
Epigenetic Interactions among Three dTph1
... of progeny with an an3mut phenotype similar to the parental line and z50% with an An31 revertant phenotype (data not shown). In progenies obtained by selfing R134/R134 or S205/S205 plants, we found at a low frequency (1 to 5%) plants with a very low spotting frequency (weakly an3 mut) that were ofte ...
... of progeny with an an3mut phenotype similar to the parental line and z50% with an An31 revertant phenotype (data not shown). In progenies obtained by selfing R134/R134 or S205/S205 plants, we found at a low frequency (1 to 5%) plants with a very low spotting frequency (weakly an3 mut) that were ofte ...
References
... candidates identified here and how their effects on parental and offspring traits are ...
... candidates identified here and how their effects on parental and offspring traits are ...
Hox, ParaHox, ProtoHox: facts and guesses
... the suggestion that numbers of Hox and ParaHox genes may well be correlated with increase in body plan complexity, and antero-posterior diversification, I propose the following hypothesis for some of the major Metazoan evolutionary transitions (Figure 3b): First, a ProtoHox cluster with two genes wa ...
... the suggestion that numbers of Hox and ParaHox genes may well be correlated with increase in body plan complexity, and antero-posterior diversification, I propose the following hypothesis for some of the major Metazoan evolutionary transitions (Figure 3b): First, a ProtoHox cluster with two genes wa ...
Applied Microbiology and Biotechnology
... of 224 U mg−1 using phytate and 49 U mg−1 using pnitrophenyl phosphate as substrate. Apparent molecular mass and specific activities of the enzyme prepared from ASR1 are similar to those described for phytase from K. terrigena (Greiner et al. 1997). Cloning and expression of alkaline and acid phosph ...
... of 224 U mg−1 using phytate and 49 U mg−1 using pnitrophenyl phosphate as substrate. Apparent molecular mass and specific activities of the enzyme prepared from ASR1 are similar to those described for phytase from K. terrigena (Greiner et al. 1997). Cloning and expression of alkaline and acid phosph ...
Gene Technology Regulation 2004
... The status of this republication appears on the bottom of each page. Editorial changes The Legislation Act 2001, part 11.3 authorises the Parliamentary Counsel to make editorial amendments and other changes of a formal nature when preparing a law for republication. Editorial changes do not change th ...
... The status of this republication appears on the bottom of each page. Editorial changes The Legislation Act 2001, part 11.3 authorises the Parliamentary Counsel to make editorial amendments and other changes of a formal nature when preparing a law for republication. Editorial changes do not change th ...
please click, ppt - Department of Statistics | Rajshahi University
... construction of a genetic linkage map that cover partly or entirely the genome. The map function that converts the recombination fraction to genetic distance can be derived from three-point analysis. Different forms of the map function are available that depend on the assumption about the presence o ...
... construction of a genetic linkage map that cover partly or entirely the genome. The map function that converts the recombination fraction to genetic distance can be derived from three-point analysis. Different forms of the map function are available that depend on the assumption about the presence o ...
HED - National Foundation for Ectodermal Dysplasias
... are), it is delicate and may change as it passes from one generation to the next. Many of the changes in DNA, called mutations, are harmful; that is, they may lead to abnormal development or function. Second, short segments of DNA control specific developmental events and are called genes. Genes are ...
... are), it is delicate and may change as it passes from one generation to the next. Many of the changes in DNA, called mutations, are harmful; that is, they may lead to abnormal development or function. Second, short segments of DNA control specific developmental events and are called genes. Genes are ...
The Nodal Pathway Acts Upstream of Hedgehog
... 1998). However, the source, exact role, site, and time of action of Hh proteins during anterior CNS patterning remain uncertain. For instance, although shh is expressed within the telencephalon, the endogenous source of Hh proteins that influence early development of this region are uncertain and pr ...
... 1998). However, the source, exact role, site, and time of action of Hh proteins during anterior CNS patterning remain uncertain. For instance, although shh is expressed within the telencephalon, the endogenous source of Hh proteins that influence early development of this region are uncertain and pr ...
Telomeres, telomerase and plant development
... now known to be present in the telomeres of all plants examined. Unlike the situation in higher plants, where almost all telomeres are composed of TTTAGGG repeats, telomeres in green algae are more variable. Although telomeres of Chlorella vulgaris contain the TTTAGGG repeat11, telomeres of Chlamydo ...
