones represent an important class. J-domain cochaperones contain a highly conserved J-domain that is responsible for the interaction with Hsp70. In addition, these cochaperones contain domains typical for protein–protein interactions, such as zinc finger or ...
The making of the Fittest: Natural Selection and Adaptation
... 3. Using the mRNA sequence determined in Step 2, determine the resulting amino acid sequence of the MC1R protein. (Note: This is only a portion of the 317 amino acids in the entire protein. The numbers above some of the columns in the tables indicate amino acid positions in the protein sequence.) Yo ...
... 3. Using the mRNA sequence determined in Step 2, determine the resulting amino acid sequence of the MC1R protein. (Note: This is only a portion of the 317 amino acids in the entire protein. The numbers above some of the columns in the tables indicate amino acid positions in the protein sequence.) Yo ...
물리화학 소개
... Tiny Particles Flag Scarce Proteins One-two punch. New detection technique tows a protein into place magnetically, then signals its presence by releasing DNA. Their target was prostate-specific antigen (PSA), a protein that can indicate prostate cancer in men and that is also being investigated as a ...
... Tiny Particles Flag Scarce Proteins One-two punch. New detection technique tows a protein into place magnetically, then signals its presence by releasing DNA. Their target was prostate-specific antigen (PSA), a protein that can indicate prostate cancer in men and that is also being investigated as a ...
Extraction of Gene/Protein Interaction from Text
... only via computing a kernel function between a pair of objects. A kernel function is a similarity function which has certain properties. That is, kernel function K over the object space X is binary function K: X×X → [0, ∞] mapping a pair of objects x, y X to their similarity score K(x, y). This is e ...
... only via computing a kernel function between a pair of objects. A kernel function is a similarity function which has certain properties. That is, kernel function K over the object space X is binary function K: X×X → [0, ∞] mapping a pair of objects x, y X to their similarity score K(x, y). This is e ...
Lecture 5 Cytoplasm, organelles Pinar Tulay_4
... • Vesicle budding is driven by the assembly of a protein coat on their cytosolic surface: coated vesicles. • After budding is complete, the coat is lost. • There are several kinds of coated vesicles, each with distinctive protein coats. • Functions of the coats: – Shapes the membrane into a vesicle ...
... • Vesicle budding is driven by the assembly of a protein coat on their cytosolic surface: coated vesicles. • After budding is complete, the coat is lost. • There are several kinds of coated vesicles, each with distinctive protein coats. • Functions of the coats: – Shapes the membrane into a vesicle ...
Protein Contact Map. - International Journal of Computer Applications
... invariant to rotations and translations. It provides useful information about protein's structure. For example, secondary structure can easily be recognized from it. Alpha-helices appear as dense patterns along the main diagonal since they involve contacts between one amino acid and its four success ...
... invariant to rotations and translations. It provides useful information about protein's structure. For example, secondary structure can easily be recognized from it. Alpha-helices appear as dense patterns along the main diagonal since they involve contacts between one amino acid and its four success ...
Determination of Fluorescent Proteins
... blue light and allows the emission of green light. This chromophore is biosynthetically created between amino acid residues 65-67 (Ser-Tyr-Gly) of the GFP protein. By using the appropriate transcription vector, researchers have been able to add the DNA sequence of their protein of interest to the GF ...
... blue light and allows the emission of green light. This chromophore is biosynthetically created between amino acid residues 65-67 (Ser-Tyr-Gly) of the GFP protein. By using the appropriate transcription vector, researchers have been able to add the DNA sequence of their protein of interest to the GF ...
Heavy Metals and Metalloids As a Cause for Protein Misfolding and
... Experiments on in vitro refolding are usually performed with a purified protein at low concentration, i.e., under conditions that maximize the yield of refolding. In contrast, in vivo folding occurs in the crowded interior of a cell at a protein concentration of 300–400 mg/mL, which greatly enhances ...
... Experiments on in vitro refolding are usually performed with a purified protein at low concentration, i.e., under conditions that maximize the yield of refolding. In contrast, in vivo folding occurs in the crowded interior of a cell at a protein concentration of 300–400 mg/mL, which greatly enhances ...
Notes S1 Simple sequence repeats and transposable elements
... (rps3) gene and one extra partial nad2 gene. The rns and rls rRNA genes and 25 tRNAs were identified. Two ORFs found are vaguely similar to each other (E-value 6e-17) and they were annotated as putative plasmid genes (Ppl1 and Ppl2), since they have low similarity hits with hypothetical plasmid prot ...
... (rps3) gene and one extra partial nad2 gene. The rns and rls rRNA genes and 25 tRNAs were identified. Two ORFs found are vaguely similar to each other (E-value 6e-17) and they were annotated as putative plasmid genes (Ppl1 and Ppl2), since they have low similarity hits with hypothetical plasmid prot ...
