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Smart thermoresponsive coatings and surfaces for tissue
Smart thermoresponsive coatings and surfaces for tissue

... structures seems to be a backward step. Thermoresponsive substrates can be created so that cells adhere and proliferate at the culture temperature, and then release the cultured cell sheets on command, by cooling below the LCST. These cell sheet engineering tools have been classified according to tw ...
d`Avanzo, N. and McCusker, Emily C. and Powl, Andrew M. and
d`Avanzo, N. and McCusker, Emily C. and Powl, Andrew M. and

... Sunday, February 3, 2013 ...
G protein-coupled receptor - Bryn Mawr School Faculty Web Pages
G protein-coupled receptor - Bryn Mawr School Faculty Web Pages

... • Cell-to-cell communication is essential for multicellular organisms • Biologists have discovered some universal mechanisms of cellular regulation • The combined effects of multiple signals determine cell response ...
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... cancerous cells that makes them different from normal somatic cells? a) Cancer cells often deactivate their apoptosis systems. ...
Supplemental Methods, Figures 1-5 and Table 1
Supplemental Methods, Figures 1-5 and Table 1

... mass had grown out of the attached blastocyst, the well was trypsinized and plated onto a preplated MEF layer in a 96 well plate similar to before. Once ES colonies were clearly apparent, the culture was serially passaged up to a T25 after which multiple freeze downs were made. ...
ECTOPIC ROOT HAIR 3 in root patterning - Development
ECTOPIC ROOT HAIR 3 in root patterning - Development

... Because of the similarity between CPC and WER and given the opposite role played by each in the development of the epidermis, a model has been proposed in which the ratio of WER to CPC determines the fate of any individual epidermal ...
Female Reproductive System
Female Reproductive System

... 1. A, B, and D, only 2. B, C, and D, only 3. B and D, only 4. A, B, C, and D ...
Summary for the non-biologist Developmental biology
Summary for the non-biologist Developmental biology

... multicellular organism starting from a much simpler form such as an embryo or an egg. A variety of organisms like frogs (Xenopus), fruit flies (Drosophila) and social amoebas like Dictyostelium discoideum are used as model systems to study these processes. Although humans and amoebas, or flies and f ...
Propranolol and Oxygen- Hemoglobin Equilibrium
Propranolol and Oxygen- Hemoglobin Equilibrium

... and twenty-four hours after administration of forty milligrams or less. The authors found no significant change in P5,. They also measured P50 in two subjects on large doses (180 and 360 mg per day) of propranolol and found it to be "within one standard deviation of their normal mean.' We have shown ...
The architecture of polarized cell growth: The unique status of
The architecture of polarized cell growth: The unique status of

... cytoskeletal structures as well as between cytoskeleton and ECM, operating with and upon a boundary membrane.(4,24) In walled cells, the major driving force for cellular shaping comes from an intracellular turgor pressure. The acquisition of a particular cell shape results ultimately from a precisel ...
Methods of Enumeration of Microorganisms
Methods of Enumeration of Microorganisms

... plated onto a suitable growth medium. The suspension is either spread onto the surface of agar plates (spread plate method), or is mixed with molten agar, poured into plates, and allowed to solidify (pour plate method). The plates are then incubated under conditions that permit microbial reproductio ...
Routes of Administration
Routes of Administration

... →subcutaneous→oral→transdermal The rate of absorption determines how soon the effects will begin. ...
Animals: Respiration
Animals: Respiration

... 1.In our blood, oxygen relatively insoluble in water (blood can carry 70 times as much as oxygen as it can be dissolved). 2.Hemoglobin (protein in red blood cells) has four subunits, each has a heme group with iron in the center and can bind one oxygen molecule. Each hemoglobin can bind 4 oxygen mol ...
Young Scientist Program:  Anatomy Teaching Team Basic Lung Pathology
Young Scientist Program: Anatomy Teaching Team Basic Lung Pathology

