Download Holes Ch 20

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Hole’s Essentials of Human
Anatomy & Physiology
David Shier
Jackie Butler
Ricki Lewis
Power Points prepared by Melanie Waite-Altringer
Biology Faculty Member of
Anoka-Ramsey Community College
APR Enhanced
Lecture Outlines
Chapter 20
Pregnancy, Growth,
Development, and
Genetics
2
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Introduction
A.
B.
Development, which includes an increase in
size (growth), is the continuous process by
which an individual changes from one life
phase to another.
The life phases are the prenatal period, which
begins at fertilization and ends at birth, and
the postnatal period, which begins at birth and
ends at death.
3
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Pregnancy
A.
Pregnancy is the presence of developing
offspring in the uterus, an event resulting from
fertilization.
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B.
Transport of Sex Cells
1.
Sperm cells must reach the upper onethird of the uterine tubes for
fertilization to occur.
2.
Under the influence of estrogen during
the first half of the menstrual cycle,
uterine secretions are thin, allowing
sperm cells to swim easily toward their
destination.
5
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C.
Fertilization
1.
With the aid of the acrosomal enzyme,
the sperms cells erode away the corona
radiata and zona pellucida surrounding
the secondary oocyte, and one sperm
cell penetrates the egg cell membrane.
2.
When penetration occurs, changes in the
egg cell membrane and zona pellucida
prevent the entry of additional sperm
cells.
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3.
Fusion of egg and sperm nuclei
completes fertilization.
4.
Fertilization results in a diploid zygote.
7
Fig20.02
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Corona radiata
First polar body
Second meiotic
spindle
Cytoplasm of secondary
oocyte
Zona pellucida
Cell membrane
of secondary
oocyte
Acrosome
containing
enzymes
Nucleus
containing
chromosomes
3
1
4
5
2
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Prenatal Period
A.
Early Embryonic Development
1.
Cells undergo a period of mitosis called
cleavage, when cells become smaller
and smaller.
2.
The dividing mass of cells (morula)
moves down the uterine tube to the
uterus, where a stage called the
blastocyst implants in the lining of the
uterus. (This marks the beginning of the
Embryonic Stage)
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3.
The offspring is called an embryo
during the first eight weeks of
development, and a fetus after that time.
4.
Some of the cells of the blastocyst
become the placenta which also
secretes hormones.
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Fig20.03
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Sperm
nucleus
Egg
nucleus
Polar
bodies
Day 0
Pronucleus
formation
begins
Zona pellucida
Zygote
Cleavages (first cleavage completed about 30 hours after fertilization)
Stem cells
Day 1
First cleavage division 2-cell stage
Day 2
4-cell stage
Day 3
Early morula
Day 4
Late morula
Stem cells
Fertilization
occurs about
12-24 hours
after ovulation
Day 6-7
Blastocyst
implantation
Endometrium
Ovulation
Uterus
11
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B.
Hormonal Changes during Pregnancy
1.
The outer layer of cells (trophoblast) of
the blastocyst stage secrete the hormone
human chorionic gonadotropin (hCG),
which maintains the corpus luteum and
thus also maintains the uterine lining
and the pregnancy.
2.
Levels of hCG remain high until the
placenta can produce enough hormones
on its own to maintain the pregnancy.
12
Fig20.05
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Trophoblast
Blastocyst
Inner cell
mass
Uterine
wall
(a)
Invading
trophoblast
13
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3.
The placenta also secretes placental
lactogen for breast development and
estrogens.
4.
Other hormonal changes during
pregnancy include increased secretions
of aldosterone (promotes fluid
retention) and parathyroid hormone (to
maintain a high calcium level in the
blood).
14
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C.
Embryonic Stage
1.
The embryonic stage lasts from the
second to the eighth week of
development, during which time the
placenta develops, and all the main
internal organs and major external
features appear.
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2.
During the second week, the embryo is
now called a gastrula and its inner cell
mass transforms into the embryonic
disc, and layers form within it.
16
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3.
These layers become the three primary
germ layers and give rise to all organ
systems.
a.
Ectoderm gives rise to the
nervous system, portions of
special sensory organs, the
epidermis and epidermal
derivatives, and the linings of the
mouth and anal canal.
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b.
c.
Mesodermal cells form all types
of muscle tissue, bone tissue,
bone marrow, blood, blood and
lymphatic vessels, internal
reproductive organs, kidneys, and
epithelial linings of the body
cavities.
Endodermal cells produce the
epithelial linings of the digestive
tract, respiratory tract, urinary
bladder, and urethra.