Table S10
... The T2SS, in general, has been accredited with the export of proteins into target host cells as well as to the extracellular milieu, thereby promoting virulence and/or environmental fitness of the concerned organism [1]. The Tad system, in its turn, is a subtype of T2SS encountered in many bacterial ...
... The T2SS, in general, has been accredited with the export of proteins into target host cells as well as to the extracellular milieu, thereby promoting virulence and/or environmental fitness of the concerned organism [1]. The Tad system, in its turn, is a subtype of T2SS encountered in many bacterial ...
enzyme powerpoint
... What are the RIGHT conditions? 1)Specific temperature ranges. (The enzymes in your body work at what temperature? The enzymes in the bacteria that live in the hot springs work at a much higher temperature). 2) Specific pH ranges (Your stomach enzymes work at what pH? Your mouth?) 3) Specific substr ...
... What are the RIGHT conditions? 1)Specific temperature ranges. (The enzymes in your body work at what temperature? The enzymes in the bacteria that live in the hot springs work at a much higher temperature). 2) Specific pH ranges (Your stomach enzymes work at what pH? Your mouth?) 3) Specific substr ...
The XPE Gene of Xeroderma Pigmentosum, Its Product and
... very sensitive to ultraviolet (UV) light exposure and prone to skin cancer. Its genetics are complex and multiallehc. Based on complementation studies, involving UV sensitivity of fused cells, initially XP was classified in 5 subgroups, XP-A to XP-E. Present studies, however, have discovered that th ...
... very sensitive to ultraviolet (UV) light exposure and prone to skin cancer. Its genetics are complex and multiallehc. Based on complementation studies, involving UV sensitivity of fused cells, initially XP was classified in 5 subgroups, XP-A to XP-E. Present studies, however, have discovered that th ...
Leukaemia Section t(5;12)(p13;p1 3) NIPBL/ETV6 Atlas of Genetics and Cytogenetics
... The NIPBL gene contains 47 exons spanning 188 kb, with the coding sequence starting in exon 2. Two different isoforms are generated by two transcript variants. A first transcript, starting in exon 2, continues to exon 47 and the second transcript continues to an expanded variant of exon 46. Protein ...
... The NIPBL gene contains 47 exons spanning 188 kb, with the coding sequence starting in exon 2. Two different isoforms are generated by two transcript variants. A first transcript, starting in exon 2, continues to exon 47 and the second transcript continues to an expanded variant of exon 46. Protein ...
Analysis of Fish Protein
... today. This theory is strongly supported by the discovery that a great deal of DNA sequence similarity exists among the genes of all modern-day organisms. For example, scientists were astounded to discover that the same family of genes (Hox genes) controls the embryonic development of animals as div ...
... today. This theory is strongly supported by the discovery that a great deal of DNA sequence similarity exists among the genes of all modern-day organisms. For example, scientists were astounded to discover that the same family of genes (Hox genes) controls the embryonic development of animals as div ...
Protein moonlighting
Protein moonlighting (or gene sharing) is a phenomenon by which a protein can perform more than one function. Ancestral moonlighting proteins originally possessed a single function but through evolution, acquired additional functions. Many proteins that moonlight are enzymes; others are receptors, ion channels or chaperones. The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non-enzymatic roles. Some examples of functions of moonlighting proteins secondary to catalysis include signal transduction, transcriptional regulation, apoptosis, motility, and structural.Protein moonlighting may occur widely in nature. Protein moonlighting through gene sharing differs from the use of a single gene to generate different proteins by alternative RNA splicing, DNA rearrangement, or post-translational processing. It is also different from multifunctionality of the protein, in which the protein has multiple domains, each serving a different function. Protein moonlighting by gene sharing means that a gene may acquire and maintain a second function without gene duplication and without loss of the primary function. Such genes are under two or more entirely different selective constraints.Various techniques have been used to reveal moonlighting functions in proteins. The detection of a protein in unexpected locations within cells, cell types, or tissues may suggest that a protein has a moonlighting function. Furthermore, sequence or structure homology of a protein may be used to infer both primary function as well as secondary moonlighting functions of a protein.The most well-studied examples of gene sharing are crystallins. These proteins, when expressed at low levels in many tissues function as enzymes, but when expressed at high levels in eye tissue, become densely packed and thus form lenses. While the recognition of gene sharing is relatively recent—the term was coined in 1988, after crystallins in chickens and ducks were found to be identical to separately identified enzymes—recent studies have found many examples throughout the living world. Joram Piatigorsky has suggested that many or all proteins exhibit gene sharing to some extent, and that gene sharing is a key aspect of molecular evolution. The genes encoding crystallins must maintain sequences for catalytic function and transparency maintenance function.Inappropriate moonlighting is a contributing factor in some genetic diseases, and moonlighting provides a possible mechanism by which bacteria may become resistant to antibiotics.