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Insulin resistance index versus glycerol and free
Insulin resistance index versus glycerol and free

... fasting the tendency to lower blood glucose in women has been noted [31]. Our results have indicated that after overnight fast plasma glucose in women was slightly, but significantly lower than in men (by 10%). Plasma glycerol levels are a reliable index of subcutaneous adipose tissue lipolysis [23] ...
Unit three: - Life Science Academy
Unit three: - Life Science Academy

... How does the development of Type 1 and Type 2 diabetes relate to how the body produces and uses insulin? What is the relationship between insulin and glucose? How does insulin assist with the movement of glucose into body cells? What is homeostasis? What does feedback refer to in the human body? How ...
Regulation of carbohydrate metabolism
Regulation of carbohydrate metabolism

... role of Fructose 2,6-P in the regulation of glycolysis and gluconeogenesis. 2. 3 key sites for the regulation of gluconeogenesis (their activation). 3. The signal pathway for the activation of glycogen degradation by glucagon. 4. Main regulators of glycogen degradation in liver and muscle. 5. Pathwa ...
MODY
MODY

... lipoproteins, resulting in decreased serum levels of triglycerides, lipoprotein (a), and apolipoproteins A-II and C-III ...
Slackers Cancer Molecular Biology Fact Stack - U
Slackers Cancer Molecular Biology Fact Stack - U

... increased in obesity. Normally, insulin would activate lipoprotein lipase in the periphery to encourage the uptake of the fatty acids in the VLDL but in insulin resistance, this action is diminished. Thus, the body creates more VLDL’s than usual but they are not degraded. As the levels of VLDL incre ...
Ceramides: a new player in the insulin
Ceramides: a new player in the insulin

... care products can help you to maintain a ‘youthful glow’. In addition to their simple structural role, it has become clear that ceramides also act as signalling molecules with multiple roles and, of interest to the diabetes field, a potential role for ceramides in the pathogenesis of insulin resista ...
Gut Tube and Digestion
Gut Tube and Digestion

... Digestion--produces most digestive enzymes Glucose metabolism-Islets of Langerhans make insulin ...
Gut Tube and Digestion
Gut Tube and Digestion

... Digestion--produces most digestive enzymes Glucose metabolism-Islets of Langerhans make insulin ...
The Glycemic Pentad: Role Of Insulin Analogues
The Glycemic Pentad: Role Of Insulin Analogues

... (CV) of FPG) is an independent risk factor for proliferative retinopathy, and is inversely related to survival of patients with type 2 diabetes (10,11). FPG of 110 mg% has been shown to increase the risk of cardiovascular events by 1.33 (1.06 -1.67) with respect to an FPG of 75 mg% (12). An effectiv ...
Direct In Vitro Effect of a Sulfonylurea to Increase Human Fibroblast
Direct In Vitro Effect of a Sulfonylurea to Increase Human Fibroblast

... sulfonylurea agent glyburide to modulate insulin receptors on nontransformed human fibroblasts in tissue culture. When glyburide was added to monolayers of human fibroblasts, a dose-dependent increase in the number of cell surface receptors was observed with a maximum effect (19% increase) seen at 1 ...
The double scandal of insulin
The double scandal of insulin

... insulin, with most studies being open-label sponsorfunded comparisons. The long-acting analogues, in particular, which are those mainly used in people with type 2 diabetes, offer few benefits unless patients have been having symptomatic hypoglycaemia, particularly at night.Yet despite the limited ev ...
Decoding the myths of Type 1 diabetes
Decoding the myths of Type 1 diabetes

... Myth: “Sugar-Free” or “Diabetic” foods are considered free foods. Fact: “Sugar-Free” or “Diabetic” foods still contain carbohydrates that can raise blood glucose levels, especially if eaten in large amounts. These products are often sweetened with sugar alcohols. These are not well absorbed from the ...
Metabolic flexibility and carnitine flux: The role of carnitine
Metabolic flexibility and carnitine flux: The role of carnitine

... muscle, acetyl-CoA was not converted to its permeable form and was not excreted from mitochondria or cells. This led to the overaccumulation of acetyl-CoA, which exerted an allosteric inhibiting effect on pyruvate dehydrogenase (PDH), a rate-limiting enzyme for pyruvate entry into the tricarboxylic ...
Lect 8 hormones 4
Lect 8 hormones 4

... ↑Glucose release into blood due to glycogen breakdown & gluconeogenesis ↑Ketones released ...
Diabetes at Work | Diabetes | CDC
Diabetes at Work | Diabetes | CDC

... families, but many people diagnosed with the disease have no close family members who have it. Lifestyle, heredity, and possibly other factors, such as certain viruses, may increase risk for the disease. It’s called sugar diabetes, so it must come from the sugar I eat. When you eat food, the ...
about diabetes - Insulin Pumpers
about diabetes - Insulin Pumpers

... ADMINISTER if unconscious and you suspect an insulin reaction. No permanent harm will result if you are wrong. In any event, call 911 and notify responding team that she is a diabetic then call parents. ...
3-4-PROV-MAtrainingc..
3-4-PROV-MAtrainingc..

