Aberrant DNA methylation in cancer: potential clinical
... affect the genetic code. The human genome exhibits a clear depletion of CpG dinucleotides, presumably due to the high rate of deamination of 5-methylcytosine to thymine (Ref. 1). However, the genome also contains small stretches, up to a few kilobases in length, that are comparatively rich in CpG di ...
... affect the genetic code. The human genome exhibits a clear depletion of CpG dinucleotides, presumably due to the high rate of deamination of 5-methylcytosine to thymine (Ref. 1). However, the genome also contains small stretches, up to a few kilobases in length, that are comparatively rich in CpG di ...
Biochemical but not clinical vitamin A deficiency results from
... Neither sibling had a history of systemic disease. Objective: Our aim was to investigate the cause of the retinol deficiency in these 2 siblings. Design: The 2 siblings and their mother were examined clinically, including administration of the relative-dose-response test, DNA sequencing of the RBP g ...
... Neither sibling had a history of systemic disease. Objective: Our aim was to investigate the cause of the retinol deficiency in these 2 siblings. Design: The 2 siblings and their mother were examined clinically, including administration of the relative-dose-response test, DNA sequencing of the RBP g ...
Contents - BITS
... detergents…) decrease the amplification efficiency… The presence of inhibitors is not only a result of the RNA extraction procedure but different tissues are known to exhibit different PCR efficiencies, caused by RT inhibitors, PCR inhibitors and by variations in the total RNA fraction pattern extra ...
... detergents…) decrease the amplification efficiency… The presence of inhibitors is not only a result of the RNA extraction procedure but different tissues are known to exhibit different PCR efficiencies, caused by RT inhibitors, PCR inhibitors and by variations in the total RNA fraction pattern extra ...
Genome-Wide Copy Number Variation in Epilepsy: Novel
... some cases, the epilepsy has a clear cause such as an abnormality in the brain or a head injury. However, in many cases there is no obvious cause. Numerous studies have shown that genetic factors are important in these types of epilepsy, but although several epilepsy genes are known, we can still on ...
... some cases, the epilepsy has a clear cause such as an abnormality in the brain or a head injury. However, in many cases there is no obvious cause. Numerous studies have shown that genetic factors are important in these types of epilepsy, but although several epilepsy genes are known, we can still on ...
PHANTASTICA Regulates Development of the Adaxial Mesophyll in
... (Lincoln et al., 1994; Schneeberger et al., 1995; Chuck et al., 1996). The Arabidopsis studies show that several KNOX genes, including KNAT1/BREVIPEDICELLUS (BP), KNAT2, and KNAT6, are ectopically expressed in the absence of AS1 function. This concerted response makes it uncertain as to which KNOX g ...
... (Lincoln et al., 1994; Schneeberger et al., 1995; Chuck et al., 1996). The Arabidopsis studies show that several KNOX genes, including KNAT1/BREVIPEDICELLUS (BP), KNAT2, and KNAT6, are ectopically expressed in the absence of AS1 function. This concerted response makes it uncertain as to which KNOX g ...
Package 'MatrixEQTL'
... heteroskedastic and/or correlated errors. Associations significant at pvOutputThreshold (pvOutputThreshold.cis) levels are saved to output_file_name (output_file_name.cis), with corresponding estimates of effect size (slope coefficient), test statistics, p-values, and q-values (false discovery rate) ...
... heteroskedastic and/or correlated errors. Associations significant at pvOutputThreshold (pvOutputThreshold.cis) levels are saved to output_file_name (output_file_name.cis), with corresponding estimates of effect size (slope coefficient), test statistics, p-values, and q-values (false discovery rate) ...
Are sperm-binding proteins among two closely related frog species
... classified as a pre-zygotic block to fertilization (versus post-zygotic mechanisms that occur due to genetic incompatibilities after zygote formation). It is thought that rapid changes in the egg's sperm-binding protein, termed ZPC or ZP3 in vertebrate species (discussed in more detail later), could ...
... classified as a pre-zygotic block to fertilization (versus post-zygotic mechanisms that occur due to genetic incompatibilities after zygote formation). It is thought that rapid changes in the egg's sperm-binding protein, termed ZPC or ZP3 in vertebrate species (discussed in more detail later), could ...
French 2003 - University of Washington
... Anterior is upper left. The dorsal side of the egg chamber is marked by the dorsal appendages, which extend anteriorly from the main body of the egg. (B) A stage-14 twk egg chamber. The arrows indicate the mutant dorsal appendages. While two appendages initially formed with proper spacing, these app ...
