New metal complexes as potential therapeutics
... displayed a significantly longer circulation time in the bloodstream and higher accumulation in tumors, as demonstrated by an in vivo biodistribution assay of Lewis lung carcinoma-bearing mice [22]. Reduced accumulation in kidney was also observed, resulting in low nephrotoxicity, one of the major ...
... displayed a significantly longer circulation time in the bloodstream and higher accumulation in tumors, as demonstrated by an in vivo biodistribution assay of Lewis lung carcinoma-bearing mice [22]. Reduced accumulation in kidney was also observed, resulting in low nephrotoxicity, one of the major ...
Deciphering Transcriptional Regulatory Elements that Encode
... TFBSs were obtained from the TRANSFAC database (release 8.2, June 2004).31 Typically, promoter sequences of a set of coregulated genes are scanned using a given PWM, and each subsequence is assigned a score that indicates how similar it is to the PWM; subsequences whose score is above some threshold ...
... TFBSs were obtained from the TRANSFAC database (release 8.2, June 2004).31 Typically, promoter sequences of a set of coregulated genes are scanned using a given PWM, and each subsequence is assigned a score that indicates how similar it is to the PWM; subsequences whose score is above some threshold ...
Ultrastructural studies of t /t mouse embryos
... cell per embryo, but embryos of both genotypes may have as many as two or three, either peripherally or centrally located. They remain larger than the other cells, which continue to divide until individually arrested. The disproportionate cell size results in aberrantly shaped embryos. Since the ?12 ...
... cell per embryo, but embryos of both genotypes may have as many as two or three, either peripherally or centrally located. They remain larger than the other cells, which continue to divide until individually arrested. The disproportionate cell size results in aberrantly shaped embryos. Since the ?12 ...
Dynamics of Nuclear DNA Quantities during Zygote
... appear to have reached the 4C DNA leve1 (74% were at 3.75C or above) than in similar time periods of the first experiment (29% were at 3.7% or above; compare Figure 2, 15-18 and 19-21 hpp, with Figure 3, 17-19 and 19-22 hpp). Yet, at the 23to 26-hpp period of the second experiment (Figure 3), only 5 ...
... appear to have reached the 4C DNA leve1 (74% were at 3.75C or above) than in similar time periods of the first experiment (29% were at 3.7% or above; compare Figure 2, 15-18 and 19-21 hpp, with Figure 3, 17-19 and 19-22 hpp). Yet, at the 23to 26-hpp period of the second experiment (Figure 3), only 5 ...
Prof_Elias_Inorg_lec_10
... Binding of O2 to Hb is cooperative. The presence of bound oxygen favor addition of more O2. The Hb molecule goes from a tense to a relaxed state. Pockets of heme gets more easy for the following O2 units to access due to breaking of some weak interactions. This happens like chain and pulley. The pul ...
... Binding of O2 to Hb is cooperative. The presence of bound oxygen favor addition of more O2. The Hb molecule goes from a tense to a relaxed state. Pockets of heme gets more easy for the following O2 units to access due to breaking of some weak interactions. This happens like chain and pulley. The pul ...
Different Roles for Simple-Cell and Complex
... al. (2001). Connections onto and from inhibitory cells may also express use-dependent changes (Gupta et al., 2000), but these have been omitted for simplicity. As described previously (Troyer et al., 1998), we defined the total synaptic strength of a given type received by a cell by the following: ( ...
... al. (2001). Connections onto and from inhibitory cells may also express use-dependent changes (Gupta et al., 2000), but these have been omitted for simplicity. As described previously (Troyer et al., 1998), we defined the total synaptic strength of a given type received by a cell by the following: ( ...
Determination and Formation of the Basic Body Pattern in Embryo of
... Miya (1950, 1952) carried out several experiments on the differentiation of primordial germ cells and the gonad formation using the similar technique and made clear the predetermination of germinal region and the relation between the segmental genital ridges and the primordial germ cells. From these ...
... Miya (1950, 1952) carried out several experiments on the differentiation of primordial germ cells and the gonad formation using the similar technique and made clear the predetermination of germinal region and the relation between the segmental genital ridges and the primordial germ cells. From these ...
