Pompe disease Geel, Tessa Marieke
... chaperone therapy was used to enhance the residual acid-α-glucosidase activity by rescuing unstable or misfolded proteins. Partial restoration of the mutant GAA enzyme was achieved using different small chemical chaperones leading to a significant increase in GAA activity in patient derived fibrobla ...
... chaperone therapy was used to enhance the residual acid-α-glucosidase activity by rescuing unstable or misfolded proteins. Partial restoration of the mutant GAA enzyme was achieved using different small chemical chaperones leading to a significant increase in GAA activity in patient derived fibrobla ...
Zinc finger nucleases: custom-designed molecular scissors for
... are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permission ...
... are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permission ...
Lung capillaries raise the hypoxia alarm
... NADPH oxidase induction (8). The PAR-1 activator thrombin also induces endothelial Ca2+ entry through the α1G channel to activate endothelial expression of the leukocyte adhesion receptor P-selectin in alveolar capillaries (9). Taking these diverse findings together, it would seem that voltage-activ ...
... NADPH oxidase induction (8). The PAR-1 activator thrombin also induces endothelial Ca2+ entry through the α1G channel to activate endothelial expression of the leukocyte adhesion receptor P-selectin in alveolar capillaries (9). Taking these diverse findings together, it would seem that voltage-activ ...
Hypothetical photosensory structure in ciliated protozoan, Blepharisma
... Ultrastructural changes during encystment (resting cyst formation) of Colpoda cucullus were observed with special reference to cyst wall formation. Within 1.5 h after encystment induction, fragmentation of some of the mitochondria occurred, followed by the appearance of a number of net-like globules ...
... Ultrastructural changes during encystment (resting cyst formation) of Colpoda cucullus were observed with special reference to cyst wall formation. Within 1.5 h after encystment induction, fragmentation of some of the mitochondria occurred, followed by the appearance of a number of net-like globules ...
The Salmonella Effector Protein SopA Modulates Innate Immune
... better understand the potential significance of its interaction with SopA, we searched for TRIM65-interacting proteins. We transduced THP-1 monocytic cells with a retroviral vector expressing FLAG epitope-tagged TRIM65 or an equally tagged irrelevant protein (as a control), and interacting proteins ...
... better understand the potential significance of its interaction with SopA, we searched for TRIM65-interacting proteins. We transduced THP-1 monocytic cells with a retroviral vector expressing FLAG epitope-tagged TRIM65 or an equally tagged irrelevant protein (as a control), and interacting proteins ...
- Lorentz Center
... The prevailing paradigm for vertebrate segmentation, does not address the issue of cleavage and mechanical separation is viewed as of secondary importance. It is believed that the principal role is played by a cellular oscillator which interacts with a traveling wave of morphogens and in this way pr ...
... The prevailing paradigm for vertebrate segmentation, does not address the issue of cleavage and mechanical separation is viewed as of secondary importance. It is believed that the principal role is played by a cellular oscillator which interacts with a traveling wave of morphogens and in this way pr ...
Study Guide for Chapter 1 Test
... o Explain how food provides energy o Distinguish between calories and Calories o Identify the 6 essential nutrients: water, carbs, fats, proteins, vitamins, minerals Explain why they are needed for life in terms of their functions Sec 38-2 o Describe the overall function of the digestive system an ...
... o Explain how food provides energy o Distinguish between calories and Calories o Identify the 6 essential nutrients: water, carbs, fats, proteins, vitamins, minerals Explain why they are needed for life in terms of their functions Sec 38-2 o Describe the overall function of the digestive system an ...
PDF
... characterized by an N-terminal bHLH domain required for DNA binding and dimerization, as well as by a PAS domain that acts as a secondary dimerization interface (Crews and Fan, 1999; Taylor and Zhulin, 1999). Transcriptional control of target genes requires heterodimerization of class I and class II ...
... characterized by an N-terminal bHLH domain required for DNA binding and dimerization, as well as by a PAS domain that acts as a secondary dimerization interface (Crews and Fan, 1999; Taylor and Zhulin, 1999). Transcriptional control of target genes requires heterodimerization of class I and class II ...
The Role of Cytoskeletal Elements in Shaping Bacterial Cells
... Beginning from the recognition of FtsZ as a bacterial tubulin homolog in the early 1990s, many bacterial cytoskeletal elements have been identified, including homologs to the major eukaryotic cytoskeletal elements (tubulin, actin, and intermediate filament) and the elements unique in prokaryotes (Pa ...
... Beginning from the recognition of FtsZ as a bacterial tubulin homolog in the early 1990s, many bacterial cytoskeletal elements have been identified, including homologs to the major eukaryotic cytoskeletal elements (tubulin, actin, and intermediate filament) and the elements unique in prokaryotes (Pa ...