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Fig20.07
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Lumen of
uterus
Endometrium
Chorion
Extraembryonic cavity
Primary germ
layers of
embryonic disc
Ectoderm
Mesoderm
Endoderm
Amnion
Amniotic cavity
Connecting stalk
Chorionic villi
Yolk sac
of embryo
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4.
5.
6.
As the embryo implants, the trophoblast
sends out extensions that develop into
chorionic villi.
By the fourth week, the heart is beating,
the head and jaws appear, and limb buds
form.
As the chorionic villi develops
(irregular spaces called lacunae form
around and between the villi),
exchanges of gases and nutrients occur
through the placental membrane.
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7.
8.
9.
By the eighth week, the trophoblast is
now the chorion, a portion of which
develops into the placenta.
During this time, another membrane,
the amnion, is developing around the
embryo and will hold cushioning
amniotic fluid.
An umbilical cord containing two
umbilical arteries and one vein forms.
21
Fig20.08
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Actual length
4 weeks
Actual
length
5 weeks
Actual
length
6 weeks
Actual
length
7 weeks
22
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10.
Two other membranes form in
association with the embryo.
a.
The yolk sac, formed during the
second week, is the first site of
blood cell formation and also
gives rise to the stem cells of the
immune system.
b.
The allantois forms during the
third week and joins the
connecting stalk of the embryo; it
forms blood cells and gives rise
to the umbilical arteries and vein.
c.
Factors that cause congenital
malformations affecting the
embryo are called teratogens.
23
Fig20.12
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Chorion
Umbilical
cord
Allantois
Amnion
Yolk
sac
Extraembryonic
cavity
Amniotic cavity
Maternal
blood
vessels
Developing
placenta
Endometrium
24
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11.
By the beginning of the eighth week,
the embryo is 30 millimeters in length
and all essential body systems have
formed.
25
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D.
Fetal Stage
1.
The fetal stage begins at the end of the
eighth week of development and lasts
until birth.
2.
During this period, growth is rapid and
body proportions change considerably.
3.
Existing structures grow and mature and
only a few new parts appear.
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4.
The body enlarges, the limbs grow to
the relative size they will maintain
throughout development, and the bones
ossify.
5.
During the fifth month, the mother may
feel the fetus move, fine
hair appears, and dead epithelial cells
and sebum cover the skin.
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6.
In the final trimester, brain cells form
rapidly and organs grow and mature as
the fetus greatly increases in size.
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Fig20.14
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Amniotic fluid
Umbilical cord
Placenta
Uterine wall
Cervix
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E.
Fetal Blood and Circulation
1.
Substances diffuse through the placental
membrane and umbilical vessels carry
them to and from the fetus; fetal blood
has a greater oxygen-carrying capacity
than maternal blood.
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2.
The umbilical vein, transporting blood
rich in oxygen and nutrients, enters the
body and travels to the liver where half
of the blood is carried into the liver and
half bypasses the liver through the
ductus venosus on its way to the inferior
vena cava.
31
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3.
4.
A foramen ovale conveys a large
portion of the blood entering the right
atrium from the inferior vena cava,
through the atrial septum, and into the
left atrium, thus bypassing the lungs.
A second lung bypass is the ductus
arteriosus, which conducts some blood
from the pulmonary trunk directly to the
aorta.
32
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5.
Umbilical arteries carry blood from the
internal iliac arteries to the placenta,
where it can exchange wastes and again
pick up nutrients and oxygen.
33
Fig20.15
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Ductus arteriosus
(becomes ligamentum
arteriosum)
Pulmonary artery
Aortic arch
Superior vena cava
Pulmonary veins
Pulmonary trunk
Foramen ovale
(becomes fossa ovalis)
Left atrium
Left ventricle
Inferior vena cava
Abdominal aorta
Ductus venosus
(becomes ligamentum
venosum)
Left renal artery
Common iliac artery
Umbilical arteries
(become medial
umbilical ligaments)
Hepatic portal vein
Umbilical vein
(becomes ligamentum
teres)
Internal iliac artery
Umbilical vein
Placenta
Umbilical arteries
Decreasing
blood
oxygen
level
34
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F.
Birth Process
1.
Pregnancy continues for thirty eight
weeks and terminates in the birth
process.
2.
As the placenta ages, less progesterone
is produced, which normally inhibits
uterine contractions.
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3.
A decreasing progesterone
concentration may stimulate the
synthesis of prostaglandins, which may
initiate labor.
4.
Stretching uterine tissues stimulates the
release of oxytocin from the posterior
pituitary, which stimulates uterine
contractions.
36
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5.
