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Phosphatidylcholine traffic to the vacuole
Phosphatidylcholine traffic to the vacuole

... To date it remains unclear how membrane lipids, which are synthesized primarily at the endoplasmic reticulum (ER), become so highly organized at both the inter- and intraorganellar level. Among the classic examples of interorganellar lipid organization is the enrichment of sterols and phosphatidylse ...
Role of cancer-associated fibroblasts in breast cancer development
Role of cancer-associated fibroblasts in breast cancer development

... The other major intermediate in the intercommunication between tumors and their stromal fibroblasts are Matrix metalloproteinases (MMPs). These prominent proteases that play crucial roles in various physiological processes including development, inflammation and ECM degradation, are abundantly and s ...
Archenteron precursor cells can organize secondary axial structures
Archenteron precursor cells can organize secondary axial structures

... gut tissue or (3) a combination of such signals could be involved (these possibilities are summarized in Fig. 1B). In order to provide experimental support for one of these alternative mechanisms, we have used a chimeric embryo approach to implant gut progenitors in ectopic locations to assess their ...
a comparative study of total hemoglobin measurement technology
a comparative study of total hemoglobin measurement technology

... Since hemoglobin concentration and oxygen saturation are indicative of a patient‟s ability to transport oxygen, it is routinely monitored or tested in any instance where oxygen transport is thought to be compromised. Additionally, hematocrit and total hemoglobin concentration are used perioperativel ...
Animals Regulation and Body Plans
Animals Regulation and Body Plans

... • An animal’s size and shape, often called body plans or designs, are fundamental aspects of form and function that significantly affect the way an animal interacts with its environment. • The terms plan and design do not mean that animal body forms are products of a conscious invention. • The body ...
The Notch-target gene hairy2a impedes the involution of
The Notch-target gene hairy2a impedes the involution of

... we proposed that the early organiser indeed contains cells that have the potential to develop either as notochord or FP, but the question of whether they constitute a mixed population or occupy different compartments within the organiser remained unanswered. In addition, we described that Notch sign ...
4. Tissue Level of Organization
4. Tissue Level of Organization

... traveling between neighboring cells. Ions, glucose, amino acids, and other small solutes can pass directly from the cytoplasm of one cell into the neighboring cell through these channels. The flow of ions between cells coordinates such cellular activities as the beating of cilia. Gap junctions are a ...
Mechanistic Modeling of Cancer Tumor Growth Using a Porous
Mechanistic Modeling of Cancer Tumor Growth Using a Porous

... be sufficient in the development of cancer. However, genetic instability can increase the rate of mutation and thus can increase the chance that a cell that has acquired a few of the hallmarks will acquire the remaining traits. However, since so many aspects of normal cell function must be perturbe ...
PDF - Blood Journal
PDF - Blood Journal

... 7.5 mM EDTA, for 20 minutes, on ice. The vesicle membranes were pelleted by centrifugation in a fixed-angle rotor (Beckman, TLA-100.1, at 200 000g, 4°C, for 30 minutes). The pellets were resuspended in lysis buffer to give an equal volume to the supernatants, and aliquots of the supernatants and pel ...
Microbiology of the Rumen - Iowa State University: Animal Science
Microbiology of the Rumen - Iowa State University: Animal Science

... 500-20,000 α-(1, 4)-D-glucose units with a few α-1, 6 branches. Amylose can form an extended shape. Hydrogen bonding occurs between aligned chains. The aligned chains may form double stranded crystallites that are resistant to amylases. Amylopectin is formed by non-random α-1, 6 branching of the amy ...
Methodological Instructions to Practical Lesson
Methodological Instructions to Practical Lesson

... disease, or it may represent the overflow of abnormal proteins into the urine in conditions such as multiple myeloma. Proteinuria also can occur secondary to nonrenal disorders and in response to various physiologic conditions such as strenuous exercise. The protein concentration in the urine obviou ...
Lysosomal enzymes and inflammation
Lysosomal enzymes and inflammation

... For as long as cells have been studied by normal light microscopy cytologists have known that many cells contain small refractile granules, about 0 *5-1 ,u in diameter. In living fibroblasts grown in proliferative tissue culture, they occur predominantly around the nucleus. In leucocytes they are th ...
Microbiology with basis immunology_1
Microbiology with basis immunology_1