Targeting Membrane-Bound Viral RNA Synthesis Reveals
... integral membrane-spanning component of the coronavirus replicase complex, and since all positive stranded RNA viruses have very similar membrane-spanning or membrane-associated replicase components implicated in anchoring the viral replication complex to host cell-derived membranes, our data sugges ...
... integral membrane-spanning component of the coronavirus replicase complex, and since all positive stranded RNA viruses have very similar membrane-spanning or membrane-associated replicase components implicated in anchoring the viral replication complex to host cell-derived membranes, our data sugges ...
Microreviews in Cell and Molecular Biology
... dynamin and the deformation of certain cellular developments. The conclusion can be made that dynamin has a more adverse affect when there is a lack in its presents and no significant changes or deformities in its over abundance. ...
... dynamin and the deformation of certain cellular developments. The conclusion can be made that dynamin has a more adverse affect when there is a lack in its presents and no significant changes or deformities in its over abundance. ...
Antibiotics for research
... malignant cells. Doxycycline, streptomycin and kanamycin are examples of antibiotics that inhibit protein synthesis by interfering with formation processes at the 30S or 50S subunits of the 70S bacterial ribosome. Finally, antibiotics like monensin and valinomycin act as ionophores and form cationic ...
... malignant cells. Doxycycline, streptomycin and kanamycin are examples of antibiotics that inhibit protein synthesis by interfering with formation processes at the 30S or 50S subunits of the 70S bacterial ribosome. Finally, antibiotics like monensin and valinomycin act as ionophores and form cationic ...
Planar cell polarity signalling regulates cell adhesion properties in
... Organ formation requires the precise assembly of progenitor cells into a functional multicellular structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) ...
... Organ formation requires the precise assembly of progenitor cells into a functional multicellular structure. Mechanical forces probably participate in this process but how they influence organ morphogenesis is still unclear. Here, we show that Wnt11- and Prickle1a-mediated planar cell polarity (PCP) ...
Coordination of Cell Cycle Progression and Mitotic
... frequently involves regulation of antisense transcription (Margaritis et al. 2012; Castelnuovo et al. 2014). While much effort has been spent to elucidate how H3K4 methylation states correlate with gene expression patterns (Briggs et al. 2001; Bernstein et al. 2002; Santos-Rosa et al. 2002; Boa et ...
... frequently involves regulation of antisense transcription (Margaritis et al. 2012; Castelnuovo et al. 2014). While much effort has been spent to elucidate how H3K4 methylation states correlate with gene expression patterns (Briggs et al. 2001; Bernstein et al. 2002; Santos-Rosa et al. 2002; Boa et ...
- PlantingScience
... T R A N S P I R A T I O N & O S M O S I S Organization for Matter and Energy Flow in Organisms (5-‐LS1.C) o Plants acquire their material for growth chiefly from air ...
... T R A N S P I R A T I O N & O S M O S I S Organization for Matter and Energy Flow in Organisms (5-‐LS1.C) o Plants acquire their material for growth chiefly from air ...
Double-Stranded RNA Induces Sickle Erythrocyte
... endothelium is posited as a major determinant of intracapillary transit time and a modulator of vaso-occlusive complications!-6 In recent years, specific adhesion pathways between both microvascular and large vein endothelium and sickle erythrocytes have been elucidated in a number of independent st ...
... endothelium is posited as a major determinant of intracapillary transit time and a modulator of vaso-occlusive complications!-6 In recent years, specific adhesion pathways between both microvascular and large vein endothelium and sickle erythrocytes have been elucidated in a number of independent st ...
Chromosomal DNA demethylation specified by
... In previous studies using the episomal system, there was strong evidence that demethylation of lacO sites is primarily determined by the occupancy of the lacO sites by LacI (Lin et al., 2000). In this study, only a fraction of the lacO sites become demethylated at any time point, and the percentage ...
... In previous studies using the episomal system, there was strong evidence that demethylation of lacO sites is primarily determined by the occupancy of the lacO sites by LacI (Lin et al., 2000). In this study, only a fraction of the lacO sites become demethylated at any time point, and the percentage ...
pdf-Dokument - Universität Bonn
... In eukaryotic cells, GTPase-Activating Proteins (GAPs) are a family of proteins, which acts on small GTP-binding proteins of the Ras superfamily. GAP proteins have a conserved structure and use similar mechanisms, promoting hydrolysis of GTP to GDP. GAPs include several groups based on their substra ...
