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Brown and Goldstein: The Cholesterol Chronicles
Brown and Goldstein: The Cholesterol Chronicles

... Brown and Goldstein had uncovered by the turn of the decade how cells keep cholesterol levels in membranes strikingly constant, despite varying supply and demand (4). “A few years after we described this process, a handful of similar paradigms came to light,” says Goldstein. For example, their work ...
atp ase-positive and metallophilic cells in the skin of frog, rana
atp ase-positive and metallophilic cells in the skin of frog, rana

... is usually difficult to make a conclusion on the absence of any migratory cell types from a tissue by observations on limited numbers of samples; however, since the epidermal structure of the bull frog was almost uniform in different areas and since the Langerhans cells, if present, are supposed to ...
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m - Biochemical Society Transactions

... cell growth through functional modulation of key molecules that are essential in transmembrane signalling. ...
AP bio Framework Book part
AP bio Framework Book part

... other vital resources. Energy deficiencies are not only detrimental to individual organisms; they also can cause disruptions at the population and ecosystem levels. Origin of life: The process of evolution explains the diversity and unity of life. A number of experimental investigations have provide ...
Unit 5 Animals
Unit 5 Animals

... Sponges inhabit all the seas including polar and tropical seas, lakes and streams. Sponges are classified as animals because they fit into the biological definition of an animal. They, like us, are multicellular eukaryotic heterotrophs whose cells lack cell walls. The sponge as an animal goes throug ...
Human Anatomy - TheVogts.com
Human Anatomy - TheVogts.com

... stimuli Helps control all other systems of the body Also responsible for consciousness, intelligence, memory ...
Lecture 6 Notes CH.6
Lecture 6 Notes CH.6

... • 6.2 Eukaryotic cells have internal membranes that compartmentalize their functions • 6.3 The eukaryotic cell's genetic instructions are housed in the nucleus and carried out by the ribosomes • 6.4 The endomembrane system regulates protein traffic and performs metabolic functions in the cell • 6.5 ...
Maintaining a Balance #3
Maintaining a Balance #3

... Most organisms are active in a limited temperature range Enzymes:  Biological catalysts. A specific enzyme controls every reaction and process within a cell. Enzymes control all the chemical processes of living systems.  Enzymes are proteins made up of amino acids that are linked and then folded t ...
FORENSIC PATHOLOGY - Los Angeles Society of Pathologists
FORENSIC PATHOLOGY - Los Angeles Society of Pathologists

... therapies) and sent to the Laboratory and/or Blood Bank should be saved for the Coroner’s Office. Any serum/plasma samples will also be useful for specialized testing. Such samples will be picked up by the Coroner’s Office staff when they come to remove the decedent. This will help with comprehensiv ...
cyanobacteria-nostoc and scytonema-2012
cyanobacteria-nostoc and scytonema-2012

... Endospores are produced endogenously like those in bacteria; exospores are the result to exogenous budding of cells, and the nanocysts are produced endogenously like endospores. The difference between an endospore and a nanocysts is that in endospore formation the parent cell concomitantly enlarges ...
1 ANIMAL KINGDOM 1 EVOLUTIONARY TRENDS and PHYLUM
1 ANIMAL KINGDOM 1 EVOLUTIONARY TRENDS and PHYLUM

... Sponges inhabit all the seas including polar and tropical seas, lakes and streams. Sponges are classified as animals because they fit into the biological definition of an animal. They, like us, are multicellular eukaryotic heterotrophs whose cells lack cell walls. The sponge as an animal goes throug ...
Border cells versus border-like cells: are they alike?
Border cells versus border-like cells: are they alike?

... from desiccation, and resistance against harmful substances (Davey and O’Toole, 2000). Such a border cell ‘biofilm’ formation in qua1-1 root is perhaps a key factor for their survival, stability, and thus their defence activity. ...
Hematopoiesis - Development
Hematopoiesis - Development

... blood-related mutants (reviewed by Hsia and Zon, 2005) that allow researchers to tease apart hematopoietic genes and their function. For example, the spadetail mutant (which carries a mutation in the tbx16 gene) has a defect in mesoderm-derived tissues, including blood, as demonstrated by a decrease ...
pH and Acidosis - SupremeFulvic.com
pH and Acidosis - SupremeFulvic.com

... impending famine, directly interpreting with the all important and very sensitive Insulin-Glucagon Axis. When this happens, it makes the body produce more insulin than usual, and in turn, produce more fats and store it. On the other hand, a healthy and slightly alkaline pH will yield normal fat burn ...
Flow Cytometrys Central Role in Diagnosis of PNH
Flow Cytometrys Central Role in Diagnosis of PNH

... There are a number of considerations when flow cytometry is the analysis of choice, not only in terms of gating strategy and antibody choice but also interpretation of results in which a detailed knowledge of the cellular distribution of GPI-linked antigens and their expression at different stages i ...
a-Catulin, a Rho signalling component, can regulate NF
a-Catulin, a Rho signalling component, can regulate NF

... IKK HLH domains may also interact with other proteins, and biochemical evidence indicates that indeed a variety of additional proteins may be loosely or transiently associated with the IKK complex (Bouwmeester et al., 2004). a-Catulin is a 73-kDa protein that has similarities to human vinculin and a ...
Reverse Engineering Models of Cell Cycle Regulation
Reverse Engineering Models of Cell Cycle Regulation

... the pieces into comprehensive mechanisms that accurately reflect cell behavior, that predict new aspects of the control systems, and that provide intellectually satisfying explanations of how cells work. A major component of this systems approach is the construction of mathematical models that captu ...
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... 6. Why do respiratory organs have large surface areas? The more surface area that is exposed to the environment, the greater the amount of gas exchange that can occur. ...
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... Apparatus - Mortar & pestle; mechanical shaking with abrasives in Mickle shakers, liquid shearing in blenders; homogenisers with power driven (Potter-Elvejham) pestle made of pyrex glass, Teflon or leucite can also be used; controlled solid shear with Hughes Press that generate pressure upto 108 Pa ...
Cultivated Meat - Marianne Heselmans
Cultivated Meat - Marianne Heselmans

... Collagen is naturally found in the connective tissue within muscle and, therefore, within meat. The trick is to let the collagen gel shrink a little in one direction, so that the muscle cells are ordered one behind the other. One must also starve the cells a little, which causes them to develop into ...
Standard PDF - Wiley Online Library
Standard PDF - Wiley Online Library

... AJs with their associated actin filaments seen during development and wound repair would not be easily accomplished if cadherin-actin linkage is stable. Endocytosis and recycling of cadherin through vesicle transport and fusion would be also inhibited by tightly associated actin filaments. It is the ...
Molecular mechanisms involved in colorectal cancer initiation and
Molecular mechanisms involved in colorectal cancer initiation and

... and help to shed light on why Wnt signalling mutations are an important pre-requisite for the development of CRC. Our studies are oriented towards the identification of the nature of the founding CRC cell and the mechanisms by which it escapes cell renewal. During 2007, we have generated several DNA ...
CHI-SQUARE(X2) DISTRIBUTION 11
CHI-SQUARE(X2) DISTRIBUTION 11

... independent ( no Association) • HA: Speech defect and SE group are not independent ( Association exist) • 2)Calculate the expected frequencies • 3)Calculate the X2 value ( calculated value) ...
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... Bioassays are free from cytotoxic components of the serum. ...
Sponges and Cnidarians
Sponges and Cnidarians

... By the end of this section, you will be able to: • Describe the organizational features of the simplest animals • Describe the organizational features of cnidarians The kingdom of animals is informally divided into invertebrate animals, those without a backbone, and vertebrate animals, those with a ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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