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Functional Genomics
Functional Genomics

... How to determine functionally related genes? • 40% if predicted genes in newly sequenced genomes cannot be assigned function based on sequence similarity. • Genes sharing a common pattern of expression in many different experiments are likely to be involved in similar processes. – Gene A regulates ...
HYRS_presentation
HYRS_presentation

... 1. Propose a minimal genome, about 10% of the original size 2. Develop methods to rapidly assemble hundred of genes 3. Develop an automated system for gene assembly ...
B1: You and Your Genes
B1: You and Your Genes

... the genome is present in every cell to control how it functions that the genome is packaged into chromosomes, which are made of DNA – a polymer of nucleotides, forming two strands in a double helix that genes are sections of DNA, and instruct cells how to make proteins from amino acids that most of ...
Genes and genomes
Genes and genomes

... experiment – it contains tightly coiled DNA around special proteins. The DNA of a human being’s 23 chromosomes, when uncoiled, is 2 meters long!! ...
Table S1.
Table S1.

... When single nucleotide variations occur in at least 1% of the population, they are considered polymorphisms or SNPs (Single Nucleotide Polymorphism). ...
No Slide Title
No Slide Title

so difficult to define a “bacterial genome”
so difficult to define a “bacterial genome”

... Mediated by bacteriophages, plasmids, transposons ... ...
Analysis of Genomes
Analysis of Genomes

... i. somewhat more genes ii. arrangement of domains iii. more paralogs - paralog iv. alternative splicing v. chemical modifications B. Repetitive DNA (>50% of human DNA) 1. transposon derived (~45%) 2. pseudogenes 3. SSRs (3%) 4. segmental duplications of 10 - 300kb pieces (5%) 5. repeates at centrome ...
Red Line - iPlant Pods
Red Line - iPlant Pods

... investigate presence/absence variation (PAV) in maize – 12 hours effort, each student group annotated 100 kb and then imported next-gen RNA-Seq data from 5 different tissues in 30 maize inbred lines for a gene that they had previously shown exhibits PAV ...
01 - HomeworkNOW.com
01 - HomeworkNOW.com

... In the space provided, write the letter of the description that best matches each term. ...
Lecture_3_2005
Lecture_3_2005

... • Database that links diseases and genes ...
The Human Genome Project
The Human Genome Project

... The Human Genome Project What is the Human Genome Project? • U.S. govt. project coordinated by the Department of Energy and the National Institutes of Health • goals (1998-2003) – identify the approximate 100,000 genes in human DNA – determine the sequences of the 3 billion bases that make up human ...
Red line Introduction
Red line Introduction

... investigate presence/absence variation (PAV) in maize – 12 hours effort, each student group annotated 100 kb and then imported next-gen RNA-Seq data from 5 different tissues in 30 maize inbred lines for a gene that they had previously shown exhibits PAV ...
DNA, Genes & Genomes
DNA, Genes & Genomes

... All life forms rely on nucleic acids (DNA & RNA) for passing on their genetic information. DNA is a complex polymer of repeating nucleotides Each nucleotide = Deoxyribose Sugar + Phosphate + Nitrogenous Base. ...
Genetic Markers
Genetic Markers

... Polymorphism in human DNA • Millions of sites in human DNA are different between individuals • Single nucleotide polymorphisms (SNPs) in genes or in non-coding DNA may or may not affect phenotype • SNPs can cause Restriction fragment length polymorphisms (RFLPs) if in a restriction enzyme site • Ta ...
Arabidopsis thaliana
Arabidopsis thaliana

... centromeric heterochromatin - hence superficially this genome resembles the Drosophila genome in organization. Indeed among plants it is unusually small. ...
Gene Expression
Gene Expression

Dr. Chris Eskiw Dept. of Food and Bioproduct Sciences University of Saskatchewan
Dr. Chris Eskiw Dept. of Food and Bioproduct Sciences University of Saskatchewan

... Transcription sites are organized into foci and are far fewer in number than the number of genes actively transcribing. This indicates that genes must share these sites. Ultrastructural imaging using energy filtering transmission electron microscopy (EFTEM) demonstrated that these foci, called trans ...
OGP
OGP

... RNAi highly effective in Ce: 90% gene knockout in 2/5 chromosomes Models for human disease: 50-60% human disease genes have Ce &Dm orthologs Models for drug development ...
Human Genome Project
Human Genome Project

... Human genome has far more repeat DNA than any other sequenced organism (over half). • Parasitic elements–45% of this repeat DNA is from selfish, parasitic DNA: – Transposable elements. – May play role in evolution. ...
omic glossary
omic glossary

... development of human diseases such as cancer or inflamation. ...
Genetic Engineering and Biotechnology Study Guide
Genetic Engineering and Biotechnology Study Guide

... How might a gel electrophoresis be used? Give TWO applications. ...
Genomes and their evolution
Genomes and their evolution

... •More than 3,700 genomes have been sequenced with thousands more in progress. •In general, bacteria and archaea have fewer genes than eukaryotes, and the number of genes in eukaryotic genomes is less than was expected. ...
Plant DNA mini
Plant DNA mini

... The genome of any organism is an amazing piece of biology. It is a highly efficient and adaptive information storage, delivery and retrieval mechanism capable of propagating, modifying and repairing itself. Understanding how genomes function is central to a broad range of disciplines including genet ...
7th grade Ch. 5 section 2 and 3 Notes
7th grade Ch. 5 section 2 and 3 Notes

... same genes as the organism in which it was produced by. • Researchers have cloned sheep and pigs. ...
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Genome evolution



Genome evolution is the process by which a genome changes in structure (sequence) or size over time. The study of genome evolution involves multiple fields such as structural analysis of the genome, the study of genomic parasites, gene and ancient genome duplications, polyploidy, and comparative genomics. Genome evolution is a constantly changing and evolving field due to the steadily growing number of sequenced genomes, both prokaryotic and eukaryotic, available to the scientific community and the public at large.
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