... now known to be present in the telomeres of all plants examined. Unlike the situation in higher plants, where almost all telomeres are composed of TTTAGGG repeats, telomeres in green algae are more variable. Although telomeres of Chlorella vulgaris contain the TTTAGGG repeat11, telomeres of Chlamydo ...
Comparative analysis of two-component signal transduction systems
... Members of the Bacillus cereus group are ubiquitously present in the environment and can adapt to a wide range of environmental fluctuations. In bacteria, these adaptive responses are generally mediated by two-component signal transduction systems (TCSs), which consist of a histidine kinase (HK) and ...
... Members of the Bacillus cereus group are ubiquitously present in the environment and can adapt to a wide range of environmental fluctuations. In bacteria, these adaptive responses are generally mediated by two-component signal transduction systems (TCSs), which consist of a histidine kinase (HK) and ...
21 hydroxylase deficiency
... POMC – ACTH increase • ACTH + possibly other peptides derived from the amino-terminal end of POMC stimulate adrenal hypertrophy and hyperplasia (most prominent finding at autopsy). ...
... POMC – ACTH increase • ACTH + possibly other peptides derived from the amino-terminal end of POMC stimulate adrenal hypertrophy and hyperplasia (most prominent finding at autopsy). ...
Rates of Spontaneous Mutation
... measured target vary by many orders of magnitude depending on the mutational target size (from 1 to .10 10 b, where b stands for base or base pair as appropriate), the average mutability per b (from 1024 to 102 11 per b per replication), and the specific mutability of a particular b (which can vary ...
... measured target vary by many orders of magnitude depending on the mutational target size (from 1 to .10 10 b, where b stands for base or base pair as appropriate), the average mutability per b (from 1024 to 102 11 per b per replication), and the specific mutability of a particular b (which can vary ...
Storage cells in the bone marrow
... Cytogenetic techniques were improving and with the introduction of chromosome banding there was a quantum leap in what could be recognized • The incorporation of cytogenetic information into leukaemia classification started, e.g. MIC Group 1986. ...
... Cytogenetic techniques were improving and with the introduction of chromosome banding there was a quantum leap in what could be recognized • The incorporation of cytogenetic information into leukaemia classification started, e.g. MIC Group 1986. ...
Non-random Allelic Variation
... “a coach selects a team of oarsmen for a crew race by repeatedly shifting oarsmen among several boats and racing them, after several trials the winning boat will have all the same oarsmen. A crew member finally chosen will have been grouped with both good and inferior ones at different times, but on ...
... “a coach selects a team of oarsmen for a crew race by repeatedly shifting oarsmen among several boats and racing them, after several trials the winning boat will have all the same oarsmen. A crew member finally chosen will have been grouped with both good and inferior ones at different times, but on ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... appreciate by Humphrey Davy from the time that nitrous oxide was first used for analgesia by Horace wells in 1844 until 1956, nitrous oxide was considered to be completely benign. The first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al in the Lancet in ...
... appreciate by Humphrey Davy from the time that nitrous oxide was first used for analgesia by Horace wells in 1844 until 1956, nitrous oxide was considered to be completely benign. The first clear association of nitrous oxide and hematologic disease came in a report by Lassen, et al in the Lancet in ...
WASP - Genome Institute, BIOTEC
... Background: Allele-specific (AS) Polymerase Chain Reaction is a convenient and inexpensive method for genotyping Single Nucleotide Polymorphisms (SNPs) and mutations. It is applied in many recent studies including population genetics, molecular genetics and pharmacogenomics. Using known AS primer de ...
... Background: Allele-specific (AS) Polymerase Chain Reaction is a convenient and inexpensive method for genotyping Single Nucleotide Polymorphisms (SNPs) and mutations. It is applied in many recent studies including population genetics, molecular genetics and pharmacogenomics. Using known AS primer de ...
Strains to Theiler`s Virus Persistent Infection the Difference of
... the Sequenase kit (Amersham, Arlington Heights, IL). Two polymorphisms were detected between the two mouse strains: a mutation in an SphI restriction enzyme site of the SJL/J genome (GCATGC3 ACATGC) and a 16-bp deletion, which we named D10Pas4, just upstream of the TATA box (see Results). The follow ...
