Winter School on Mathematical Methods in Life
... Reverse Transcription: Retroviruses such as Feline Leukemia, HIV RNA Replication: RNA to RNA transfer in viruses Direct Translation: DNA to Protein (typically in cell fragments) ...
... Reverse Transcription: Retroviruses such as Feline Leukemia, HIV RNA Replication: RNA to RNA transfer in viruses Direct Translation: DNA to Protein (typically in cell fragments) ...
REVIEW A STRUCTURAL APPROACH TO G
... Guanine nucleotide binding proteins regulate a variety of physiological processes, including sensual perception, protein synthesis, hormonal regulation, vesicular and nuclear transport, cell growth and differentiation. They act as molecular mediators, cycling between inactive guanosine diphosphate ( ...
... Guanine nucleotide binding proteins regulate a variety of physiological processes, including sensual perception, protein synthesis, hormonal regulation, vesicular and nuclear transport, cell growth and differentiation. They act as molecular mediators, cycling between inactive guanosine diphosphate ( ...
UtroUp is a novel six zinc finger artificial transcription factor that
... the mouse model of DMD (mdx) and in the dystrophindeficient dog ameliorates the pathology, the huge size of the utrophin gene is a critical disadvantage [10]. Therefore, studies developing natural or synthetic small molecules that upregulate utrophin could accelerate the clinical translation process ...
... the mouse model of DMD (mdx) and in the dystrophindeficient dog ameliorates the pathology, the huge size of the utrophin gene is a critical disadvantage [10]. Therefore, studies developing natural or synthetic small molecules that upregulate utrophin could accelerate the clinical translation process ...
Centromere dynamics
... alternative hypothesis that the centromere adopts a unique shape and/or structure that is conserved throughout phylogeny (see below). This structure could be the basis for epigenetic specification of centromere. A study from the pathogenic yeast reveals that pre-existing centromeres remain functiona ...
... alternative hypothesis that the centromere adopts a unique shape and/or structure that is conserved throughout phylogeny (see below). This structure could be the basis for epigenetic specification of centromere. A study from the pathogenic yeast reveals that pre-existing centromeres remain functiona ...
Proposal - people.vcu.edu
... There is a sufficient amount of evidence to support the view that the HIFs’ are ubiquitous, instantaneously up-regulated upon hypoxia, and short-lived when sufficient oxygen is reestablished. That being said, however, there is not much evidence as to how the absence of one HIF alpha sub unit affects ...
... There is a sufficient amount of evidence to support the view that the HIFs’ are ubiquitous, instantaneously up-regulated upon hypoxia, and short-lived when sufficient oxygen is reestablished. That being said, however, there is not much evidence as to how the absence of one HIF alpha sub unit affects ...
Predicting TF affinities to Promoters of tissue specific genes
... The RNA polymerase II holoenzyme is a multi protein complex that consists of the actual enzyme and several associated basal TFs which are required for proper binding to core promoters and subsequently for initiating transcription (Hahn 2004, Butler et al., 2002). Several sequence motifs found in ty ...
... The RNA polymerase II holoenzyme is a multi protein complex that consists of the actual enzyme and several associated basal TFs which are required for proper binding to core promoters and subsequently for initiating transcription (Hahn 2004, Butler et al., 2002). Several sequence motifs found in ty ...
Gene Section PKD1 (protein kinase D1) Atlas of Genetics and Cytogenetics
... Waldron RT, Rozengurt E. Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain. J ...
... Waldron RT, Rozengurt E. Protein kinase C phosphorylates protein kinase D activation loop Ser744 and Ser748 and releases autoinhibition by the pleckstrin homology domain. J ...
A systematic approach to reconstructing transcription networks in Saccharomyces cerevisiae.
... other annotation information, such as protein–protein interaction and the hierarchy of known signaling pathways, obtained from suitable databases. We first identify conserved core regulatory motifs in a wide range of microarray experiments by using the REDUCER algorithm recently proposed by Bussemak ...
... other annotation information, such as protein–protein interaction and the hierarchy of known signaling pathways, obtained from suitable databases. We first identify conserved core regulatory motifs in a wide range of microarray experiments by using the REDUCER algorithm recently proposed by Bussemak ...
