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Regulated protein degradation controls PKA function and cell
Regulated protein degradation controls PKA function and cell

... that is required at several stages during Dictyostelium development. culA null cells are defective in inducing cell-type-specific gene expression and exhibit defects during aggregation, including reduced chemotaxis. PKA is an important regulator of Dictyostelium development. The levels of intracellu ...
Biological synthesis of fluorescent nanoparticles by cadmium and
Biological synthesis of fluorescent nanoparticles by cadmium and

... Background:  Fluorescent nanoparticles or quantum dots (QDs) have been intensely studied for basic and applied research due to their unique size-dependent properties. There is an increasing interest in developing ecofriendly methods to synthesize these nanoparticles since they improve biocompatibili ...
gauze bandages with a bound antimicrobial polymer suppress
gauze bandages with a bound antimicrobial polymer suppress

... Gauze bandages and pads are commonly used as dressings for patients with large wounds. However, a disadvantage of gauze bandages is the absorption of exudates into the dressing. Exudates absorption contributes to the development of high levels of bacteria in the dressing. A new gauze bandage with a ...
Comparing The Effects of Small Molecules BIX
Comparing The Effects of Small Molecules BIX

... treatment for a week improved the percentage of Oct4-GFP-positive cells by more than 100-fold and 50-fold for three-factor (Oct4, Sox2 and Klf4) and four-factor (Oct4, Sox2, Klf4 and c-Myc) reprogramming respectively. VPA enhances reprogramming efficiency and consequently provides a chance for reduc ...
Infusion of a biotinylated bis-glucose photolabel
Infusion of a biotinylated bis-glucose photolabel

... GLUT1 is also expressed in the heart, both in cardiac myocytes, where it has a role in basal glucose uptake (14, 41, 51), and in endothelial cells (9). GLUT1 undergoes modest translocation to the sarcolemma with insulin and ischemia (14, 51), as it does in adipocytes (50). GLUT1 is also regulated at ...
441_2009_904_MOESM1_ESM - Springer Static Content Server
441_2009_904_MOESM1_ESM - Springer Static Content Server

1 Organisation of resp syst
1 Organisation of resp syst

... 2. Exchange O2 & CO2 between lungs (alveoli) and blood (pulmonary capillaries) by diffusion 3. Transportation of O2 & CO2 between lungs and tissues 4. Exchange O2 & CO2 between blood and body tissues by ...
Mechanism System by a Fas Ligand-Dependent of Inflammation in
Mechanism System by a Fas Ligand-Dependent of Inflammation in

... and gld mice, which carry spontaneous mutations in the Fas and FasL genes, respectively (10). Mice carrying either mutation are susceptible to dysregulation of homeostasis within the immune system that can result in autoimmunity (10, 11). In the animal model of the human autoimmune CNS demyelinating ...
Unprocessed Proinsulin Promotes Cell Survival During
Unprocessed Proinsulin Promotes Cell Survival During

... related to or independent of hyperglycemia, may contribute to the appearence of congenital abnormalities. Low insulin levels were reported to cause retarded growth and development in cultured rat embryos (9), but the inaccessibility of neurulating embryos in mammalian models limits in vivo studies. ...
Liu_umd_0117E_10287 - University of Maryland Libraries
Liu_umd_0117E_10287 - University of Maryland Libraries

... 1. Figure 1.1 The structural comparison of FcRn and MHC class I……….….6 2. Figure 1.2 The model for FcRn function………………………………..……14 3. Figure 2.1 FcRn expression in response to cytokine stimulation……………...37 4. Figure 2.2 FcRn expression in response to CpG or LPS stimulation………….39 5. Figure 2.3 Effe ...
The 21-day postnatal rat ventricular cardiac muscle cell in culture as
The 21-day postnatal rat ventricular cardiac muscle cell in culture as

... medium to the experimental set of cardiomyocytes. DMSO (Sigma; 0.02%), the vehicle for TPA, was added to the control set of cardiomyocytes. Cell cycle-specific expression array protocol RNA isolated from 21-day ventricular cardiac muscle cells cultured in the presence or absence of TPA was dissolved ...
Design of Filled One Step Chip Attach Materials for
Design of Filled One Step Chip Attach Materials for

... increased the shear thinning behavior can increase as well but a loading level is reached where the system begins to thicken with shear from the interactions between the filler particles [7] which can work against uniform flow during die placement. At high filler loading levels the high shear viscos ...
Global microRNA depletion suppresses tumor angiogenesis Please share
Global microRNA depletion suppresses tumor angiogenesis Please share

... MicroRNAs are a class of 20- to 22-nucleotide (nt) small RNAs that regulate diverse biological processes (Bartel 2009). The majority of genes in the mammalian genome are regulated by one or more microRNAs (Friedman et al. 2009; Ebert and Sharp 2012). Individual microRNAs and microRNA families have b ...
PHYT 622 Clinical Gross Anatomy
PHYT 622 Clinical Gross Anatomy