... Anterior is upper left. The dorsal side of the egg chamber is marked by the dorsal appendages, which extend anteriorly from the main body of the egg. (B) A stage-14 twk egg chamber. The arrows indicate the mutant dorsal appendages. While two appendages initially formed with proper spacing, these app ...
TIB_34 - Stored Product Insect and Engineering Research
... conditions for both sexes in Reps 1-3 (see Table 5 and 6). Additionally, disregarding the effect of the environment in which the selections were practiced, the crowded testing conditions produced a significantly greater mean in both sexes for Reps 1,3 and 4 (see Tables 5 and 7). These results imply ...
... conditions for both sexes in Reps 1-3 (see Table 5 and 6). Additionally, disregarding the effect of the environment in which the selections were practiced, the crowded testing conditions produced a significantly greater mean in both sexes for Reps 1,3 and 4 (see Tables 5 and 7). These results imply ...
Annotation Strategy Guide - GEP Community Server
... While extension of an open reading frame is important for conserving the length of the coding exon, it is also important to consider selecting the best-supported splice site. For example, let’s look at the first coding exon (1_2365_0) of Dyrk3 in D. mojavensis. Found on contig37, the blastx track on ...
... While extension of an open reading frame is important for conserving the length of the coding exon, it is also important to consider selecting the best-supported splice site. For example, let’s look at the first coding exon (1_2365_0) of Dyrk3 in D. mojavensis. Found on contig37, the blastx track on ...
Molecular Plant-Microbio Interactions
... 0.47 kb of the first open reading frame (ORF) downstream of the Tn5lacZ insertion and was cloned into pIC20H with PstI and KpnI, resulting in pMP5401. Screening of the genomic library resulted in the isolation of a DNA fragment of approximately 11 kb, which was cloned into a pBluescript vector (Stra ...
... 0.47 kb of the first open reading frame (ORF) downstream of the Tn5lacZ insertion and was cloned into pIC20H with PstI and KpnI, resulting in pMP5401. Screening of the genomic library resulted in the isolation of a DNA fragment of approximately 11 kb, which was cloned into a pBluescript vector (Stra ...
Understanding the Scurred condition in Polled Cattle
... Understanding the Scurred condition in Polled Cattle Most calves that are horned can be identified at birth or shortly after, and almost always by weaning time. Distinguishing between smooth-polled and scurred-polled is more difficult. Scurs, a rudimentary horn growth, are often not seen until cattl ...
... Understanding the Scurred condition in Polled Cattle Most calves that are horned can be identified at birth or shortly after, and almost always by weaning time. Distinguishing between smooth-polled and scurred-polled is more difficult. Scurs, a rudimentary horn growth, are often not seen until cattl ...
TRIPTYCHON and CAPRICE mediate lateral inhibition during
... epidermis, although this particular ®nding was interpreted as an unspeci®c competition with the trichome-promoting factor GL1 (Wada et al., 1997). In this work, we report the positional cloning and molecular characterization of the TRY gene. TRY encodes a MYB-related protein with high sequence simil ...
... epidermis, although this particular ®nding was interpreted as an unspeci®c competition with the trichome-promoting factor GL1 (Wada et al., 1997). In this work, we report the positional cloning and molecular characterization of the TRY gene. TRY encodes a MYB-related protein with high sequence simil ...
Are you your grandmother`s favorite
... male or a female. Thus, the transmission likelihood for any particular X-linked gene is 0.5 inheritance from MGM to mother, and 0.5 from mother to child. Therefore, the likelihood of a grandchild inheriting any particular gene from the MGM is 25 per cent (0.5 ! 0.5 ¼ 0.25). It is worth noting that f ...
... male or a female. Thus, the transmission likelihood for any particular X-linked gene is 0.5 inheritance from MGM to mother, and 0.5 from mother to child. Therefore, the likelihood of a grandchild inheriting any particular gene from the MGM is 25 per cent (0.5 ! 0.5 ¼ 0.25). It is worth noting that f ...
Lac Operon - Faculty Web Pages
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT)
... AmpC β-lactamases are cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, and β-lactamase inhibitor-β-lactam combinations. [1]. The emission of bacteria into th ...
... AmpC β-lactamases are cephalosporinases encoded on the chromosomes of many of the Enterobacteriaceae and a few other organisms, where they mediate resistance to cephalothin, cefazolin, cefoxitin, most penicillins, and β-lactamase inhibitor-β-lactam combinations. [1]. The emission of bacteria into th ...
Bacterial Gene Expression—Lac Operon
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
... Study Guide/Outline—Bacterial Gene Regulation Bacterial Gene Regulation • What is an operon? How is it different from a eukaryotic gene? • In the lac operon, what cellular or environmental conditions must exist in order for the (WT) lac operon to express its genes? How do these environmental conditi ...