6.
As the fetal head stretches the cervix, a
positive feedback mechanism results in
stronger and stronger uterine
contractions and a greater release of
oxytocin.
Positive feedback causes abdominal
muscles to contract with greater force
and the fetus is forced through the birth
canal to the outside.
37
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7.
Following birth, the placenta is expelled
by the continued uterine contractions
(afterbirth).
38
Fig20.16
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Amniotic sac
Pubic
symphysis
Urinary
bladder
Ruptured
amniotic
sac
Urethra
Placenta
Vagina
Cervix
Rectum
(a)
(b)
Uterus
Placenta
Placenta
Umbilical
cord
(c)
(d)
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Postnatal Period
A.
Following birth, mother and newborn
experience physiological and structural
changes.
40
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B.
Milk Production and Secretion
1.
Following childbirth, the action of
prolactin is no longer inhibited and the
mammary glands are stimulated to
produce large quantities of milk.
2.
First milk, or colostrum, is a watery
fluid rich in proteins and antibodies.
41
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3.
Milk does not readily flow into the
ductile system, but must be triggered to
do so by a reflex involving the infant
suckling at the breast, which triggers
release of oxytocin from the posterior
pituitary.
4.
Human milk is the best possible food
for human babies.
42
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C.
Neonatal Period
1.
The neonatal period begins abruptly at
birth and lasts for four weeks.
2.
The first breath must be forceful to
inflate the lungs for the first time.
a.
Surfactant in a full-term newborn
reduces surface tension.
43
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3.
At birth, the newborn must live off its
fat stores for two to three days until the
mother’s milk comes in.
4.
The newborn is susceptible to
dehydration since the homeostatic
mechanisms involving water
conservation in the kidneys are not yet
fully functioning.
44
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5.
A number of changes occur in the
newborn’s circulation: umbilical vessels
constrict, the ductus venosus constricts,
the foramen ovale closes, and the ductus
arteriosis constricts.
a.
Most of these circulatory changes
are gradual and occur during the
first fifteen minutes after birth,
although it may take up to a year
for the foramen ovale to close.
45
Fig20.18
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Aorta
Ductus arteriosus
constricts and
becomes solid
ligamentum
arteriosum
Foramen ovale
closes and becomes
fossa ovalis
Ductus venosus
constricts and
becomes solid
ligamentum
venosum
Deoxygenated
blood
Liver
Oxygenated
blood
Umbilical
vein becomes
solid
ligamentum
teres
Inferior vena cava
Distal portions
of umbilical
arteries constrict
and become
medial umbilical
ligaments
Proximal portions of
umbilical arteries persist
as superior vesical arteries
46
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Aging
A.
Passive Aging
1.
Passive aging is the breakdown of
structures and slowing of function.
2.
Faulty genetic instructions due to
biochemical abnormalities during cell
division and the breakdown of lipids are
present.
3.
Highly reactive free radicals will kill cells
by destabilizing adjacent molecules.
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B.
Active Aging
1.
Begins prior to birth as certain cells die
as a part of development. This process of
programmed cell death is called apoptosis.
2.
Cells continue to die throughout our
lives so new, healthy cells may replace
them.
48
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Genetics
A.
B.
Inherited traits are determined by DNA
sequences that comprise genes. The field of
genetics investigates how genes confer specific
characteristics that affect health or contribute to
our natural variation, and how genes are passed
from generation to generation.
Mutations occur when the gene’s DNA
sequence changes.
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C.
Chromosomes and Genes Come in Pairs
1.
Charts called karyotypes display the
23 chromosome pairs of a human
somatic cell.
2.
Autosomes are pairs 1 through 22,
and do not carry the genes that
determine sex.
3.
The other two chromosomes, the X
and the Y, determine sex and are
called sex chromosomes.
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4.
5.
6.
7.
Alleles are copies of genes identical or
slightly different.
Identical alleles are homozygous.
Two different alleles are heterozygous.
A combination of alleles is one’s genotype.
The characteristic associated with a
particular genotype is its’ phenotype.
51
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D.
Modes of Inheritance
1.
Patterns of inheritance through
families are called modes of
inheritance.
2.
Dominant and recessive inheritance
a.
Three major modes of inheritance
are autosomal recessive, autosomal
dominant, and X-linked recessive.
b.
A Punnett Square symbolizes the
logic used to determine probabilities
of genotypes in offspring.
c.
A pedigree shows family members
how they are related.
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E.
Multifactorial Traits
1. Most traits are influenced to some
extent by environmental factors, such
as nutrition, physical activity, and
exposure to toxins.
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