... or obstructed, limiting airflow in and out of them. Specifically, emphysema occurs when a person is exposed to a toxic substance, mainly cigarette smoke, for a long long time. What happens when an individual inhales tobacco smoke? Well, first all of the small particulates in the smoke [thanks to the ...
Plasmablast and Plasma Cell Production and Distribution in Trout
Plasmablast and Plasma Cell Production and Distribution in Trout

... were washed with PBS before the membrane was removed from the apparatus. The membrane was gently wiped (Kimwipes; Kimberly-Clark, Roswell, GA) to remove any cellular debris still attached to the membrane, then blocked by the addition of the blocking solution for 1 h. Biotinylated mAb 1–14 (0.5 ␮g/ml ...
STUDY GUIDE SECTION 46-1 The Circulatory System
STUDY GUIDE SECTION 46-1 The Circulatory System

... 2. ______Exchange of nutrients and waste between blood and body tissues occurs across a. arterioles b. capillaries c. arteries d. veins ...
Activity of isatizon according to adenoviral infection in vitro
Activity of isatizon according to adenoviral infection in vitro

... activity of methisazone and izatizon. It displayed in strong decrease of cytocidal activity of virus and in two-fold decrease synthesis of capsule albumen. The decrease of synthesis of the viral hexone we observed in Ad1- infected cells of HEp-2 line treated with izatizon. It is necessary to mention ...
The Cell Cycle Notes from Pearson
The Cell Cycle Notes from Pearson

... As an organism grows, its cells cannot simply get larger and larger. The reason is that as cells get bigger, their surface area to volume ratio decreases. If a cell gets too big, its surface area is not large enough to get adequate oxygen and nutrients in and waste out through the cell membrane. Cel ...
Chapter 17-18 Late Adulthood
Chapter 17-18 Late Adulthood

... • Stereotypes against older adults are often negative • Most frequent form is disrespect, followed by assumptions about ailments or frailty caused by age ...
Chapter 2: Basic Biological Principles Lesson 2: Structural and
Chapter 2: Basic Biological Principles Lesson 2: Structural and

... processes, a cell must be able to quickly pass substances into and out of the cell. For example, it must be able to pass nutrients and oxygen into the cell and waste products out of the cell. Anything that enters or leaves a cell must cross its outer surface. It is this need to pass substances acros ...
2001 AP Biology Scoring Guidelines - AP Central
2001 AP Biology Scoring Guidelines - AP Central

... • plasma membrane (neurilemma) • Na+/K+ pump-gated channels • synaptic knobs/dendrite membrane receptors • axon hillock (i.e., neck of cell body) Nephron * (Renal) tubules and capillaries (glomerulus) OR * Tubular excretory unit of the kidney • filtering unit • PCT, loop of Henle, DCT, collecting du ...
concept - Oslo University Hospital
concept - Oslo University Hospital

... that this is based on a logical flaw. Let us take a closer look at the steady-state growth of a culture. All cell constituents double in amount from mitosis to mitosis, from one initiation of DNA replication to the next, or from cytokinesis to cytokinesis. Fig. 3 is a schematic, two-parametric repre ...
Respiratory System
Respiratory System

... Simple animals that lack specialized exchange surfaces have flattened, tubular, or thin shaped body plans, which are the most efficient for gas exchange. However, these simple animals are rather small in size. Large animals cannot maintain gas exchange by diffusion across their outer surface. They d ...
Bloodborne Pathogens Glossary
Bloodborne Pathogens Glossary

... Aerosolization: Spattering, spraying or otherwise creating droplets in the air or onto surfaces. AIDS: (acquired immunodeficiency syndrome) – A disease related to the exposure to HIV where the immune system is weakened and unable to fight off opportunistic infections due to a low T-cell count. Amnio ...
FIG./ CURRENT (,uA)
FIG./ CURRENT (,uA)

< 1 ... 532 533 534 535 536 537 538 539 540 ... 1638 >

Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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