Extracellular ATP: a Potential Molecule Regulating the Defence
... Extracellular ATP: a Potential Molecule Regulating the Defence Response of Plants to Biotic Stresses – a Review Lingyun Jia, Jingyue Bai, Dongdong Guan, Kun Sun, Qingsong Jiao and Hanqing Feng College of Life Science, Northwest Normal University, Lanzhou, P.R. China Abstract Jia L., Bai J., Guan D., ...
... Extracellular ATP: a Potential Molecule Regulating the Defence Response of Plants to Biotic Stresses – a Review Lingyun Jia, Jingyue Bai, Dongdong Guan, Kun Sun, Qingsong Jiao and Hanqing Feng College of Life Science, Northwest Normal University, Lanzhou, P.R. China Abstract Jia L., Bai J., Guan D., ...
CD95 ligation and intracellular membrane flow
... signalling [5]. Despite these uncertainties in defining the role of endocytosis in apoptosis induction in type II cells, these and previous observations by Matarrese et al. [6,7] open an interesting field of research on the interplay between death receptor engagement and intracellular membrane flow. ...
... signalling [5]. Despite these uncertainties in defining the role of endocytosis in apoptosis induction in type II cells, these and previous observations by Matarrese et al. [6,7] open an interesting field of research on the interplay between death receptor engagement and intracellular membrane flow. ...
Subthreshold High-Frequency Electrical Field
... onto six-well dishes (140685; Nunc, Schwerte, Germany) at a density of 3 × 105 cells per well. Cells were grown in DMEM/Ham’s F-12 + l-glutamine (FG-4815; Biochrom) supplemented with 10% horse serum (B15-021; PPA) and 5% fetal bovine serum (A-15-101; PPA). After 24 h, the serum medium was removed, a ...
... onto six-well dishes (140685; Nunc, Schwerte, Germany) at a density of 3 × 105 cells per well. Cells were grown in DMEM/Ham’s F-12 + l-glutamine (FG-4815; Biochrom) supplemented with 10% horse serum (B15-021; PPA) and 5% fetal bovine serum (A-15-101; PPA). After 24 h, the serum medium was removed, a ...
Quantifying the range of a lipid phosphate signal in vivo
... that the extracellular part of Wunens acts as a membrane-bound ligand, therefore germ cells would have to make direct contact with the somatic Wunen-expressing cells in order to sense them (Zhang et al., 1997). Subsequent work has demonstrated that the catalytic activity of Wunens is essential for t ...
... that the extracellular part of Wunens acts as a membrane-bound ligand, therefore germ cells would have to make direct contact with the somatic Wunen-expressing cells in order to sense them (Zhang et al., 1997). Subsequent work has demonstrated that the catalytic activity of Wunens is essential for t ...
Abstract
... cells (Iwamoto et al., 1995), rat neonatal cardiomyocytes (Iwamoto et al., 1996), and rat hepatocytes (Ikari et al., 1998). But PKC down-regulates the NCX activity in other cell types, such as bovine chromaffin cells (Tokumura et al., 1998). Recently, macromolecular complexes have been found to regu ...
... cells (Iwamoto et al., 1995), rat neonatal cardiomyocytes (Iwamoto et al., 1996), and rat hepatocytes (Ikari et al., 1998). But PKC down-regulates the NCX activity in other cell types, such as bovine chromaffin cells (Tokumura et al., 1998). Recently, macromolecular complexes have been found to regu ...
ATM - dump.no
... types of traffic simultaneously, including realtime voice, video, and bursty TCP traffic Way in which data flow is handled depends on the characteristics of the traffic flow and requirements of the application (ex. Real-time video must be delivered within minimum variation in delay) Primary serv ...
... types of traffic simultaneously, including realtime voice, video, and bursty TCP traffic Way in which data flow is handled depends on the characteristics of the traffic flow and requirements of the application (ex. Real-time video must be delivered within minimum variation in delay) Primary serv ...
Divergent mechanisms underlie Smad4
... cells was retained. Rather, Smad4 induced mesenchymal to epithelial reversion through induction of E-cadherin [15,17]. We also found that Smad4-positive SW480 cells in contrast to Smad4-negative clones deposited an adhesive matrix in vitro on tissue culture plastic. Based on this observation we iden ...
... cells was retained. Rather, Smad4 induced mesenchymal to epithelial reversion through induction of E-cadherin [15,17]. We also found that Smad4-positive SW480 cells in contrast to Smad4-negative clones deposited an adhesive matrix in vitro on tissue culture plastic. Based on this observation we iden ...