... In eukaryotic cells, GTPase-Activating Proteins (GAPs) are a family of proteins, which acts on small GTP-binding proteins of the Ras superfamily. GAP proteins have a conserved structure and use similar mechanisms, promoting hydrolysis of GTP to GDP. GAPs include several groups based on their substra ...
Cell and Developmental Biology
... BIOL 331 – Developmental Biology BIOL 332 – Protistology BIOL 337 – Introductory Genetics Laboratory BIOL 338 – Introduction to Genomics BIOL 351 – Plant Physiology I BIOL 352 – Plant Physiology II: Plant Development BIOL 361 – Physiology of Sensory, Nervous & Muscular Systems BIOL 362 – Cellular Ph ...
... BIOL 331 – Developmental Biology BIOL 332 – Protistology BIOL 337 – Introductory Genetics Laboratory BIOL 338 – Introduction to Genomics BIOL 351 – Plant Physiology I BIOL 352 – Plant Physiology II: Plant Development BIOL 361 – Physiology of Sensory, Nervous & Muscular Systems BIOL 362 – Cellular Ph ...
Evidence for particleinduced horizontal gene transfer and serial
... and other organisms (Lengeler et al., 1999). Virus-mediated transfer of genetic elements between bacteria has become a major research topic in the last two decades, whereby conjugation, transduction and transformation are wellinvestigated mechanisms resulting in HGT between prokaryotic organisms. Ho ...
... and other organisms (Lengeler et al., 1999). Virus-mediated transfer of genetic elements between bacteria has become a major research topic in the last two decades, whereby conjugation, transduction and transformation are wellinvestigated mechanisms resulting in HGT between prokaryotic organisms. Ho ...
The role of AMPK and CREB-1 in the regulation of mitochondrial
... element binding protein 1 (CREB-1) as promising candidates, which could control the process of mitochondrial proliferation. To analyze whether AMPK regulates the cytochrome c promoter, a cell line stably expressing a constitutively active AMPKα1-CA was generated. Indeed, AMPKα1-CA kinase activity wa ...
... element binding protein 1 (CREB-1) as promising candidates, which could control the process of mitochondrial proliferation. To analyze whether AMPK regulates the cytochrome c promoter, a cell line stably expressing a constitutively active AMPKα1-CA was generated. Indeed, AMPKα1-CA kinase activity wa ...
Pausing of Golgi Bodies on Microtubules Regulates
... images (Figures 1P and 1Q). In addition to Golgi bodies, we identified a second, relatively rare population (<1 observed per cell per 10 min imaging period) of smaller, homogeneously labeled particles with the same rapid, nonlinear movement as Golgi bodies (Figures 1J and 1K). These particles were i ...
... images (Figures 1P and 1Q). In addition to Golgi bodies, we identified a second, relatively rare population (<1 observed per cell per 10 min imaging period) of smaller, homogeneously labeled particles with the same rapid, nonlinear movement as Golgi bodies (Figures 1J and 1K). These particles were i ...
PLC Biology
... Identify the structures of the respiratory system Describe gas exchange in the lungs Describe the mechanism of ventilation Evaluate the use of artificial ventilators Exchange systems in plants Identify where exchange happens in plants Explain how the roots and leaves are adapted for exchange Describ ...
... Identify the structures of the respiratory system Describe gas exchange in the lungs Describe the mechanism of ventilation Evaluate the use of artificial ventilators Exchange systems in plants Identify where exchange happens in plants Explain how the roots and leaves are adapted for exchange Describ ...
Glucose-6-phosphate Metabolic Preferential Destinations
... transport of the oocyte in the oviduct is achieved by ciliary beating of the oviductal epithelial cells and by contraction of the oviductal smooth muscle [13]. The massaging and gamete transport events require energy from the cells along the oviduct. We suggest that the accumulation of pyruvate in t ...
... transport of the oocyte in the oviduct is achieved by ciliary beating of the oviductal epithelial cells and by contraction of the oviductal smooth muscle [13]. The massaging and gamete transport events require energy from the cells along the oviduct. We suggest that the accumulation of pyruvate in t ...