... – Made up of closely packed Type I collagenous fibers – arranged nearly in parallel manner to give tensile strength – Arrangement of Collagen Fibers • 1. Less parallel in ligaments to allow these structures to sustain predominant tensile strength in one direction and smaller stresses in other direct ...
Serotonin synchronises convergent extension of
Serotonin synchronises convergent extension of

... in the ectoderm is dependent upon the establishment of striped expression patterns for pair-rule genes which would generate adhesive differences between alternate parasegments of cells. To date, mutational analysis has failed to identify gene products that directly generate an adhesive heterogeneity ...
arteries - Markus Rothkranz
arteries - Markus Rothkranz

... the effect that occurs when you cut an apple in half and it gradually turns yellow. Such anti-glycosylation may be beneficial for diabetes, cataracts, neuropathy, kidney failure and skin conditions, as well as more general anti-aging properties, especially improving skin condition.! ...
1 Organisation of resp syst
1 Organisation of resp syst

... 2. Exchange O2 & CO2 between lungs (alveoli) and blood (pulmonary capillaries) by diffusion 3. Transportation of O2 & CO2 between lungs and tissues 4. Exchange O2 & CO2 between blood and body tissues by ...
Using monoclonal antibodies to label living root hairs: a novel tool
Using monoclonal antibodies to label living root hairs: a novel tool

... hair viability, labeling quality/intensity with and without the inclusion of a detergent (0.85 mM Triton-X100) in the labeling protocol and noted no discernable difference in labeling results. Control experiments also showed that the labeling was specific. Table 1 provides a summary of antibodies us ...
Holes Ch 20
Holes Ch 20

... Development, which includes an increase in size (growth), is the continuous process by which an individual changes from one life phase to another. The life phases are the prenatal period, which begins at fertilization and ends at birth, and the postnatal period, which begins at birth and ends at dea ...
Human Body Systems - MrsWigginsScience
Human Body Systems - MrsWigginsScience

... On Page 10 of your booklet: Write the below statement and fill in the blank. ...
FREE Sample Here
FREE Sample Here

... Ans: Living organisms (1) are chemically complex and highly organized; (2) extract, transform, and use energy from their environment; (3) have the capacity to precisely self-replicate and self-assemble; (4) exploit a chemical interplay with their environment; (5) possess programmatically defined fun ...
invited review - AJP
invited review - AJP

... carbohydrate groups (for review, see Ref. 28). In addition, there are two O-linked groups, including chondroitin sulfate units and phosphate (28). During its transit through the Golgi apparatus, some high-mannose type N-glycans are converted into N-acetyllactosamine chains, some of which have access ...
Physical and Chemical Basis of Cytoplasmic Streaming
Physical and Chemical Basis of Cytoplasmic Streaming

... There are a numberof reviews and symposia reports dealing with various aspects ofnonmuscularcell motility including cytoplasmic streaming (8, 10, 11, 23, 28, 31, 36, 48, 53, 59, 60, 62, 99, 100, 134, 136, 139, 15o, 151, 159). They will provide readers with more comprehensive information on the subje ...
Supplementary information
Supplementary information

... A. ATP dependence of Hsp90β and Hsp70-Hdj1 were compared by the incubation of indicated molecular chaperones with WT p53 (protein concentrations as in main text, Fig. 3), in the presence of 0, 5 and 7 mM of ATP, at temperatures and time periods that allow to distinguish specific activities of both c ...
Causes of Device Accidents
Causes of Device Accidents

... • Malfunction of ESU Active Pencil • Failure to use holster • Failure to use activation tone ...
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Organ-on-a-chip

An organ-on-a-chip (OC) is a multi-channel 3-D microfluidic cell culture chip that simulates the activities, mechanics and physiological response of entire organs and organ systems. It constitutes the subject matter of significant biomedical engineering research, more precisely in bio-MEMS. The convergence of labs-on-chips (LOCs) and cell biology has permitted the study of human physiology in an organ-specific context, introducing a novel model of in vitro multicellular human organisms. One day, they will perhaps abolish the need for animals in drug development and toxin testing.Although multiple publications claim to have translated organ functions onto this interface, the movement towards this microfluidic application is still in its infancy. Organs-on-chips will vary in design and approach between different researchers. As such, validation and optimization of these systems will likely be a long process. Organs that have been simulated by microfluidic devices include the heart, the lung, kidney, artery, bone, cartilage, skin and more.Nevertheless, building valid artificial organs requires not only a precise cellular manipulation, but a detailed understanding of the human body’s fundamental intricate response to any event. A common concern with organs-on-chips lies in the isolation of organs during testing. ""If you don’t use as close to the total physiological system that you can, you’re likely to run into troubles"" says William Haseltine, founder of Rockville, Maryland. Microfabrication, microelectronics and microfluidics offer the prospect of modeling sophisticated in vitro physiological responses under accurately simulated conditions.
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