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Plant grafting: Insights into tissue regeneration
Plant grafting: Insights into tissue regeneration

... For millennia, people have cut and joined different plants together through a process known as grafting. The severed tissues adhere, the cells divide and the vasculature differentiates through a remarkable process of regeneration between two genetically distinct organisms as they become one. Graftin ...
Hydrogen-Peroxide-Enhanced Nonthermal Plasma Effluent for
Hydrogen-Peroxide-Enhanced Nonthermal Plasma Effluent for

... our normal operational mode and included both DBD and hydrogen peroxide solution as in the previously described bacteria tests. The sample size for each mode was six spore discs, and the evaporator was always at room temperature. The best inactivation rate (close to 90%) occurs for the “plasma + H2 ...
Transcription factor AP-2 is tissue-specific in
Transcription factor AP-2 is tissue-specific in

... pigmented cells) and vegetal hemispheres, using watchmakers forceps. Epidermis was removed from tailbud stages by drawing the embryo into and expelling it from a drawn-out Pasteur pipette. The epidermis was then cleaned in dissociating 67 mM sodium phosphate, pH7.6. All the cells of each embryo were ...
2 - Liu Lab
2 - Liu Lab

... BET bromodomain inhibitors, which have shown efficacy in several models of cancer4–6, have not been evaluated in TNBC. These inhibitors displace BET bromodomain proteins such as BRD4 from chromatin by competing with their acetyl-lysine recognition modules, leading to inhibition of oncogenic transcri ...
Blood flow
Blood flow

... The aortic sinus reflex regulates systemic blood pressure Example: BP falls- the baroreceptors are stretched less, they send nerve impulses at a slower rate to the cardiovascular center • CV center decreases parasympathetic stimulation of the heart via vagus N & increases sympathetic stimulation to ...
owner`s manual
owner`s manual

... is noticeable. If the blower is rotating correctly, the access door will be closed by the negative pressure within the cabinet. Single-phase units (i.e., 115/1/50-60) are prewired for proper rotation and line hook-up. Simply connect to single phase input circuit and unit is ready for operation. Inpu ...
Abstract
Abstract

... Cytosolic Ca2+ plays an important role in intracellular signaling. Na+/Ca2+ exchanger (NCX) is a plasma membrane protein and involved in cellular Ca2+ homeostasis especially in cells that require influx of Ca2+ for their physiological activities such as cardiac myocytes and neurons. NCX contains 9 t ...
Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative
Detoxifying Enzymes at the Cross-Roads of Inflammation, Oxidative

... Phase I and II enzymes are involved in the metabolism of endogenous reactive compounds as well as xenobiotics, including toxicants and drugs. Genotyping studies have established several drug metabolizing enzymes as markers for risk of drug hypersensitivity. However, other candidates are emerging tha ...
Glial Cell Inhibition of Neurons by Release of ATP
Glial Cell Inhibition of Neurons by Release of ATP

... and the generation of an outward current in a neuron. The voltage and current traces were recorded in sequential trials from the same neuron. Resting membrane potential and holding potential are ⫺72 mV. B, Activation of glial cells by ejection of 1 mM dopamine and 500 ␮M LPA and by mechanical (mech) ...
Concanavalin A-induced posterior subcapsular cataract
Concanavalin A-induced posterior subcapsular cataract

... Purpose. To evaluate the effect of Concanavalin A (Con A) on cataract formation in New Zealand Albino rabbits. Uveitis is a chronic inflammatory condition of the eye involving the anterior and/or posterior segments. It may be acute or chronic and is associated with the development of posterior subsc ...
The complex life of simple sphingolipids
The complex life of simple sphingolipids

... phytosphingosine) to which a fatty acid is attached by an amide bond to carbon 2 (Fig 1). The simplest sphingolipid, ceramide (Merrill, 2002), functions both as a key player in cell signalling and as the precursor of more complex sphingolipids. In contrast to complex sphingolipids, which contain a h ...
Guidance for FDA Reviewers and Sponsors
Guidance for FDA Reviewers and Sponsors