Charcot-Marie
... genes responsible for CMT, not all of the genes associated with CMT have yet been identified. This means that the electrical test (nerve conduction studies) is still often very useful in making the diagnosis. An exception is when there is a clear family history of autosomal dominant inheritance (see ...
... genes responsible for CMT, not all of the genes associated with CMT have yet been identified. This means that the electrical test (nerve conduction studies) is still often very useful in making the diagnosis. An exception is when there is a clear family history of autosomal dominant inheritance (see ...
Parents AUTOSOMAL RECESSIVE: one parent affected
... has a child with the same condition, their unaffected partner must be a carrier for a mutation at the same gene locus. This is rare if the partner is unrelated and from the general population. • Where a partner is a carrier for the same recessive disorder, the risk to a child of having the condition ...
... has a child with the same condition, their unaffected partner must be a carrier for a mutation at the same gene locus. This is rare if the partner is unrelated and from the general population. • Where a partner is a carrier for the same recessive disorder, the risk to a child of having the condition ...
chicken.db - Bioconductor
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
... indicates the chromosome. Due to inconsistencies that may exist at the time the object was built, these vectors may contain more than one chromosome and/or location. If the chromosomal location is unknown, the vector will contain an NA. Chromosomal locations on both the sense and antisense strands a ...
C. neoformans
... N2 nematodes were fed on lawns of C. neoformans and then at different time-points transferred to lawns of non-pathogenic cryptococci. All nematodes that survived transfer were rescued, regained normal non-distended anatomy and no C. neoformans yeast cells could be cultured followed “grinding” of the ...
... N2 nematodes were fed on lawns of C. neoformans and then at different time-points transferred to lawns of non-pathogenic cryptococci. All nematodes that survived transfer were rescued, regained normal non-distended anatomy and no C. neoformans yeast cells could be cultured followed “grinding” of the ...
- Zurich Open Repository and Archive
... complementing a rice sgr mutant with rice SGR gene exhibiting a 6-bp-insertion, it was concluded that the analogous mutation present in Mendel’s green pea SGR gene abolished SGR function (Sato et al., 2007). The Festuca sid mutant is a classical representative of the so-called ‘cosmetic’ type C stay ...
... complementing a rice sgr mutant with rice SGR gene exhibiting a 6-bp-insertion, it was concluded that the analogous mutation present in Mendel’s green pea SGR gene abolished SGR function (Sato et al., 2007). The Festuca sid mutant is a classical representative of the so-called ‘cosmetic’ type C stay ...
Drosophila rhino Encodes a Female-Specific Chromo
... This frequency of fertile revertants is unusually low and may be due to the insertion of both P elements in coding regions (see results). Presumably, perfect double-strand break repair must occur with the wild-type homolog to generate precise excisions and restore a valid open reading frame (Engels ...
... This frequency of fertile revertants is unusually low and may be due to the insertion of both P elements in coding regions (see results). Presumably, perfect double-strand break repair must occur with the wild-type homolog to generate precise excisions and restore a valid open reading frame (Engels ...
Rolling circle transcription on smallest size double stranded DNA
... While DNA is much more stable than its twin RNA owing to the absence of the latter’s ribose 2’ Hydroxyl group it is still very much affected by its surroundings. The major modes of damage to hydrolysed DNA are depurination of the sugar base, deamination of the base itself and general oxidative proce ...
... While DNA is much more stable than its twin RNA owing to the absence of the latter’s ribose 2’ Hydroxyl group it is still very much affected by its surroundings. The major modes of damage to hydrolysed DNA are depurination of the sugar base, deamination of the base itself and general oxidative proce ...
Site-specific recombinase technology
Nearly every human gene has a counterpart in the mouse (regardless of the fact that a minor set of orthologues had to follow species specific selection routes). This made the mouse the major model for elucidating the ways in which our genetic material encodes information. In the late 1980s gene targeting in murine embryonic stem (ES-)cells enabled the transmission of mutations into the mouse germ line and emerged as a novel option to study the genetic basis of regulatory networks as they exist in the genome. Still, classical gene targeting proved to be limited in several ways as gene functions became irreversibly destroyed by the marker gene that had to be introduced for selecting recombinant ES cells. These early steps led to animals in which the mutation was present in all cells of the body from the beginning leading to complex phenotypes and/or early lethality. There was a clear need for methods to restrict these mutations to specific points in development and specific cell types. This dream became reality when groups in the USA were able to introduce bacteriophage and yeast-derived site-specific recombination (SSR-) systems into mammalian cells as well as into the mouse