... A. A bacterium is a one-cell organism that has a distinct nucleus. B. A bacterium is a multicellar organism that does not have a distinct nucleus. C. A bacterium is a multicellar organism that has a distinct nucleus D. All anwers are true E. A bacterium is a one-cell organism that does not have a di ...
Research Article Ammonium-Dependent Shortening of CLS in Yeast
Research Article Ammonium-Dependent Shortening of CLS in Yeast

... results provide new insights in the modulation of CLS by NH4 + , linking NH4 + toxicity to amino acid limitation. This scenario of enhanced NH4 + toxicity in amino acid starvation conditions is present in hyperammonemic patients, who are often on dietary protein restriction [26]. The use of a simple ...
Membrane traffic and fusion at post-Golgi compartments
Membrane traffic and fusion at post-Golgi compartments

... Plant cells have different types of vacuoles with specific physiological and functional features, depending on the developmental stage (Marty, 1999). Two types of vacuoles have been best studied: (i) the α-tonoplast intrinsic protein (α-TIP)-positive PSV that is built during embryogenesis and serves ...
A molecular framework for the inhibition of
A molecular framework for the inhibition of

... application of BA reduces the size of root meristems, correlating with the inhibition of root growth. The decrease in meristem size is caused by a reduction of cell division. Mitotic cell number significantly decreases and the expression level of key core cell cycle regulators is modulated. The modu ...
Better Health Briefing17 The social consequences of sickle cell and
Better Health Briefing17 The social consequences of sickle cell and

... understood by some health care professionals. Parents, for example, struggle to make a decision, particularly when many have little prior understanding of the condition. Understanding of thalassaemia among South Asian communities is a particular issue (Shaw, 2009). Community engagement, which attemp ...
Effect of nanoparticles on the activity of the electrone ion pumps in
Effect of nanoparticles on the activity of the electrone ion pumps in

... respiration and so on ). Therefore, the studying of MP kinetics in cells with this or other factor influence gives information about active ion pumps function in plasmatic membrane. As noted above two types of active proton pumps parallel activate in plant cells. One of these is H-ATFase proton comp ...
Centrosome misorientation mediates slowing of the cell cycle under
Centrosome misorientation mediates slowing of the cell cycle under

... Revised: Jan 30, 2012 Accepted: Feb 17, 2012 ...
What Is a Mollusk?
What Is a Mollusk?

... Heart ...
Different Roles for Simple-Cell and Complex
Different Roles for Simple-Cell and Complex

... data are used in most of our later studies (Kayser et al., 2001; Krukowski and Miller, 2001; Lauritzen et al., 2001; Troyer et al., 2002) but not in our original study (Troyer et al., 1998); these data are used because they are the only published data of which we are aware that includes responses bo ...
AOPT 8th Scientific Meeting Abstracts
AOPT 8th Scientific Meeting Abstracts

... independence, objectivity, and scientific rigor. Planning must be free of the influence or control of a commercial entity, and promote improvements or quality in healthcare. Faculty participating in UCSD sponsored CME programs are expected to disclose to the activity participants any conflict(s) of ...
Document
Document

... tubes which finally terminate into balloon like structures called alveoli. These alveoli provide a surface where exchange of gases can take place. The walls of the alveoli are richly supplied with blood vessels. Q2.Draw a labeled diagram of the detailed structure of a nephron. Ans:- ...
Development - Columbia University Medical Center
Development - Columbia University Medical Center

... 1998; Puelles et al., 2000; Puelles et al., 1999). Thus, examination of when and how these profiles of gene expression are established in the telencephalon may reveal how telencephalic cells acquire their early dorsal, intermediate and ventral characters. The diverse and interdependent functions of ...
Staphylococcus aureus , and Streptococcus pneumoniae , coli
Staphylococcus aureus , and Streptococcus pneumoniae , coli

... be operative in response to a specific stimulus, the relative importance of each may vary depending on the nature of the inflammatory stimulus (e.g., bacterial species). In addition, the role of specific endothelial cell adhesion molecules in pneumonia caused by microbial pathogens has been difficul ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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