... inherent in the components used to generate the final product, such as the source of cells (i.e., autologous or allogeneic), the potential for adventitious agent contamination, the need for aseptic processing, and in the case of ex vivo genetically modified cell therapies the inability to “sterilize ...
Single-Cell Phenotyping within Transparent Intact Tissue through
Single-Cell Phenotyping within Transparent Intact Tissue through

... methods and optimized protocols were only presented for clearing brain tissue, and occasionally for the spinal cord (Ertürk et al., 2012a; Zhang et al., 2014) or whole embryo (Dodt et al., 2007; Hama et al., 2011). 3DISCO represents, to date, the most complete elucidation of a clearing method acros ...
Oxidized LDL-Containing Immune Complexes Induce Fc Gamma
Oxidized LDL-Containing Immune Complexes Induce Fc Gamma

Dynamics of the Cell Cycle: Checkpoints, Sizers, and Timers
Dynamics of the Cell Cycle: Checkpoints, Sizers, and Timers

... depends strongly on the strength of the feedback, whereas the period of limit cycle depends strongly on the time delay of negative feedback. The cell cycle checkpoint in this model is thus a Hopf bifurcation point, rather than a saddle-node bifurcation as in the models by Tyson and colleagues (Tyson ...
Biochemical bases of appearance and texture changes in fresh
Biochemical bases of appearance and texture changes in fresh

... of the most fundamental factors affecting the quality of fresh-cut products. The intent is to provide a level of understanding that can be used to underpin future research directions in order to resolve existing issues that limit fresh-cut quality and shelf life. The biochemical mechanisms for enzym ...
Modern Strategies for Hairy Cell Leukemia
Modern Strategies for Hairy Cell Leukemia

... may occur in patients.26 An updated inventory of the types of infections and other disease manifestations would also be informative. Patients may present with autoimmune complications, vasculitis, hemolysis, and lytic bone disease. The outstanding responses in hairy cell leukemia expected with purin ...
Final scope
Final scope

... provided by the device can be subtracted from a person’s current weight (or added if the overhydration value is negative) to identify their normohydration weight, that is the weight they would be if their body tissue was normally hydrated. This resulting value can be used by clinicians to assist the ...
Metabolism, cell growth and the bacterial cell cycle
Metabolism, cell growth and the bacterial cell cycle

... that the factors triggering initiation differ depending on growth rate45,47,48. For these reasons, we favour an integrated model in which multiple factors control origin firing. each factor would be more or less important depending on the growth rate — for example, factor ‘X’ could be important at r ...
how proteins move lipids and lipids move proteins
how proteins move lipids and lipids move proteins

... diverse array of small molecules across membranes. MULTIDRUG TRANSPORTER ...
1030ExamIV
1030ExamIV

... do it. Furthermore, I will have the time to read and evaluate your answers over the Thanksgiving break. This can count as much as any one sectional exam, that is up to 10% of the entire class grade, enough to easily move you from one grade bracket to the next, if you do well enough: On the back side ...
Hydrocortisone Diffusion Through Synthetic Membrane
Hydrocortisone Diffusion Through Synthetic Membrane

... the cream was found to be linear and directly proportional to the square root of time or followed Higuchi's diffusion controlled model. T h e H C release was faster from 2.5% compared to 1% creams, which in turn was faster than froin 0.5% H C cream [3]. T h e release rate ranged between 0.61 and 2.6 ...
How migration occurs
How migration occurs

... Cycle between a GDP-bound, inactive form GTP-bound, active form. The cycle is regulated by ...
PDF
PDF

... It has previously been demonstrated that in vitro T cell proliferation and cytokine production can be suppressed by the immobilized recombinant PD-L1 Ig (16, 24–26). To begin to test the sensitivity of Cbl-b−/− T cells to PD-L1-mediated suppression, we tested the ability of plate-bound PD-L1 Ig to s ...
Slam and germ cell migration - Development
Slam and germ cell migration - Development

... to gain insights into these processes, as germ cell migration shares with them key features such as invasion through an epithelium, cell-cell adhesion and directed migration to a target tissue. Germ cell migration is a well-conserved process in species such as human, mouse, fish and fly. Drosophila ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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