A glucose-responsive transcription factor that regulates
... a high-carbohydrate diet and shown to consist of a single polypeptide with an apparent molecular mass of 100 kDa. The amino acid sequences of four peptides generated by tryptic digestion were determined. Each peptide was found to match the Williams–Beuren syndrome critical region 14 protein (WBSCR14 ...
... a high-carbohydrate diet and shown to consist of a single polypeptide with an apparent molecular mass of 100 kDa. The amino acid sequences of four peptides generated by tryptic digestion were determined. Each peptide was found to match the Williams–Beuren syndrome critical region 14 protein (WBSCR14 ...
Bordoli Discussion Questions
... III. Use the figure-specific questions on p. 2 of the assignment to help guide you through analyzing each figure (do not include answers to these questions in the written assignment). We will be discussing the figures in-depth in class on October 10. See the Table on the next page for the figure you ...
... III. Use the figure-specific questions on p. 2 of the assignment to help guide you through analyzing each figure (do not include answers to these questions in the written assignment). We will be discussing the figures in-depth in class on October 10. See the Table on the next page for the figure you ...
Document
... S. cerevisiae transcriptional regulatory network (Derived from YPD database) R. Milo, et al, "Networkmotifs: simple building blocks of complex networks," Science, vol. 298, pp. 824-7, 2002. M. C. Costanzo, et al, "YPD, PombePD and WormPD: model organism volumes of the BioKnowledge library, an integr ...
... S. cerevisiae transcriptional regulatory network (Derived from YPD database) R. Milo, et al, "Networkmotifs: simple building blocks of complex networks," Science, vol. 298, pp. 824-7, 2002. M. C. Costanzo, et al, "YPD, PombePD and WormPD: model organism volumes of the BioKnowledge library, an integr ...
Drosophila C-terminal Binding Protein Functions as a Context
... therein). Transcriptional repression plays a major role in segmentation gene expression that leads to proper body patterning during early Drosophila development (cf. Refs. 1 and 4). A number of different transcriptional repressors present in the early Drosophila embryo have been shown to encode sequ ...
... therein). Transcriptional repression plays a major role in segmentation gene expression that leads to proper body patterning during early Drosophila development (cf. Refs. 1 and 4). A number of different transcriptional repressors present in the early Drosophila embryo have been shown to encode sequ ...
amp activated protein kinase-á2 protects heart from left ventricular
... synthesis. Activation of AMPK attenuates cardiomyocyte hypertrophy. However, the relative physiological role of AMPK-alpha1 and AMPK-alpha2 in the development of ventricular hypertrophy and congestive heart failure is not clear. We studied the response of AMPK-alpha2 KO mice and AMPK-alpha1 KO mice ...
... synthesis. Activation of AMPK attenuates cardiomyocyte hypertrophy. However, the relative physiological role of AMPK-alpha1 and AMPK-alpha2 in the development of ventricular hypertrophy and congestive heart failure is not clear. We studied the response of AMPK-alpha2 KO mice and AMPK-alpha1 KO mice ...
McHughSpr11
... interactions between proteins, and it relies on the fact that transcription factors have distinct binding and activating domains. These domains do not need to be connected for the transcription factor to function; they simply need to be close together. In order to perform this test, the binding doma ...
... interactions between proteins, and it relies on the fact that transcription factors have distinct binding and activating domains. These domains do not need to be connected for the transcription factor to function; they simply need to be close together. In order to perform this test, the binding doma ...
Detecting Proteins that Interact with the Mbp1 Protein Using Yeast
... interactions between proteins, and it relies on the fact that transcription factors have distinct binding and activating domains. These domains do not need to be connected for the transcription factor to function; they simply need to be close together. In order to perform this test, the binding doma ...
... interactions between proteins, and it relies on the fact that transcription factors have distinct binding and activating domains. These domains do not need to be connected for the transcription factor to function; they simply need to be close together. In order to perform this test, the binding doma ...
single molecule elasticity of dna
... (mechanical denaturation) nanomechanical properties of an individual module or domain (many domains in series lead to huge extensibility) ...
... (mechanical denaturation) nanomechanical properties of an individual module or domain (many domains in series lead to huge extensibility) ...