Guidance of mesoderm cell migration in the Xenopus
... migration is essential for gastrulation in the chicken (Harrisson et al., 1993), and contributes to germ layer formation in carp (Gevers et al., 1993) and zebrafish (Yamashita et al., 2002). In the mouse, null mutations for various integrins and matrix proteins have not yet provided conclusive evide ...
... migration is essential for gastrulation in the chicken (Harrisson et al., 1993), and contributes to germ layer formation in carp (Gevers et al., 1993) and zebrafish (Yamashita et al., 2002). In the mouse, null mutations for various integrins and matrix proteins have not yet provided conclusive evide ...
Control of cell pattern in the neural tube: regulation of cell
... or a response to inductive factors that are distinct from the ventralizing signals that derive from the notochord and floor plate. To identify signals that might regulate cell differentiation within the neural tube, we have searched for genes encoding secreted factors that are expressed in a restric ...
... or a response to inductive factors that are distinct from the ventralizing signals that derive from the notochord and floor plate. To identify signals that might regulate cell differentiation within the neural tube, we have searched for genes encoding secreted factors that are expressed in a restric ...
Active Stable Maintenance Functions in Low Copy
... and Ceglowski, 2005). Initial studies have shown that the effect of Zeta in B. subtilis cells is bacteriocidal; it provoked changes in cell morphology (smaller and finer cells) and has led to cell lysis, whereas the Zeta action in E. coli cells is bacteriostatic, cells tend to form filaments, what s ...
... and Ceglowski, 2005). Initial studies have shown that the effect of Zeta in B. subtilis cells is bacteriocidal; it provoked changes in cell morphology (smaller and finer cells) and has led to cell lysis, whereas the Zeta action in E. coli cells is bacteriostatic, cells tend to form filaments, what s ...
Adenovirus Overrides Cellular Checkpoints for Protein Translation
... we have been unable to detect any binding at all, of either wild type or mutant E4-ORF4, to endogenous c-Src. These data suggest that the ability of E4-ORF4 to activate mTOR is most likely through its binding and modulation of the regulatory B subunit of PP2A. Thus, E4-ORF4 may reveal a novel role f ...
... we have been unable to detect any binding at all, of either wild type or mutant E4-ORF4, to endogenous c-Src. These data suggest that the ability of E4-ORF4 to activate mTOR is most likely through its binding and modulation of the regulatory B subunit of PP2A. Thus, E4-ORF4 may reveal a novel role f ...
Symbiotic Nitrogen Fixation
... proteins that synthesize or add various substituents. These substitutions determine host specificity as well as the biological activity of the molecules. For example, in R. meliloti, the nodH and nodPQ genes are the major host range determinants (Roche et al., 1991). NodPQ proteins have been shown t ...
... proteins that synthesize or add various substituents. These substitutions determine host specificity as well as the biological activity of the molecules. For example, in R. meliloti, the nodH and nodPQ genes are the major host range determinants (Roche et al., 1991). NodPQ proteins have been shown t ...
The Type II Arabidopsis Formin14 Interacts with Microtubules and
... Significant evidence indicates that the classical formins play important roles in microfilament organization. Therefore, fluorescently labeled phalloidin was used to visualize microfilaments in BY-2 cells. In control uninduced cells, microfilaments formed a cage around the spindle, and very few fila ...
... Significant evidence indicates that the classical formins play important roles in microfilament organization. Therefore, fluorescently labeled phalloidin was used to visualize microfilaments in BY-2 cells. In control uninduced cells, microfilaments formed a cage around the spindle, and very few fila ...
Differences between Edexcel `A` and `B`
... electron microscopy Understand the importance of staining specimens in microscopy CORE PRACTICAL 2: Use of the light microscope, including simple stage and eyepiece micrometers and drawing small numbers of cells from a specialised tissue. Understand that the classification of viruses is based on str ...
... electron microscopy Understand the importance of staining specimens in microscopy CORE PRACTICAL 2: Use of the light microscope, including simple stage and eyepiece micrometers and drawing small numbers of cells from a specialised tissue. Understand that the classification of viruses is based on str ...
Circulation is established in a stepwise pattern in the mammalian
... Figure 1. Asymmetric blood formation and first blood flow in early somite pair embryos. In rodents, the embryo proper develops within the amnionic sac, which itself is within the yolk sac. In this figure, the yolk sac was photographed with the embryo proper inside, except for panels D and I, where t ...
... Figure 1. Asymmetric blood formation and first blood flow in early somite pair embryos. In rodents, the embryo proper develops within the amnionic sac, which itself is within the yolk sac. In this figure, the yolk sac was photographed with the embryo proper inside, except for panels D and I, where t ...