... carbohydrates. • This food item has 10 grams carbs. for ½ cup ...
Glycogenolytic effect of pancreastatin in the rat
Glycogenolytic effect of pancreastatin in the rat

... Pancreastatin, a new 49-amino acid peptide with a C-terminal gylcine amide, was recently isolated from porcine pancreatic extracts by using the amide structure as a marker during the isolation procedure (1). Pancreastatin is widely distributed throughout the central nervous system (2) and in endocri ...
Diabetes - Government of New Brunswick
Diabetes - Government of New Brunswick

... accumulates in the blood instead of being used for energy. In order to use glucose, the body needs insulin, a hormone secreted by the pancreas. ...
Metabolic changes in Diabetes mellitus (DM)
Metabolic changes in Diabetes mellitus (DM)

... - almost no or absolute no functional insulin is produced - glucagon is present in relative excess - individuals are prone to ketoacidosis ...
nutrition_cancer_pre..
nutrition_cancer_pre..

... Populations at low risk for Western cancers are quasi-vegan, and are characterized by lifelong leanness and good insulin sensitivity reflecting leanness, regular physical activity, and a diet low in fats and especially saturated fats A moderate intake of protein, primarily from “low quality” plant s ...
Dear Notetaker:
Dear Notetaker:

... - Once enzyme portion of cell is activated, those transporters become inserted into plasma membrane - Allow glucose to freely diffuse inside the cell via facilitated diffusion o Transporter is called GLUT 4 - GLUT 4 is insulin dependent glucose transporter - Resting muscle o Main cell type where GLU ...
OVERVIEW OF LIPID METABOLISM
OVERVIEW OF LIPID METABOLISM

... the 1 or the 3 ester bonds, but not the bond in the central 2 position (see below). As a result of this conversion, 2-monoglycerides (2-monoacylglycerols) are major endproducts of triglyceride digestion. Less than 10% of triglycerides remain unhydrolyzed in the intestine. ...
Type 2 Diabetes
Type 2 Diabetes

...  The risk for diabetes increases as the body mass index (a measure of body fat content) increases. It is not only the absolute amount but also the distribution of body fat that has an effect on insulin sensitivity:  central obesity (abdominal fat) is more likely to be linked with insulin resistanc ...
File
File

... – Chain A with 21 amino acids – Chain B with 30 amino acids – Two disulfide bridges covalently connect the chains ...
< 1 ... 11 12 13 14 15 16 17 18 19 ... 30 >

Insulin

Insulin (from the Latin, insula meaning island) is a peptide hormone produced by beta cells in the pancreas. It regulates the metabolism of carbohydrates and fats by promoting the absorption of glucose from the blood to skeletal muscles and fat tissue and by causing fat to be stored rather than used for energy. Insulin also inhibits the production of glucose by the liver.Except in the presence of the metabolic disorder diabetes mellitus and metabolic syndrome, insulin is provided within the body in a constant proportion to remove excess glucose from the blood, which otherwise would be toxic. When blood glucose levels fall below a certain level, the body begins to use stored glucose as an energy source through glycogenolysis, which breaks down the glycogen stored in the liver and muscles into glucose, which can then be utilized as an energy source. As a central metabolic control mechanism, its status is also used as a control signal to other body systems (such as amino acid uptake by body cells). In addition, it has several other anabolic effects throughout the body.When control of insulin levels fails, diabetes mellitus can result. As a consequence, insulin is used medically to treat some forms of diabetes mellitus. Patients with type 1 diabetes depend on external insulin (most commonly injected subcutaneously) for their survival because the hormone is no longer produced internally. Patients with type 2 diabetes are often insulin resistant and, because of such resistance, may suffer from a ""relative"" insulin deficiency. Some patients with type 2 diabetes may eventually require insulin if dietary modifications or other medications fail to control blood glucose levels adequately. Over 40% of those with Type 2 diabetes require insulin as part of their diabetes management plan.Insulin is a very old protein that may have originated more than a billion years ago. The molecular origins of insulin go at least as far back as the simplest unicellular eukaryotes. Apart from animals, insulin-like proteins are also known to exist in Fungi and Protista kingdoms. The human insulin protein is composed of 51 amino acids, and has a molecular mass of 5808 Da. It is a dimer of an A-chain and a B-chain, which are linked together by disulfide bonds. Insulin's structure varies slightly between species of animals. Insulin from animal sources differs somewhat in ""strength"" (in carbohydrate metabolism control effects) from that in humans because of those variations. Porcine insulin is especially close to the human version.The crystal structure of insulin in the solid state was determined by Dorothy Hodgkin; she was awarded the Nobel Prize in Chemistry in 1964.
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