Number 49, 2002 13 Balázs Csóka , Tamás Zeke
... BimG11 was described as a temperature-sensitive recessive mutation that causes the block of m itosis accompanied with the overphosphorylation of nuclear proteins and distinct morphological changes in Aspergillus nidulans (Doonan and Morris, 1989 Cell 57: 987996). In addition the mutant was defective ...
... BimG11 was described as a temperature-sensitive recessive mutation that causes the block of m itosis accompanied with the overphosphorylation of nuclear proteins and distinct morphological changes in Aspergillus nidulans (Doonan and Morris, 1989 Cell 57: 987996). In addition the mutant was defective ...
Transcription and Translation
... Transcription: chain termination • Most known about bacterial chain termination • Termination is signaled by a sequence that can form a hairpin loop. • The polymerase and the new RNA molecule are released upon formation of the loop. • Review the transcription animation. ...
... Transcription: chain termination • Most known about bacterial chain termination • Termination is signaled by a sequence that can form a hairpin loop. • The polymerase and the new RNA molecule are released upon formation of the loop. • Review the transcription animation. ...
Fundamentals of Nucleic Acid Biochemistry: RNA
... Hormone Regulation: Example Of Short-term Regulation Of Transcription ...
... Hormone Regulation: Example Of Short-term Regulation Of Transcription ...
Why the activity of a gene depends on its neighbors
... middle of the gene or the terminus). Because TNFAIP2 is only 11 kb, it is soon transcribed and detaches; however, it often reattaches to be retranscribed (arrows). After 30 min the pioneer has transcribed 60 kb into SAMD4A, and reattached TNFAIP2 now lies close to the middle of SAMD4A (but no longer ...
... middle of the gene or the terminus). Because TNFAIP2 is only 11 kb, it is soon transcribed and detaches; however, it often reattaches to be retranscribed (arrows). After 30 min the pioneer has transcribed 60 kb into SAMD4A, and reattached TNFAIP2 now lies close to the middle of SAMD4A (but no longer ...
The tale beyond the tail: histone core domain
... (57,58). Crystal structures have been determined for fragments of the human and yeast Dot1p enzymes revealing that they share some structural properties of the SET domain proteins and also have features similar to those found in protein arginine methyltransferases (59,60). Modeling studies suggest t ...
... (57,58). Crystal structures have been determined for fragments of the human and yeast Dot1p enzymes revealing that they share some structural properties of the SET domain proteins and also have features similar to those found in protein arginine methyltransferases (59,60). Modeling studies suggest t ...
Conservation of the three-dimensional structure in non
... consisting of six alpha helices [12]. The number of helices can be altered in different families of globin-like proteins. These helices are not randomly distributed in the protein, but they are oriented following standard helixhelix packing rules in order to form a globular structure. Globin-like fo ...
... consisting of six alpha helices [12]. The number of helices can be altered in different families of globin-like proteins. These helices are not randomly distributed in the protein, but they are oriented following standard helixhelix packing rules in order to form a globular structure. Globin-like fo ...
Histone acetylation and deacetylation
Histone acetylation and deacetylation are the processes by which the lysine residues within the N-terminal tail protruding from the histone core of the nucleosome are acetylated and deacetylated as part of gene regulation. Histone acetylation and deacetylation are essential parts of gene regulation. These reactions are typically catalysed by enzymes with ""histone acetyltransferase"" (HAT) or ""histone deacetylase"" (HDAC) activity. Acetylation is the process where an acetyl functional group is transferred from one molecule (in this case, Acetyl-Coenzyme A) to another. Deacetylation is simply the reverse reaction where an acetyl group is removed from a molecule.Acetylated histones, octameric proteins that organize chromatin into nucleosomes and ultimately higher order structures, represent a type of epigenetic marker within chromatin. Acetylation removes the positive charge on the histones, thereby decreasing the interaction of the N termini of histones with the negatively charged phosphate groups of DNA. As a consequence, the condensed chromatin is transformed into a more relaxed structure that is associated with greater levels of gene transcription. This relaxation can be reversed by HDAC activity. Relaxed, transcriptionally active DNA is referred to as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation can be brought about by processes including deacetylation and methylation; the action of methylation is indirect and has no effect upon charge.