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BIO 420 – Mammalian Physiology
BIO 420 – Mammalian Physiology

... V. Dihybrid Crosses with Mendelian Deviations A. Dihybrid crosses involving at least one non-classical ratio will result in F2 progeny with altered ratios as well. B. Example – Inheritance of albinism and blood type in the same individual VI. Gene Interaction A. Definition – phenotype may be affecte ...
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... inactivation (a two base pair deletion) occurred 2.4 million years ago, predating the appearance of Homo ergaster/erectus in Africa.  The period that followed was marked by a strong increase in cranial capacity, promoting speculation that the loss of the gene may have removed an evolutionary constr ...
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... mutations account for 91% of CF chromosomes in a Northern European Population, 81% of African American, and 82% of Hispanic. The table below describes the carrier frequency and mutation detection rate in different racial or ethnic groups. The maximum turn around time for this analysis is 7 days. The ...
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... glycoprotein (glycophorin); two different forms of this protein exist, M and N ...
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Epistasis



Epistasis is a phenomenon that consists of the effect of one gene being dependent on the presence of one or more 'modifier genes' (genetic background). Similarly, epistatic mutations have different effects in combination than individually. It was originally a concept from genetics but is now used in biochemistry, population genetics, computational biology and evolutionary biology. It arises due to interactions, either between genes, or within them leading to non-additive effects. Epistasis has a large influence on the shape of evolutionary landscapes which leads to profound consequences for evolution and evolvability of traits.
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