... the Sequenase kit (Amersham, Arlington Heights, IL). Two polymorphisms were detected between the two mouse strains: a mutation in an SphI restriction enzyme site of the SJL/J genome (GCATGC3 ACATGC) and a 16-bp deletion, which we named D10Pas4, just upstream of the TATA box (see Results). The follow ...
Flowering Newsletter bibliography for 2007
... Biochemistry and Molecular Biology 40, 1083–1089. Cockram J, Chiapparino E, Taylor S, Stamati K, Donini P, Laurie DA, O’Sullivan D. 2007. Haplotype analysis of vernalization loci in European barley germplasm reveals novel VRN-H1 alleles and a predominant winter VRN-H1/VRN-H2 multi-locus haplotype. T ...
... Biochemistry and Molecular Biology 40, 1083–1089. Cockram J, Chiapparino E, Taylor S, Stamati K, Donini P, Laurie DA, O’Sullivan D. 2007. Haplotype analysis of vernalization loci in European barley germplasm reveals novel VRN-H1 alleles and a predominant winter VRN-H1/VRN-H2 multi-locus haplotype. T ...
Independent functions of viral protein and nucleic
... dried samples sufficiently small to avoid losses by self-absorption. For absolute measurements, reference solutions of P~ obtained from the National Bureau of Standards, as well as a permanent simulated standard, were used. For absolute measurements of Ss5 we relied on the assays (4-20 per cent) fur ...
... dried samples sufficiently small to avoid losses by self-absorption. For absolute measurements, reference solutions of P~ obtained from the National Bureau of Standards, as well as a permanent simulated standard, were used. For absolute measurements of Ss5 we relied on the assays (4-20 per cent) fur ...
CHK2 kinase: cancer susceptibility and cancer therapy – two sides
... the mouse Chek2 gene obliterates p53-dependent cell death following radiation23,33–35. Moreover, the DNAdependent protein kinase, DNA-PK (also known as PRKDC), which functions in the NHEJ pathway, can act synergistically with CHK2 to activate p53-dependent apoptosis in response to DNA damage, as wel ...
... the mouse Chek2 gene obliterates p53-dependent cell death following radiation23,33–35. Moreover, the DNAdependent protein kinase, DNA-PK (also known as PRKDC), which functions in the NHEJ pathway, can act synergistically with CHK2 to activate p53-dependent apoptosis in response to DNA damage, as wel ...
(From the Department of Genetics, Carnegie Institution of
... dried samples sufficiently small to avoid losses by self-absorption. For absolute measurements, reference solutions of P~ obtained from the National Bureau of Standards, as well as a permanent simulated standard, were used. For absolute measurements of Ss5 we relied on the assays (4-20 per cent) fur ...
... dried samples sufficiently small to avoid losses by self-absorption. For absolute measurements, reference solutions of P~ obtained from the National Bureau of Standards, as well as a permanent simulated standard, were used. For absolute measurements of Ss5 we relied on the assays (4-20 per cent) fur ...
Fragaria multicipita - DigitalCommons@University of Nebraska
... standards used were PhiX174 RF HaeIII digest (Life Technologies) and 1.6 kb ladder (Fermentas AB, Vilnius, Lithuania). RFLP patterns were compared with those previously published (Davis et al., 1997; Jomantiene et al. 1998a,b, 2002; Lee et al. 1998). Phytoplasma 16S rRNA group and subgroup designati ...
... standards used were PhiX174 RF HaeIII digest (Life Technologies) and 1.6 kb ladder (Fermentas AB, Vilnius, Lithuania). RFLP patterns were compared with those previously published (Davis et al., 1997; Jomantiene et al. 1998a,b, 2002; Lee et al. 1998). Phytoplasma 16S rRNA group and subgroup designati ...
Evidence that MEK1 positively promotes
... segregation of homologous chromosomes to opposite poles is dependent upon the interhomologue joints mediated by crossovers and sister chromatid cohesion. Without crossovers or sister chromatid cohesion homologue segregation becomes randomized, causing first meiotic non-disjunction. In some organisms ...
... segregation of homologous chromosomes to opposite poles is dependent upon the interhomologue joints mediated by crossovers and sister chromatid cohesion. Without crossovers or sister chromatid cohesion homologue segregation becomes randomized, causing first meiotic non-disjunction. In some organisms ...
Site-specific recombinase technology

Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse